{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:05:09Z","timestamp":1790917509371,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.toxicon.2005.03.009","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T11:02:16Z","timestamp":1117191736000},"page":"16-23","source":"Crossref","is-referenced-by-count":37,"title":["Microcystin-LR and embryo\u2013larval development of medaka fish, Oryzias latipes. I. Effects on the digestive tract and associated systems"],"prefix":"10.1016","volume":"46","author":[{"given":"C\u00e9line","family":"Huynh-Delerme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Edery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Huet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Puiseux-Dao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Crespeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaury","family":"de Luze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2005.03.009_bib1","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1042\/bj2780887","article-title":"Swelling of rat hepatocytes activates acetyl-CoA carboxylase in parallel to glycogen synthase","volume":"278","author":"Baquet","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2005.03.009_bib2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/icb\/21.2.377","article-title":"Energy metabolism in fish development","volume":"21","author":"Boulekbache","year":"1981","journal-title":"Am. Zool."},{"key":"10.1016\/j.toxicon.2005.03.009_bib3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2672.1992.tb01858.x","article-title":"Cyanobacteria secondary metabolites\u2014The cyanotoxins","volume":"75","author":"Carmichael","year":"1992","journal-title":"J. Appl. Bacteriol."},{"key":"10.1016\/j.toxicon.2005.03.009_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF00397049","article-title":"Physiological and biochemical aspects of embryonic and larval development of the winter flounder Pseudopleuronectes americanus","volume":"71","author":"Cetta","year":"1982","journal-title":"Mar. Biol. (Berlin)"},{"key":"10.1016\/j.toxicon.2005.03.009_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0273-1223(95)00692-3","article-title":"Cyanobacterial toxins: occurrence, properties and biological significance","volume":"32","author":"Codd","year":"1995","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.toxicon.2005.03.009_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0300-9629(84)90521-8","article-title":"Utilization of body stores in embryonated ova and larvae of two coregonid species (Coregonus lavaretus L. and C. albula L.)","volume":"79A","author":"Dabrowski","year":"1984","journal-title":"Comp. Biochem. Physiol. A"},{"key":"10.1016\/j.toxicon.2005.03.009_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1097(03)00100-9","article-title":"Role of oxydative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatoxicity","volume":"220","author":"Ding","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.toxicon.2005.03.009_bib8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1289\/ehp.00108605","article-title":"Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular gluthation in hepatocytes","volume":"108","author":"Ding","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxicon.2005.03.009_bib9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/(SICI)1097-4652(199706)171:3<259::AID-JCP4>3.0.CO;2-N","article-title":"Inhibition of serine\u2013threonine protein phosphatases decreases barrier function of rat pulmonary microvascular endothelial cells","volume":"171","author":"Diwan","year":"1997","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.toxicon.2005.03.009_bib10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000140715","article-title":"The structure of the liver of vertebrates","volume":"14","author":"Elias","year":"1952","journal-title":"Acta Anat."},{"key":"10.1016\/j.toxicon.2005.03.009_bib11","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0006-291X(05)80936-2","article-title":"Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatase","volume":"173","author":"Eriksson","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2005.03.009_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0009-2797(92)90033-H","article-title":"Cytoskeletal changes in hepatocytes induced by microcystis toxins and their relation to hyperphosphorylation of cells proteins","volume":"81","author":"Falconer","year":"1992","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.toxicon.2005.03.009_bib12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1071\/BI9810179","article-title":"Liver pathology in mice in poisoning by the blue\u2013green alga Microcystis aeruginosa","volume":"34","author":"Falconer","year":"1981","journal-title":"Aust. J. Biol. Sci."},{"key":"10.1016\/j.toxicon.2005.03.009_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(03)01447-9","article-title":"Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response","volume":"557","author":"Gehringer","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2005.03.009_bib15","series-title":"Fish Physiology","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1546-5098(08)60203-4","article-title":"Yolk absorption in embryonic and larval fishes","volume":"vol. XI","author":"Heming","year":"1988"},{"key":"10.1016\/j.toxicon.2005.03.009_bib16","first-page":"291","article-title":"Morphological survey of teleost organs important in carcinogenesis with attention to fixation","volume":"65","author":"Hinton","year":"1984","journal-title":"Natl Cancer Inst. Monogr."},{"key":"10.1016\/j.toxicon.2005.03.009_bib17","doi-asserted-by":"crossref","first-page":"19401","DOI":"10.1016\/S0021-9258(17)45384-1","article-title":"Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases","volume":"265","author":"Honkanen","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2005.03.009_bib18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.toxicon.2003.11.010","article-title":"Effects of microcystin-LR on development of Medaka (Oryzias latipes)","volume":"43","author":"Jacquet","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.03.009_bib19","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1139\/f82-147","article-title":"Pattern of nitrogen excretion and oxygen consumption during ontogenesis of common carp (Cyprinus carpio)","volume":"39","author":"Kaushik","year":"1982","journal-title":"Can. J. Fish Aquat. Sci."},{"key":"10.1016\/j.toxicon.2005.03.009_bib20","first-page":"620","article-title":"Cantharidin enhances norepinephrine-induced vasoconstriction in an endothelium-dependent fashion","volume":"294","author":"Knapp","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxicon.2005.03.009_bib21","doi-asserted-by":"crossref","first-page":"26074","DOI":"10.1074\/jbc.M003843200","article-title":"Glycogen synthetase association with the striated muscle glycogen targeting subunit of protein phosphatase-1","volume":"275","author":"Liu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2005.03.009_bib22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0041-0101(01)00173-8","article-title":"The toxic effects of microcystin-LR on embryo\u2013larval and juvenile development of loach (Migurnuns mizolepsis Gunthe)","volume":"40","author":"Liu","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.03.009_bib23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1440-169X.1961.tb00120.x","article-title":"The pattern of transfer of the yolk material to the embryo during the development of the teleostean fish Oryzias latipes","volume":"6","author":"Monroy","year":"1961","journal-title":"Embryologia"},{"key":"10.1016\/j.toxicon.2005.03.009_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/BF01570074","article-title":"Cyclic peptides and depsipeptides from cyanobacteria: a review","volume":"16","author":"Moore","year":"1996","journal-title":"J. Ind. Microbiol."},{"key":"10.1016\/j.toxicon.2005.03.009_bib25","series-title":"Cyanotoxins: Occurrence, Causes, Consequences","first-page":"240","article-title":"Effects of cyanotoxins on early life stages of fish and amphibians","author":"Oberemm","year":"2001"},{"key":"10.1016\/j.toxicon.2005.03.009_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<77::AID-TOX11>3.0.CO;2-F","article-title":"Effects of microcystin-LR and cyanobacterial crude extracts on the development of fish and amphibians","volume":"14","author":"Oberemm","year":"1999","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.toxicon.2005.03.009_bib27","first-page":"545","article-title":"Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A","volume":"273","author":"Runnegar","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxicon.2005.03.009_bib28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1006\/taap.1995.1192","article-title":"Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters","volume":"134","author":"Runnegar","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxicon.2005.03.009_bib29","first-page":"56","article-title":"Ultrastructural aspects of yolk absorption in the vitellin syncitium of the embryonic rockfish (Sebastes schegeli)","volume":"27","author":"Shimizu","year":"1980","journal-title":"J. Ichthiol."},{"key":"10.1016\/j.toxicon.2005.03.009_bib30","first-page":"98","article-title":"Organogenesis and functional revelation of alimentary tract and kidney of chum salmon","volume":"29","author":"Takahashi","year":"1978","journal-title":"Tohoku J. Agric. Res."},{"key":"10.1016\/j.toxicon.2005.03.009_bib31","first-page":"261","article-title":"Metabolism and energy conversion during early development","volume":"vol. 8","author":"Terner","year":"1979"},{"key":"10.1016\/j.toxicon.2005.03.009_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1242\/jcs.110.1.23","article-title":"Protein phosphatases maintain the organization and structural interaction of hepatic keratin intermediate filaments","volume":"110","author":"Toivola","year":"1997","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.toxicon.2005.03.009_bib33","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1136\/bmj.300.6737.1440","article-title":"Pneumonia associated with contact with cyanobacteria","volume":"300","author":"Turner","year":"1990","journal-title":"Br. Med. J."},{"key":"10.1016\/j.toxicon.2005.03.009_bib34","first-page":"164","article-title":"Gastroenteritis in Salisbury European children: a five years study","volume":"12","author":"Zilberg","year":"1966","journal-title":"Cent. Afr. J. Med."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010105001108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010105001108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T02:19:15Z","timestamp":1625969955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010105001108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0041010105001108"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2005.03.009","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}