{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:29:38Z","timestamp":1780723778271,"version":"3.54.1"},"reference-count":108,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":2329,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.toxicon.2006.11.021","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T12:12:37Z","timestamp":1164975157000},"page":"531-549","source":"Crossref","is-referenced-by-count":82,"title":["Insecticidal toxins from black widow spider venom"],"prefix":"10.1016","volume":"49","author":[{"given":"A.","family":"Rohou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.A.","family":"Ushkaryov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2006.11.021_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0928-4257(93)90023-M","article-title":"Lack of involvement of [Ca2+]i in the external Ca2+-independent release of acetylcholine evoked by veratridine, ouabain and \u03b1-latrotoxin: possible role of [Na+]i","volume":"87","author":"Adam-Vizi","year":"1993","journal-title":"J. Physiol. Paris"},{"key":"10.1016\/j.toxicon.2006.11.021_bib2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1083\/jcb.138.3.681","article-title":"Cellular redistribution of protein tyrosine phosphatases LAR and PTP\u03c3 by inducible proteolytic processing","volume":"138","author":"Aicher","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib3","first-page":"175","article-title":"Alternative splicing of pre-mRNA encoding the Musca domestica latrophilin-like protein (LLP): primary structures of four spliced forms of mRNA and their protein products","volume":"31","author":"Andreev","year":"2005","journal-title":"Bioorg. Khim."},{"key":"10.1016\/j.toxicon.2006.11.021_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0300-9084(00)00199-1","article-title":"Tetramerisation of \u03b1-latrotoxin by divalent cations is responsible for toxin-induced non-vesicular release and contributes to the Ca2+-dependent vesicular exocytosis from synaptosomes","volume":"82","author":"Ashton","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2006.11.021_bib5","doi-asserted-by":"crossref","first-page":"44695","DOI":"10.1074\/jbc.M108088200","article-title":"\u03b1-Latrotoxin, acting via two Ca2+-dependent pathways, triggers exocytosis of two pools of synaptic vesicles","volume":"276","author":"Ashton","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib6","first-page":"1","article-title":"On the mode of action of Latrodectus spp. venom","volume":"7","author":"Bettini","year":"1971","journal-title":"Ann. Ist. Super. Sanita."},{"key":"10.1016\/j.toxicon.2006.11.021_bib7","doi-asserted-by":"crossref","first-page":"39803","DOI":"10.1074\/jbc.C000656200","article-title":"Mints as adaptors. Direct binding to neurexins and recruitment of munc18","volume":"275","author":"Biederer","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2005.08.026","article-title":"A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to \u03b1- and \u03b2-neurexins","volume":"48","author":"Boucard","year":"2005","journal-title":"Neuron %20"},{"key":"10.1016\/j.toxicon.2006.11.021_bib9","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0896-6273(95)90154-X","article-title":"Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila","volume":"15","author":"Broadie","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.toxicon.2006.11.021_bib10","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1523\/JNEUROSCI.23-10-04044.2003","article-title":"The \u03b1-latrotoxin mutant LTXN4C enhances spontaneous and evoked transmitter release in CA3 pyramidal neurons","volume":"23","author":"Capogna","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxicon.2006.11.021_bib11","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1021\/bi00357a068","article-title":"A functional domain on the \u03b1-latrotoxin molecule, distinct from the binding site, involved in catecholamine secretion from PC12 cells: identification with monoclonal antibodies","volume":"25","author":"Cattaneo","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2006.11.021_bib12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/0041-0101(87)90159-0","article-title":"Characterization and some properties of the venom gland extract of a theridiid spider (Steatoda paykulliana) frequently mistaken for black widow spider (Latrodectus tredecimguttatus)","volume":"25","author":"Cavalieri","year":"1987","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1083\/jcb.87.1.297","article-title":"Ca2+-dependent recycling of synaptic vesicles at the frog neuromuscular junction","volume":"87","author":"Ceccarelli","year":"1980","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-5793(03)00695-1","article-title":"Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif","volume":"547","author":"Chang","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2006.11.021_bib15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00234999","article-title":"Correlations between changes in membrane capacitance induced by changes in ionic environment and the conductance of channels incorporated into bilayer lipid membranes","volume":"137","author":"Chanturiya","year":"1994","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/241353a0","article-title":"Action of black widow spider venom on an aminergic synapse","volume":"241","author":"Cull-Candy","year":"1973","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2006.11.021_bib18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0041-0101(69)90076-2","article-title":"Effect of the venom of the black widow spider, Latrodectus mactans tredecimguttatus, on evoked action potentials in the isolated nerve cord of Periplaneta americana","volume":"7","author":"D\u2019Ajello","year":"1969","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0041-0101(71)90002-X","article-title":"The effect of the venom of the black widow spider Latrodectus mactans tredecimguttatus on the giant neurones of Periplaneta americana","volume":"9","author":"D\u2019Ajello","year":"1971","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1086\/394503","article-title":"The black widow spider","volume":"11","author":"D\u2019Amour","year":"1936","journal-title":"Q. Rev. Biol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib20","first-page":"537","article-title":"Cloning and structure of gene encoded \u03b1-latrocrustoxin from the Black widow spider venom","volume":"25","author":"Danilevich","year":"1999","journal-title":"Bioorg. Khim."},{"key":"10.1016\/j.toxicon.2006.11.021_bib21","doi-asserted-by":"crossref","first-page":"23903","DOI":"10.1074\/jbc.270.41.23903","article-title":"High affinity binding of \u03b1-latrotoxin to recombinant neurexin I\u03b1","volume":"270","author":"Davletov","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib23","doi-asserted-by":"crossref","first-page":"23239","DOI":"10.1074\/jbc.271.38.23239","article-title":"Isolation and biochemical characterization of a Ca2+-independent \u03b1-latrotoxin-binding protein","volume":"271","author":"Davletov","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib22","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1093\/emboj\/17.14.3909","article-title":"Vesicle exocytosis stimulated by \u03b1-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+","volume":"17","author":"Davletov","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.toxicon.2006.11.021_bib24","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1471-4159.1993.tb03255.x","article-title":"Effect of \u03b1-latrotoxin on acetylcholine release and intracellular Ca2+ concentration in synaptosomes: Na+-dependent and Na+-independent components","volume":"60","author":"Deri","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib25","doi-asserted-by":"crossref","first-page":"7535","DOI":"10.1074\/jbc.271.13.7535","article-title":"Cloning and structure of \u03b4-latroinsectotoxin, a novel insect-specific member of the latrotoxin family: functional expression requires C-terminal truncation","volume":"271","author":"Dulubova","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib26","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1126\/science.948756","article-title":"Black widow spider venom: effect of purified toxin on lipid bilayer membranes","volume":"193","author":"Finkelstein","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2006.11.021_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0742-8413(88)90155-7","article-title":"Behavioural observations and neurophysiological responses of cockroaches envenomated with Latrodectus katipo venom","volume":"89","author":"Franklin","year":"1988","journal-title":"Comp. Biochem. Physiol. C."},{"key":"10.1016\/j.toxicon.2006.11.021_bib28","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0006-291X(03)00026-3","article-title":"There exist at least 30 human G-protein-coupled receptors with long Ser\/Thr-rich N-termini","volume":"301","author":"Fredriksson","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2006.11.021_bib29","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/283486a0","article-title":"Different components of black widow spider venom mediate transmitter release at vertebrate and lobster neuromuscular junctions","volume":"283","author":"Fritz","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2006.11.021_bib31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0003-9861(64)90178-X","article-title":"Separation of three toxicologically different protein components from the venom of the spider Latrodectus tredecimguttatus","volume":"106","author":"Frontali","year":"1964","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2006.11.021_bib30","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1083\/jcb.68.3.462","article-title":"Purification from black widow spider venom of a protein factor causing the depletion of synaptic vesicles at neuromuscular junctions","volume":"68","author":"Frontali","year":"1976","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib32","doi-asserted-by":"crossref","first-page":"19803","DOI":"10.1016\/S0021-9258(17)32091-4","article-title":"The low molecular weight protein which co-purifies with \u03b1-latrotoxin is structurally related to crustacean hyperglycemic hormones","volume":"269","author":"Gasparini","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib33","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1067\/mem.2001.113033","article-title":"Red-back spider (Latrodectus hasselti) antivenom prevents the toxicity of widow spider venoms","volume":"37","author":"Graudins","year":"2001","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.toxicon.2006.11.021_bib34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0041-0101(01)00280-X","article-title":"Clinical and in vitro evidence for the efficacy of Australian redback spider (Latrodectus hasselti) antivenom in the treatment of Brown cupboard spider (Steatoda grossa) envenomation","volume":"40","author":"Graudins","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib35","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.4049\/jimmunol.157.12.5438","article-title":"CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation","volume":"157","author":"Gray","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0041-0101(73)90035-4","article-title":"Action of black widow spider venom at insect neuromuscular junctions","volume":"11","author":"Griffiths","year":"1973","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib37","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0041-0101(98)00162-7","article-title":"Black widow spider toxins: the present and the future","volume":"36","author":"Grishin","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0014-5793(93)80803-3","article-title":"Modulation of functional activities of the neurotoxin from black widow spider venom","volume":"336","author":"Grishin","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2006.11.021_bib39","doi-asserted-by":"crossref","first-page":"3013.1","DOI":"10.1186\/gb-2001-2-12-reviews3013","article-title":"Family-B G-protein-coupled receptors","volume":"2","author":"Harmar","year":"2001","journal-title":"Genome Biol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib40","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1523\/JNEUROSCI.16-08-02488.1996","article-title":"CASK: a novel dlg\/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins","volume":"16","author":"Hata","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxicon.2006.11.021_bib41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/10799890009150640","article-title":"A family of heptahelical receptors with adhesion-like domains: a marriage between two super families","volume":"20","author":"Hayflick","year":"2000","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.toxicon.2006.11.021_bib42","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/0076-6879(90)83041-7","article-title":"Unified approach to alignment and phylogenies","volume":"183","author":"Hein","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib43","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1124\/mol.57.3.519","article-title":"Calcium-independent receptor for \u03b1-latrotoxin and neurexin 1\u03b1 facilitate toxin-induced channel formation: evidence that channel formation results from tethering of toxin to membrane","volume":"57","author":"Hlubek","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00211072","article-title":"\u03b1-Latrotoxin channels in neuroblastoma cells","volume":"138","author":"Hurlbut","year":"1994","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib46","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1093\/emboj\/17.21.6188","article-title":"\u03b1-Latrotoxin action probed with recombinant toxin: receptors recruit \u03b1-latrotoxin but do not transduce an exocytotic signal","volume":"17","author":"Ichtchenko","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.toxicon.2006.11.021_bib45","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1074\/jbc.274.9.5491","article-title":"A novel ubiquitously expressed \u03b1-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors","volume":"274","author":"Ichtchenko","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib47","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4269\/ajtmh.1960.9.477","article-title":"Seasonal variation in venom of black widow spiders","volume":"10","author":"Keegan","year":"1960","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2006.11.021_bib48","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1093\/emboj\/19.13.3250","article-title":"\u03b1-Latrotoxin triggers transmitter release via direct insertion into the presynaptic plasma membrane","volume":"19","author":"Khvotchev","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.toxicon.2006.11.021_bib51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-5793(90)81250-R","article-title":"Cloning and structure of cDNA encoding \u03b1-latrotoxin from black widow spider venom","volume":"270","author":"Kiyatkin","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2006.11.021_bib49","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0041-0101(92)90012-T","article-title":"Structure of the low molecular weight protein copurified with \u03b1-latrotoxin","volume":"30","author":"Kiyatkin","year":"1992","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib50","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1432-1033.1993.tb17741.x","article-title":"Cloning and structural analysis of \u03b1-latroinsectotoxin cDNA. Abundance of ankyrin-like repeats","volume":"213","author":"Kiyatkin","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib52","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1432-1033.1995.tb20628.x","article-title":"Functional characterization of black widow spider neurotoxins synthesised in insect cells","volume":"230","author":"Kiyatkin","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0306-4522(86)90005-9","article-title":"Black widow spider venom-induced release of neurotransmitters: mammalian synaptosomes are stimulated by a unique venom component (\u03b1-latrotoxin), insect synaptosomes by multiple components","volume":"19","author":"Knipper","year":"1986","journal-title":"Neuroscience"},{"key":"10.1016\/j.toxicon.2006.11.021_bib55","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0005-2736(92)90262-K","article-title":"Comparative analysis of latrotoxin channels of different conductance in planar lipid bilayers. Evidence for cluster organization","volume":"1112","author":"Krasilnikov","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2006.11.021_bib54","first-page":"79","article-title":"Resistance of various protein channels to proteolytic degradation","volume":"30","author":"Krasil\u2019nikov","year":"1985","journal-title":"Biofizika"},{"key":"10.1016\/j.toxicon.2006.11.021_bib56","doi-asserted-by":"crossref","first-page":"46518","DOI":"10.1074\/jbc.M206415200","article-title":"Post-translational proteolytic processing of the calcium-independent receptor of \u03b1-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS) motif","volume":"277","author":"Krasnoperov","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib60","first-page":"1138","article-title":"Isolation and properties of insect-specific neurotoxins from venoms of the spider Lactodectus mactans tredecimguttatus","volume":"16","author":"Krasnoperov","year":"1990","journal-title":"Bioorg. Khim."},{"key":"10.1016\/j.toxicon.2006.11.021_bib61","first-page":"716","article-title":"Interaction of \u03b1-125latrocrustotoxin with nerve cell membranes from the river crab Astacus astacus","volume":"17","author":"Krasnoperov","year":"1991","journal-title":"Bioorg. Khim."},{"key":"10.1016\/j.toxicon.2006.11.021_bib57","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1006\/bbrc.1996.1598","article-title":"The calcium-independent receptor of \u03b1-latrotoxin is not a neurexin","volume":"227","author":"Krasnoperov","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2006.11.021_bib58","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0896-6273(00)80332-3","article-title":"\u03b1-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor","volume":"18","author":"Krasnoperov","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.toxicon.2006.11.021_bib59","doi-asserted-by":"crossref","first-page":"35887","DOI":"10.1074\/jbc.M205478200","article-title":"Protein tyrosine phosphatase-\u03c3 is a novel member of the functional family of \u03b1-latrotoxin receptors","volume":"277","author":"Krasnoperov","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib62","doi-asserted-by":"crossref","first-page":"21504","DOI":"10.1074\/jbc.272.34.21504","article-title":"\u03b1-Latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors","volume":"272","author":"Lelianova","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib63","doi-asserted-by":"crossref","first-page":"10188","DOI":"10.1523\/JNEUROSCI.3560-05.2005","article-title":"N-terminal insertion and C-terminal ankyrin-like repeats of \u03b1-latrotoxin are critical for Ca2+-dependent exocytosis","volume":"25","author":"Li","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxicon.2006.11.021_bib64","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/225701a0","article-title":"Effects of black widow spider venom on the frog neuromuscular junction. Effects on end-plate potential, miniature end-plate potential and nerve terminal spike","volume":"225","author":"Longenecker","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2006.11.021_bib65","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1523\/JNEUROSCI.5462-03.2004","article-title":"A conserved postsynaptic transmembrane protein affecting neuromuscular signaling in Caenorhabditis elegans","volume":"24","author":"Loria","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxicon.2006.11.021_bib66","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0306-4522(92)90017-V","article-title":"Selective presynaptic insectotoxin (\u03b1-latroinsectotoxin) isolated from black widow spider venom","volume":"46","author":"Magazanik","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.toxicon.2006.11.021_bib67","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0022-1910(72)90029-7","article-title":"Effect of black widow spider venom on the cockroach heart","volume":"18","author":"Majori","year":"1972","journal-title":"J. Insect. Physiol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib68","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0014-5793(99)00005-8","article-title":"The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution","volume":"443","author":"Matsushita","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2006.11.021_bib69","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1111\/j.1471-4159.1990.tb05793.x","article-title":"\u03b1-Latrotoxin releases both vesicular and cytoplasmic glutamate from isolated nerve terminals","volume":"55","author":"McMahon","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib70","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/bj20031213","article-title":"Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans","volume":"378","author":"Mee","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2006.11.021_bib71","unstructured":"Meir, A., 2003. \u03b1-Latrotoxin: a molecular tool for induction of neurotransmitter release. Alomone Labs Modulator No. 17."},{"key":"10.1016\/j.toxicon.2006.11.021_bib72","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/0306-4522(83)90238-5","article-title":"The effect of \u03b1-latrotoxin on the neurosecretory PC12 cell line: studies on toxin binding and stimulation of transmitter release","volume":"10","author":"Meldolesi","year":"1983","journal-title":"Neuroscience"},{"key":"10.1016\/j.toxicon.2006.11.021_bib73","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1073\/pnas.76.2.991","article-title":"Action of black widow spider venom on quantized release of acetylcholine at the frog neuromuscular junction: dependence upon external Mg2+","volume":"76","author":"Misler","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.toxicon.2006.11.021_bib75","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0168-9525(97)01324-3","article-title":"Neurexins: three genes and 1001 products","volume":"14","author":"Missler","year":"1998","journal-title":"Trends Genet."},{"key":"10.1016\/j.toxicon.2006.11.021_bib74","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1046\/j.1471-4159.1998.71041339.x","article-title":"The making of neurexins","volume":"71","author":"Missler","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib76","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1110\/ps.03554604","article-title":"The ankyrin repeat as molecular architecture for protein recognition","volume":"13","author":"Mosavi","year":"2004","journal-title":"Protein Sci."},{"key":"10.1016\/j.toxicon.2006.11.021_bib77","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0041-0101(65)90002-4","article-title":"The effect of Latrodectus mactans tredecimguttatus venom on the endogenous activity of Periplaneta americana nerve cord","volume":"3","author":"Neri","year":"1965","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib78","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/71247","article-title":"Structure of \u03b1-latrotoxin oligomers reveals that divalent cation-dependent tetramers form membrane pores","volume":"7","author":"Orlova","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib79","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0041-0101(76)90030-1","article-title":"Isolation of a neurotoxin with A presynaptic action from the venom of the black widow spider (Latrodectus mactans, Fabr.)","volume":"14","author":"Ornberg","year":"1976","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib80","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1091\/mbc.E02-01-0036","article-title":"Fluorescence resonance energy transfer detection of synaptophysin I and vesicle-associated membrane protein 2 interactions during exocytosis from single live synapses","volume":"13","author":"Pennuto","year":"2002","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.toxicon.2006.11.021_bib81","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1432-1033.1995.0322i.x","article-title":"The cloning of a cDNA encoding a protein (latrodectin) which co-purifies with the \u03b1-latrotoxin from the black widow spider Latrodectus tredecimguttatus (Theridiidae)","volume":"230","author":"Pescatori","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib82","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1002\/j.1460-2075.1990.tb08331.x","article-title":"Isolation and properties of the \u03b1-latrotoxin receptor","volume":"9","author":"Petrenko","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.toxicon.2006.11.021_bib83","doi-asserted-by":"crossref","first-page":"19688","DOI":"10.1016\/S0021-9258(18)55047-X","article-title":"Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase","volume":"266","author":"Pot","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib84","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/0736-5748(90)90061-6","article-title":"Motor nerve terminal restoration after focal destruction in young and old mice","volume":"8","author":"Robbins","year":"1990","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.toxicon.2006.11.021_bib85","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0163-7258(89)90024-7","article-title":"\u03b1-Latrotoxin and related toxins","volume":"42","author":"Rosenthal","year":"1989","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.toxicon.2006.11.021_bib86","first-page":"917","article-title":"Mode of action of \u03b1-latrotoxin: role of divalent cations in Ca2+-dependent and Ca2+-independent effects mediated by the toxin","volume":"38","author":"Rosenthal","year":"1990","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib87","first-page":"168","article-title":"Blocking of the latrotoxin channel by cadmium ions","volume":"38","author":"Sabirov","year":"1993","journal-title":"Biofizika"},{"key":"10.1016\/j.toxicon.2006.11.021_bib88","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1111\/j.1471-4159.1989.tb09213.x","article-title":"Interactions between \u03b1-latrotoxin and trivalent cations in rat striatal synaptosomal preparations","volume":"52","author":"Scheer","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib89","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1139\/y90-158","article-title":"Interactions between the presynaptically active neurotoxins \u03b1-latrotoxin and omega-conotoxin GVIA: studies on calcium fluxes and binding parameters in rat and chicken synaptosomes","volume":"68","author":"Scheer","year":"1990","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.toxicon.2006.11.021_bib90","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0092-8674(00)80877-6","article-title":"Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons","volume":"101","author":"Scheiffele","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.toxicon.2006.11.021_bib91","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0968-0004(99)01426-7","article-title":"The ankyrin repeat: a diversity of interactions on a common structural framework","volume":"24","author":"Sedgwick","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.toxicon.2006.11.021_bib92","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0005-2736(94)00226-F","article-title":"Interaction of \u03b1-latroinsectotoxin from Latrodectus mactans venom with bilayer lipid membranes","volume":"1233","author":"Shatursky","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2006.11.021_bib93","series-title":"Animal Toxins","first-page":"1","article-title":"Structure of the venom gland of the black widow spider Latrodectus mactans. A preliminary light and electron microscopic study","author":"Smith","year":"1966"},{"key":"10.1016\/j.toxicon.2006.11.021_bib94","doi-asserted-by":"crossref","first-page":"9143","DOI":"10.1021\/bi00102a004","article-title":"Olfactomedin: purification, characterization, and localization of a novel olfactory glycoprotein","volume":"30","author":"Snyder","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2006.11.021_bib95","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0968-0004(00)01583-8","article-title":"LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors","volume":"25","author":"Stacey","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.toxicon.2006.11.021_bib96","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0896-6273(00)80704-7","article-title":"Neurexins are functional \u03b1-latrotoxin receptors","volume":"22","author":"Sugita","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.toxicon.2006.11.021_bib97","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1006\/geno.2002.6780","article-title":"Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing","volume":"79","author":"Tabuchi","year":"2002","journal-title":"Genomics"},{"key":"10.1016\/j.toxicon.2006.11.021_bib98","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0006-8993(78)90073-2","article-title":"The effect of the purified major protein factor (\u03b1-latrotoxin) of black widow spider venom on the release of acetylcholine and norepinephrine from mouse cerebral cortex slices","volume":"139","author":"Tzeng","year":"1978","journal-title":"Brain Res."},{"key":"10.1016\/j.toxicon.2006.11.021_bib99","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0306-4522(98)00664-2","article-title":"Electrical and optical monitoring of \u03b1-latrotoxin action at Drosophila neuromuscular junctions","volume":"87","author":"Umbach","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.toxicon.2006.11.021_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0041-0101(01)00204-5","article-title":"\u03b1-Latrotoxin: from structure to some functions","volume":"40","author":"Ushkaryov","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib101","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.1621094","article-title":"Neurexins: synaptic cell surface proteins related to the \u03b1-latrotoxin receptor and laminin","volume":"257","author":"Ushkaryov","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2006.11.021_bib102","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1046\/j.1460-9568.2000.00282.x","article-title":"\u03b1-Latrotoxin forms calcium-permeable membrane pores via interactions with latrophilin or neurexin","volume":"12","author":"Van Renterghem","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.toxicon.2006.11.021_bib103","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.287.5454.864","article-title":"Synaptic assembly of the brain in the absence of neurotransmitter secretion","volume":"287","author":"Verhage","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2006.11.021_bib104","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0041-0101(94)00166-6","article-title":"Low molecular weight components from black widow spider venom","volume":"33","author":"Volkova","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.11.021_bib105","doi-asserted-by":"crossref","first-page":"31058","DOI":"10.1074\/jbc.M210395200","article-title":"Mutant \u03b1-latrotoxin (LTXN4C) does not form pores and causes secretion by receptor stimulation. This action does not require neurexins","volume":"278","author":"Volynski","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib106","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1038\/sj.emboj.7600443","article-title":"Latrophilin fragments behave as independent proteins that associate and signal on binding of LTXN4C","volume":"23","author":"Volynski","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.toxicon.2006.11.021_bib107","doi-asserted-by":"crossref","first-page":"41175","DOI":"10.1074\/jbc.M005857200","article-title":"Latrophilin, neurexin and their signaling-deficient mutants facilitate \u03b1-latrotoxin insertion into membranes but are not involved in pore formation","volume":"275","author":"Volynski","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.11.021_bib108","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cub.2004.07.056","article-title":"Latrotoxin receptor signaling engages the UNC-13-dependent vesicle-priming pathway in C. elegans","volume":"14","author":"Willson","year":"2004","journal-title":"Curr. Biol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010106004326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010106004326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T21:39:00Z","timestamp":1683668340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010106004326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":108,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0041010106004326"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2006.11.021","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}