{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:54:50Z","timestamp":1791057290040,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373543"],"award-info":[{"award-number":["82373543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473596"],"award-info":[{"award-number":["82473596"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.tox.2026.154587","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:46:08Z","timestamp":1789515968000},"page":"154587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Arsenic-induced SAM depletion and m6A dysregulation contribute to impaired insulin secretion in MIN6 cells"],"prefix":"10.1016","volume":"527","author":[{"given":"Huajie","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangpo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naijun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2026.154587_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbaexp.2005.05.009","article-title":"Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1","volume":"1730","author":"Aramata","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tox.2026.154587_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072194","article-title":"Both PAX4 and MAFA are expressed in a substantial proportion of normal human pancreatic alpha cells and deregulated in patients with type 2 diabetes","volume":"8","author":"Bonnavion","year":"2013","journal-title":"PLoS. One"},{"key":"10.1016\/j.tox.2026.154587_bib3","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1007\/s00125-012-2666-2","article-title":"Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes","volume":"55","author":"Butler","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.tox.2026.154587_bib4","doi-asserted-by":"crossref","first-page":"E464","DOI":"10.1152\/ajpendo.00302.2018","article-title":"Arsenic modifies serotonin metabolism through glucuronidation in pancreatic beta-cells","volume":"316","author":"Carmean","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2026.154587_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154734","article-title":"The MafA-target gene PPP1R1A regulates GLP1R-mediated amplification of glucose-stimulated insulin secretion in beta-cells","volume":"118","author":"Cataldo","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.tox.2026.154587_bib6","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2438471","article-title":"Novel role of FTO in regulation of gut-brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure","volume":"17","author":"Chen","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.tox.2026.154587_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.910868","article-title":"The m(6)A methyltransferase METTL3 ameliorates methylglyoxal-induced impairment of insulin secretion in pancreatic beta cells by regulating MafA expression","volume":"13","author":"Cheng","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tox.2026.154587_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global burden of disease study 2021","volume":"402","author":"Collaborators","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.tox.2026.154587_bib9","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1038\/s41467-021-22469-6","article-title":"Autophagy of the m(6)A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis","volume":"12","author":"Cui","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2026.154587_bib10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s42255-019-0089-9","article-title":"m(6)A mRNA methylation regulates human beta-cell biology in physiological states and in type 2 diabetes","volume":"1","author":"De Jesus","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tox.2026.154587_bib11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.taap.2005.11.015","article-title":"Sodium arsenite impairs insulin secretion and transcription in pancreatic beta-cells","volume":"214","author":"Diaz-Villasenor","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2026.154587_bib12","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00204-017-2074-y","article-title":"Arsenite and methylarsonite inhibit mitochondrial metabolism and glucose-stimulated insulin secretion in INS-1 832\/13 beta cells","volume":"92","author":"Dover","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2026.154587_bib13","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s00204-022-03279-1","article-title":"Research for type 2 diabetes mellitus in endemic arsenism areas in central China: role of low level of arsenic exposure and KEAP1 rs11545829 polymorphism","volume":"96","author":"Fan","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2026.154587_bib14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.tox.2026.154587_bib15","doi-asserted-by":"crossref","first-page":"R294","DOI":"10.1152\/ajpregu.00522.2016","article-title":"Arsenic exposure induces glucose intolerance and alters global energy metabolism","volume":"314","author":"Kirkley","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.tox.2026.154587_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140536","article-title":"Urinary arsenic metabolism, genetic susceptibility, and their interaction on type 2 diabetes","volume":"345","author":"Li","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2026.154587_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.117410","article-title":"Association of urinary arsenic metabolism with type 2 diabetes and glucose homeostasis: cross-sectional and longitudinal associations","volume":"239","author":"Li","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2026.154587_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154702","article-title":"METTL3 is required for maintaining beta-cell function","volume":"116","author":"Li","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.tox.2026.154587_bib19","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1007\/s00125-023-05900-z","article-title":"Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice","volume":"66","author":"Li","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.tox.2026.154587_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/biom12040535","article-title":"MafA regulation in beta-cells: from transcriptional to post-translational mechanisms","volume":"12","author":"Liang","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.tox.2026.154587_bib21","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2337\/db08-0693","article-title":"Regulation of MafA expression in pancreatic beta-cells in db\/db mice with diabetes","volume":"59","author":"Matsuoka","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.tox.2026.154587_bib22","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00204-022-03248-8","article-title":"Arsenic 3 methyltransferase (AS3MT) automethylates on cysteine residues in vitro","volume":"96","author":"Mersaoui","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2026.154587_bib23","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s41467-020-20632-z","article-title":"PDX1(LOW) MAFA(LOW) beta-cells contribute to islet function and insulin release","volume":"12","author":"Nasteska","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2026.154587_bib24","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s00125-014-3464-9","article-title":"MafA is critical for maintenance of the mature beta cell phenotype in mice","volume":"58","author":"Nishimura","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.tox.2026.154587_bib25","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s10565-022-09703-7","article-title":"AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance","volume":"39","author":"Qiu","year":"2023","journal-title":"Cell. Biol. Toxicol."},{"key":"10.1016\/j.tox.2026.154587_bib26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1476-511X-10-115","article-title":"Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells","volume":"10","author":"Sargsyan","year":"2011","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.tox.2026.154587_bib27","doi-asserted-by":"crossref","first-page":"97004","DOI":"10.1289\/EHP12207","article-title":"Effects of gestational arsenic exposures on placental and fetal development in mice: the role of Cyr61 m6A","volume":"131","author":"Song","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2026.154587_bib28","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/toxsci\/kfy150","article-title":"miR-149 negative regulation of mafA is involved in the arsenite-induced dysfunction of insulin synthesis and secretion in pancreatic beta cells","volume":"167","author":"Sun","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2026.154587_bib29","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.2337\/db19-0906","article-title":"m(6)A mRNA methylation controls functional maturation in neonatal murine beta-cells","volume":"69","author":"Wang","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.tox.2026.154587_bib30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cmet.2023.11.018","article-title":"Repression of latent NF-kappaB enhancers by PDX1 regulates beta cell functional heterogeneity","volume":"36","author":"Weidemann","year":"2024","journal-title":"Cell. Metab."},{"key":"10.1016\/j.tox.2026.154587_bib31","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1007\/s10653-022-01366-x","article-title":"Exposure to multiple metals and diabetes mellitus risk in dong ethnicity in China: from the China multi-ethnic cohort study","volume":"45","author":"Yang","year":"2023","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.tox.2026.154587_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114968","article-title":"Interactions of arsenic metabolism with arsenic exposure and individual factors on diabetes occurrence: baseline findings from Arsenic and Non-Communicable disease cohort (AsNCD) in China","volume":"265","author":"Zhang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2026.154587_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164761","article-title":"Metabolic biomarkers linking urinary arsenic species to gestational diabetes mellitus: a cross-sectional study in Chinese pregnant women","volume":"892","author":"Zhang","year":"2023","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.tox.2026.154587_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130468","article-title":"N(6)-methyladenosine plays a dual role in arsenic carcinogenesis by temporal-specific control of core target AKT1","volume":"445","author":"Zhao","year":"2023","journal-title":"J. Hazard. Mater."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X26001940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X26001940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:42:42Z","timestamp":1791056562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X26001940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":34,"alternative-id":["S0300483X26001940"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2026.154587","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arsenic-induced SAM depletion and m6A dysregulation contribute to impaired insulin secretion in MIN6 cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2026.154587","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154587"}}