{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:10:17Z","timestamp":1762917017557},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.toxicon.2006.09.028","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T11:37:56Z","timestamp":1160566676000},"page":"299-305","source":"Crossref","is-referenced-by-count":19,"title":["The effect of treatment with crotapotin on the evolution of experimental autoimmune neuritis induced in Lewis rats"],"prefix":"10.1016","volume":"49","author":[{"given":"Fabiano R.","family":"Castro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro S.","family":"Farias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L.F.","family":"Proen\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane","family":"de La Hoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Langone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine C.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos H.","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Marangoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonilda M.B.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.toxicon.2006.09.028_bib1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/1097-4547(20001201)62:5<709::AID-JNR10>3.0.CO;2-T","article-title":"Lipid-free versus lipid-bound P2 protein-induced experimental allergic neuritis: clinicopathological, neurophysiological and immunological study","volume":"62","author":"Cavaletti","year":"2000","journal-title":"J. Neurosci Res."},{"issue":"5176","key":"10.1016\/j.toxicon.2006.09.028_bib2","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1126\/science.7520605","article-title":"Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis","volume":"265","author":"Chen","year":"1994","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.toxicon.2006.09.028_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0041-0101(03)00198-3","article-title":"Crotapotin induced modification of T lymphocyte proliferative response through interference with PGE2 synthesis","volume":"42","author":"Garcia","year":"2003","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.toxicon.2006.09.028_bib4","first-page":"328","article-title":"Experimental allergic neuritis (EAN) as a model for the immune-mediated demyelinating neuropathies","volume":"152","author":"Hahn","year":"1996","journal-title":"Rev. Neurol. (Paris)"},{"issue":"7","key":"10.1016\/j.toxicon.2006.09.028_bib5","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1073\/pnas.68.7.1560","article-title":"Biological roles of the two components of crotoxin","volume":"68","author":"Hendon","year":"1971","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.toxicon.2006.09.028_bib6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3109\/08923979909007122","article-title":"Sequence determinants of modified cobra venom neurotoxin which induce immune resistance to experimental allergic encephalomyelitis: molecular mechanisms for immunologic action","volume":"21","author":"Hinman","year":"1999","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"1","key":"10.1016\/j.toxicon.2006.09.028_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0165-5728(01)00276-4","article-title":"Oral tolerance in experimental autoimmune neuritis (EAN) of the Lewis rat. II. Adjuvant effects and bystander suppression in P2 peptide-induced EAN","volume":"116","author":"Jung","year":"2001","journal-title":"J. Neuroimmunol."},{"issue":"15","key":"10.1016\/j.toxicon.2006.09.028_bib8","first-page":"3754","article-title":"A novel disintegrin salmosin inhibits tumor angiogenesis","volume":"59","author":"Kang","year":"1999","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.toxicon.2006.09.028_bib9","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1084\/jem.176.5.1355","volume":"176","author":"Khoury","year":"1992","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.toxicon.2006.09.028_bib10","doi-asserted-by":"crossref","first-page":"757","DOI":"10.4049\/jimmunol.170.2.757","article-title":"Mechanisms of enhanced macrophage-mediated prostaglandin E2 production and its suppressive role in Th1 activation in Th2-dominant BALB\/c mice","volume":"170","author":"Kuroda","year":"2003","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.toxicon.2006.09.028_bib11","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1476-5381.1995.tb17178.x","article-title":"Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2","volume":"114","author":"Landucci","year":"1995","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.toxicon.2006.09.028_bib12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0041-0101(99)00143-9","article-title":"Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2","volume":"38","author":"Landucci","year":"2000","journal-title":"Toxicon"},{"issue":"10","key":"10.1016\/j.toxicon.2006.09.028_bib13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd1197","article-title":"Therapeutic potential of venom peptides","volume":"2","author":"Lewis","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.toxicon.2006.09.028_bib14","first-page":"359","article-title":"Bioactivities of nerve growth factor from Chinese cobra venom","volume":"8","author":"Li","year":"1999","journal-title":"J. Nat. Toxins"},{"issue":"1","key":"10.1016\/j.toxicon.2006.09.028_bib16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.4049\/jimmunol.177.1.246","article-title":"FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism","volume":"177","author":"Mahic","year":"2006","journal-title":"J. Immunol."},{"issue":"123","key":"10.1016\/j.toxicon.2006.09.028_bib17","first-page":"7","article-title":"Cellular immunity in inflammatory autoimmune neuropathies","volume":"158","author":"Maurer","year":"2002","journal-title":"Rev. Neurol. (Paris)"},{"issue":"8","key":"10.1016\/j.toxicon.2006.09.028_bib18","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.4049\/jimmunol.171.8.3913","article-title":"Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori","volume":"171","author":"Meyer","year":"2003","journal-title":"J. Immunol."},{"issue":"1\u20133","key":"10.1016\/j.toxicon.2006.09.028_bib19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1385\/IR:29:1-3:187","article-title":"Modulating TH1\/TH2 responses with microbes, dendritic cells, and pathogen recognition receptors","volume":"29","author":"Pulendran","year":"2004","journal-title":"Immunol. Res."},{"issue":"2","key":"10.1016\/j.toxicon.2006.09.028_bib20","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0003-2697(87)90587-2","article-title":"Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100kDa","volume":"166","author":"Schagger","year":"1987","journal-title":"Anal. Biochem."},{"issue":"5","key":"10.1016\/j.toxicon.2006.09.028_bib21","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1084\/jem.20041982","article-title":"Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization","volume":"201","author":"Setoguchi","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.toxicon.2006.09.028_bib23","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1146\/annurev.immunol.21.120601.140942","article-title":"Molecular mechanisms regulating Th1 immune responses","volume":"21","author":"Szabo","year":"2003","journal-title":"Annu Rev. Immunol."},{"issue":"5","key":"10.1016\/j.toxicon.2006.09.028_bib24","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/00007890-199609150-00024","article-title":"Cobra venom factor stimulates anti-alpha-galactose antibody production in baboons. Implications for pig-to-human xenotransplantation","volume":"62","author":"Taniguchi","year":"1996","journal-title":"Transplantation"},{"issue":"8","key":"10.1016\/j.toxicon.2006.09.028_bib25","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0041-0101(03)00085-0","article-title":"Structural enzymatic and biological properties of new PLA(2) isoform from Crotalus durissus terrificus venom","volume":"41","author":"Toyama","year":"2003","journal-title":"Toxicon"},{"issue":"10","key":"10.1016\/j.toxicon.2006.09.028_bib26","first-page":"849","article-title":"Eighty-three years of the Guillain\u2013Barre syndrome: clinical and immunopathologic aspects, current and future treatments","volume":"155","author":"Toyka","year":"1999","journal-title":"Rev. Neurol. (Paris)"},{"issue":"5","key":"10.1016\/j.toxicon.2006.09.028_bib27","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1124\/mol.59.5.1333","article-title":"Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective alpha(v)beta (3) blockade of endothelial cells","volume":"59","author":"Yeh","year":"2001","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.toxicon.2006.09.028_bib28","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/intimm\/dxh390","article-title":"Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells","author":"Zhang","year":"2006","journal-title":"Int. Immunol."},{"issue":"2","key":"10.1016\/j.toxicon.2006.09.028_bib29","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.expneurol.2004.08.017","article-title":"Anti-cytokine autoantibodies in experimental autoimmune neuritis in Lewis rats","volume":"190","author":"Zhu","year":"2004","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.toxicon.2006.09.028_bib30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/1097-4547(20001201)62:5<717::AID-JNR11>3.0.CO;2-P","article-title":"P0 protein peptide 180\u2013199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57Bl\/6 mice","volume":"62","author":"Zou","year":"2000","journal-title":"J. Neurosci. Res."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101010600362X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101010600362X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T16:27:54Z","timestamp":1555864074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004101010600362X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S004101010600362X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2006.09.028","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}