{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:09:08Z","timestamp":1777867748605,"version":"3.51.4"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.tox.2026.154428","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:03:40Z","timestamp":1771488220000},"page":"154428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cl-PFESA disrupts thyroid hormone secretion in human thyrocytes and nonmonotonic effects of iodide co-exposure"],"prefix":"10.1016","volume":"522","author":[{"given":"Mengying","family":"Teng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhui","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7549-2446","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-4811","authenticated-orcid":false,"given":"Melvin E.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8678-7013","authenticated-orcid":false,"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tox.2026.154428_bib1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s40618-021-01660-y","article-title":"Gene expression profile in functioning and non-functioning nodules of autonomous multinodular goiter from an area of iodine deficiency: unexpected common characteristics between the two entities","volume":"45","author":"Agretti","year":"2022","journal-title":"J. Endocrinol. Invest"},{"key":"10.1016\/j.tox.2026.154428_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2019.114907","article-title":"Removal of F-53B as PFOS alternative in chrome plating wastewater by UV\/Sulfite reduction","volume":"163","author":"Bao","year":"2019","journal-title":"Water Res"},{"issue":"45","key":"10.1016\/j.tox.2026.154428_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj1561","article-title":"DNA methylation at a nutritionally sensitive region of the PAX8 gene is associated with thyroid volume and function in Gambian children","volume":"7","author":"Candler","year":"2021","journal-title":"Sci. Adv."},{"issue":"9","key":"10.1016\/j.tox.2026.154428_bib4","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1210\/jcem.86.9.7823","article-title":"Ca(2+)\/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids","volume":"86","author":"Cardoso","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2026.154428_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.mce.2017.01.038","article-title":"Thyroid hormone biosynthesis and release","volume":"458","author":"Carvalho","year":"2017","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.tox.2026.154428_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2025.100600","article-title":"An integrated approach to assess exposure and early health effects in human populations exposed to micro- and nanoplastics","volume":"40","author":"Catalan","year":"2025","journal-title":"NanoImpact"},{"issue":"14","key":"10.1016\/j.tox.2026.154428_bib7","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1158\/0008-5472.CAN-08-0058","article-title":"PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma","volume":"68","author":"Chen","year":"2008","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.tox.2026.154428_bib8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/cpt.1664","article-title":"Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities","volume":"107","author":"Chenoweth","year":"2020","journal-title":"Clin. Pharm. Ther."},{"issue":"6","key":"10.1016\/j.tox.2026.154428_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41574-019-0184-8","article-title":"The role of thyroglobulin in thyroid hormonogenesis","volume":"15","author":"Citterio","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.tox.2026.154428_bib10","doi-asserted-by":"crossref","first-page":"46001","DOI":"10.1289\/EHP10092","article-title":"Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis","volume":"130","author":"Costello","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2026.154428_bib11","article-title":"Mixture toxicity revisited: A translational review of experimental evidence from animal models to human health risk assessment","volume":"520","author":"Domingo","year":"2025","journal-title":"Toxicology"},{"issue":"8","key":"10.1016\/j.tox.2026.154428_bib12","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model"},{"issue":"8","key":"10.1016\/j.tox.2026.154428_bib13","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1210\/endo.140.8.6893","article-title":"Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium\/iodide symporter messenger ribonucleic acid and protein","volume":"140","author":"Eng","year":"1999","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.tox.2026.154428_bib14","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1017\/S0007114523000326","article-title":"Urinary iodine excretion and optimal time point for sampling when estimating 24-h urinary iodine","volume":"130","author":"Eriksson","year":"2023","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.tox.2026.154428_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171151","article-title":"Environmental occurrence, bioaccumulation and human risks of emerging fluoroalkylether substances: Insight into security of alternatives","volume":"922","author":"Feng","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.tox.2026.154428_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062849","article-title":"New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells","volume":"8","author":"Fernandez","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.tox.2026.154428_bib17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nprot.2016.051","article-title":"Computational protein-ligand docking and virtual drug screening with the AutoDock suite","volume":"11","author":"Forli","year":"2016","journal-title":"Nat. Protoc."},{"issue":"7","key":"10.1016\/j.tox.2026.154428_bib18","doi-asserted-by":"crossref","first-page":"77004","DOI":"10.1289\/EHP7169","article-title":"A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish (Danio rerio)","volume":"129","author":"Han","year":"2021","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.tox.2026.154428_bib19","doi-asserted-by":"crossref","DOI":"10.1530\/EC-22-0236","article-title":"High concentration of estradiol has a negative correlation with free thyroxine during the second trimester of pregnancy","volume":"11","author":"He","year":"2022","journal-title":"Endocr. Connect"},{"issue":"11","key":"10.1016\/j.tox.2026.154428_bib20","doi-asserted-by":"crossref","DOI":"10.1289\/EHP535","article-title":"A Prospective Study of Environmental Exposures and Early Biomarkers in Autism Spectrum Disorder: Design, Protocols, and Preliminary Data from the MARBLES Study","volume":"126","author":"Hertz-Picciotto","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2026.154428_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mce.2016.11.012","article-title":"Regenerative therapy for hypothyroidism: Mechanisms and possibilities","volume":"445","author":"Hollenberg","year":"2017","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.tox.2026.154428_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108582","article-title":"Evidence of promoting effects of 6:2 Cl-PFESA on hepatocellular carcinoma proliferation in humans: An ideal alternative for PFOS in terms of environmental health?","volume":"186","author":"Hong","year":"2024","journal-title":"Environ. Int"},{"issue":"3","key":"10.1016\/j.tox.2026.154428_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/toxics8030054","article-title":"Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats","volume":"8","author":"Hong","year":"2020","journal-title":"Toxics"},{"issue":"6","key":"10.1016\/j.tox.2026.154428_bib24","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1172\/JCI108734","article-title":"Triiodothyronine, thyroxine, and iodine in purified thyroglobulin from patients with Graves' disease","volume":"59","author":"Izumi","year":"1977","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.tox.2026.154428_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.157824","article-title":"Seco-neokadsuranic acid A antagonizes SH3BP1 to suppress hepatocellular carcinoma progression through PPAR pathway activation","volume":"151","author":"Jia","year":"2026","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.tox.2026.154428_bib26","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/cen.13421","article-title":"The application of serum iodine in assessing individual iodine status","volume":"87","author":"Jin","year":"2017","journal-title":"Clin. Endocrinol. (Oxf. )"},{"key":"10.1016\/j.tox.2026.154428_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.992883","article-title":"Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion","volume":"13","author":"Jing","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"6","key":"10.1016\/j.tox.2026.154428_bib28","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1089\/thy.2022.0694","article-title":"Thyrotropin Receptor Antagonism by a Novel Small Molecule: Preclinical In Vitro Observations","volume":"33","author":"Kahaly","year":"2023","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.tox.2026.154428_bib29","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1038\/s41467-020-15955-w","article-title":"Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas","volume":"11","author":"Krishnan","year":"2020","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.tox.2026.154428_bib30","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvaa146","article-title":"Reevaluation of the Effect of Iodine on Thyroid Cell Survival and Function Using PCCL3 and Nthy-ori 3-1 Cells","volume":"4","author":"Kurashige","year":"2020","journal-title":"J. Endocr. Soc."},{"issue":"2","key":"10.1016\/j.tox.2026.154428_bib31","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0014-5793(84)81327-7","article-title":"Forskolin stimulation of thyroid secretion of T4 and T3","volume":"170","author":"Laurberg","year":"1984","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tox.2026.154428_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2025.154308","article-title":"Human proteome-wide molecular interaction analysis based on AlphaFold3 to evaluate toxicity between PFOS and its alternative F-53B","volume":"519","author":"Li","year":"2026","journal-title":"Toxicology"},{"issue":"28","key":"10.1016\/j.tox.2026.154428_bib33","doi-asserted-by":"crossref","first-page":"14249","DOI":"10.1021\/acs.est.5c02319","article-title":"6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson's Disease-like Disorders in C. elegans at Low Concentrations","volume":"59","author":"Li","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2026.154428_bib34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.scitotenv.2017.04.158","article-title":"Fluoride and iodine enrichment in groundwater of North China Plain: Evidences from speciation analysis and geochemical modeling","volume":"598","author":"Li","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2026.154428_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129580","article-title":"Photodegradation of per- and polyfluoroalkyl substances in water: A review of fundamentals and applications","volume":"439","author":"Liu","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.tox.2026.154428_bib36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.envint.2019.03.035","article-title":"Structure-based investigation on the association between perfluoroalkyl acids exposure and both gestational diabetes mellitus and glucose homeostasis in pregnant women","volume":"127","author":"Liu","year":"2019","journal-title":"Environ. Int"},{"issue":"31","key":"10.1016\/j.tox.2026.154428_bib37","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1021\/acs.est.3c03952","article-title":"6:2 Chlorinated Polyfluoroalkyl Ether Sulfonates Exert Stronger Thyroid Homeostasis Disruptive Effects in Newborns than Perfluorooctanesulfonate: Evidence Based on Bayesian Benchmark Dose Values from a Population Study","volume":"57","author":"Liu","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2026.154428_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.654569","article-title":"Unraveling the Complex Interplay Between Transcription Factors and Signaling Molecules in Thyroid Differentiation and Function, From Embryos to Adults","volume":"12","author":"Lopez-Marquez","year":"2021","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"Pt A","key":"10.1016\/j.tox.2026.154428_bib39","article-title":"Plant rhizosphere defense system respond differently to emerging polyfluoroalkyl substances F-53B and PFOS stress","volume":"443","author":"Lu","year":"2023","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.tox.2026.154428_bib40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13148-021-01109-2","article-title":"Genome\u2011wide profiling of DNA methylation and gene expression unravel the epigenetic landscape in diabetes-related hypothyroidism","volume":"13","author":"Luo","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.tox.2026.154428_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137114","article-title":"Co-exposure to polystyrene nanoplastics and F-53B induces vascular endothelial cell pyroptosis through the NF-kappaB\/NLRP3 pathway","volume":"486","author":"Lv","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.tox.2026.154428_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/srep36805","article-title":"Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring","volume":"6","author":"Lv","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tox.2026.154428_bib43","doi-asserted-by":"crossref","first-page":"7354","DOI":"10.1038\/s41467-022-35042-6","article-title":"Deficiency and excess of groundwater iodine and their health associations","volume":"13","author":"Ma","year":"2022","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.tox.2026.154428_bib44","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1289\/ehp.10486","article-title":"Association of thyroid hormone concentrations with levels of organochlorine compounds in cord blood of neonates","volume":"115","author":"Maervoet","year":"2007","journal-title":"Environ. Health Perspect."},{"issue":"7","key":"10.1016\/j.tox.2026.154428_bib45","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1089\/thy.2019.0046","article-title":"Novel Sodium\/Iodide Symporter Compound Heterozygous Pathogenic Variants Causing Dyshormonogenic Congenital Hypothyroidism","volume":"29","author":"Martin","year":"2019","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.tox.2026.154428_bib46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1476-069X-12-53","article-title":"Dispelling urban myths about default uncertainty factors in chemical risk assessment--sufficient protection against mixture effects?","volume":"12","author":"Martin","year":"2013","journal-title":"Environ. Health"},{"issue":"27","key":"10.1016\/j.tox.2026.154428_bib47","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1002\/anie.201601116","article-title":"Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones","volume":"55","author":"Mondal","year":"2016","journal-title":"Angew. Chem. Int Ed. Engl."},{"issue":"1","key":"10.1016\/j.tox.2026.154428_bib48","doi-asserted-by":"crossref","DOI":"10.1530\/ETJ-23-0244","article-title":"The ETA-ESE statement on the European Chemicals Agency opinion on iodine as an endocrine disruptor","volume":"13","author":"Moreno-Reyes","year":"2024","journal-title":"Eur. Thyroid J."},{"issue":"12","key":"10.1016\/j.tox.2026.154428_bib49","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1089\/thy.2016.0323","article-title":"Thyrotropin and Insulin-Like Growth Factor 1 Receptor Crosstalk Upregulates Sodium-Iodide Symporter Expression in Primary Cultures of Human Thyrocytes","volume":"26","author":"Morgan","year":"2016","journal-title":"Thyroid"},{"issue":"2","key":"10.1016\/j.tox.2026.154428_bib50","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physrev.00030.2013","article-title":"Thyroid hormone regulation of metabolism","volume":"94","author":"Mullur","year":"2014","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.tox.2026.154428_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0968-0004(99)01535-2","article-title":"Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation","volume":"25","author":"Orlando","year":"2000","journal-title":"Trends Biochem Sci."},{"key":"10.1016\/j.tox.2026.154428_bib52","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.envpol.2019.07.021","article-title":"Subchronic exposure of environmentally relevant concentrations of F-53B in mice resulted in gut barrier dysfunction and colonic inflammation in a sex-independent manner","volume":"253","author":"Pan","year":"2019","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.tox.2026.154428_bib53","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0014-4827(03)00341-0","article-title":"Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide","volume":"290","author":"Pi","year":"2003","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.tox.2026.154428_bib54","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/690704","article-title":"Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto's Thyroiditis","volume":"2014","author":"Poplawska-Kita","year":"2014","journal-title":"Int J. Endocrinol."},{"key":"10.1016\/j.tox.2026.154428_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123971","article-title":"Mixed exposure to haloacetaldehyde disinfection by-products exacerbates lipid aggregation in the liver of mice","volume":"350","author":"Qiu","year":"2024","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.tox.2026.154428_bib56","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nbt936","article-title":"Rational siRNA design for RNA interference","volume":"22","author":"Reynolds","year":"2004","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.tox.2026.154428_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-65746-4","article-title":"Unravelling the magnitude and drivers of PFAS trophic magnification: a meta-analysis","volume":"16","author":"Ricolfi","year":"2025","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.tox.2026.154428_bib58","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1172\/JCI107474","article-title":"Suppression of pituitary TSH secretion in the patient with a hyperfunctioning thyroid nodule","volume":"52","author":"Ridgway","year":"1973","journal-title":"J. Clin. Invest"},{"issue":"11","key":"10.1016\/j.tox.2026.154428_bib59","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.1021\/acs.est.5b01010","article-title":"Identification of Novel Polyfluorinated Ether Sulfonates as PFOS Alternatives in Municipal Sewage Sludge in China","volume":"49","author":"Ruan","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.tox.2026.154428_bib60","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-029471","article-title":"Three contaminated sites in southern Italy. The Neonatal Environment and Health Outcomes cohort: protocol for a longitudinal birth cohort study","volume":"9","author":"Ruggieri","year":"2019","journal-title":"BMJ Open"},{"issue":"Pt B","key":"10.1016\/j.tox.2026.154428_bib61","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.envpol.2018.09.120","article-title":"Two-generational reproductive toxicity assessment of 6:2 chlorinated polyfluorinated ether sulfonate (F-53B, a novel alternative to perfluorooctane sulfonate) in zebrafish","volume":"243","author":"Shi","year":"2018","journal-title":"Environ. Pollut."},{"issue":"24","key":"10.1016\/j.tox.2026.154428_bib62","doi-asserted-by":"crossref","first-page":"14156","DOI":"10.1021\/acs.est.5b04299","article-title":"Tissue Distribution and Whole Body Burden of the Chlorinated Polyfluoroalkyl Ether Sulfonic Acid F-53B in Crucian Carp (Carassius carassius): Evidence for a Highly Bioaccumulative Contaminant of Emerging Concern","volume":"49","author":"Shi","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.tox.2026.154428_bib63","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/toxsci\/kfaf060","article-title":"Interference with systemic negative feedback as a potential mechanism for nonmonotonic dose-responses of endocrine-disrupting chemicals","volume":"206","author":"Shi","year":"2025","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.tox.2026.154428_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147048","article-title":"Hypothyroidism Side Effect in Patients Treated with Sunitinib or Sorafenib: Clinical and Structural Analyses","volume":"11","author":"Shu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2026.154428_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133919","article-title":"Angiotoxic effects of chlorinated polyfluorinated ether sulfonate, a novel perfluorooctane sulfonate substitute, in vivo and in vitro","volume":"469","author":"Tan","year":"2024","journal-title":"J. Hazard Mater."},{"issue":"20","key":"10.1016\/j.tox.2026.154428_bib66","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1016\/S0021-9258(18)99701-2","article-title":"Conversion of iodate to iodide in vivo and in vitro","volume":"241","author":"Taurog","year":"1966","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2026.154428_bib67","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.scitotenv.2018.05.313","article-title":"Global distribution potential and regional environmental risk of F-53B","volume":"640-641","author":"Ti","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.tox.2026.154428_bib68","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"22","key":"10.1016\/j.tox.2026.154428_bib69","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1021\/acs.est.9b03820","article-title":"Bioconcentration and Metabolic Effects of Emerging PFOS Alternatives in Developing Zebrafish","volume":"53","author":"Tu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2026.154428_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105694","article-title":"Polybrominated diphenyl ether (PBDE) and poly- and perfluoroalkyl substance (PFAS) exposures during pregnancy and maternal depression","volume":"139","author":"Vuong","year":"2020","journal-title":"Environ. Int"},{"key":"10.1016\/j.tox.2026.154428_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108687","article-title":"Per- and polyfluoroalkyl substances induce lipid metabolic impairment in fish: Integration on field investigation and laboratory study","volume":"187","author":"Wang","year":"2024","journal-title":"Environ. Int"},{"issue":"3","key":"10.1016\/j.tox.2026.154428_bib72","first-page":"1678","article-title":"Combined exposure to 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone and microsytin-LR increases genotoxicity in Chinese hamster ovary cells through oxidative stress","volume":"47","author":"Wang","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"9","key":"10.1016\/j.tox.2026.154428_bib73","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1021\/es305133k","article-title":"Organic extract contaminants from drinking water activate Nrf2-mediated antioxidant response in a human cell line","volume":"47","author":"Wang","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.tox.2026.154428_bib74","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1210\/endo-42-6-468","article-title":"Plasma inorganic iodide, a chemical regulator of normal thyroid function","volume":"42","author":"Wolff","year":"1948","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2026.154428_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107779","article-title":"Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: A nationally representative cross-sectional study","volume":"172","author":"Wu","year":"2023","journal-title":"Environ. Int"},{"key":"10.1016\/j.tox.2026.154428_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111290","article-title":"6:2 chlorinated polyfluoroalkyl ether sulfonate (F-53B) induced nephrotoxicity associated with oxidative stress, inflammation and fibrosis in mice","volume":"405","author":"Wu","year":"2025","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.tox.2026.154428_bib77","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ecoenv.2019.01.010","article-title":"Toxicokinetics and toxic effects of a Chinese PFOS alternative F-53B in adult zebrafish","volume":"171","author":"Wu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2026.154428_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1240752","article-title":"Relationship between gut microbiota and thyroid function: a two-sample Mendelian randomization study","volume":"14","author":"Xie","year":"2023","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tox.2026.154428_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126527","article-title":"Neurobehavioral response in zebrafish exposed to perfluorooctane sulfonate and its substitutes: Underestimated ecological risks","volume":"379","author":"Xie","year":"2025","journal-title":"Environ. Pollut."},{"issue":"16","key":"10.1016\/j.tox.2026.154428_bib80","doi-asserted-by":"crossref","first-page":"9412","DOI":"10.1021\/acs.est.8b01494","article-title":"Chlorinated Polyfluoroalkylether Sulfonates Exhibit Similar Binding Potency and Activity to Thyroid Hormone Transport Proteins and Nuclear Receptors as Perfluorooctanesulfonate","volume":"52","author":"Xin","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2026.154428_bib81","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.csbj.2015.09.001","article-title":"Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model","volume":"13","author":"Yadav","year":"2015","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"28","key":"10.1016\/j.tox.2026.154428_bib82","doi-asserted-by":"crossref","first-page":"12356","DOI":"10.1021\/acs.est.3c11009","article-title":"Disinfection Byproducts of Haloacetaldehydes Disrupt Hepatic Lipid Metabolism and Induce Lipotoxicity in High-Fat Culture Conditions","volume":"58","author":"Yang","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"42","key":"10.1016\/j.tox.2026.154428_bib83","doi-asserted-by":"crossref","first-page":"22676","DOI":"10.1021\/acs.est.5c05377","article-title":"Toxicity Impacts of Trace-Level of F-53B in Atmospheric Particles: Implications for Low-Exposure Risk Assessment","volume":"59","author":"Yang","year":"2025","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.tox.2026.154428_bib84","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/acs.est.3c07003","article-title":"Structure-Related Thyroid Disrupting Effect of Perfluorooctanesulfonate-like Substances in Zebrafish Larvae","volume":"58","author":"Yi","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2026.154428_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135069","article-title":"Efficient degradation of F-53B as PFOS alternative in water by plasma discharge: Feasibility and mechanism insights","volume":"476","author":"Zhang","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.tox.2026.154428_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178461","article-title":"SHIP1 agonist rosiptor inhibits platelet activation and thrombosis by modulating cAMP\/cGMP and PI3K\/PKC pathway","volume":"1011","author":"Zhang","year":"2026","journal-title":"Eur. J. Pharm."},{"issue":"15","key":"10.1016\/j.tox.2026.154428_bib87","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.7150\/thno.45359","article-title":"Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"issue":"15","key":"10.1016\/j.tox.2026.154428_bib88","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1021\/acs.est.2c08627","article-title":"Thyroid-Disrupting Effects of Exposure to Fipronil and Its Metabolites from Drinking Water Based on Human Thyroid Follicular Epithelial Nthy-ori 3-1 Cell Lines","volume":"57","author":"Zhuang","year":"2023","journal-title":"Environ. Sci. Technol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X26000351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X26000351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:51:06Z","timestamp":1777546266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X26000351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":88,"alternative-id":["S0300483X26000351"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2026.154428","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cl-PFESA disrupts thyroid hormone secretion in human thyrocytes and nonmonotonic effects of iodide co-exposure","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2026.154428","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154428"}}