{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:47:08Z","timestamp":1785739628730,"version":"3.56.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tox.2026.154543","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:39:07Z","timestamp":1784590747000},"page":"154543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Triclocarban drives intrahepatic cholangiocyte injury by triggering ferroptosis via the SLC7A11\/GSH\/GPX4 axis"],"prefix":"10.1016","volume":"526","author":[{"given":"Jiadi","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4118-3419","authenticated-orcid":false,"given":"Shengmin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2026.154543_bib1","doi-asserted-by":"crossref","DOI":"10.21608\/ajps.2018.46644","article-title":"Cholestasis: molecular mechanism, pathogenesis and possible management","author":"Al-Botaty","year":"2018","journal-title":"Al-Azhar J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.tox.2026.154543_bib2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1742-7843.2009.00455.x","article-title":"Human Exposure to Triclosan via Toothpaste does not change CYP3A4 Activity or Plasma Concentrations of Thyroid Hormones","volume":"105","author":"Allmyr","year":"2009","journal-title":"Basic. Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2026.154543_bib3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41580-026-00974-0","article-title":"New developments and applications of human organoids","volume":"27","author":"Andersson-Rolf","year":"2026","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib4","first-page":"7","article-title":"Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice","volume":"10","author":"Bai","year":"2023","journal-title":"Mil. Med. Res."},{"issue":"5","key":"10.1016\/j.tox.2026.154543_bib5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41575-019-0125-y","article-title":"Cholangiocyte pathobiology","volume":"16","author":"Banales","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"21","key":"10.1016\/j.tox.2026.154543_bib6","doi-asserted-by":"crossref","first-page":"14923","DOI":"10.1021\/acs.est.2c00406","article-title":"Triclosan is the Predominant Antibacterial Compound in Ontario Sewage Sludge","volume":"56","author":"Barrett","year":"2022","journal-title":"Environ. Sci. & Technol."},{"key":"10.1016\/j.tox.2026.154543_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109580","article-title":"Dichloromethane increases mutagenic DNA damage and transformation ability in cholangiocytes and enhances metastatic potential in cholangiocarcinoma cell lines","volume":"346","author":"Buranarom","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2026.154543_bib8","article-title":"Molecular code of ferroptosis: emerging multi-dimensional modifications and therapeutic targets in hepatic disorders","volume":"175","author":"Cai","year":"2025","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.tox.2026.154543_bib9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1289\/ehp.10768","article-title":"Urinary concentrations of triclosan in the U.S. population: 2003-2004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2026.154543_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jhazmat.2018.08.014","article-title":"Assessment of human exposure to triclocarban, triclosan and five parabens in U.S. indoor dust using dispersive solid phase extraction followed by liquid chromatography tandem mass spectrometry","volume":"360","author":"Chen","year":"2018","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.tox.2026.154543_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","article-title":"The multifaceted role of ferroptosis in liver disease","volume":"29","author":"Chen","year":"2022","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.tox.2026.154543_bib12","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jhazmat.2018.11.021","article-title":"Nationwide reconnaissance of five parabens, triclosan, triclocarban and its transformation products in sewage sludge from China","volume":"365","author":"Chen","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2026.154543_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126953","article-title":"Investigating the mechanisms of Triclocarban-induced liver injury: A comprehensive analysisbased on network toxicology and in vivo experiments","volume":"384","author":"Fang","year":"2025","journal-title":"Environ. Pollut."},{"issue":"18","key":"10.1016\/j.tox.2026.154543_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800311","article-title":"GPX4 at the crossroads of lipid homeostasis and ferroptosis","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"issue":"12","key":"10.1016\/j.tox.2026.154543_bib15","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell. Biol."},{"issue":"31","key":"10.1016\/j.tox.2026.154543_bib16","doi-asserted-by":"crossref","first-page":"13687","DOI":"10.1021\/acs.est.4c04940","article-title":"Sex-specific and trimester-specific associations of prenatal exposure to bisphenols, parabens, and triclosan with neonatal birth size and gestational age","volume":"58","author":"Fu","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jhep.2024.09.032","article-title":"Bile acid metabolism and signalling in liver disease","volume":"82","author":"Fuchs","year":"2025","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.tox.2026.154543_bib18","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/hep.24613","article-title":"Ductular reactions in human liver: diversity at the interface","volume":"54","author":"Gouw","year":"2011","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.tox.2026.154543_bib19","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/j.gastro.2024.07.044","article-title":"Portal fibrosis and the ductular reaction: pathophysiological role in the progression of liver disease and translational opportunities","volume":"168","author":"Gupta","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2026.154543_bib20","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1039\/c2sc21649c","article-title":"A highly selective turn-on fluorescent probe for iron(II) to visualize labile iron in living cells","volume":"4","author":"Hirayama","year":"2013","journal-title":"Chem. Sci."},{"issue":"15","key":"10.1016\/j.tox.2026.154543_bib21","article-title":"Lipid metabolism disorders contribute to hepatotoxicity of triclosan in mice","volume":"384","author":"Huang","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"7436","key":"10.1016\/j.tox.2026.154543_bib22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature11826","article-title":"vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration","volume":"494","author":"Huch","year":"2013","journal-title":"Nature"},{"issue":"1-2","key":"10.1016\/j.tox.2026.154543_bib23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.tox.2026.154543_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109032","article-title":"Exposure and potential risks of thirteen endocrine- disrupting chemicals in pharmaceuticals and personal care products for breastfed infants in China","volume":"192","author":"Ji","year":"2024","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.tox.2026.154543_bib25","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"9","key":"10.1016\/j.tox.2026.154543_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e30104","article-title":"Microcystin-leucine arginine induces the proliferation of cholangiocytes and cholangiocarcinoma cells through the activation of the Wnt\/\u03b2-catenin signaling pathway","volume":"10","author":"Kongsintaweesuk","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.tox.2026.154543_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117330","article-title":"Mitigation of polystyrene microplastic-induced hepatotoxicity in human hepatobiliary organoids through bile extraction","volume":"288","author":"Li","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2026.154543_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116989","article-title":"Triclosan exposure causes abnormal bile acid metabolism through IL-1\u03b2-NF-\u03baB-Fxr signaling pathway","volume":"284","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2026.154543_bib29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jes.2023.02.004","article-title":"Chronic administration of triclosan leads to liver fibrosis through hepcidin-ferroportin axis-mediated iron overload","volume":"137","author":"Liu","year":"2024","journal-title":"J. Environ. Sci. (China)"},{"key":"10.1016\/j.tox.2026.154543_bib30","article-title":"Heterogeneity and plasticity of cholangiocytes in liver injury: a journey from pathophysiology to therapeutic utility","volume":"334763","author":"Lou","year":"2025","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/HEP.0000000000000186","article-title":"Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish","volume":"78","author":"Ma","year":"2023","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.tox.2026.154543_bib32","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/JOM.0000000000000183","article-title":"Health care worker exposures to the antibacterial agent triclosan","volume":"56","author":"Macisaac","year":"2014","journal-title":"J. Occup. Environ. Med."},{"issue":"5","key":"10.1016\/j.tox.2026.154543_bib33","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.stem.2021.04.005","article-title":"Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids","volume":"28","author":"Marsee","year":"2021","journal-title":"Cell. Stem Cell."},{"issue":"4","key":"10.1016\/j.tox.2026.154543_bib34","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41588-023-01335-9","article-title":"Bipotent transitional liver progenitor cells contribute to liver regeneration","volume":"55","author":"Pu","year":"2023","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.tox.2026.154543_bib35","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/HEP.0000000000001225","article-title":"The immunological landscape of primary biliary cholangitis: Mechanisms and therapeutic prospects","volume":"82","author":"Ronca","year":"2025","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/hep.31037","article-title":"Large-scale production of LGR5-positive bipotential human liver stem cells","volume":"72","author":"Schneeberger","year":"2020","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12989-024-00598-2","article-title":"Genome-wide DNA methylation sequencing reveals the involvement of ferroptosis in hepatotoxicity induced by dietary exposure to food-grade titanium dioxide","volume":"21","author":"Shang","year":"2024","journal-title":"Part. Fibre Toxicol."},{"issue":"Pt 4","key":"10.1016\/j.tox.2026.154543_bib38","article-title":"Characterization of triclosan-induced hepatotoxicity and triclocarban-triggered enterotoxicity in mice by multiple omics screening","volume":"838","author":"Song","year":"2022","journal-title":"Sci. Total. Environ."},{"issue":"14","key":"10.1016\/j.tox.2026.154543_bib39","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.tox.2026.154543_bib40","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib41","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1038\/s41467-021-23575-1","article-title":"Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo","volume":"12","author":"Tanimizu","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/hep.28521","article-title":"Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice","volume":"64","author":"Tanimizu","year":"2016","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.tox.2026.154543_bib43","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1002\/etc.3370","article-title":"Human health risk assessment of triclosan in land-applied biosolids","volume":"35","author":"Verslycke","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"issue":"7","key":"10.1016\/j.tox.2026.154543_bib44","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1021\/acs.chemrestox.9b00148","article-title":"Industrial, biocide, and cosmetic chemical inducers of cholestasis","volume":"32","author":"Vilas-Boas","year":"2019","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12940-021-00767-2","article-title":"Exposure to environmental phenols and parabens, and relation to body mass index, eczema and respiratory outcomes in the Norwegian RHINESSA study","volume":"20","author":"Vindenes","year":"2021","journal-title":"Environ. Health"},{"key":"10.1016\/j.tox.2026.154543_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121458","article-title":"Immunotoxicity induced by triclocarban exposure in zebrafish triggering the risk of pancreatic cancer","volume":"325","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib47","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13287-024-03692-6","article-title":"Cholangiocyte organoids to study drug-induced injury","volume":"15","author":"Wang","year":"2024","journal-title":"Stem Cell. Res. Ther."},{"issue":"8","key":"10.1016\/j.tox.2026.154543_bib48","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/10937404.2017.1399306","article-title":"Triclosan exposure, transformation, and human health effects","volume":"20","author":"Weatherly","year":"2017","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib49","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1038\/s41467-022-31947-4","article-title":"Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice","volume":"13","author":"Weber","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2026.154543_bib50","first-page":"1097","article-title":"Suppressing MASH fibrotic progression by blocking succinate-GPR91 signaling in HSCs","volume":"10","author":"Xie","year":"2025","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.tox.2026.154543_bib51","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1021\/acs.est.3c06127","article-title":"Ferroptosis induced by pollutants: an emerging mechanism in environmental toxicology","volume":"58","author":"Yang","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.tox.2026.154543_bib52","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.scib.2024.11.037","article-title":"Human cardiac organoid model reveals antibacterial triclocarban promotes myocardial hypertrophy by interfering with endothelial cell metabolism","volume":"70","author":"Yang","year":"2025","journal-title":"Sci. Bull. (Beijing)"},{"issue":"443","key":"10.1016\/j.tox.2026.154543_bib53","doi-asserted-by":"crossref","first-page":"4116","DOI":"10.1126\/scitranslmed.aan4116","article-title":"A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice","volume":"10","author":"Yang","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tox.2026.154543_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107706","article-title":"Diesel exhaust PM2.5 greatly deteriorates fibrosis process in pre-existing pulmonary fibrosis via ferroptosis","volume":"171","author":"Yue","year":"2023","journal-title":"Environ. Int."},{"issue":"49","key":"10.1016\/j.tox.2026.154543_bib55","doi-asserted-by":"crossref","first-page":"31259","DOI":"10.1073\/pnas.2017129117","article-title":"Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease","volume":"117","author":"Yueh","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"48","key":"10.1016\/j.tox.2026.154543_bib56","doi-asserted-by":"crossref","first-page":"17200","DOI":"10.1073\/pnas.1419119111","article-title":"The commonly used antimicrobial additive triclosan is a liver tumor promoter","volume":"111","author":"Yueh","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tox.2026.154543_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121944","article-title":"Fate, risk and removal of triclocarban: a critical review","volume":"387","author":"Yun","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"8","key":"10.1016\/j.tox.2026.154543_bib58","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1021\/acs.est.0c08273","article-title":"Continuous dermal exposure to triclocarban perturbs the homeostasis of liver-gut axis in mice: insights from metabolic interactions and microbiome shifts","volume":"55","author":"Zhang","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2026.154543_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162114","article-title":"A holistic review on triclosan and triclocarban exposure: epidemiological outcomes, antibiotic resistance, and health risk assessment","volume":"872","author":"Zhang","year":"2023","journal-title":"Sci. Total. Environ."},{"issue":"9","key":"10.1016\/j.tox.2026.154543_bib60","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1021\/acs.est.8b07281","article-title":"Integration of metabolomics and lipidomics reveals metabolic mechanisms of triclosan-induced toxicity in human hepatocytes","volume":"53","author":"Zhang","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2026.154543_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126707","article-title":"Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis","volume":"421","author":"Zhang","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.tox.2026.154543_bib62","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1038\/s41467-022-32575-8","article-title":"Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.tox.2026.154543_bib63","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell. Metab."},{"issue":"3","key":"10.1016\/j.tox.2026.154543_bib64","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1053\/jhep.2001.22646","article-title":"Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases","volume":"33","author":"Zollner","year":"2001","journal-title":"Hepatology"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X26001502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X26001502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:22:08Z","timestamp":1785738128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X26001502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":64,"alternative-id":["S0300483X26001502"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2026.154543","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triclocarban drives intrahepatic cholangiocyte injury by triggering ferroptosis via the SLC7A11\/GSH\/GPX4 axis","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2026.154543","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154543"}}