{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:38:18Z","timestamp":1791031098021,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.toxicon.2005.07.002","type":"journal-article","created":{"date-parts":[[2005,9,15]],"date-time":"2005-09-15T14:15:38Z","timestamp":1126793738000},"page":"625-634","source":"Crossref","is-referenced-by-count":42,"title":["Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators"],"prefix":"10.1016","volume":"46","author":[{"given":"Rapha\u00eble","family":"Boydron-Le Garrec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Benoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin-Pierre","family":"Sauviat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Molg\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2005.07.002_bib1_1","first-page":"503","article-title":"Screening of traditional remedies used in ciguatera fish poisoning treatment","volume":"2","author":"Amade","year":"1992","journal-title":"Rec. Adv. Toxinol. Res."},{"key":"10.1016\/j.toxicon.2005.07.002_bib33","unstructured":"Bagnis, R.A., 1973. L'ichtyosarcotoxisme dans le Pacifique sud. Commission du Pacifique Sud, Noum\u00e9a, Nouvelle-Cal\u00e9donie, 112 p."},{"issue":"Suppl","key":"10.1016\/j.toxicon.2005.07.002_bib2","first-page":"33","article-title":"Reversal of Pacific-ciguatoxin-1B effects on myelinated axons by agents used in ciguatera treatment","volume":"24","author":"Benoit","year":"2000","journal-title":"Cybium"},{"key":"10.1016\/j.toxicon.2005.07.002_bib3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0378-8741(92)90017-L","article-title":"Traditional remedies used in the western pacific for the treatment of ciguatera poisoning","volume":"36","author":"Bourdy","year":"1992","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxicon.2005.07.002_bib4","series-title":"Rencontres en toxinologie: Explorer, exploiter les toxines et ma\u00eetriser les organismes producteurs","first-page":"63","article-title":"Un test biologique destin\u00e9 \u00e0 identifier les principes actifs des plantes utilis\u00e9es comme rem\u00e8des traditionnels contre l'intoxication ciguat\u00e9rique en Nouvelle-Cal\u00e9donie","author":"Boydron","year":"2001"},{"key":"10.1016\/j.toxicon.2005.07.002_bib5","series-title":"Rencontres en toxinologie: Toxines et recherches biom\u00e9dicales","first-page":"101","article-title":"L'h\u00e9molyse des \u00e9rythrocytes humains par la P-CTX-1: une m\u00e9thode pour \u00e9valuer le potentiel th\u00e9rapeutique des rem\u00e8des traditionnels utilis\u00e9s en Nouvelle-Cal\u00e9donie pour traiter la ciguat\u00e9ra","author":"Boydron","year":"2002"},{"key":"10.1016\/j.toxicon.2005.07.002_bib6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/15563658708992645","article-title":"Treatment of ciguatera fish poisoning with amitryptyline and nifedipine","volume":"25","author":"Calvert","year":"1987","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.toxicon.2005.07.002_bib7","first-page":"936","article-title":"Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing","volume":"47","author":"Carmichael","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxicon.2005.07.002_bib8","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","article-title":"Molecular mechanisms of neurotoxin action on voltage-gated sodium channels","volume":"82","author":"Cest\u00e8le","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2005.07.002_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0041-0101(98)00169-X","article-title":"Ciguatoxins and brevetoxins, neurotoxic polyether compounds active on sodium channels","volume":"37","author":"Dechraoui","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.07.002_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0041-0101(76)90120-3","article-title":"Duboisia myoporoides: native antidote against ciguatera poisoning","volume":"14","author":"Dufva","year":"1976","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.07.002_bib11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1055\/s-2006-957981","article-title":"Kavain inhibits non-stereospecifically veratridine-activated Na+ channels","volume":"62","author":"Gleitz","year":"1996","journal-title":"Planta Med."},{"key":"10.1016\/j.toxicon.2005.07.002_bib12","series-title":"Poisonous and Venomous Marine Animals of The World (Revised Edition)","author":"Halstead","year":"1978"},{"key":"10.1016\/j.toxicon.2005.07.002_bib13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2331\/suisan.35.316","article-title":"Ciguatera in the Ryukyu and Amami Islands","volume":"35","author":"Hashimoto","year":"1969","journal-title":"Bull. Jpn. Soc. Sci. Fish."},{"key":"10.1016\/j.toxicon.2005.07.002_bib14","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/0002-9343(88)90320-8","article-title":"Potential benefit of tocainide in the treatment of ciguatera: report of three cases","volume":"84","author":"Lange","year":"1988","journal-title":"Am. J. Med."},{"key":"10.1016\/j.toxicon.2005.07.002_bib15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-8741(90)90055-X","article-title":"Behavioral effects of Euphorbia hirta L.: sedative and anxiolytic properties","volume":"29","author":"Lanhers","year":"1990","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxicon.2005.07.002_bib16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1055\/s-2006-960079","article-title":"Analgesic, antipyretic and anti-inflammatory properties of Euphorbia hirta","volume":"57","author":"Lanhers","year":"1991","journal-title":"Planta Med."},{"key":"10.1016\/j.toxicon.2005.07.002_bib17","unstructured":"Laurent, D., Amade, P., 1992. La ciguatera: \u00e9pid\u00e9miologie et \u00e9tiologie, toxicologie et rem\u00e8des traditionnels. Ed. ORSTOM, Noum\u00e9a."},{"key":"10.1016\/j.toxicon.2005.07.002_bib18","unstructured":"Laurent, D., Bourdy, G., Amade, P., Cabalion, P., Bourret, D., 1993. La gratte ou ciguatera. Ses rem\u00e8des traditionnels dans le Pacifique Sud. Ed. ORSTOM, Paris."},{"key":"10.1016\/j.toxicon.2005.07.002_bib19","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/0041-0101(91)90209-A","article-title":"Purification and characterization of ciguatoxins from moray eel (Lycodontis javanicus, Muraenidae)","volume":"29","author":"Lewis","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.07.002_bib20","doi-asserted-by":"crossref","first-page":"19659","DOI":"10.1016\/S0021-9258(17)32067-7","article-title":"Na+,K+-ATPase","volume":"269","author":"Lingrel","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2005.07.002_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/abio.1993.1476","article-title":"Tetrazolium-based cell bioassay for neurotoxins active on voltage-sensitive sodium channels: semiautomated assay for saxitoxins, brevetoxins, and ciguatoxins","volume":"214","author":"Manger","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.toxicon.2005.07.002_bib23","first-page":"571","article-title":"Cell bioassay for the detection of ciguatoxins, brevetoxins, and saxitoxins","volume":"34","author":"Manger","year":"1994","journal-title":"Mem. Qd. Mus."},{"key":"10.1016\/j.toxicon.2005.07.002_bib22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/jaoac\/78.2.521","article-title":"Detection of sodium channel toxin: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts","volume":"78","author":"Manger","year":"1995","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.toxicon.2005.07.002_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.toxicon.2005.07.002_bib34","unstructured":"Noro, T., Nishihara, G.N., Terada, R., Yoropiy, A., 2003. Ciguatera fish poisoning in Ulithi Atoll, Yap state, Micronesia. In: Aoyama, T. (Ed.), The Progress Report of the 2000 and 2001 Survey of the Research Project \u201cSocial Homeostasis of Small Island in an Island-Zone\u201d, Yap Proper and Ulithi Atoll, Micronesia. Kagoshima University Research Center for the Pacific Islands, Kagoshima, Japan, Occasional Papers No. 39, Section 2, Report 9, pp. 83\u201386."},{"key":"10.1016\/j.toxicon.2005.07.002_bib25","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1001\/jama.259.18.2740","article-title":"Successful treatment of ciguatera fish poisoning with intravenous mannitol","volume":"259","author":"Palafox","year":"1988","journal-title":"JAMA"},{"key":"10.1016\/j.toxicon.2005.07.002_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5694\/j.1326-5377.1989.tb101165.x","article-title":"Ciguatera and mannitol: experience with a new treatment regimen","volume":"151","author":"Pearn","year":"1989","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.toxicon.2005.07.002_bib27","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJM200103013440919","article-title":"Treatment of ciguatera poisoning with gabapentin","volume":"344","author":"Perez","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.toxicon.2005.07.002_bib28","unstructured":"Rageau, J., 1973. Les plantes m\u00e9dicinales de la Nouvelle-Cal\u00e9donie. Travaux et Documents de l'ORSTOM, N\u00b023, Ed. ORSTOM, Paris."},{"key":"10.1016\/j.toxicon.2005.07.002_bib29","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1212\/WNL.58.6.873","article-title":"Ciguatera fish poisoning: a double-blind randomized trial of mannitol therapy","volume":"58","author":"Schnorf","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.toxicon.2005.07.002_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/15563659309000371","article-title":"Ciguatera","volume":"31","author":"Swift","year":"1993","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.toxicon.2005.07.002_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0028-3908(91)90045-D","article-title":"Delta-9-tetrahydrocannabinol depresses inward sodium current in mouse neuroblastoma cells","volume":"30","author":"Turkanis","year":"1991","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.toxicon.2005.07.002_bib32","first-page":"569","article-title":"Les usages m\u00e9dicinaux de quelques plantes communes de la flore des \u00eeles Banks (Vanuatu)","volume":"18","author":"Vienne","year":"1981","journal-title":"Cahiers de l'ORSTOM, s\u00e9rie Sciences Humaines"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010105002370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010105002370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T16:01:17Z","timestamp":1626537677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010105002370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0041010105002370"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2005.07.002","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}