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Biochem."},{"key":"10.1016\/j.toxicon.2006.11.015_bib80","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0969-2126(98)00111-7","article-title":"An excitatory scorpion toxin with a distinctive feature: an additional \u03b1-helix at the C-terminus and its implications for interaction with insect sodium channels","volume":"6","author":"Oren","year":"1998","journal-title":"Structure"},{"key":"10.1016\/j.toxicon.2006.11.015_bib81","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1242\/jeb.97.1.67","article-title":"Actions of insect toxin and other toxins derived from the venom of the scorpion Androctonus australis on the isolated giant axons of the cockroach (Periplaneta americana)","volume":"97","author":"Pelhate","year":"1982","journal-title":"J. Exp. 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Neurosci."},{"key":"10.1016\/j.toxicon.2006.11.015_bib91","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1099\/0022-1317-78-10-2657","article-title":"Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors","volume":"78","author":"Shoji","year":"1997","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.toxicon.2006.11.015_bib92","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/BF00584030","article-title":"Effects of toxins VI and VII from the scorpion Centruroides sculpturatus on the Na currents of the frog node of Ranvier","volume":"406","author":"Simard","year":"1986","journal-title":"Pfl\u00fcgers Archiv."},{"key":"10.1016\/j.toxicon.2006.11.015_bib93","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0022-1910(95)00120-4","article-title":"BotIT2, a toxin paralytic to insects from the Buthus occitanus tunetanus venom modifying the activity of insect sodium channels","volume":"42","author":"Stankiewicz","year":"1996","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.toxicon.2006.11.015_bib94","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/352085a0","article-title":"Construction of an improved baculovirus insecticide containing an insect-specific toxin gene","volume":"352","author":"Stewart","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2006.11.015_bib95","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1021\/bi050235t","article-title":"Genetic polymorphism and expression of a highly potent scorpion depressant toxin enables refinement of the effects on insect Na-channels and illuminates the key role of Asn-58","volume":"44","author":"Strugatsky","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2006.11.015_bib96","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.biotechadv.2005.09.001","article-title":"Baculoviruses\u2014re-emerging biopesticides","volume":"24","author":"Szewczyk","year":"2006","journal-title":"Biotechnol. 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Physiol."},{"key":"10.1016\/j.toxicon.2006.11.015_bib99","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/prep.1997.0724","article-title":"In vitro folding and functional analysis of an anti-insect selective scorpion depressant neurotoxin produced in E coli","volume":"9","author":"Turkov","year":"1997","journal-title":"Prot. Express. Purific."},{"key":"10.1016\/j.toxicon.2006.11.015_bib100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1049-9644(02)00172-X","article-title":"Effect of signal sequence and promoter on the speed of action of a genetically modified Autographa californica nucleopolyhedrovirus expressing the scorpion toxin LqhIT2","volume":"27","author":"van Beek","year":"2003","journal-title":"Biol. 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