{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:03:51Z","timestamp":1790683431706,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073585"],"award-info":[{"award-number":["82073585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.tox.2026.154568","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T06:05:58Z","timestamp":1786773958000},"page":"154568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hepatocyte necroptosis triggers macrophage NOD-like receptor family pyrin domain-containing 3 inflammasome activation in N, N-dimethylformamide-induced liver injury"],"prefix":"10.1016","volume":"527","author":[{"given":"Xiu-Ning","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3673-9929","authenticated-orcid":false,"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1145-2059","authenticated-orcid":false,"given":"Tao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2026.154568_bib1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-025-00837-0","article-title":"Mechanistic insights into gasdermin-mediated pyroptosis","volume":"26","author":"Bai","year":"2025","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.tox.2026.154568_bib2","series-title":"Dimethylformamide (DMF) - Chemical Economics Handbook (CEH) |","author":"CEH","year":"2024"},{"key":"10.1016\/j.tox.2026.154568_bib3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.gendis.2021.12.006","article-title":"Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: therapeutic potential for liver fibrosis","volume":"10","author":"Charan","year":"2023","journal-title":"Genes. Dis."},{"key":"10.1016\/j.tox.2026.154568_bib4","doi-asserted-by":"crossref","first-page":"6928","DOI":"10.1021\/bi00078a017","article-title":"Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates","volume":"32","author":"Dai","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.tox.2026.154568_bib5","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/hep.27939","article-title":"Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis","volume":"62","author":"Dara","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2026.154568_bib6","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.1038\/s41467-025-61324-w","article-title":"Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18","volume":"16","author":"Fan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2026.154568_bib7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11814-018-0182-x","article-title":"Use of multiple inter-reboilers to achieve energy savings and improve thermodynamic efficiency of the distillation of N,N-dimethylformamide wastewater","volume":"36","author":"Gao","year":"2019","journal-title":"Korean J. Chem. Eng."},{"key":"10.1016\/j.tox.2026.154568_bib8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2020.07.041","article-title":"Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis","volume":"74","author":"Gaul","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tox.2026.154568_bib9","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.7150\/thno.71400","article-title":"Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation","volume":"12","author":"Guo","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.tox.2026.154568_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/jat.4590","article-title":"The potential health risks of N,N-dimethylformamide: An updated review","author":"Hong","year":"2024","journal-title":"Journal applied toxicology JAT"},{"key":"10.1016\/j.tox.2026.154568_bib11","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/jat.4590","article-title":"The potential health risks of N,N-dimethylformamide: An updated review","volume":"44","author":"Hong","year":"2024","journal-title":"Journal applied toxicology JAT"},{"key":"10.1016\/j.tox.2026.154568_bib12","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00352.2011","article-title":"P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice","volume":"302","author":"Hoque","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tox.2026.154568_bib13","article-title":"NIR-actuated ferroptosis nanomotor for enhanced tumor penetration and therapy","volume":"36","author":"Hu","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.tox.2026.154568_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3727\/105221621X16104581979144","article-title":"Ferroptosis and acetaminophen hepatotoxicity: are we going down another rabbit hole?","volume":"20","author":"Jaeschke","year":"2021","journal-title":"Gene Expr."},{"key":"10.1016\/j.tox.2026.154568_bib15","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.tox.2026.154568_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2024.100195","article-title":"Subcellular expression of CYP2E1 in HepG2 cells impacts response to free oleic and palmitic acid","volume":"7","author":"Killingsworth","year":"2024","journal-title":"Curr. Res. Toxicol."},{"key":"10.1016\/j.tox.2026.154568_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41418-018-0179-3","article-title":"Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation","volume":"26","author":"Kim","year":"2019","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.tox.2026.154568_bib18","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.scitotenv.2018.08.161","article-title":"Long-term performance of UASB in treating N, N-dimethylformamide-containing wastewater with a rapid start-up by inoculating mixed sludge","volume":"648","author":"Kong","year":"2019","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.tox.2026.154568_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.127396","article-title":"Carbon-neutral treatment of N, N-dimethylformamide-containing industrial wastewater by anaerobic membrane bioreactor (AnMBR): bio-energy recovery and CO(2) emission reduction","volume":"358","author":"Kong","year":"2022","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.tox.2026.154568_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202103302","article-title":"N,N-dimethylformamide-assisted shape evolution of highly uniform and shape-pure colloidal copper nanocrystals","volume":"17","author":"Lee","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.tox.2026.154568_bib21","first-page":"5659","article-title":"N,N-dimethylformamide-induced acute hepatic failure: a case report and literature review","volume":"14","author":"Lei","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.tox.2026.154568_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134370","article-title":"A comparative long-term operation using up-flow anaerobic sludge blanket (UASB) and anaerobic membrane bioreactor (AnMBR) for the upgrading of anaerobic treatment of N, N-dimethylformamide-containing wastewater","volume":"699","author":"Li","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.tox.2026.154568_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114198","article-title":"Allyl methyl disulfide (AMDS) prevents N,N-dimethyl formamide-induced liver damage by suppressing oxidative stress and NLRP3 inflammasome activation","volume":"182","author":"Li","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2026.154568_bib24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cbi.2018.12.011","article-title":"The deleterious effects of N,N-dimethylformamide on liver: A mini-review","volume":"298","author":"Li","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2026.154568_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22190","article-title":"Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide","volume":"32","author":"Li","year":"2018","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tox.2026.154568_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113609","article-title":"N,N-dimethylformamide-induced acute liver damage is driven by the activation of NLRP3 inflammasome in liver macrophages of mice","volume":"238","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2026.154568_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133719","article-title":"Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells","volume":"467","author":"Liu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2026.154568_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152838","article-title":"Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2\/ARE axis","volume":"458","author":"Liu","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2026.154568_bib29","article-title":"piR-16404 drives ferroptotic liver injury via CASTOR1\/mTORC1\/GPX4 dysregulation in HepG2 cells and mice: a novel toxicity mechanism of N, N-dimethylformamide","author":"Ma","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2026.154568_bib30","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jhep.2019.11.008","article-title":"Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease","volume":"72","author":"Majdi","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tox.2026.154568_bib31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/j.gastro.2010.03.052","article-title":"Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice","volume":"139","author":"Miura","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2026.154568_bib32","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1172\/JCI74985","article-title":"Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD","volume":"124","author":"Mizumura","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tox.2026.154568_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.139144","article-title":"Short-chain chlorinated paraffins at environmentally relevant doses disrupt glucose homeostasis and insulin signaling by macrophage-mediated inflammation","volume":"495","author":"Mu","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2026.154568_bib34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41419-024-06640-7","article-title":"The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression","volume":"15","author":"Nie","year":"2024","journal-title":"Cell. death & Dis."},{"key":"10.1016\/j.tox.2026.154568_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biortech.2015.02.042","article-title":"Biodegradation and utilization of dimethylformamide by biofilm forming Paracoccus sp. strains MKU1 and MKU2","volume":"188","author":"Nisha","year":"2015","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.tox.2026.154568_bib36","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/JOM.0000000000000983","article-title":"Low-Dose N,N-Dimethylformamide Exposure and Liver Injuries in a Cohort of Chinese Leather Industry Workers","volume":"59","author":"Qi","year":"2017","journal-title":"J. Occup. Environ. Med. Am. Coll. Occup. Environ. Med."},{"key":"10.1016\/j.tox.2026.154568_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124401","article-title":"Degradation of liquid phase N,N-dimethylformamide by dielectric barrier discharge plasma: Mechanism and degradation pathways","volume":"236","author":"Sang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2026.154568_bib38","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.tox.2026.154568_bib39","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41575-018-0065-y","article-title":"Apoptosis and necroptosis in the liver: a matter of life and death","volume":"15","author":"Schwabe","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tox.2026.154568_bib40","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41420-023-01581-0","article-title":"Different types of cell death and their shift in shaping disease","volume":"9","author":"Shen","year":"2023","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.tox.2026.154568_bib41","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.jcmgh.2021.11.009","article-title":"Hepatocytes are resistant to cell death from canonical and non-canonical inflammasome-activated pyroptosis","volume":"13","author":"Sun","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tox.2026.154568_bib42","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1038\/s41596-020-0374-9","article-title":"A comprehensive guide to studying inflammasome activation and cell death","volume":"15","author":"Tweedell","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tox.2026.154568_bib43","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jhep.2015.11.020","article-title":"Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles","volume":"64","author":"Verma","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tox.2026.154568_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138604","article-title":"Association of urinary dimethylformamide metabolite with lung function decline: the potential mediating role of systematic inflammation estimated by C-reactive protein","volume":"726","author":"Wang","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.tox.2026.154568_bib45","doi-asserted-by":"crossref","unstructured":"Wang, C., Huang, C., Wei, Y., Zhu, Q., Tian, W. and Zhang, Q. 2014. Short-term exposure to dimethylformamide and the impact on digestive system disease: an outdoor study for volatile organic compound. Environmental pollution (Barking, Essex: 1987) 190, 133-138.","DOI":"10.1016\/j.envpol.2014.03.026"},{"key":"10.1016\/j.tox.2026.154568_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116306","article-title":"Facilitated bio-mineralization of N,N-dimethylformamide in anoxic denitrification system: Long-term performance and biological mechanism","volume":"186","author":"Wang","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.tox.2026.154568_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.117180","article-title":"PPARbeta\/delta agonist GW0742 mitigates acute liver damage induced by acetaminophen overdose in mice","volume":"494","author":"Wang","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2026.154568_bib48","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1007\/s00204-019-02567-7","article-title":"The essential role of CYP2E1 in metabolism and hepatotoxicity of N,N-dimethylformamide using a novel Cyp2e1 knockout mouse model and a population study","volume":"93","author":"Wu","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2026.154568_bib49","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1021\/acs.chemrestox.8b00306","article-title":"Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation","volume":"31","author":"Xia","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2026.154568_bib50","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jhazmat.2016.07.037","article-title":"An Eco-tank system containing microbes and different aquatic plant species for the bioremediation of N,N-dimethylformamide polluted river waters","volume":"320","author":"Xiao","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2026.154568_bib51","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3892\/mmr.2014.2281","article-title":"Bafilomycin A1 inhibits autophagy and induces apoptosis in MG63 osteosarcoma cells","volume":"10","author":"Xie","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tox.2026.154568_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156218","article-title":"N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro","volume":"839","author":"Xu","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.tox.2026.154568_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115338","article-title":"Necrosulfonamide ameliorates intestinal inflammation via inhibiting GSDMD-medicated pyroptosis and MLKL-mediated necroptosis","volume":"206","author":"Yang","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2026.154568_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.freeradbiomed.2021.07.034","article-title":"RIP1 kinase inactivation protects against acetaminophen-induced acute liver injury in mice","volume":"174","author":"Yi","year":"2021","journal-title":"Free. Radic. Biol. & Med."},{"key":"10.1016\/j.tox.2026.154568_bib55","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-025-04106-z","article-title":"Environmental occurrence, human exposure routes, toxicity, and risk assessments of medium-chain chlorinated paraffins (MCCPs): a comprehensive review","author":"Yu","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2026.154568_bib56","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.redox.2017.09.018","article-title":"Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver","volume":"14","author":"Zeng","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.tox.2026.154568_bib57","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2131\/jts.42.241","article-title":"Alteration of gut microbial community after N,N-Dimethylformamide exposure","volume":"42","author":"Zhang","year":"2017","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2026.154568_bib58","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1007\/s11356-013-2336-z","article-title":"Risk assessment of N,N-dimethylformamide on residents living near synthetic leather factories","volume":"21","author":"Zhang","year":"2014","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tox.2026.154568_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172653","article-title":"NLRP3 inflammasome activation triggers severe inflammatory liver injury in N, N-dimethylformamide-exposed mice","volume":"929","author":"Zhang","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.tox.2026.154568_bib60","doi-asserted-by":"crossref","first-page":"9141","DOI":"10.1039\/C8NR00554K","article-title":"Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis","volume":"10","author":"Zhang","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.tox.2026.154568_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172653","article-title":"NLRP3 inflammasome activation triggers severe inflammatory liver injury in N, N-dimethylformamide-exposed mice","volume":"929","author":"Zhang","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.tox.2026.154568_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.157853","article-title":"Spermidine alleviates ethanol-induced hepatocyte ferroptosis by restoring hepatic iron homeostasis via the gut-liver axis","volume":"152","author":"Zhang","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tox.2026.154568_bib63","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/jat.4028","article-title":"Aberrant expression of miRNA-192-5p contributes to N,N-dimethylformamide-induced hepatic apoptosis","volume":"40","author":"Zhang","year":"2020","journal-title":"Journal applied toxicology JAT"},{"key":"10.1016\/j.tox.2026.154568_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153872","article-title":"Biphasic effects of ethanol consumption on N,N-dimethylformamide-induced liver injury in mice","volume":"506","author":"Zheng","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2026.154568_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1157054","article-title":"The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia\/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tox.2026.154568_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109725","article-title":"Microglial pyroptosis in hippocampus mediates sevolfurane-induced cognitive impairment in aged mice via ROS-NLRP3 inflammasome pathway","volume":"116","author":"Zhou","year":"2023","journal-title":"Int. Immunopharmacol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X26001757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X26001757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:31:39Z","timestamp":1790681499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X26001757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":66,"alternative-id":["S0300483X26001757"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2026.154568","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatocyte necroptosis triggers macrophage NOD-like receptor family pyrin domain-containing 3 inflammasome activation in N, N-dimethylformamide-induced liver injury","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2026.154568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154568"}}