{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:48:15Z","timestamp":1790826495546,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon: X"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.toxcx.2022.100130","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T16:59:37Z","timestamp":1654880377000},"page":"100130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Proteomic insight into the venom composition of the largest European rear-fanged snake, Malpolon monspessulanus monspessulanus"],"prefix":"10.1016","volume":"15","author":[{"given":"Dominique","family":"Koua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anicet","family":"Ebou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Habbouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Ballouard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Caron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-1484","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Dutertre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxcx.2022.100130_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/toxins10050177","article-title":"Proteopeptidomic, functional and immunoreactivity characterization of Bothrops moojeni snake venom: influence of snake gender on venom composition","volume":"10","author":"Amorim","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.toxcx.2022.100130_bib2","doi-asserted-by":"crossref","unstructured":"Ballouard J.M., Schmitt C, Bonnet X, Renet J, Caron S, Reynoard J, de Haro L, Deso G., (in press). Envenomation by montpellier snake, Malpolon monspessulanus following prolonged bites. Wilderness and Environmental Medecine. https:\/\/doi: 10.1016\/j.wem.2022.02.011.","DOI":"10.1016\/j.wem.2022.02.011"},{"key":"10.1016\/j.toxcx.2022.100130_bib3","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/sj.emboj.7600620","article-title":"Crystal structure of a Cbtx\u2013AChBP complex reveals essential interactions between snake \u03b1-neurotoxins and nicotinic receptors","volume":"24","author":"Bourne","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.toxcx.2022.100130_bib4","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.ympev.2006.03.028","article-title":"Phylogeny, biogeography, and evolution of two Mediterranean snakes, Malpolon monspessulanus and Hemorrhois hippocrepis (Squamata, Colubridae), using mtDNA sequences","volume":"40","author":"Carranza","year":"2006","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.toxcx.2022.100130_bib5","series-title":"Venom: Purification, Characterization and Gene Organization","first-page":"1397","article-title":"Muscarinic toxin-like proteins from Taiwan banded Krait (Bungarus multicinctus)","volume":"383","author":"Chung","year":"2002"},{"key":"10.1016\/j.toxcx.2022.100130_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.toxicon.2017.02.014","article-title":"Diversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics","volume":"130","author":"Degueldre","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.toxcx.2022.100130_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002195","article-title":"Accelerated profile HMM searches","volume":"7","author":"Eddy","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.toxcx.2022.100130_bib8","first-page":"379","article-title":"A case of cannibalism by an extra large female of Malpolon monspessulanus (Montpellier snake) in the Iberian Peninsula","volume":"6","author":"Franch","year":"2013","journal-title":"Herpetol. Notes"},{"key":"10.1016\/j.toxcx.2022.100130_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1074\/mcp.M700094-MCP200","article-title":"Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia)","volume":"7","author":"Fry","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.toxcx.2022.100130_bib10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1142\/S0219720005001247","article-title":"Spider: software for protein identification from sequence tags with de novo sequencing error","author":"Han","year":"2005","journal-title":"J. Bioinf. Comput. Biol."},{"key":"10.1016\/j.toxcx.2022.100130_bib11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2307\/1446896","article-title":"Northern Pacific rattlesnakes (Crotalus viridis oreganus) meter venom when feeding on prey of different sizes","volume":"1995","author":"Hayes","year":"1995","journal-title":"Copeia"},{"key":"10.1016\/j.toxcx.2022.100130_bib12","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0041-0101(00)00091-X","article-title":"Characterization of venom (Duvernoy's secretion) from twelve species of colubrid snakes and partial sequence of four venom proteins","volume":"38","author":"Hill","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxcx.2022.100130_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/toxins9080245","article-title":"Spider neurotoxins, short linear cationic peptides and venom protein classification improved by an automated competition between exhaustive profile HMM classifiers","volume":"9","author":"Koua","year":"2017","journal-title":"Toxins"},{"key":"10.1016\/j.toxcx.2022.100130_bib14","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1002\/rcm.1196","article-title":"PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry","volume":"17","author":"Ma","year":"2003","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.toxcx.2022.100130_bib15","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1093\/icb\/icw110","article-title":"Understanding biological roles of venoms among the Caenophidia: the importance of rear-fanged snakes","volume":"56","author":"Mackessy","year":"2016","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.toxcx.2022.100130_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3389\/fevo.2019.00279","article-title":"Venoms of rear-fanged snakes: new proteins and novel activities","volume":"7","author":"Modahl","year":"2019","journal-title":"Front. Ecol. Evol."},{"key":"10.1016\/j.toxcx.2022.100130_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jprot.2018.08.004","article-title":"Transcriptome-facilitated proteomic characterization of rear-fanged snake venoms reveal abundant metalloproteinases with enhanced activity","volume":"187","author":"Modahl","year":"2018","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.toxcx.2022.100130_bib18","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.bbagen.2006.12.014","article-title":"Purification and characterization of patagonfibrase, a metalloproteinase showing \u03b1-fibrinogenolytic and hemorrhagic activities, from Philodryas patagoniensis snake venom","volume":"1770","author":"Peichoto","year":"2007","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.toxcx.2022.100130_bib19","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.toxicon.2007.06.008","article-title":"Envenomation by Montpellier snake (Malpolon monspessulanus) with cranial nerve disturbances","volume":"50","author":"Pommier","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxcx.2022.100130_bib20","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1096\/fj.07-8658com","article-title":"\u03b2-Cardiotoxin: a new three-finger toxin from Ophiophagus hannah (king cobra) venom with beta-blocker activity","volume":"21","author":"Rajagopalan","year":"2007","journal-title":"Faseb. J."},{"key":"10.1016\/j.toxcx.2022.100130_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/jez.1402330103","article-title":"Lethal factors and enzymes in the secretion from Duvernoy's gland of three colubrid snakes","volume":"233","author":"Rosenberg","year":"1985","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.toxcx.2022.100130_bib22","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/0041-0101(92)90391-H","article-title":"The secretion of Duvernoy's gland of Malpolon monspessulanus induces haemorrhage in the lungs of mice","volume":"30","author":"Rosenberg","year":"1992","journal-title":"Toxicon"},{"key":"10.1016\/j.toxcx.2022.100130_bib23","doi-asserted-by":"crossref","first-page":"434a","DOI":"10.1016\/j.bpj.2014.11.2369","article-title":"MmTX1 and MmTX2 from coral snake venom potently modulate GABA(A) receptor activity","volume":"108","author":"Rosso","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.toxcx.2022.100130_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/15569543.2014.942040","article-title":"Rear-fanged snake venoms: an untapped source of novel compounds and potential drug leads","volume":"33","author":"Saviola","year":"2014","journal-title":"Toxin Rev."},{"key":"10.1016\/j.toxcx.2022.100130_bib25","series-title":"Progress in Medicinal Chemistry","first-page":"1","article-title":"Chapter One - utilisation of compounds from venoms in drug discovery","author":"Trim","year":"2021"},{"key":"10.1016\/j.toxcx.2022.100130_bib26","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","author":"UniProt Consortium","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxcx.2022.100130_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00726-010-0516-4","article-title":"Venomics: a new paradigm for natural products-based drug discovery","volume":"40","author":"Vetter","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.toxcx.2022.100130_bib28","series-title":"Venomous\u201d Bites from Non-venomous Snakes","article-title":"Front-matter","year":"2011"},{"key":"10.1016\/j.toxcx.2022.100130_bib29","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.biochi.2012.02.006","article-title":"Alsophinase, a new P-III metalloproteinase with \u03b1-fibrinogenolytic and hemorrhagic activity from the venom of the rear-fanged Puerto Rican Racer Alsophis portoricensis (Serpentes: dipsadidae)","volume":"94","author":"Weldon","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.toxcx.2022.100130_bib30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12915-021-01208-9","article-title":"Dynamic genetic differentiation drives the widespread structural and functional convergent evolution of snake venom proteinaceous toxins","volume":"20","author":"Xie","year":"2022","journal-title":"BMC Biol."},{"key":"10.1016\/j.toxcx.2022.100130_bib31","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.010587","article-title":"Peaks DB: de novo sequencing assisted database search for sensitive and accurate peptide identification","volume":"11","author":"Zhang","year":"2012","journal-title":"Mol. Cell. Proteomics"}],"container-title":["Toxicon: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590171022000406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590171022000406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:11:44Z","timestamp":1762917104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590171022000406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":31,"alternative-id":["S2590171022000406"],"URL":"https:\/\/doi.org\/10.1016\/j.toxcx.2022.100130","relation":{},"ISSN":["2590-1710"],"issn-type":[{"value":"2590-1710","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic insight into the venom composition of the largest European rear-fanged snake, Malpolon monspessulanus monspessulanus","name":"articletitle","label":"Article Title"},{"value":"Toxicon: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxcx.2022.100130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100130"}}