{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:21:16Z","timestamp":1787498476664,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific &amp; Industrial Research","doi-asserted-by":"publisher","award":["09\/1150(0017)\/2020-EMR-1"],"award-info":[{"award-number":["09\/1150(0017)\/2020-EMR-1"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research, South Africa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science &amp; Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR46380\/AAQ\/1\/863\/2022"],"award-info":[{"award-number":["BT\/PR46380\/AAQ\/1\/863\/2022"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.tox.2025.154296","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T19:57:19Z","timestamp":1759435039000},"page":"154296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Chronic oral exposure to chlorpyrifos disrupts hepatic epigenetic regulation and induces metabolic dysfunction in mice"],"prefix":"10.1016","volume":"519","author":[{"given":"Meenakshi","family":"Mansukhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-8821","authenticated-orcid":false,"given":"Nirmalya","family":"Ganguli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subeer S.","family":"Majumdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6811-3773","authenticated-orcid":false,"given":"Souvik","family":"Sen Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2025.154296_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115122","article-title":"Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2\/HO-1 axis","volume":"262","author":"Abdel-Naim","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2025.154296_bib2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.chemosphere.2012.05.059","article-title":"Chlorpyrifos acute exposure induces hyperglycemia and hyperlipidemia in rats","volume":"89","author":"Acker","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2025.154296_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/bcpt.12878","article-title":"Understanding epigenetic effects of endocrine disrupting chemicals: from mechanisms to novel test methods","volume":"122","author":"Alavian-Ghavanini","year":"2018","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2025.154296_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.151287","article-title":"Toxicological impact of chronic chlorpyrifos exposure: DNA damage and epigenetic alterations induces neoplastic transformation of liver cells","volume":"746","author":"Balakrishnan","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2025.154296_bib5","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3389\/fimmu.2019.02014","article-title":"Interleukin-1 family cytokines: keystones in liver inflammatory diseases","volume":"10","author":"Barbier","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tox.2025.154296_bib6","doi-asserted-by":"crossref","first-page":"12455","DOI":"10.1021\/acs.jafc.8b03407","article-title":"Chlorpyrifos induction of testicular-cell apoptosis through generation of reactive oxygen species and phosphorylation of AMPK","volume":"66","author":"Chen","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tox.2025.154296_bib7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-Step method of RNA isolation by acid guanidinium thiocyanate\u2013phenol\u2013chloroform extraction","volume":"162","author":"Chomczyskni","year":"1987","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.tox.2025.154296_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/MOG.0b013e32834e7b4b","article-title":"Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression","volume":"28","author":"Corbin","year":"2012","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.tox.2025.154296_bib9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.scitotenv.2015.11.162","article-title":"Hepatotoxicity and nephrotoxicity induced by the chlorpyrifos and chlorpyrifos-methyl metabolite, 3,5,6-trichloro-2-pyridinol, in orally exposed mice","volume":"544","author":"Deng","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154296_bib10","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3390\/nu12061731","article-title":"Choline, neurological development and brain function: a systematic review focusing on the first 1000 days","volume":"12","author":"Derbyshire","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.tox.2025.154296_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/10408440802272158","article-title":"Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment","volume":"38","author":"Eaton","year":"2008","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tox.2025.154296_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171711","article-title":"Exposure to the environmental pollutant chlorpyrifos induces hepatic toxicity through activation of the JAK\/STAT and MAPK pathways","volume":"928","author":"Fu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154296_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1289\/ehp.9087245","article-title":"Mechanism of action of organophosphorus and carbamate insecticides","volume":"87","author":"Fukuto","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2025.154296_bib14","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/hep.21071","article-title":"Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation","volume":"43","author":"Garc\u00eda-Ayll\u00f3n","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2025.154296_bib15","doi-asserted-by":"crossref","first-page":"18566","DOI":"10.1007\/s11356-024-32201-8","article-title":"Grape seed extract prevents chlorpyrifos-induced toxicity in rat liver through the modulation of phase I detoxification pathway","volume":"31","author":"Ghrir","year":"2024","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tox.2025.154296_bib16","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399411002110","article-title":"Molecular mechanisms underlying chemical liver injury","volume":"14","author":"Gu","year":"2012","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.tox.2025.154296_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.gde.2014.06.005","article-title":"Environmentally induced epigenetic transgenerational inheritance of Male infertility","volume":"26","author":"Guerrero-Bosagna","year":"2014","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.tox.2025.154296_bib18","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2022.06.004","article-title":"The role of glutathione Peroxidase-1 in health and disease","volume":"188","author":"Handy","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tox.2025.154296_bib19","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1080\/07391102.2021.1875885","article-title":"Disruption of androgen receptor signaling by chlorpyrifos (CPF) and its environmental degradation products: a structural insight","volume":"40","author":"Hazarika","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.tox.2025.154296_bib20","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/carcin\/21.5.983","article-title":"Dietary choline restriction causes complex I dysfunction and increased H2O2 generation in liver mitochondria","volume":"21","author":"Hensley","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tox.2025.154296_bib21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S2213-8587(20)30129-7","article-title":"Endocrine-disrupting chemicals: implications for human health","volume":"8","author":"Kahn","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.tox.2025.154296_bib22","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/hep.28563","article-title":"DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration","volume":"64","author":"Kaji","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2025.154296_bib23","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/annweh\/wxaa124","article-title":"Disruption of the diurnal cortisol hormone pattern by pesticide use in a longitudinal study of farmers in Thailand","volume":"65","author":"Kongtip","year":"2021","journal-title":"Ann. Work Expo. Heal"},{"key":"10.1016\/j.tox.2025.154296_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0003-2697(62)90014-3","article-title":"A method for the colorimetric estimation of glycogen with lodine","volume":"4","author":"Krisman","year":"1962","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.tox.2025.154296_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s12276-022-00919-5","article-title":"Dnmt1\/Tet2-mediated changes in cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Ppar\u03b3-CD36 axis","volume":"55","author":"Lee","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.tox.2025.154296_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0378-4274(95)80006-Y","article-title":"Paraoxonase protects against chlorpyrifos toxicity in mice","volume":"76","author":"Li","year":"1995","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2025.154296_bib27","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1111\/liv.15461","article-title":"Organophosphate pesticide exposure and biomarkers of liver injury\/liver function","volume":"42","author":"Li","year":"2022","journal-title":"Liver Int"},{"key":"10.1016\/j.tox.2025.154296_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-019-0635-4","article-title":"Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance through impacting gut and gut microbiota","volume":"7","author":"Liang","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.tox.2025.154296_bib29","article-title":"Chlorpyrifos induces neuronal cell death via both oxidative stress and akt activation downstream-regulated CHOP-triggered apoptotic pathways","volume":"Vitr. 86","author":"Lin","year":"2023","journal-title":"Toxicol"},{"key":"10.1016\/j.tox.2025.154296_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrg.2017.80","article-title":"The DNA methyltransferase family: a versatile toolkit for epigenetic regulation","volume":"19","author":"Lyko","year":"2017","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.tox.2025.154296_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF03160916","article-title":"Weight gain associated with chronic exposure to chlorpyrifos in rats","volume":"3","author":"Meggs","year":"2007","journal-title":"J. Med. Toxicol."},{"key":"10.1016\/j.tox.2025.154296_bib32","first-page":"339","article-title":"Choline\u2019s role in maintaining liver function: new evidence for epigenetic mechanisms","volume":"16","author":"Mehedint","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.tox.2025.154296_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114933","article-title":"Chlorpyrifos induces cytotoxicity via oxidative stress and mitochondrial dysfunction in HepG2 cells","volume":"192","author":"Montanar\u00ed","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2025.154296_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109022","article-title":"Chlorpyrifos modulates the mouse gut microbiota and metabolic activity","volume":"192","author":"Nichols","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2025.154296_bib35","doi-asserted-by":"crossref","first-page":"20859","DOI":"10.1007\/s11356-017-9617-x","article-title":"Low doses of chlorpyrifos interfere with spermatogenesis of rats through reduction of sex hormones","volume":"24","author":"Peiris","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.tox.2025.154296_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043777","article-title":"Expression of human paraoxonase 1 decreases superoxide levels and alters bacterial colonization in the gut of drosophila melanogaster","volume":"7","author":"Pezzulo","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2025.154296_bib37","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1073\/pnas.1203396109","article-title":"Brain anomalies in children exposed prenatally to a common organophosphate pesticide","volume":"109","author":"Rauh","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2025.154296_bib38","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tox.2025.154296_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.117543","article-title":"An updated status of currently used pesticides in India: human dietary exposure from an Indian food basket","volume":"242","author":"Soman","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2025.154296_bib40","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00204-024-03934-9","article-title":"Involvement of gut microbiota in chlorpyrifos-induced subchronic toxicity in mice","volume":"99","author":"Song","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2025.154296_bib41","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5563759","article-title":"A common feature of pesticides: oxidative Stress\u2014The role of oxidative stress in Pesticide-Induced toxicity","volume":"2022","author":"Sule","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tox.2025.154296_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114470","article-title":"The role of the gut microbiota in depressive-like behavior induced by chlorpyrifos in mice","volume":"250","author":"Sun","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2025.154296_bib43","article-title":"Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes","volume":"29","author":"Tang","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2025.154296_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2025.154296_bib45","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3389\/fimmu.2019.01545","article-title":"A General Introduction to Glucocorticoid Biology","volume":"10","author":"Timmermans","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.tox.2025.154296_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142649","article-title":"A comprehensive review on chlorpyrifos toxicity with special reference to endocrine disruption: evidence of mechanisms, exposures and mitigation strategies","volume":"755","author":"Ubaid ur Rahman","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154296_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsbmb.2015.10.010","article-title":"Pesticide chlorpyrifos acts as an endocrine disruptor in adult rats causing changes in mammary gland and hormonal balance","volume":"156","author":"Ventura","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"12","key":"10.1016\/j.tox.2025.154296_bib48","first-page":"1","article-title":"The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue","volume":"121","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2025.154296_bib49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.toxlet.2025.03.011","article-title":"Dose-dependent effects of chlorpyrifos on liver injury, intestinal dysbiosis, and metabolic perturbations in C57BL\/6J mice","volume":"407","author":"Wei","year":"2025","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2025.154296_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130417","article-title":"Chlorpyrifos pesticide promotes oxidative stress and increases inflammatory states in BV-2 microglial cells: a role in neuroinflammation","volume":"278","author":"Weis","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2025.154296_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph191912209","article-title":"Chlorpyrifos occurrence and toxicological risk assessment: a review","volume":"19","author":"Wo\u0142ejko","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tox.2025.154296_bib52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11103-012-9885-2","article-title":"miRDeepFinder: a miRNA analysis tool for deep sequencing of plant small RNAs","volume":"80","author":"Xie","year":"2012","journal-title":"Plant Mol. Biol."},{"key":"10.1016\/j.tox.2025.154296_bib53","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/toxres\/tfaa108","article-title":"Effects of chlorpyrifos exposure on liver inflammation and intestinal flora structure in mice","volume":"10","author":"Zhang","year":"2021","journal-title":"Toxicol. Res. (Camb. )."},{"key":"10.1016\/j.tox.2025.154296_bib54","first-page":"1","article-title":"TET (Ten-eleven translocation) family proteins: structure, biological functions and applications","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.tox.2025.154296_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117010","article-title":"Chronic chlorpyrifos exposure induces oxidative stress, apoptosis and immune dysfunction in largemouth bass (Micropterus salmoides)","volume":"282","author":"Zhao","year":"2021","journal-title":"Environ. Pollut."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25002550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25002550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:13:11Z","timestamp":1773148391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X25002550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":55,"alternative-id":["S0300483X25002550"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2025.154296","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic oral exposure to chlorpyrifos disrupts hepatic epigenetic regulation and induces metabolic dysfunction in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2025.154296","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154296"}}