{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:16:21Z","timestamp":1774048581922,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.toxicon.2007.01.017","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T16:25:57Z","timestamp":1172593557000},"page":"1090-1098","source":"Crossref","is-referenced-by-count":31,"title":["Long-lasting anti-inflammatory properties of Crotalus durissus terrificus snake venom in mice"],"prefix":"10.1016","volume":"49","author":[{"given":"Fernanda P.B.","family":"Nunes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra C.","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo L.","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina C.","family":"Sousa-e-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2007.01.017_bib1","first-page":"63","article-title":"Envenenamento botr\u00f3pico e crot\u00e1lico","volume":"23","author":"Amorim","year":"1951","journal-title":"Mem\u00f3rias Instituto Butantan"},{"key":"10.1016\/j.toxicon.2007.01.017_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0041-0101(02)00238-6","article-title":"Bothrops lanceolatus (Fer de Lance) venom stimulates leukocyte migration into the peritoneal cavity of mice","volume":"41","author":"Arruda","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.01.017_bib3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejphar.2005.09.023","article-title":"Selective in vivo anti-inflammatory action of the galactolipid monogalactosyldiacylglycerol","volume":"524","author":"Bruno","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0041-0101(96)00134-1","article-title":"Effect of Crotalus venom on the humoral and cellular immune response","volume":"35","author":"Cardoso","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.01.017_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/09629350124986","article-title":"Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions","volume":"10","author":"Cardoso","year":"2001","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.toxicon.2007.01.017_bib6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cca.2004.07.010","article-title":"Effect of crotapotin on the biological activity of Asp49 and Lys49 phospholipases A2 from Bothrops snake venoms","volume":"138","author":"Cecchini","year":"2004","journal-title":"Comp. Biochem. Physiol. C. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0041-0101(03)00007-2","article-title":"Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants","volume":"41","author":"Chachur","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.01.017_bib8","unstructured":"Cury, Y., Sampaio, S.C., Brigatte, P., Curi, R., Sousa-e-Silva, M.C.C., 2006. Effect of Crotalus durissus terrificus snake venom and crotoxin on cytokine secretion by macrophage. Abstract book of 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 311."},{"issue":"6","key":"10.1016\/j.toxicon.2007.01.017_bib42","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000196365","article-title":"The anti-inflammatory drug nimesulide inhibits neutrophil adherence to and migration across monolayers of cytokine activated endothelial cells","volume":"61","author":"Dapino","year":"1994","journal-title":"Respiration"},{"key":"10.1016\/j.toxicon.2007.01.017_bib9","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.4049\/jimmunol.163.9.5094","article-title":"Role of IL-6 in the pleurisy and lung injury caused by carrageenan","volume":"163","author":"Cuzzocrea","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib10","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0041-0101(00)00213-0","article-title":"Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom","volume":"39","author":"de Faria","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.01.017_bib11","first-page":"S21","article-title":"Interleukin-1 and its relevance in patients treated with hemodialysis","volume":"24","author":"Dinarello","year":"1988","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.toxicon.2007.01.017_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/path.1711040103","article-title":"Studies of the acute inflammatatory response induced in rats at different sites by carrageenan and turpentine","volume":"104","author":"Di Rosa","year":"1971","journal-title":"J. Pathol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/jlb.64.2.214","article-title":"Antinociceptive effect of the calcium-binding protein MRP-14 and the role played by neutrophils on the control of inflammatory pain","volume":"64","author":"Giorgi","year":"1998","journal-title":"J. Leukoc Biol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib14","first-page":"298","article-title":"Comparison of the biodistribution of free or liposome-entrapped Crotalus durissus terrificus (South American rattlesnake) venom in mice","volume":"131","author":"Gomes","year":"2002","journal-title":"Comparative Biochem. Physiol. Part C"},{"key":"10.1016\/j.toxicon.2007.01.017_bib15","first-page":"243","article-title":"Mouse paw edema. A new model for inflammation","volume":"20","author":"Henriques","year":"1987","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.toxicon.2007.01.017_bib16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0192-0561(89)90064-7","article-title":"Release of eicosanoids in rat peritoneal cavity during the Arthus reaction. Effect of the PAF-antagonist BN-52021 and indomethacin","volume":"11","author":"Jancar","year":"1989","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib17","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1476-5381.1995.tb17178.x","article-title":"Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2","volume":"114","author":"Landucci","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0041-0101(99)00143-9","article-title":"Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2","volume":"38","author":"Landucci","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.01.017_bib19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0024-3205(69)90021-6","article-title":"Carrageenan paw edema in the mouse","volume":"8","author":"Levy","year":"1969","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2007.01.017_bib20","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJM198709103171107","article-title":"Neutrophils in human diseases","volume":"317","author":"Malech","year":"1987","journal-title":"N. England. J. Med."},{"key":"10.1016\/j.toxicon.2007.01.017_bib21","unstructured":"Minist\u00e9rio da Sa\u00fade, 1998. Manual de diagn\u00f3stico de tratamentos de acidentes por animais pe\u00e7onhentos.Bras\u00edlia: Funda\u00e7\u00e3o Nacional de Sa\u00fade, pp. 9\u201335."},{"key":"10.1016\/j.toxicon.2007.01.017_bib22","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0140-6736(87)91413-9","article-title":"Serum levels of interleukin-6 and acute phase responses","volume":"2","author":"Nijsten","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.toxicon.2007.01.017_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-2999(99)00934-6","article-title":"Delta-opioid receptors and nitric oxide mediate the analgesic effect of Crotalus durissus terrificus snake venom","volume":"391","author":"Picolo","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.bjp.0705650","article-title":"Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression","volume":"142","author":"Posadas","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib25","doi-asserted-by":"crossref","DOI":"10.1055\/s-2006-931562","article-title":"Anti-inflammatory and antiallergic activity in vivo of lipophilic Isatis tinctoria extracts and tryptanthrin","author":"Recio","year":"2006","journal-title":"Planta Med."},{"key":"10.1016\/j.toxicon.2007.01.017_bib26","first-page":"345","article-title":"Syntomatology, pathology and treatment of snake bites in South America","volume":"Vol. 2","author":"Rosenfeld","year":"1971"},{"key":"10.1016\/j.toxicon.2007.01.017_bib27","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0196-9781(99)00086-8","article-title":"Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan","volume":"20","author":"Saleh","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.toxicon.2007.01.017_bib28","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1189\/jlb.70.4.551","article-title":"Crotalus durissus terrificus snake venom regulates macrophage metabolism and function","volume":"70","author":"Sampaio","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0041-0101(03)00069-2","article-title":"Contribution of crotoxin for the inhibitory effect of Crotalus durissus terrificus snake venom on macrophage function","volume":"41","author":"Sampaio","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.01.017_bib30","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.toxicon.2005.01.009","article-title":"Inhibitory effect of phospholipase A2 isolated from Crotalus durissus terrificus venom on macrophage function","volume":"45","author":"Sampaio","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.01.017_bib31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.toxicon.2005.11.008","article-title":"Lipoxygenase-derived eicosanoids are involved in the inhibitory effect of Crotalus durissus terrificus venom or crotoxin on rat macrophage phagocytosis","volume":"47","author":"Sampaio","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.01.017_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1155\/S0962935196000038","article-title":"The venom of South American ratllesnake inhibits macrophage functions and is endowed with anti-inflammatory properties","volume":"5","author":"Sousa-e-Silva","year":"1996","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.toxicon.2007.01.017_bib33","first-page":"505","article-title":"Estudos qu\u00edmicos sobre os venenos of\u00eddicos. Purifica\u00e7\u00e3o e cristaliza\u00e7\u00e3o do veneno da cobra cascavel","volume":"12","author":"Slottta","year":"1938","journal-title":"Mem\u00f3rias Instituto Butantan"},{"key":"10.1016\/j.toxicon.2007.01.017_bib34","first-page":"775","article-title":"Anti-inflammatory effects of selective COX-2 inhibitors","volume":"56","author":"S\u00fcleyman","year":"2004","journal-title":"Pol. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib35","series-title":"Inflammation: Basic Principles and Clinical Correlates","first-page":"433","article-title":"Cytokines in normal and pathogenic inflammatory responses","author":"Sundy","year":"1999"},{"key":"10.1016\/j.toxicon.2007.01.017_bib36","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1248\/bpb.29.96","article-title":"Anti-inflammatory effect of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema","volume":"29","author":"Tan-No","year":"2006","journal-title":"Biol. Pharmacol. Bull."},{"key":"10.1016\/j.toxicon.2007.01.017_bib37","first-page":"745","article-title":"Involvement of eicosanoids and PAF in immune-complex alveolitis","volume":"22","author":"Tavares-de-Lima","year":"1989","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.toxicon.2007.01.017_bib38","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.4049\/jimmunol.147.6.1803","article-title":"Sequential appearance of IL-1 and IL-6 activities in rat carrageenin-induced pleurisy","volume":"147","author":"Utsunomiya","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib39","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3181\/00379727-143-37397","article-title":"Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat","volume":"143","author":"Vinegar","year":"1973","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.toxicon.2007.01.017_bib40","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/sj.bjp.0702420","article-title":"Limited anti-inflammatory efficacy of cyclo-oxygenase-2-inhibition in carrageenan-airpouch inflammation","volume":"126","author":"Wallace","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2007.01.017_bib41","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","article-title":"Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs","volume":"111","author":"Winter","year":"1962","journal-title":"Proc. Soc. Exp. Biol. Med."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010107000475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010107000475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T07:35:14Z","timestamp":1707636914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010107000475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0041010107000475"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2007.01.017","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}