{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T08:24:45Z","timestamp":1794385485060,"version":"4.9.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304164"],"award-info":[{"award-number":["82304164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tox.2026.154524","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:43:47Z","timestamp":1781019827000},"page":"154524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cadmium exposure activates ferroptosis through downregulated PPAR\u03b3 expression in preeclampsia placenta"],"prefix":"10.1016","volume":"526","author":[{"given":"Xuemeng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiding","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancai","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiru","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.tox.2026.154524_bib1","doi-asserted-by":"crossref","first-page":"47014","DOI":"10.1289\/EHP10825","article-title":"Individual, independent, and joint associations of toxic metals and manganese on hypertensive disorders of pregnancy: results from the mirec canadian pregnancy cohort","volume":"131","author":"Borghese","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2026.154524_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135814","article-title":"Investigating the potential risk of cadmium exposure on seizure severity and anxiety-like behaviors through the ferroptosis pathway in epileptic mice: an integrated multi-omics approach","volume":"480","author":"Chang","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.tox.2026.154524_bib3","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ajog.2015.07.027","article-title":"The association between maternal antioxidant levels in midpregnancy and preeclampsia","volume":"213","author":"Cohen","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.tox.2026.154524_bib4","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.tox.2026.154524_bib5","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/joim.13349","article-title":"The roles of free iron, heme, haemoglobin, and the scavenger proteins haemopexin and alpha-1-microglobulin in preeclampsia and fetal growth restriction","volume":"290","author":"Erlandsson","year":"2021","journal-title":"J. Intern. Med."},{"issue":"10","key":"10.1016\/j.tox.2026.154524_bib6","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1289\/ehp.1204952","article-title":"Mercury, cadmium, and lead levels in human placenta: a systematic review","volume":"120","author":"Esteban-Vasallo","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.tox.2026.154524_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"issue":"21","key":"10.1016\/j.tox.2026.154524_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/cells11213514","article-title":"The potential for placental activation of ppar\u03b3 to improve the angiogenic profile in preeclampsia","volume":"11","author":"Grimaldi","year":"2022","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.tox.2026.154524_bib9","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1161\/HYPERTENSIONAHA.123.21645","article-title":"Rosiglitazone-mediated activation of ppar\u03b3 restores ho1 expression in the human preeclamptic placenta","volume":"80","author":"Grimaldi","year":"2023","journal-title":"Hypertension"},{"issue":"14","key":"10.1016\/j.tox.2026.154524_bib10","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf669","article-title":"Pparg-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts","volume":"53","author":"Guo","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2026.154524_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103179","article-title":"Mitochondrial gpx4 acetylation is involved in cadmium-induced renal cell ferroptosis","volume":"73","author":"Guo","year":"2024","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.tox.2026.154524_bib12","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41467-025-56344-5","article-title":"Palmitoylation-dependent regulation of gpx4 suppresses ferroptosis","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.tox.2026.154524_bib13","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/s42255-025-01313-x","article-title":"Fibroblast lipid metabolism through acsl4 regulates epithelial sensitivity to ferroptosis in ibd","volume":"7","author":"Huang","year":"2025","journal-title":"Nat. Metab."},{"issue":"4","key":"10.1016\/j.tox.2026.154524_bib14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.tox.2026.154524_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/cvr\/cvae270","article-title":"Iron, lipid peroxidation, and ferroptosis play pathogenic roles in atherosclerosis","volume":"121","author":"Jinson","year":"2025","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.tox.2026.154524_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s42003-024-06063-2","article-title":"Ppar\u03b3 alleviates preeclampsia development by regulating lipid metabolism and ferroptosis","volume":"7","author":"Lai","year":"2024","journal-title":"Commun. Biol."},{"issue":"9","key":"10.1016\/j.tox.2026.154524_bib17","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.166608","article-title":"Impaired ppar\u03b3 activation by cadmium exacerbates infection-induced lung injury","volume":"8","author":"Larson-Casey","year":"2023","journal-title":"Jci Insight"},{"key":"10.1016\/j.tox.2026.154524_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114055","article-title":"Maternal cadmium exposure impairs placental angiogenesis in preeclampsia through disturbing thyroid hormone receptor signaling","volume":"244","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"12","key":"10.1016\/j.tox.2026.154524_bib19","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell."},{"key":"10.1016\/j.tox.2026.154524_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.108934","article-title":"Cadmium exposure causes trophoblast abnormal syncytization and endocrine dysfunction in preeclampsia","volume":"135","author":"Lin","year":"2025","journal-title":"Reprod. Toxicol."},{"issue":"9","key":"10.1016\/j.tox.2026.154524_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.419","article-title":"Angptl4 mediates the protective role of ppar\u03b3 activators in the pathogenesis of preeclampsia","volume":"8","author":"Liu","year":"2017","journal-title":"Cell. Death Dis."},{"issue":"15","key":"10.1016\/j.tox.2026.154524_bib22","article-title":"The placenta regulates intrauterine fetal growth via exosomal ppar\u03b3","volume":"12","author":"Luo","year":"2025","journal-title":"Adv. Sci."},{"issue":"12","key":"10.1016\/j.tox.2026.154524_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10121864","article-title":"Iron overload, oxidative stress, and ferroptosis in the failing heart and liver","volume":"10","author":"Mancardi","year":"2021","journal-title":"Antioxid."},{"issue":"5","key":"10.1016\/j.tox.2026.154524_bib24","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/bph.12069","article-title":"Ppar-\u03b3 -- a possible drug target for complicated pregnancies","volume":"168","author":"McCarthy","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.tox.2026.154524_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13050591","article-title":"Oxidative stress, lipid peroxidation and ferroptosis are major pathophysiological signatures in the placental tissue of women with late-onset preeclampsia","volume":"13","author":"Ortega","year":"2024","journal-title":"Antioxid."},{"issue":"4","key":"10.1016\/j.tox.2026.154524_bib26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/CIRCRESAHA.124.325119","article-title":"Placental hypoxia-induced ferroptosis drives vascular damage in preeclampsia","volume":"136","author":"Park","year":"2025","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.tox.2026.154524_bib27","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.tcb.2023.05.003","article-title":"Regulation of ferroptosis by lipid metabolism","volume":"33","author":"Pope","year":"2023","journal-title":"Trends Cell. Biol."},{"issue":"11","key":"10.1016\/j.tox.2026.154524_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/nu15112459","article-title":"Understanding ppar\u03b3 and its agonists on trophoblast differentiation and invasion: potential therapeutic targets for gestational diabetes mellitus and preeclampsia","volume":"15","author":"Qin","year":"2023","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.tox.2026.154524_bib29","doi-asserted-by":"crossref","first-page":"27003","DOI":"10.1289\/EHP3730","article-title":"The role of peroxisome proliferator\u2013activated receptor gamma (ppar\u03b3) in mono(2-ethylhexyl) phthalate (mehp)-mediated cytotrophoblast differentiation","volume":"127","author":"Shoaito","year":"2019","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.tox.2026.154524_bib30","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/uog.26032","article-title":"Clinical utility of sflt-1 and plgf in screening, prediction, diagnosis and monitoring of pre-eclampsia and fetal growth restriction","volume":"61","author":"Stepan","year":"2023","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"11","key":"10.1016\/j.tox.2026.154524_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112367","article-title":"The role of ppars in disease","volume":"9","author":"Wagner","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.tox.2026.154524_bib32","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.tox.2019.05.013","article-title":"Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction","volume":"423","author":"Xu","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2026.154524_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102555","article-title":"Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling","volume":"58","author":"Yang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.tox.2026.154524_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116259","article-title":"Cadmium exposure activates mitophagy through downregulating thyroid hormone receptor\/pgc1\u03b1 signal in preeclampsia","volume":"276","author":"Yu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.tox.2026.154524_bib35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1414838","article-title":"Predictive value of the sflt-1: plgf ratio in women with suspected preeclampsia","volume":"374","author":"Zeisler","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tox.2026.154524_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101402","article-title":"Mir-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia","volume":"29","author":"Zhang","year":"2020","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.tox.2026.154524_bib37","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1038\/s41467-024-51736-5","article-title":"Lipid synthesis, triggered by ppar\u03b3 t166 dephosphorylation, sustains reparative function of macrophages during tissue repair","volume":"15","author":"Zuo","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X26001319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X26001319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T07:37:44Z","timestamp":1794382664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X26001319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":37,"alternative-id":["S0300483X26001319"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2026.154524","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium exposure activates ferroptosis through downregulated PPAR\u03b3 expression in preeclampsia placenta","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2026.154524","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154524"}}