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Fibre Toxicol."},{"key":"10.1016\/j.tox.2026.154550_bib88","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/d41586-021-01143-3","article-title":"Microplasticsare everywhere\u2014but aretheyharmful?","volume":"593","author":"Lim","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tox.2026.154550_bib89","article-title":"Airborne toxicological assessment: the potential of lung-on-a-chip as an alternative to animal testing","volume":"14","author":"Lin","year":"2022","journal-title":"Mater. Today Adv."},{"key":"10.1016\/j.tox.2026.154550_bib90","doi-asserted-by":"crossref","first-page":"12483","DOI":"10.1021\/acs.est.2c03980","article-title":"Metabolomics reveal nanoplastic-induced mitochondrial damage in human liver and lung cells","volume":"56","author":"Lin","year":"2022","journal-title":"Environ. Sci. 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Mater."},{"key":"10.1016\/j.tox.2026.154550_bib108","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41586-020-2724-8","article-title":"Homeostatic mini-intestines through scaffold-guided organoid morphogenesis","volume":"585","author":"Nikolaev","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tox.2026.154550_bib109","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41377-025-01949-0","article-title":"Visualizing the internalization and biological impact of nanoplastics in live intestinal organoids by fluorescence lifetime imaging microscopy (FLIM)","volume":"14","author":"Okkelman","year":"2025","journal-title":"Light. Sci. Appl."},{"key":"10.1016\/j.tox.2026.154550_bib110","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aat5847","article-title":"Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons","volume":"4","author":"Osaki","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tox.2026.154550_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171681","article-title":"Neurotoxic effects of polystyrene nanoplastics on memory and microglial activation: Insights from in vivo and in vitro studies","volume":"924","author":"Paing","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.tox.2026.154550_bib112","article-title":"High-resolution label-free detection of biocompatible polymeric nanoparticles in cells","volume":"35","author":"Pancani","year":"2018","journal-title":"Part. & Part. Syst. Charact."},{"key":"10.1016\/j.tox.2026.154550_bib113","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1038\/s41467-019-10588-0","article-title":"Hypoxia-enhanced blood-brain barrier chip recapitulates human barrier function and shuttling of drugs and antibodies","volume":"10","author":"Park","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2026.154550_bib114","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1038\/s41467-021-26066-5","article-title":"Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption","volume":"12","author":"Pediaditakis","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2026.154550_bib115","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/toxics11010040","article-title":"First evidence of microplastics in human urine, a preliminary study of intake in the human body","volume":"11","author":"Pironti","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.tox.2026.154550_bib116","unstructured":"Plastics E. (2021) History of plastics \u2022 plastics europe. In: Plastics Europe. https:\/\/plasticseurope.org\/plastics-explained\/history-of-plastics\/. Accessed 3 June 2025."},{"key":"10.1016\/j.tox.2026.154550_bib117","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/s41467-024-45710-4","article-title":"A microfluidic platform integrating functional vascularized organoids-on-chip","volume":"15","author":"Quintard","year":"2024","journal-title":"Nat. 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Assess."},{"key":"10.1016\/j.tox.2026.154550_bib121","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/acel.12650","article-title":"The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore","volume":"16","author":"Rottenberg","year":"2017","journal-title":"Aging Cell."},{"key":"10.1016\/j.tox.2026.154550_bib122","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202302907","article-title":"A multisystemic approach revealed aminated polystyrene nanoparticles-induced neurotoxicity","volume":"20","author":"Schr\u00f6ter","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.tox.2026.154550_bib123","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of various microplastics in human stool: a prospective case series","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.tox.2026.154550_bib124","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1073\/pnas.1222878110","article-title":"Genomic responses in mouse models poorly mimic human inflammatory diseases","volume":"110","author":"Seok","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tox.2026.154550_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134261","article-title":"Polystyrene nanoplastics penetrate across the blood-brain barrier and induce activation of microglia in the brain of mice","volume":"298","author":"Shan","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2026.154550_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136168","article-title":"Polystyrene nanoplastics enhance thrombosis through adsorption of plasma proteins","volume":"480","author":"Sheng","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2026.154550_bib127","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1080\/01926230601080502","article-title":"Translocation pathway of the intratracheally instilled ultrafine particles from the lung into the blood circulation in the mouse","volume":"34","author":"Shimada","year":"2006","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2026.154550_bib128","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/s41596-021-00674-3","article-title":"3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert","volume":"17","author":"Shin","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tox.2026.154550_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.115658","article-title":"Identification and visualisation of microplastics\/nanoplastics by raman imaging (i): down to 100 nm","volume":"174","author":"Sobhani","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.tox.2026.154550_bib130","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1039\/c3lc41017j","article-title":"Microfabricated mammalian organ systems and their integration into models of whole animals and humans","volume":"13","author":"Sung","year":"2013","journal-title":"Lab. 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Saf."},{"key":"10.1016\/j.tox.2026.154550_bib133","doi-asserted-by":"crossref","DOI":"10.1126\/science.adl2746","article-title":"Twenty years of microplastic pollution research\u2014what have we learned?","volume":"386","author":"Thompson","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.tox.2026.154550_bib134","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. 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