{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:10:51Z","timestamp":1773249051873,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.toxicon.2005.08.013","type":"journal-article","created":{"date-parts":[[2005,9,30]],"date-time":"2005-09-30T11:17:14Z","timestamp":1128079034000},"page":"814-819","source":"Crossref","is-referenced-by-count":17,"title":["Microvessel damage by B. jararacussu snake venom: pathogenesis and influence on muscle regeneration"],"prefix":"10.1016","volume":"46","author":[{"given":"Humberto Santo","family":"Neto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J\u00falia","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2005.08.013_bib1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0041-0101(96)00222-X","article-title":"Isolation and characterization of new clotting factor from Bothrops jararacussu (jararacu\u00e7u) venom","volume":"35","author":"Andri\u00e3o-Escarso","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib2","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0041-0101(02)00140-X","article-title":"Purification, characterization and crystallization of jararacussin-I, a fibrinogen-clotting enzyme isolated from the venom of Bothrops jararacussu","volume":"40","author":"Bortoleto","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib3","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/nm963","article-title":"Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates","volume":"9","author":"Camargo","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.toxicon.2005.08.013_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s100720200060","article-title":"Macrophage secreted myogenic factors: a promising tool for greatly enhancing the proliferative capacity of myoblasts in vitro and in vivo","volume":"23","author":"Cantini","year":"2002","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.toxicon.2005.08.013_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/physrev.00019.2003","article-title":"Cellular and molecular regulation of muscle regeneration","volume":"84","author":"Charg\u00e9","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.toxicon.2005.08.013_bib6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0041-0101(02)00287-8","article-title":"Epidemiology of snakebite in a central region of Brazil","volume":"41","author":"da Silva","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib7","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.279.5356.1528","article-title":"Muscle regeneration by bone marrow derived myogenic progenitors","volume":"279","author":"Ferrari","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2005.08.013_bib8","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.biochi.2004.07.001","article-title":"Signal transduction pathways involved in the platelet aggregation induced by a D-49 phospholipase A2 isolated from Bothrops jararacussu snake venom","volume":"86","author":"Fuly","year":"2004","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2005.08.013_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-4800(91)90002-F","article-title":"Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase-A2 isolated from the venom of the snake Bothrops jararacussu","volume":"55","author":"Guti\u00e9rrez","year":"1991","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.toxicon.2005.08.013_bib11","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0300-9084(00)01163-9","article-title":"Snake metalloproteinases: their role in the pathogenesis of local tissue damage","volume":"82","author":"Guti\u00e9rrez","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2005.08.013_bib10","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.toxicon.2003.11.005","article-title":"Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity","volume":"42","author":"Guti\u00e9rrez","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib12","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.toxicon.2003.11.011","article-title":"Myotoxic phospholipases A2 and the regeneration of skeletal muscles","volume":"42","author":"Harris","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0041-0101(88)90244-9","article-title":"Fractionation of Bothrops jararacussu snake venom: partial chemical characterization and biological activity of bothropstoxin","volume":"26","author":"Homsi-Brandeburgo","year":"1988","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib14","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/00034989958393","article-title":"Prognostic factors for amputation in the case of envenoming by snakes of the genus Bothrops (Viperidae)","volume":"93","author":"Jorge","year":"1999","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.toxicon.2005.08.013_bib15","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0041-0101(96)00017-7","article-title":"Insights into the mechanism of hemorrhage caused by snake venom metalloproteinases","volume":"34","author":"Kamiguti","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib16","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0041-0101(02)00171-X","article-title":"Vascular endothelial cell injury induced by Bothrops jararaca; non-significance of hemorrhagic metalloproteinase","volume":"40","author":"Kawano","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.toxicon.2004.06.002","article-title":"A new metalloprotease from Bothrops jararacussu snake venom: isolation and biochemical characterization","volume":"44","author":"Mazzi","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib18","doi-asserted-by":"crossref","first-page":"47804","DOI":"10.1074\/jbc.M209778200","article-title":"Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa","volume":"277","author":"Peek","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2005.08.013_bib20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0041-0101(84)90077-1","article-title":"Muscle necrosis and regeneration after envenomation by Bothrops jararacussu snake venom","volume":"22","author":"Queir\u00f3z","year":"1984","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib19","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/S0041-0101(02)00166-6","article-title":"Acute local nerve lesions induced by Bothrops jararacussu snake venom","volume":"40","author":"Queir\u00f3z","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib21","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1590\/S0036-46651990000600008","article-title":"Clinical and epidemiologic features of bites by adult and young Bothrops jararaca","volume":"32","author":"Ribeiro","year":"1990","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"10.1016\/j.toxicon.2005.08.013_bib22","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.toxicon.2004.08.007","article-title":"Insights into the loss of muscle mass following B. jararacussu venom in mice","volume":"44","author":"Santo Neto","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib23","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.toxicon.2003.10.010","article-title":"Snake venom metalloproteinases: structure\/function relationship studies using monoclonal antibodies","volume":"42","author":"Tanjoni","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.08.013_bib24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/mus.10453","article-title":"Neutrophils do not contribute to local tissue damage, but play a key role in the skeletal muscle regeneration, in mice injected with Bothrops asper snake venom","volume":"28","author":"Teixeira","year":"2003","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.toxicon.2005.08.013_bib25","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1182\/blood-2004-03-1051","article-title":"Adult vasculogenesis occurs through in situ recruitment, proliferation and tubulization of circulating bone-marrow-derived cells","volume":"105","author":"Tepper","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.toxicon.2005.08.013_bib26","first-page":"345","article-title":"Inflammatory processes in muscle injury and repair","volume":"288","author":"Tidball","year":"2005","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.toxicon.2005.08.013_bib27","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0041-0101(96)00006-2","article-title":"Purification and characterization of a fibrinogen-clotting enzyme isolated from the venom of jararacu\u00e7u (Bothrops jararacussu)","volume":"34","author":"Zaganelli","year":"1996","journal-title":"Toxicon"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010105003120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010105003120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T01:59:53Z","timestamp":1548122393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010105003120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0041010105003120"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2005.08.013","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}