{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:30:08Z","timestamp":1791275408430,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.toxicon.2005.07.009","type":"journal-article","created":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T12:40:03Z","timestamp":1126874403000},"page":"672-686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Classification of spider neurotoxins using structural motifs by primary structure features. Single residue distribution analysis and pattern analysis techniques"],"prefix":"10.1016","volume":"46","author":[{"given":"Sergey","family":"Kozlov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Grishin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.toxicon.2005.07.009_bib1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0021-9258(19)40129-4","article-title":"Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom","volume":"265","author":"Adams","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.toxicon.2005.07.009_bib2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0026-895X(25)13240-9","article-title":"Structure and properties of omega-agatoxin IVB, a new antagonist of P-type calcium channels","volume":"44","author":"Adams","year":"1993","journal-title":"Mol. Pharmacol."},{"issue":"2\u20133","key":"10.1016\/j.toxicon.2005.07.009_bib3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0014-5793(00)01593-3","article-title":"Purification, structure determination and synthesis of covalitoxin-II, a short insect-specific neurotoxic peptide from the venom of the Coremiocnemis validus (Singapore tarantula)","volume":"474","author":"Balaji","year":"2000","journal-title":"FEBS Lett."},{"issue":"6446","key":"10.1016\/j.toxicon.2005.07.009_bib4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/365496a0","article-title":"Fatty acylated toxin structure","volume":"365","author":"Branton","year":"1993","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.toxicon.2005.07.009_bib5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1042\/bj2500401","article-title":"Amino acid sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web spider Atrax versutus","volume":"250","author":"Brown","year":"1988","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.toxicon.2005.07.009_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jms.577","article-title":"De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis","volume":"39","author":"Budnik","year":"2004","journal-title":"J. Mass Spectrom."},{"issue":"7","key":"10.1016\/j.toxicon.2005.07.009_bib7","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0041-0101(03)00011-4","article-title":"Molecular cloning and characterization of Phoneutria nigriventer toxins active on calcium channels","volume":"41","author":"Cardoso","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.07.009_bib8","unstructured":"Chong, Y., Khalife, A.A., Hains, P.G., Broady, K.R., Nicholson, G.M., unpubl. Direct Submission."},{"issue":"2","key":"10.1016\/j.toxicon.2005.07.009_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0014-5793(92)81318-G","article-title":"The purification and amino acid sequences of four Tx2 neurotoxins from the venom of the Brazilian \u2018armed\u2019 spider Phoneutria nigriventer (Keys)","volume":"310","author":"Cordeiro Mdo","year":"1992","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.toxicon.2005.07.009_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0041-0101(93)90354-L","article-title":"Purification and amino acid sequences of six Tx3 type neurotoxins from the venom of the Brazilian \u2018armed\u2019 spider Phoneutria nigriventer (Keys)","volume":"31","author":"Cordeiro Mdo","year":"1993","journal-title":"Toxicon"},{"issue":"18","key":"10.1016\/j.toxicon.2005.07.009_bib11","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1046\/j.1432-1327.2000.01653.x","article-title":"Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae)","volume":"267","author":"Corzo","year":"2000","journal-title":"Eur. J. Biochem."},{"issue":"26","key":"10.1016\/j.toxicon.2005.07.009_bib12","doi-asserted-by":"crossref","first-page":"23627","DOI":"10.1074\/jbc.M200511200","article-title":"Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins","volume":"277","author":"Corzo","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1\u20133","key":"10.1016\/j.toxicon.2005.07.009_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0014-5793(03)00666-5","article-title":"Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel","volume":"547","author":"Corzo","year":"2003","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.toxicon.2005.07.009_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0041-0101(82)90138-6","article-title":"Two types of scorpion receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel","volume":"20","author":"Couraud","year":"1982","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.07.009_bib15","unstructured":"Dai, L., Naoki, H., Nakajima, T., unpubl. Direct Submission."},{"issue":"3","key":"10.1016\/j.toxicon.2005.07.009_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.toxicon.2004.05.028","article-title":"Identification and molecular cloning of insecticidal toxins from the venom of the brown spider Loxosceles intermedia","volume":"44","author":"de Castro","year":"2004","journal-title":"Toxicon"},{"issue":"7","key":"10.1016\/j.toxicon.2005.07.009_bib17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.toxicon.2003.08.007","article-title":"cDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena","volume":"42","author":"Diao","year":"2003","journal-title":"Toxicon"},{"issue":"21","key":"10.1016\/j.toxicon.2005.07.009_bib18","doi-asserted-by":"crossref","first-page":"15340","DOI":"10.1016\/S0021-9258(18)82260-8","article-title":"Sequence of the cDNA coding for the lethal neurotoxin Tx1 from the Brazilian \u2018armed\u2019 spider Phoneutria nigriventer predicts the synthesis and processing of a preprotoxin","volume":"268","author":"Diniz","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.toxicon.2005.07.009_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/sj.bjp.0702283","article-title":"Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis","volume":"126","author":"Diochot","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"17","key":"10.1016\/j.toxicon.2005.07.009_bib20","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.1021\/bi00183a013","article-title":"Type III omega-agatoxins: a family of probes for similar binding sites on L- and N-type calcium channels","volume":"33","author":"Ertel","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2005.07.009_bib21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0041-0101(97)90300-7","article-title":"Two novel peptide neurotoxins from the venom of the tarantula Lasiodora parahybana","volume":"35","author":"Escoubas","year":"1996","journal-title":"Toxicon"},{"issue":"9\u201310","key":"10.1016\/j.toxicon.2005.07.009_bib22","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0300-9084(00)01166-4","article-title":"Structure and pharmacology of spider venom neurotoxins","volume":"82","author":"Escoubas","year":"2000","journal-title":"Biochimie"},{"issue":"33","key":"10.1016\/j.toxicon.2005.07.009_bib23","doi-asserted-by":"crossref","first-page":"25116","DOI":"10.1074\/jbc.M003643200","article-title":"Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels","volume":"275","author":"Escoubas","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.toxicon.2005.07.009_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1124\/mol.62.1.48","article-title":"Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies","volume":"62","author":"Escoubas","year":"2002","journal-title":"Mol. Pharmacol."},{"issue":"7","key":"10.1016\/j.toxicon.2005.07.009_bib25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nsb0797-559","article-title":"The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider","volume":"4","author":"Fletcher","year":"1997","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.toxicon.2005.07.009_bib26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2220\/biomedres.11.181","article-title":"Complete amino acid sequence of a new type of neurotoxin from the venom of the spider, Agelena opulenta","volume":"11","author":"Hagiwara","year":"1990","journal-title":"Biomed. Res."},{"key":"10.1016\/j.toxicon.2005.07.009_bib27","unstructured":"Hayes, J., Wen, S., Yang, Q., Hains, P.G., Broady, K.R., Nicholson, G.M., Unpubl. Direct Submission."},{"issue":"1","key":"10.1016\/j.toxicon.2005.07.009_bib28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/(SICI)1520-6327(1998)38:1<19::AID-ARCH3>3.0.CO;2-Q","article-title":"Novel insecticidal peptides from Tegenaria agrestis spider venom may have a direct effect on the insect central nervous system","volume":"38","author":"Johnson","year":"1998","journal-title":"Arch. Insect Biochem. Physiol."},{"issue":"1","key":"10.1016\/j.toxicon.2005.07.009_bib29","first-page":"43","article-title":"Molecular cloning of two cDNAs encoding an insecticidal toxin from the spider, Araneus ventricosus, and construction of a recombinant baculovirus expressing a spider toxin","volume":"4","author":"Jung","year":"2002","journal-title":"Int. J. Ind. Entomol."},{"issue":"9","key":"10.1016\/j.toxicon.2005.07.009_bib30","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0041-0101(94)90392-1","article-title":"Primary structures of two proteins from the venom of the Mexican red knee tarantula (Brachypelma smithii)","volume":"32","author":"Kaiser","year":"1994","journal-title":"Toxicon"},{"issue":"12","key":"10.1016\/j.toxicon.2005.07.009_bib31","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/S0041-0101(98)00127-5","article-title":"Cloning, cDNA sequence analysis and patch clamp studies of a toxin from the venom of the armed spider (Phoneutria nigriventer)","volume":"36","author":"Kalapothakis","year":"1998","journal-title":"Toxicon"},{"issue":"12","key":"10.1016\/j.toxicon.2005.07.009_bib32","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0041-0101(98)00105-6","article-title":"Cloning of cDNAS encoding neurotoxic peptides from the spider Phoneutria nigriventer","volume":"36","author":"Kalapothakis","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.07.009_bib33","unstructured":"Kelbaugh, P.R., Saccomano, N.A., Volkmann, R.A., 1999. Patent US 5627154."},{"issue":"1","key":"10.1016\/j.toxicon.2005.07.009_bib34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/prot.20390","article-title":"A novel strategy for the identification of toxin like structures in spider venom","volume":"59","author":"Kozlov","year":"2005","journal-title":"Proteins"},{"issue":"9","key":"10.1016\/j.toxicon.2005.07.009_bib35","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0965-1748(95)00029-U","article-title":"Characterization and cloning of insecticidal peptides from the primitive weaving spider Diguetia canities","volume":"25","author":"Krapcho","year":"1995","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"13","key":"10.1016\/j.toxicon.2005.07.009_bib36","doi-asserted-by":"crossref","first-page":"11208","DOI":"10.1074\/jbc.M111099200","article-title":"Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae)","volume":"277","author":"Kuhn-Nentwig","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2005.07.009_bib37","unstructured":"Lampe, R.A., 2000. Patent US 5877026."},{"issue":"2","key":"10.1016\/j.toxicon.2005.07.009_bib38","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0026-895X(25)13204-5","article-title":"Isolation and pharmacological characterization of omega-grammotoxin SIA, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses","volume":"44","author":"Lampe","year":"1993","journal-title":"Mol. Pharmacol."},{"issue":"10","key":"10.1016\/j.toxicon.2005.07.009_bib39","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/rcm.1442","article-title":"Nanospray analysis of the venom of the tarantula Theraphosa leblondi: a powerful method for direct venom mass fingerprinting and toxin sequencing","volume":"18","author":"Legros","year":"2004","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"5","key":"10.1016\/j.toxicon.2005.07.009_bib40","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0965-1748(95)00070-4","article-title":"Molecular cloning and sequencing of cDNAs encoding insecticidal peptides from the primitive hunting spider, Plectreurys tristis (Simon)","volume":"26","author":"Leisy","year":"1996","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.toxicon.2005.07.009_bib41","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0014-5793(03)01303-6","article-title":"Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana","volume":"555","author":"Li","year":"2003","journal-title":"FEBS Lett."},{"issue":"5","key":"10.1016\/j.toxicon.2005.07.009_bib42","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.toxicon.2004.02.005","article-title":"An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)]","volume":"43","author":"Liang","year":"2004","journal-title":"Toxicon"},{"issue":"7","key":"10.1016\/j.toxicon.2005.07.009_bib43","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0041-0101(95)00033-I","article-title":"A lectin-like peptide isolated from the venom of the Chinese bird spider Selenocosmia huwena","volume":"33","author":"Liang","year":"1995","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.toxicon.2005.07.009_bib44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0041-0101(01)00181-7","article-title":"Novel insecticidal toxins from the venom of the spider Segestria florentina","volume":"40","author":"Lipkin","year":"2002","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.toxicon.2005.07.009_bib45","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1007\/s00018-003-2354-x","article-title":"Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana","volume":"60","author":"Liu","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.toxicon.2005.07.009_bib46","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1432-1327.1999.00726.x","article-title":"Isolation, amino acid sequence and functional assays of SGTx1. The first toxin purified from the venom of the spider Scodra griseipes","volume":"265","author":"Marvin","year":"1999","journal-title":"Eur. J. Biochem."},{"issue":"50","key":"10.1016\/j.toxicon.2005.07.009_bib47","doi-asserted-by":"crossref","first-page":"14734","DOI":"10.1021\/bi026546a","article-title":"Two tarantula peptides inhibit activation of multiple sodium channels","volume":"41","author":"Middleton","year":"2002","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.toxicon.2005.07.009_bib48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0896-6273(95)90057-8","article-title":"The charybdotoxin family of K+ channel-blocking peptides","volume":"15","author":"Miller","year":"1995","journal-title":"Neuron"},{"issue":"6363","key":"10.1016\/j.toxicon.2005.07.009_bib49","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/355827a0","article-title":"P-type calcium channels blocked by the spider toxin omega-Aga-IVA","volume":"355","author":"Mintz","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2005.07.009_bib50","unstructured":"Nason II, D.M., Heck, S.D., Ronau, R.T., Saccomano, N.A., Volkmann, R.A., 1998. Calcium channel blocking polypeptides from filistata hibernalis. Patent US 5804554."},{"key":"10.1016\/j.toxicon.2005.07.009_bib51","first-page":"1276","article-title":"Amino acid sequence of the toxic spider peptide CSTX-2 and its structural and physiological differences to CSTX-1","volume":"36","author":"Nentwig","year":"1998","journal-title":"Toxicon"},{"issue":"26","key":"10.1016\/j.toxicon.2005.07.009_bib52","doi-asserted-by":"crossref","first-page":"8341","DOI":"10.1021\/bi00026a015","article-title":"SNX-325, a novel calcium antagonist from the spider Segestria florentina","volume":"34","author":"Newcomb","year":"1995","journal-title":"Biochemistry"},{"issue":"44","key":"10.1016\/j.toxicon.2005.07.009_bib53","doi-asserted-by":"crossref","first-page":"15353","DOI":"10.1021\/bi981255g","article-title":"Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas","volume":"37","author":"Newcomb","year":"1998","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.toxicon.2005.07.009_bib54","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0041-0101(00)00157-4","article-title":"Conotoxins, in retrospect","volume":"39","author":"Oliveraa","year":"2001","journal-title":"Toxicon"},{"issue":"7","key":"10.1016\/j.toxicon.2005.07.009_bib55","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.toxicon.2003.10.009","article-title":"PnTx4-3, a new insect toxin from Phoneutria nigriventer venom elicits the glutamate uptake inhibition exhibited by PhTx4 toxic fraction","volume":"42","author":"Oliveira","year":"2003","journal-title":"Toxicon"},{"issue":"37","key":"10.1016\/j.toxicon.2005.07.009_bib56","doi-asserted-by":"crossref","first-page":"34443","DOI":"10.1074\/jbc.M202715200","article-title":"Solution structure of peptide toxins that block mechanosensitive ion channels","volume":"277","author":"Oswald","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.toxicon.2005.07.009_bib57","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0041-0101(99)00237-8","article-title":"Molecular cloning of cDNAs encoding insecticidal neurotoxic peptides from the spider Phoneutria nigriventer","volume":"38","author":"Penaforte","year":"2000","journal-title":"Toxicon"},{"issue":"9\u201310","key":"10.1016\/j.toxicon.2005.07.009_bib58","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0300-9084(00)01167-6","article-title":"Peptides and genes coding for scorpion toxins that affect ion-channels","volume":"82","author":"Possani","year":"2000","journal-title":"Biochimie"},{"issue":"15","key":"10.1016\/j.toxicon.2005.07.009_bib59","doi-asserted-by":"crossref","first-page":"11098","DOI":"10.1016\/S0021-9258(19)78096-X","article-title":"Isolation and sequencing of insecticidal peptides from the primitive hunting spider, Plectreurys tristis (Simon)","volume":"269","author":"Quistad","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2005.07.009_bib60","unstructured":"Richardson, M., Pimenta, A.M.C., Bemquerer, M.P., Santoro, M.M., Figueiredo, S.G., Lima, M.E., Cordeiro, M.N., unpubl. Direct Submission."},{"issue":"10","key":"10.1016\/j.toxicon.2005.07.009_bib61","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1021\/bi011932y","article-title":"Solution structures of the cis- and trans-Pro30 isomers of a novel 38-residue toxin from the venom of Hadronyche Infensa sp. that contains a cystine-knot motif within its four disulfide bonds","volume":"41","author":"Rosengren","year":"2002","journal-title":"Biochemistry"},{"issue":"6928","key":"10.1016\/j.toxicon.2005.07.009_bib62","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature01473","article-title":"Functional analysis of an archaebacterial voltage-dependent K+ channel","volume":"422","author":"Ruta","year":"2003","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.toxicon.2005.07.009_bib63","first-page":"1013","article-title":"Toxic components of the venom of the cellar spider Segestria florentina","volume":"13","author":"Sagdiev","year":"1987","journal-title":"Bioorg. Khim."},{"issue":"3","key":"10.1016\/j.toxicon.2005.07.009_bib64","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0026-895X(24)13491-8","article-title":"Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels","volume":"51","author":"Sanguinetti","year":"1997","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.toxicon.2005.07.009_bib65","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.toxicon.2004.05.012","article-title":"Rapid and efficient identification of cysteine-rich peptides by random screening of a venom gland cDNA library from the hexathelid spider Macrothele gigas","volume":"44","author":"Satake","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.07.009_bib66","unstructured":"Satake, H., Corzo, G., Villegas, E., unpubl. Direct Submission."},{"issue":"5","key":"10.1016\/j.toxicon.2005.07.009_bib67","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1515\/bchm3.1989.370.1.485","article-title":"Tarantula (Eurypelma californicum) venom, a multicomponent system","volume":"370","author":"Savel-Niemann","year":"1989","journal-title":"Biol. Chem. Hoppe-Seyler"},{"issue":"10","key":"10.1016\/j.toxicon.2005.07.009_bib68","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1007\/PL00000794","article-title":"CSTX-9, a toxic peptide from the spider Cupiennius salei: amino acid sequence, disulphide bridge pattern and comparison with other spider toxins containing the cystine knot structure","volume":"58","author":"Schalle","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.toxicon.2005.07.009_bib69","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0014-5793(85)81132-7","article-title":"Complete amino acid sequence of a new type of lethal neurotoxin from the venom of the funnel-web spider Atrax robustus","volume":"181","author":"Sheumack","year":"1985","journal-title":"FEBS Lett."},{"issue":"5","key":"10.1016\/j.toxicon.2005.07.009_bib70","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1034\/j.1399-3011.1999.00039.x","article-title":"Purification and characterization of huwentoxin-II, a neurotoxic peptide from the venom of the Chinese bird spider Selenocosmia huwena","volume":"53","author":"Shu","year":"1999","journal-title":"J. Pept. Res."},{"issue":"43","key":"10.1016\/j.toxicon.2005.07.009_bib71","doi-asserted-by":"crossref","first-page":"33464","DOI":"10.1074\/jbc.M001491200","article-title":"Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family","volume":"275","author":"Silva","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.toxicon.2005.07.009_bib72","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/S0021-9258(18)94154-2","article-title":"Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta","volume":"264","author":"Skinner","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.toxicon.2005.07.009_bib73","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0041-0101(92)90049-B","article-title":"Identification of insecticidal peptides from venom of the trap-door spider, Aptostichus schlingeri (Ctenizidae)","volume":"30","author":"Skinner","year":"1992","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.toxicon.2005.07.009_bib74","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/S0021-9258(19)39939-9","article-title":"Curtatoxins. Neurotoxic insecticidal polypeptides isolated from the funnel-web spider Hololena curta","volume":"265","author":"Stapleton","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.toxicon.2005.07.009_bib75","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0896-6273(95)90184-1","article-title":"An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula","volume":"15","author":"Swartz","year":"1995","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.toxicon.2005.07.009_bib76","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0014-5793(00)01339-9","article-title":"Isolation and pharmacological characterisation of delta-atracotoxin-Hv1b, a vertebrate-selective sodium channel toxin","volume":"470","author":"Szeto","year":"2000","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.toxicon.2005.07.009_bib77","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0041-0101(99)00174-9","article-title":"Isolation of a funnel-web spider polypeptide with homology to mamba intestinal toxin 1 and the embryonic head inducer Dickkopf-1","volume":"38","author":"Szeto","year":"2000","journal-title":"Toxicon"},{"issue":"11","key":"10.1016\/j.toxicon.2005.07.009_bib78","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0165-6147(99)01398-X","article-title":"A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies","volume":"20","author":"Tytgat","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.toxicon.2005.07.009_bib79","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1016\/S0021-9258(18)45925-X","article-title":"Antagonism of synaptosomal calcium channels by subtypes of omega-agatoxins","volume":"267","author":"Venema","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.toxicon.2005.07.009_bib80","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1046\/j.1432-1327.1999.00646.x","article-title":"Structure-function studies of omega-atracotoxin, a potent antagonist of insect voltage-gated calcium channels","volume":"264","author":"Wang","year":"1999","journal-title":"Eur. J. Biochem."},{"issue":"6","key":"10.1016\/j.toxicon.2005.07.009_bib81","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/75921","article-title":"Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge","volume":"7","author":"Wang","year":"2000","journal-title":"Nat. Struct. Biol."},{"issue":"43","key":"10.1016\/j.toxicon.2005.07.009_bib82","doi-asserted-by":"crossref","first-page":"40306","DOI":"10.1074\/jbc.M105206200","article-title":"Discovery and structure of a potent and highly specific blocker of insect calcium channels","volume":"276","author":"Wang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2005.07.009_bib83","unstructured":"Wilson, D.T., Drinkwater, R., Alewood, P.F., Unpublished. Molecules identified from the venom of Australian funnel-web spiders."},{"issue":"31","key":"10.1016\/j.toxicon.2005.07.009_bib84","doi-asserted-by":"crossref","first-page":"11251","DOI":"10.1073\/pnas.0402226101","article-title":"CSTX-13, a highly synergistically acting two-chain neurotoxic enhancer in the venom of the spider Cupiennius salei (Ctenidae)","volume":"101","author":"Wullschleger","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.toxicon.2005.07.009_bib85","unstructured":"Xiao, Y.C., unpubl. Direct Submission."},{"issue":"6","key":"10.1016\/j.toxicon.2005.07.009_bib86","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0041-0101(02)00280-5","article-title":"Purification and characterization of Hainantoxin-V, a tetrodotoxin-sensitive sodium channel inhibitor from the venom of the spider Selenocosmia hainana","volume":"41","author":"Xiao","year":"2003","journal-title":"Toxicon"},{"issue":"25","key":"10.1016\/j.toxicon.2005.07.009_bib87","doi-asserted-by":"crossref","first-page":"26220","DOI":"10.1074\/jbc.M401387200","article-title":"Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes","volume":"279","author":"Xiao","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.toxicon.2005.07.009_bib88","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1074\/jbc.273.4.2059","article-title":"Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis","volume":"273","author":"Yan","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.toxicon.2005.07.009_bib89","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0041-0101(02)00361-6","article-title":"Purification and characterization of raventoxin-I and raventoxin-III, two neurotoxic peptides from the venom of the spider Macrothele raveni","volume":"41","author":"Zeng","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.07.009_bib90","unstructured":"Zhu, Q., Liu, Z.H., Liang, S.P., unpubl. Direct Submission."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010105002618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010105002618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:05:58Z","timestamp":1758575158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010105002618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":90,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0041010105002618"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2005.07.009","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Classification of spider neurotoxins using structural motifs by primary structure features. Single residue distribution analysis and pattern analysis techniques","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2005.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}