{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:16:26Z","timestamp":1774048586766,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.toxicon.2006.05.004","type":"journal-article","created":{"date-parts":[[2006,5,20]],"date-time":"2006-05-20T11:22:17Z","timestamp":1148124137000},"page":"227-237","source":"Crossref","is-referenced-by-count":63,"title":["l-Amino acid oxidase from Vipera lebetina venom: Isolation, characterization, effects on platelets and bacteria"],"prefix":"10.1016","volume":"48","author":[{"given":"K\u00fclli","family":"T\u00f5nism\u00e4gi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Samel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Trummal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunilla","family":"R\u00f6nnholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcri","family":"Siigur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisse","family":"Kalkkinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ene","family":"Siigur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2006.05.004_bib1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1006\/abbi.2000.2130","article-title":"Isolation, structural, and functional characterization of an apoptosis-inducing l-amino acid oxidase from leaf-nosed viper (Eristocophis macmahoni) snake venom","volume":"384","author":"Ali","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2006.05.004_bib2","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.toxicon.2006.05.004_bib3","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1002\/pmic.200402024","article-title":"Snake venomics: comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina","volume":"5","author":"Bazaa","year":"2005","journal-title":"Proteomics"},{"key":"10.1016\/j.toxicon.2006.05.004_bib4","first-page":"149","article-title":"l-amino acid oxidase","volume":"vol. 2","author":"Bergmeyer","year":"1983"},{"key":"10.1016\/j.toxicon.2006.05.004_bib5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0041-0101(02)00102-2","article-title":"Snake venom l-amino acid oxidases","volume":"40","author":"Du","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.05.004_bib6","series-title":"Snake Venoms","first-page":"61","article-title":"Enzymes in snake venoms","author":"Iwanaga","year":"1979"},{"key":"10.1016\/j.toxicon.2006.05.004_bib7","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1128\/AEM.64.6.2079-2085.1998","article-title":"Isolation, characterization, molecular cloning and sequencing of a novel phytase from Bacillus subtilis","volume":"64","author":"Kerovuo","year":"1998","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.toxicon.2006.05.004_bib8","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2006.05.004_bib9","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/0041-0101(94)90407-3","article-title":"Purification and characterization of l-amino acid oxidase from king cobra (Ophiophagus hannah) venom and its effects on human platelet aggregation","volume":"32","author":"Li","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.05.004_bib10","first-page":"305","article-title":"Purification and characterization of l-amino acid oxidase from Agkistrodon halys pallas venom","volume":"34","author":"Liu","year":"2002","journal-title":"Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)"},{"key":"10.1016\/j.toxicon.2006.05.004_bib11","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1046\/j.1432-1033.2001.02042.x","article-title":"l-Amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma. Comparative sequence analysis and characterization of active and inactive forms of the enzyme","volume":"268","author":"Macheroux","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2006.05.004_bib12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1055\/s-0038-1657280","article-title":"Impairment of platelet aggregation by Echis colorata venom mediated by l-amino acid oxidase or H2O2","volume":"48","author":"Nathan","year":"1982","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.toxicon.2006.05.004_bib13","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1093\/emboj\/19.16.4204","article-title":"The structure of l-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site","volume":"19","author":"Pawelek","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.toxicon.2006.05.004_bib14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1006\/abbi.1994.1401","article-title":"Purification and properties of the l-amino acid oxidase from Malayan pit viper (Calloselasma rhodostoma) venom","volume":"313","author":"Ponnudurai","year":"1994","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2006.05.004_bib15","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/rcm.424","volume":"15","author":"Poutanen","year":"2001","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.toxicon.2006.05.004_bib16","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1006\/bbrc.1998.9024","article-title":"Primary structure of the snake venom l-amino acid oxidase shows high homology with the mouse B cell interleukin 4-induced Fig1 protein","volume":"248","author":"Raibekas","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2006.05.004_bib17","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/S0041-0101(01)00133-7","article-title":"Inhibition of human platelet aggregation by l-amino acid oxidase purified from Naja naja kaouthia venom","volume":"39","author":"Sakurai","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.05.004_bib18","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels","volume":"68","author":"Shevchenko","year":"1996","journal-title":"Anal. Chem."},{"key":"10.1016\/j.toxicon.2006.05.004_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0167-4838(98)00232-5","article-title":"Isolation, properties and N-terminal amino acid sequence of a factor V activator from Vipera lebetina (Levantine viper) snake venom","volume":"1429","author":"Siigur","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2006.05.004_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0049-3848(98)00009-7","article-title":"Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom","volume":"90","author":"Siigur","year":"1998","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2006.05.004_bib21","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/j.bmc.2004.03.049","article-title":"Platelet aggregation and antibacterial effects of an l-amino acid oxidase purified from Bothrops alternatus snake venom","volume":"12","author":"Stabeli","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.toxicon.2006.05.004_bib22","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0041-0101(91)90210-I","article-title":"Antibacterial effects of different snake venoms: purification and characterization of antibacterial proteins from Pseudechis australis (Australian king brown or mulga snake) venom","volume":"29","author":"Stiles","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.05.004_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/bbrc.1996.0996","article-title":"Identification of the snake venom substance that induces apoptosis","volume":"224","author":"Suhr","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2006.05.004_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0887-2333(03)00010-9","article-title":"Apoptotic effect in the glioma cells induced by a specific protein extracted from Okinawa Habu (Trimeresurus flavoviridis) venom in relation to oxidative stress","volume":"17","author":"Sun","year":"2003","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxicon.2006.05.004_bib25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0167-4838(00)00229-6","article-title":"Molecular characterization of l-amino acid oxidase from Agkistrodon halys blomhoffii with special reference to platelet aggregation","volume":"1544","author":"Takatsuka","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2006.05.004_bib26","series-title":"Enzymes From Snake Venom","first-page":"579","article-title":"l-amino acid oxidases and lactate dehydrogenases","author":"Tan","year":"1998"},{"key":"10.1016\/j.toxicon.2006.05.004_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0020-711X(91)90114-3","article-title":"Substrate specificity of king cobra (Ophiophagus hannah) venom l-amino acid oxidase","volume":"23","author":"Tan","year":"1991","journal-title":"Int. J. Biochem."},{"key":"10.1016\/j.toxicon.2006.05.004_bib28","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0020-711X(92)90105-A","article-title":"Purification and properties of the l-amino acid oxidase from the monocellate cobra (Naja naja kaouthia) venom","volume":"24","author":"Tan","year":"1992","journal-title":"Int. J. Biochem."},{"key":"10.1016\/j.toxicon.2006.05.004_bib29","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1006\/bbrc.2000.4175","article-title":"Bothrops moojeni venom kills Leishmania spp. with hydrogen peroxide generated by its l-amino acid oxidase","volume":"280","author":"Tempone","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2006.05.004_bib30","doi-asserted-by":"crossref","first-page":"9539","DOI":"10.1074\/jbc.272.14.9539","article-title":"Apoxin I, a novel apoptosis-inducing factor with l-amino acid oxidase activity purified from Western diamondback rattlesnake venom","volume":"272","author":"Torii","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.05.004_bib31","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1021\/bi992416z","article-title":"Molecular cloning and functional analysis of apoxin I, a snake venom-derived apoptosis-inducing factor with l-amino acid oxidase activity","volume":"39","author":"Torii","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2006.05.004_bib32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.toxicon.2005.09.008","article-title":"Isolation of a new l-amino acid oxidase from Crotalus durissus cascavella venom","volume":"47","author":"Toyama","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.05.004_bib33","first-page":"219","article-title":"Purification, characterization and biological activity of an l-amino acid oxidase from Trimeresurus mucrosquamatus venom","volume":"35","author":"Wei","year":"2002","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.toxicon.2006.05.004_bib34","first-page":"336","article-title":"Hydrogen peroxide produced by two amino acid oxidases mediates antibacterial actions","volume":"42","author":"Zhang","year":"2004","journal-title":"J. Microbiol."},{"key":"10.1016\/j.toxicon.2006.05.004_bib35","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.bbrc.2003.08.044","article-title":"Molecular characterization of Trimeresurus stejnegeri venom l-amino acid oxidase with potential anti-HIV activity","volume":"309","author":"Zhang","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010106001693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010106001693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T23:45:34Z","timestamp":1586907934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010106001693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0041010106001693"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2006.05.004","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}