{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:58:08Z","timestamp":1788217088598,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.toxicon.2006.12.003","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T10:12:11Z","timestamp":1166609531000},"page":"833-842","source":"Crossref","is-referenced-by-count":28,"title":["Ammodytase, a metalloprotease from Vipera ammodytes ammodytes venom, possesses strong fibrinolytic activity"],"prefix":"10.1016","volume":"49","author":[{"given":"Adrijana","family":"Leonardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay W.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alenka","family":"Trampu\u0161-Bakija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Kri\u017eaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2006.12.003_bib1","first-page":"147","article-title":"Biochemical characteristics of fibrolase, a fibrinolytic protease from snake venom","volume":"20","author":"Ahmed","year":"1990","journal-title":"Haemostasis"},{"key":"10.1016\/j.toxicon.2006.12.003_bib2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0041-0101(80)90007-0","article-title":"Fibrinolytic enzyme(s) in western diamondback rattlesnake (Crotalus atrox) venom","volume":"18","author":"Bajwa","year":"1980","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0003-9861(89)90350-0","article-title":"Degradation of extracellular matrix proteins by hemorrhagic metalloproteinases","volume":"275","author":"Baramova","year":"1989","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2006.12.003_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.biochi.2005.07.008","article-title":"Isolation and biochemical characterization of a fibrinolytic proteinase from Bothrops leucurus (white-tailed Jararaca) snake venom","volume":"88","author":"Bello","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2006.12.003_bib5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0163-7258(94)90049-3","article-title":"Hemorrhagic metalloproteinases from snake venoms","volume":"62","author":"Bjarnason","year":"1994","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.toxicon.2006.12.003_bib6","first-page":"345","article-title":"Snake venom metalloendopeptidases: reprolysins","volume":"Vol. 248 (Part E)","author":"Bjarnason","year":"1995"},{"key":"10.1016\/j.toxicon.2006.12.003_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0049-3848(83)90076-2","article-title":"The action of prothrombin activated by ecarin on fibrinogen","volume":"30","author":"Dyr","year":"1983","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2006.12.003_bib8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0041-0101(99)00134-8","article-title":"Neutralization of the hemorrhagic activity of Bothrops and Lachesis snake venoms by a monoclonal antibody against mutalysin\u2014II","volume":"38","author":"Estevao-Costa","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0304-4165(94)00115-E","article-title":"Purification and characterization of a non-hemorrhagic metalloprotease from Agkistrodon halys brevicaudus venom","volume":"1243","author":"Fujimura","year":"1995","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.toxicon.2006.12.003_bib10","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0041-0101(95)00008-A","article-title":"Purification and characterization of piscivorase I and II, the fibrinolytic enzymes from eastern cottonmouth moccasin venom (Agkistrodon piscivorus piscivorus)","volume":"33","author":"Hahn","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib11","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1099\/00221287-146-10-2495","article-title":"Comparison of proteins expressed by Pseudomonas aeruginosa strains representing initial and chronic isolates from a cystic fibrosis patient: an analysis by 2-D gel electrophoresis and capillary column liquid chromatography-tandem mass spectrometry","volume":"146","author":"Hanna","year":"2000","journal-title":"Microbiology"},{"key":"10.1016\/j.toxicon.2006.12.003_bib12","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1152\/ajpheart.00649.2005","article-title":"Effect of thrombolysis on myocardial injury: recombinant tissue plasminogen activator vs. alfimeprase","volume":"290","author":"Hong","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.toxicon.2006.12.003_bib13","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0041-0101(96)00108-0","article-title":"Snake venom metalloproteinases: structure, function and relationship to the ADAMs family of proteins","volume":"34","author":"Jia","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib14","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1074\/jbc.272.20.13094","article-title":"Function of disintegrin-like\/cysteine-rich domains of atrolysin A. Inhibition of platelet aggregation by recombinant protein and peptide antagonists","volume":"272","author":"Jia","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.12.003_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0014-5793(03)00799-3","article-title":"Identification of sites in the cysteine-rich domain of the class P-III snake venom metalloproteinases responsible for inhibition of platelet function","volume":"549","author":"Kamiguti","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2006.12.003_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.7883\/yoken1952.13.43","article-title":"Studies on the quantitative method for the determination of hemorrhagic activity of Habu snake venom","volume":"13","author":"Kondo","year":"1960","journal-title":"Jpn. J. Med. Sci. Biol."},{"key":"10.1016\/j.toxicon.2006.12.003_bib17","first-page":"73","article-title":"On the influence of Echis carinata toxin on blood coagulation in vitro","volume":"80","author":"Kornalik","year":"1963","journal-title":"Folia Haematol."},{"key":"10.1016\/j.toxicon.2006.12.003_bib18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1590\/S0104-79301999000200002","article-title":"The improvement and standardization of antivenom production in developing: comparing antivenom quality, therapeutical efficiency and cost","volume":"2","author":"Krifi","year":"1999","journal-title":"J. Venom. Anim. Toxins"},{"key":"10.1016\/j.toxicon.2006.12.003_bib19","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2006.12.003_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0041-0101(01)00188-X","article-title":"Purification and characterisation of two hemorrhagic metalloproteinases from the venom of the long-nosed viper, Vipera ammodytes ammodytes","volume":"40","author":"Leonardi","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0003-9861(03)00385-0","article-title":"Characterization of \u2018Basparin A,\u2019 a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis","volume":"418","author":"Lor\u00eda","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2006.12.003_bib22","first-page":"191","article-title":"Venomous snakebites in the southern Croatia","volume":"30","author":"Luk\u0161i\u0107","year":"2006","journal-title":"Coll. Antropol."},{"key":"10.1016\/j.toxicon.2006.12.003_bib23","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0041-0101(82)90098-8","article-title":"Isolation and characterization of a proteolytic enzyme from the venom of the snake Bothrops jararaca (Jararaca)","volume":"20","author":"Mandelbaum","year":"1982","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib24","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0041-0101(98)00126-3","article-title":"Snake venoms and the hemostatic system","volume":"36","author":"Markland","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib25","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1200\/JCO.2006.05.8438","article-title":"Phase II trial of alfimeprase, a novel-acting fibrin degradation agent, for occluded central venous access devices","volume":"24","author":"Moll","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.toxicon.2006.12.003_bib26","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1021\/bi00005a034","article-title":"cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom","volume":"34","author":"Nishida","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2006.12.003_bib27","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1097\/01.RVI.0000167863.10122.2A","article-title":"A phase I trial of alfimeprase for peripheral arterial thrombolysis","volume":"16","author":"Ouriel","year":"2005","journal-title":"J. Vasc. Interv. Radiol."},{"key":"10.1016\/j.toxicon.2006.12.003_bib28","first-page":"298","article-title":"Fibrinogenolytic enzymes of Trimeresurus mucrosquamatus venom","volume":"420","author":"Ouyang","year":"1976","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2006.12.003_bib29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0049-3848(97)00258-2","article-title":"Purification and characterization of multisquamase, the prothrombin activator present in Echis multisquamatus venom","volume":"88","author":"Petrovan","year":"1997","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2006.12.003_bib30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S1046-5928(02)00644-7","article-title":"Expression, refolding, and in vitro activation of a recombinant snake venom pro-metalloprotease","volume":"28","author":"Ramos","year":"2003","journal-title":"Prot. Expr. Purif."},{"key":"10.1016\/j.toxicon.2006.12.003_bib31","first-page":"183","article-title":"Evolutionary families of metallopeptidases","volume":"Vol. 248 (Part E)","author":"Rawlings","year":"1995"},{"key":"10.1016\/j.toxicon.2006.12.003_bib32","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0049-3848(94)90151-1","article-title":"Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin","volume":"74","author":"Retzios","year":"1994","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2006.12.003_bib33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/abbi.2000.1958","article-title":"Structural and functional characterization of neuwiedase, a nonhemorrhagic fibrin(ogen)olytic metalloprotease from Bothrops neuwiedi snake venom","volume":"381","author":"Rodrigues","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2006.12.003_bib34","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0300-9084(01)01282-2","article-title":"Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom","volume":"83","author":"Rodrigues","year":"2001","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2006.12.003_bib35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0304-4165(91)90156-B","article-title":"Purification and characterization of lebetase, a fibrinolytic enzyme from Vipera lebetina (snake) venom","volume":"1074","author":"Siigur","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2006.12.003_bib36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0049-3848(98)00009-7","article-title":"Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom","volume":"90","author":"Siigur","year":"1998","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2006.12.003_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbapap.2004.07.007","article-title":"Factor X activator from Vipera lebetina venom is synthesized from different genes","volume":"1702","author":"Siigur","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2006.12.003_bib38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/bj20020449","article-title":"A prothrombin activator from Bothrops erythromelas (Jararaca-da-seca) snake venom: characterization and molecular cloning","volume":"369","author":"Silva","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2006.12.003_bib39","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.toxicon.2005.02.027","article-title":"Snake venom fibrin(ogen)olytic enzymes","volume":"45","author":"Swenson","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib40","doi-asserted-by":"crossref","first-page":"14109","DOI":"10.1016\/S0021-9258(19)49685-3","article-title":"Coagulation factor X activating enzyme from Russell's viper venom (RVV-X)","volume":"267","author":"Takeya","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2006.12.003_bib41","first-page":"141","article-title":"Alfimeprase: pharmacology of a novel fibrinolytic metalloproteinase for thrombolysis","volume":"31","author":"Toombs","year":"2001","journal-title":"Haemostasis"},{"key":"10.1016\/j.toxicon.2006.12.003_bib42","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1471-4892(01)00030-3","article-title":"New directions in thrombolytic therapy","volume":"1","author":"Toombs","year":"2001","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.toxicon.2006.12.003_bib43","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0041-0101(96)00106-7","article-title":"Biochemical characterization of atroxase and nucleotide sequence encoding the fibrinolytic enzyme","volume":"34","author":"Tu","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib44","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.toxicon.2005.02.030","article-title":"Snake venoms and coagulopathy","volume":"45","author":"White","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib45","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.toxicon.2005.02.025","article-title":"Snake venom probes of platelet adhesion receptors and their ligands","volume":"45","author":"Wijeyewickrema","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2006.12.003_bib47","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/oxfordjournals.jbchem.a021862","article-title":"Purification and characterization of a Ca2+ -dependent prothrombin activator, multactivase, from the venom of Echis multisquamatus","volume":"122","author":"Yamada","year":"1997","journal-title":"J. Biochem."},{"key":"10.1016\/j.toxicon.2006.12.003_bib46","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.1074\/jbc.271.9.5200","article-title":"Isolation and characterization of carinactivase, a novel prothrombin activator in Echis carinatus venom with a unique catalytic mechanism","volume":"271","author":"Yamada","year":"1996","journal-title":"J. Biol. Chem."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010106004661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010106004661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T19:32:32Z","timestamp":1628278352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010106004661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0041010106004661"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2006.12.003","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}