{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:14:31Z","timestamp":1785446071733,"version":"3.56.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.toxicon.2005.10.001","type":"journal-article","created":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T12:31:07Z","timestamp":1132662667000},"page":"75-86","source":"Crossref","is-referenced-by-count":25,"title":["Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A2 homologue on a lymphoblastoid cell line"],"prefix":"10.1016","volume":"47","author":[{"given":"Rodrigo","family":"Mora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Valverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2005.10.001_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signaling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/eji.1830240208","article-title":"The phosphoprotein phosphatase calcineurin controls calcium-dependent apoptosis in B cell lines","volume":"24","author":"Bonnefoy","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib4","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.1471-4159.1993.tb03251.x","article-title":"Specific in vitro biological activity of snake venom myotoxins","volume":"60","author":"Brus\u00e9s","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2005.10.001_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0167-4889(93)90080-9","article-title":"Effects on cultured mammalian cells of myotoxin III, a phospholipase A2 isolated from Bothrops asper (terciopelo) venom","volume":"1179","author":"Bultr\u00f3n","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2005.10.001_bib6","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1073\/pnas.87.6.2162","article-title":"Neuropeptide stimulation of calcium flux in human lung cancer cells: delineation of alternative pathways","volume":"87","author":"Bunn","year":"1990","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.toxicon.2005.10.001_bib7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/meth.2000.1002","article-title":"Analysis of free intracellular calcium by flow cytometry: multiparameter and pharmacologic applications","volume":"21","author":"Burchiel","year":"2000","journal-title":"Methods"},{"key":"10.1016\/j.toxicon.2005.10.001_bib8","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0041-0101(03)00007-2","article-title":"Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants","volume":"41","author":"Chacur","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.10.001_bib9","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1042\/bj20020092","article-title":"Distinct sites for myotoxic and membrane-damaging activities in the C-terminal region of a Lys49-phospholipase A2","volume":"366","author":"Chioato","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2005.10.001_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-1097(03)00471-3","article-title":"Contribution of intracellular calcium stores to an increase in cytosolic calcium concentration induced by Mannheimia haemolytica leukotoxin","volume":"225","author":"Cudd","year":"2003","journal-title":"FEMS Micobiol Lett."},{"key":"10.1016\/j.toxicon.2005.10.001_bib11","doi-asserted-by":"crossref","first-page":"13057","DOI":"10.1016\/S0021-9258(17)36794-7","article-title":"Diversity of group types, regulation, and function of phospholipase A2","volume":"269","author":"Dennis","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2005.10.001_bib12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0005-2736(91)90086-N","article-title":"The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities","volume":"1070","author":"D\u00edaz","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2005.10.001_bib13","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature01259","article-title":"Computational approaches to cellular rhythms","volume":"420","author":"Goldbeter","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2005.10.001_bib14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0014-5793(00)02268-7","article-title":"Use of ruthenium red as an inhibitor of mitochondrial Ca2+ uptake in single rat cardiomyocytes","volume":"486","author":"Griffiths","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2005.10.001_bib15","first-page":"211","article-title":"Local tissue damage induced by Bothrops snake venoms. A review","volume":"51","author":"Guti\u00e9rrez","year":"1989","journal-title":"Mem. Inst. Butantan"},{"key":"10.1016\/j.toxicon.2005.10.001_bib16","series-title":"Animais Peconhentos no BrasilBiologia, Cl\u00ednica e Terapeutica dos Accidentes","first-page":"310","article-title":"Efectos locales en el envenenamiento of\u00eddico en Am\u00e9rica Latina","author":"Guti\u00e9rrez","year":"2003"},{"key":"10.1016\/j.toxicon.2005.10.001_bib17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0742-8413(86)90183-0","article-title":"Pharmacological activities of a toxic phospholipase A isolated from the venom of the snake Bothrops asper","author":"Guti\u00e9rrez","year":"1986","journal-title":"Comp. Biochem. Physiol. 84C"},{"key":"10.1016\/j.toxicon.2005.10.001_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-4800(91)90002-F","article-title":"Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu","volume":"55","author":"Guti\u00e9rrez","year":"1991","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib19","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.toxicon.2003.11.005","article-title":"Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity","volume":"42","author":"Guti\u00e9rrez","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.10.001_bib20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0014-4800(84)90054-6","article-title":"Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper","volume":"40","author":"Guti\u00e9rrez","year":"1984","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0892-0354(90)90001-9","article-title":"Muscle necrosis caused by snake venoms and toxins","volume":"3","author":"Harris","year":"1990","journal-title":"Electron Microsc. Rev."},{"key":"10.1016\/j.toxicon.2005.10.001_bib22","doi-asserted-by":"crossref","first-page":"E810","DOI":"10.1152\/ajpendo.00038.2001","article-title":"Function-specific calcium stores selectively regulate growth hormone secretion, storage, and mRNA level","volume":"282","author":"Johnson","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.toxicon.2005.10.001_bib23","series-title":"Venom Phospholipase A2 Enzymes: Structure, Function and Mechanism","first-page":"1","article-title":"Phospholipase A2\u2014a complex multifunctional protein puzzle","author":"Kini","year":"1997"},{"key":"10.1016\/j.toxicon.2005.10.001_bib24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/PL00006450","article-title":"Accelerated evolution and molecular surface of venom phospholipase A2 enzymes","volume":"48","author":"Kini","year":"1999","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib25","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2005.10.001_bib26","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.185.8.1481","article-title":"Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptois and necrosis","volume":"185","author":"Leist","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.toxicon.2005.10.001_bib27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cyto.990200210","article-title":"Single step procedure for labeling DNA strand breaks with fluorescein- or BODIPY-conjugated deoxynucleotides. Detection of apoptosis and bromodeoxyuridine incorporation","volume":"20","author":"Li","year":"1995","journal-title":"Cytometry"},{"key":"10.1016\/j.toxicon.2005.10.001_bib28","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0041-0101(89)90039-1","article-title":"A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo)","volume":"27","author":"Lomonte","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.10.001_bib29","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/0041-0101(94)90408-1","article-title":"Broad cytolytic specificity of myotoxin II, a lysine-49 phospholipase A2 of Bothrops asper snake venom","volume":"32","author":"Lomonte","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.10.001_bib30","doi-asserted-by":"crossref","first-page":"29867","DOI":"10.1016\/S0021-9258(18)43961-0","article-title":"Neutralizing interaction between heparins and myotoxin II, a Lysine 49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling","volume":"269","author":"Lomonte","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2005.10.001_bib31","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.toxicon.2003.11.008","article-title":"An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action","volume":"42","author":"Lomonte","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.10.001_bib32","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.toxicon.2005.01.008","article-title":"A Lys49 phospholipase A2 homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line","volume":"45","author":"Mora","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.10.001_bib33","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1021\/tx00018a001","article-title":"The role of Ca2+ in cell killing","volume":"3","author":"Nicotera","year":"1990","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/cyto.990170205","article-title":"Improved sensitivity in flow cytometric intracellular ionized calcium measurement using Fluo-3\/Fura Red fluorescence ratios","volume":"17","author":"Novak","year":"1994","journal-title":"Cytometry"},{"key":"10.1016\/j.toxicon.2005.10.001_bib35","series-title":"Perspectives in Molecular Toxinology","first-page":"387","article-title":"Accelerated and regional evolution of snake venom gland isozymes","author":"Ohno","year":"2002"},{"key":"10.1016\/j.toxicon.2005.10.001_bib36","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.toxicon.2003.11.003","article-title":"Molecular evolution of myotoxic phospholipases A2 from snake venom","volume":"42","author":"Ohno","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.10.001_bib37","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1002\/ana.410320708","article-title":"Calcium ions and oxidative cell injury","volume":"32","author":"Orrenius","year":"1992","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib38","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrm1150","article-title":"Regulation of cell death: the calcium-apoptosis link","volume":"4","author":"Orrenius","year":"2003","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib39","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0041-0101(98)00188-3","article-title":"Lysine 49 phospholipase A2 proteins","volume":"37","author":"Ownby","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.10.001_bib40","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1046\/j.1432-1327.1998.2530452.x","article-title":"Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothrops asper snake venom. Synthetic Lys49 myotoxin II-(115\u2013129)-peptide identifies its bactericidal region","volume":"253","author":"P\u00e1ramo","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2005.10.001_bib41","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0196-9781(99)00132-1","article-title":"Concentration-dependent differential induction of necrosis or apoptosis by HIV-1 lytic peptide 1","volume":"20","author":"Plymale","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.toxicon.2005.10.001_bib42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/taap.1998.8580","article-title":"The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187","volume":"154","author":"Quian","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib43","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1046\/j.1460-9568.11-2.02244.x","article-title":"Modulation of secretion by the endoplasmic reticulum in mouse chromaffin cells","volume":"16","author":"Rigual","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.toxicon.2005.10.001_bib44","series-title":"Handbook of Toxinology","first-page":"67","article-title":"Phospholipases","author":"Rosenberg","year":"1990"},{"key":"10.1016\/j.toxicon.2005.10.001_bib45","doi-asserted-by":"crossref","first-page":"12424","DOI":"10.1021\/bi00164a018","article-title":"Calcium ion independent membrane leakage induced by phospholipase-like myotoxins","volume":"31","author":"Rufini","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2005.10.001_bib46","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1042\/bj3200467","article-title":"Proliferative effect of ammodytin L from the venom of Vipera ammodytes on 208F rat fibroblasts in culture","volume":"320","author":"Rufini","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2005.10.001_bib47","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1074-5521(96)90253-7","article-title":"Photodegradation of Indo-1 and its effect on apparent Ca2+ concentrations","volume":"3","author":"Scheenen","year":"1996","journal-title":"Chem. Biol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib48","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1046\/j.0014-2956.2001.02720.x","article-title":"Modelling of simple and complex calcium oscillations. From single-cell responses to intercellular signalling","volume":"269","author":"Schuster","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2005.10.001_bib49","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0301-4622(98)00127-6","article-title":"A model of mitochondrial Ca2+-induced Ca2+ release simulating the Ca2+ oscillations and spikes generated by mitochondria","volume":"72","author":"Selivanov","year":"1998","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.toxicon.2005.10.001_bib50","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1046\/j.1471-4159.2003.02035.x","article-title":"Induction by \u03b2-bungarotoxin of apoptosis in cultured hippocampal neurons is mediated by Ca2+-dependent formation of reactive oxygen species","volume":"87","author":"Shakhman","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2005.10.001_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(00)00105-0","article-title":"The expanding superfamily of phospholipase A2 enzymes: classification and characterization","volume":"1488","author":"Six","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2005.10.001_bib52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/abbi.1999.1492","article-title":"Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from Bothrops moojeni (caissaca) snake venom","volume":"373","author":"Soares","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2005.10.001_bib53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0041-008X(03)00327-2","article-title":"Cardiotoxin III selectively enhances activation-induced apoptosis of human CD8+T lymphocytes","volume":"193","author":"Su","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxicon.2005.10.001_bib54","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.toxicon.2003.11.006","article-title":"Inflammatory effects of snake venom myotoxic phospholipases A2","volume":"42","author":"Teixeira","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2005.10.001_bib55","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0300-9084(00)01168-8","article-title":"What can venom phospholipases A2 tell us about the functional diversity of mammalian secreted phospholipases A2?","volume":"82","author":"Valentin","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2005.10.001_bib56","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1432-1033.1988.tb14288.x","volume":"176","author":"van den Bergh","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2005.10.001_bib57","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1242\/jcs.00455","article-title":"Biochemical characterization, distribution and phylogenetic analysis of Drosophila melanogaster ryanodine and IP3 receptors, and thapsigargin-sensitive Ca2+-ATPase","volume":"116","author":"V\u00e1zquez-Mart\u00ednez","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.toxicon.2005.10.001_bib58","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1042\/0264-6021:3620089","article-title":"Active-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysis","volume":"362","author":"Ward","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2005.10.001_bib59","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0143-4160(90)90061-X","article-title":"Intracellular calibration of the fluorescent calcium indicator Fura-2","volume":"11","author":"Williams","year":"1990","journal-title":"Cell Calcium"},{"key":"10.1016\/j.toxicon.2005.10.001_bib60","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.toxicon.2004.11.004","article-title":"Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity","volume":"45","author":"Zuliani","year":"2005","journal-title":"Toxicon"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010105003582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010105003582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T04:39:39Z","timestamp":1626755979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010105003582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0041010105003582"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2005.10.001","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}