{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:00:35Z","timestamp":1772110835750,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.toxicon.2003.10.024","type":"journal-article","created":{"date-parts":[[2003,12,9]],"date-time":"2003-12-09T11:55:53Z","timestamp":1070970953000},"page":"77-83","source":"Crossref","is-referenced-by-count":10,"title":["Effects of ACL myotoxin, a Lys49 phospholipase A2 from Agkistrodon contortrix laticinctus snake venom, on water transport in the isolated toad urinary bladder"],"prefix":"10.1016","volume":"43","author":[{"given":"R.S","family":"Leite","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.L","family":"Ownby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.S","family":"Selistre-de-Araujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2003.10.024_BIB1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0041-0101(96)00036-0","article-title":"Phospholipase A2\u2014a structural review","volume":"34","author":"Arni","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB2","first-page":"F154","article-title":"Cholinergic modulation of water transport in the toad bladder","volume":"239","author":"Arruda","year":"1980","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1677\/joe.0.0170201","article-title":"The effects of neurohypophysial extracts on the water transfer across the wall of the isolated urinary bladder of toad, Bufo Marinus","volume":"17","author":"Bentley","year":"1958","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB4","first-page":"142","article-title":"Inhibition of prostaglandin synthesis antagonizes the colchicine-induced reduction of vasopressin-stimulated water flow in the toad urinary bladder","volume":"21","author":"Burch","year":"1981","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB6","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0041-0101(98)00147-0","article-title":"Lys49 phospholipase A2 myotoxins lyse cell cultures by two distinct mechanisms","volume":"36","author":"Fletcher","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB5","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0041-0101(96)00105-5","article-title":"Similarities and differences in mechanisms of cardiotoxins, melittin and other myotoxins","volume":"34","author":"Fletcher","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB7","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1152\/ajplegacy.1972.223.6.1392","article-title":"Endogenous prostaglandins and osmotic water flow in the toad bladder","volume":"233","author":"Flores","year":"1972","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/lsm.10166","article-title":"Effects of low intensity infrared laser irradiation on the water transport in the isolated toad urinary bladder","volume":"32","author":"Franco","year":"2003","journal-title":"Laser Surg. Med."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB9","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/0041-0101(95)00085-Z","article-title":"Phospholipase A2 myotoxins from Bothrops snake venoms","volume":"33","author":"Gutierrez","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB11","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/ki.1981.87","article-title":"Vasopressin\u2013prostaglandin interactions in the regulation of epithelial cell permeability to water","volume":"19","author":"Handler","year":"1981","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB10","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1152\/ajplegacy.1968.215.5.1024","article-title":"Effect of adrenergic agents on toad bladder response to ADH, 3\u20325\u2032cAMP, and theophyline","volume":"215","author":"Handler","year":"1968","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB12","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1083\/jcb.76.3.787","article-title":"Intracellular calcium as a modulator of transepithelial permeability to water in frog urinary bladder","volume":"76","author":"Hardy","year":"1978","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF01869254","article-title":"Reversible inhibition by lanthanum of the hydrosmotic response to serosal hypertonicity in toad urinary bladder","volume":"48","author":"Hardy","year":"1979","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB15","first-page":"905","article-title":"Studies on the movement of water through the isolated toad bladder and its modification by vasopressin","volume":"45","author":"Hays","year":"1962","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB17","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/ki.1996.251","article-title":"Cellular and molecular events in the action of antidiuretic hormone","volume":"49","author":"Hays","year":"1996","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB18","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0041-0101(88)90244-9","article-title":"Fractionation of Bothrops jararacussu snake venom: partial chemical characterization and biological activity of bothropstoxin","volume":"26","author":"Homsi-Brandeburgo","year":"1988","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0041-0101(93)90143-7","article-title":"Isolation of a myotoxin from the venom of Agkistrodon contortrix laticinctus (broad-banded copperhead) and pathogenesis of myonecrosis induced by it in mice","volume":"31","author":"Johnson","year":"1993","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB20","first-page":"359","article-title":"The role of extracellular ions in the pathogenesis of myonecrosis induced by a myotoxin isolated from broad-banded copperhead (Agkistrodon contrortrix laticinctus)","volume":"107","author":"Johnson","year":"1994","journal-title":"Comp. Biochem. Physiol. (Part C)"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB21","first-page":"895","article-title":"Myotoxicity and physiological effects of three Trimeresurus flavoviridis phospholipases A2","volume":"28","author":"Kihara","year":"1992","journal-title":"Biochem. Int."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0090-6980(02)00020-5","article-title":"Phospholipase A2 enzymes","volume":"68\u201369","author":"Kudo","year":"2002","journal-title":"Prostag. Lipid Mediators"},{"issue":"Renal Fluid Electrolyte Physiol.","key":"10.1016\/j.toxicon.2003.10.024_BIB23","first-page":"F103","article-title":"From toad bladder to kidney","volume":"242","author":"Leaf","year":"1982","journal-title":"Am. J. Physiol"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB24","first-page":"129","article-title":"Effects of cholinergica gents on the vasopressin-mediated water transport in the isolated toad bladder","volume":"129","author":"Leite","year":"2001","journal-title":"Comp. Biochem. Physiol. (Part C)"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB25","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1172\/JCI110081","article-title":"Effects of trifluoperazine on function and structure of toad urinary bladder","volume":"67","author":"Levine","year":"1981","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0163-7258(90)90081-C","article-title":"Myotoxic components of snake venoms: their biochemical and biological activities","volume":"48","author":"Mebs","year":"1990","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB27","first-page":"317","article-title":"The influence of amlodipine and verapamil on ion and water transport in the nephron, skin and urinary bladder of amphibians","volume":"98C","author":"Natochin","year":"1991","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0041-0101(98)00188-3","article-title":"Lysine 49 phospholipase A2 proteins","volume":"37","author":"Ownby","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB29","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0167-4889(96)00175-9","article-title":"Role of prostaglandin E2 in regulation of low and high water osmotic permeability in frog urinary bladder","volume":"1356","author":"Parnova","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB30","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1172\/JCI104943","article-title":"Calcium inhibition of the action of vasopressin on the urinary bladder of the vasopressin","volume":"43","author":"Petersen","year":"1964","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB31","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/0041-0101(95)00089-5","article-title":"No role for enzymatic activity or dantrolene-sensitive Ca+2 stores in the muscular effects of Bothropstoxin, a Lys49 phospholipase A2 myotoxin","volume":"33","author":"Rodrigues-Simioni","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB32","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1172\/JCI112060","article-title":"Inhibition of vasopressin-stimulated water flow in toad bladder by phorbol myristate acetate, dioctanolglycerol and RHC-80267","volume":"76","author":"Scholondorff","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/abbi.1996.0042","article-title":"cDNA cloning and sequence analysis of a lysine-49 phospholipase A2 myotoxin from Agkistrodon contortrix laticinctus snake venom","volume":"326","author":"Selistre-de-Araujo","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(00)00105-0","article-title":"The expanding superfamily of phospholipase A2 enzymes: classification and characterization","volume":"1488","author":"Six","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2003.10.024_BIB35","first-page":"F929","article-title":"Muscarinic receptor activation inhibits AVP-induced water flow in rabbit cortical collecting ducts","volume":"260","author":"Snyder","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB36","first-page":"43","article-title":"Role of cytossolic free calcium and its measurement in a vasopressin-sensitive epithelium","volume":"8","author":"Taylor","year":"1985","journal-title":"Mol. Physiol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB37","first-page":"F1028","article-title":"Cytosolic calcium and the action of vasopressin in toad urinary bladder","volume":"252","author":"Taylor","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.toxicon.2003.10.024_BIB38","first-page":"19","article-title":"Lys-49-phospholipases A2 as active enzyme for \u03b2-arachidonoyl phospholipid bilayer membranes","volume":"43","author":"Yamaguchi","year":"1997","journal-title":"Biochem. Mol. Biol. Int."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010103003192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010103003192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T22:21:25Z","timestamp":1585347685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010103003192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0041010103003192"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2003.10.024","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}