{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:55:06Z","timestamp":1768539306307,"version":"3.49.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.toxicon.2005.01.010","type":"journal-article","created":{"date-parts":[[2005,3,3]],"date-time":"2005-03-03T07:54:01Z","timestamp":1109836441000},"page":"677-680","source":"Crossref","is-referenced-by-count":7,"title":["Antigenic relationships and relative immunogenicities of isolated metalloproteinases from Echis ocellatus venom"],"prefix":"10.1016","volume":"45","author":[{"given":"J.-M.","family":"Howes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.D.G.","family":"Theakston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.D.","family":"Laing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2005.01.010_bib1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0041-0101(97)00011-1","article-title":"Pathogenesis of hemorrhage induced by proteinase H from eastern diamondback rattlesnake (Crotalus adamanteus) venom","volume":"35","author":"Anderson","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.01.010_bib2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0041-0101(02)00358-6","article-title":"Comparative evaluation of immunological and structural similarities of snake venom C-type lectin proteins","volume":"41","author":"Castro","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.01.010_bib3","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0041-0101(00)00218-X","article-title":"Sandwich-ELISA detection of venom antigens in envenoming by Phoneutria nigriventer spider","volume":"39","author":"Chavez-Olortegui","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.01.010_bib4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0006-2952(00)00302-6","article-title":"Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper","volume":"60","author":"Escalante","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxicon.2005.01.010_bib5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0049-3848(00)00259-0","article-title":"Action of metalloproteinases mutalysin I and II on several components of the hemostatic and fibrinolytic systems","volume":"99","author":"Est\u00eav\u00e2o-Costa","year":"2000","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2005.01.010_bib6","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0041-0101(98)00145-7","article-title":"Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom","volume":"36","author":"Guti\u00e9rrez","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.01.010_bib7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0041-0101(02)00360-4","article-title":"The conserved structure of snake venom toxins confers extensive immunological cross-reactivity to toxin-specific antibody","volume":"41","author":"Harrison","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.01.010_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0041-0101(03)00096-5","article-title":"The purification and partial characterisation of two novel metalloproteinases from the venom of the West African carpet viper Echis ocellatus","volume":"42","author":"Howes","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.01.010_bib9","unstructured":"Howes, J.-M., Kamiguti, A.S., Theakston, R.D.G., Laing, G.D., submitted. Effects of three novel metalloproteinases from the venom of the West African saw-scaled viper Echis ocellatus on blood coagulation and platelets. Biochim. Biophys. Acta."},{"key":"10.1016\/j.toxicon.2005.01.010_bib10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0041-0101(87)90113-9","article-title":"A study of the pathogenesis of local skin necrosis induced by Naja nigricollis (spitting cobra) venom using simple histological staining techniques","volume":"25","author":"Iddon","year":"1987","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.01.010_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0041-0101(03)00098-9","article-title":"A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa","volume":"42","author":"Laing","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.01.010_bib12","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0140-6736(02)08456-8","article-title":"The African challenge","volume":"359","author":"Lalloo","year":"2002","journal-title":"The Lancet"},{"key":"10.1016\/j.toxicon.2005.01.010_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4269\/ajtmh.1997.56.291","article-title":"First clinical experiences with a new ovine Fab Echis ocellatus snake bite antivenom in Nigeria: Randomized comparative trial with Institute Pasteur serum (Ipser) Africa antivenom","volume":"56","author":"Meyer","year":"1997","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2005.01.010_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1432-1033.1994.00483.x","article-title":"Cloning of metalloprotease genes in the carpet viper (Echis pyramidum leakeyi). Further members of the metalloprotease\/disintegrin gene family","volume":"224","author":"Paine","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2005.01.010_bib15","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0300-9084(01)01282-2","article-title":"Patholgical alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom","volume":"83","author":"Rodrigues","year":"2001","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2005.01.010_bib16","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S0041-0101(98)00268-2","article-title":"Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom","volume":"37","author":"Rucavado","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.01.010_bib17","first-page":"500","article-title":"Antigen-antibody relations in the present antivenom production of Brazil","volume":"31","author":"Sch\u00f6ttler","year":"1954","journal-title":"Am. J. Trop. Med."},{"issue":"5","key":"10.1016\/j.toxicon.2005.01.010_bib18","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4269\/ajtmh.1992.47.593","article-title":"Use of enzyme immunoassay to compare the effect and assay the dosage regimens of three Brazilian Bothrops antivenoms","volume":"47","author":"Theakston","year":"1992","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2005.01.010_bib19","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1016\/S0140-6736(05)74319-1","article-title":"Crisis in antivenom supply for Africa","volume":"356","author":"Theakston","year":"2000","journal-title":"The Lancet"},{"key":"10.1016\/j.toxicon.2005.01.010_bib20","first-page":"307","article-title":"The importance of bites by the saw-scaled or carpet viper (Echis carinatus): epidemiological studies in Nigeria and a review of the world literature","volume":"33","author":"Warrell","year":"1976","journal-title":"Acta Trop."},{"key":"10.1016\/j.toxicon.2005.01.010_bib21","first-page":"33","article-title":"Poisoning by bites of the saw-scaled or carpet viper (Echis carinatus) in Nigeria","volume":"181","author":"Warrell","year":"1977","journal-title":"Quart. J. Med."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101010500022X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101010500022X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T12:15:20Z","timestamp":1548936920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004101010500022X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S004101010500022X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2005.01.010","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}