{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:10:44Z","timestamp":1788340244011,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.toxicon.2007.06.011","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T09:03:25Z","timestamp":1183021405000},"page":"816-824","source":"Crossref","is-referenced-by-count":21,"title":["The mechanism of cytotoxicity by Naja naja atra cardiotoxin 3 is physically distant from its membrane-damaging effect"],"prefix":"10.1016","volume":"50","author":[{"given":"Ku-Chung","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Hsiu","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinne-Ren","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Sen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2007.06.011_bib1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/jmbi.1994.1357","article-title":"X-ray structure at 1.55\u00c5 of toxin \u03b3, a cardiotoxin from Naja nigricollis venom. Crystal packing reveals a model for insertion into membranes","volume":"239","author":"Bilwes","year":"1994","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.toxicon.2007.06.011_bib2","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1006\/bbrc.2001.4878","article-title":"Purification and characterization of a chymotrypsin inhibitor from the venom of Ophiophagus hannah (King cobra)","volume":"283","author":"Chang","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2007.06.011_bib3","series-title":"Snake Toxins","first-page":"259","article-title":"The structure and pharmacology of elapid cytotoxins","author":"Dufton","year":"1991"},{"key":"10.1016\/j.toxicon.2007.06.011_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/BJ20041892","article-title":"Cancer cell injury by cytotoxins from cobra venom is mediated through lysosomal damage","volume":"390","author":"Feofanov","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2007.06.011_bib5","doi-asserted-by":"crossref","first-page":"21980","DOI":"10.1074\/jbc.M208650200","article-title":"Structural basis of membrane-induced cardiotoxin A3 oligomerization","volume":"278","author":"Forouhar","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2007.06.011_bib6","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1021\/bi00399a004","article-title":"Role of tyrosine and tryptophan residues in the structure\u2013activity relationships of a cardiotoxin from Naja nigricollis venom","volume":"26","author":"Gatineau","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2007.06.011_bib7","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1021\/bi00479a021","article-title":"Delineation of the functional site of a snake venom cardiotoxin: preparation, structure, and function of monoacetylated derivatives","volume":"29","author":"Gatineau","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2007.06.011_bib8","series-title":"Flow Cytometry Protocols","author":"Hawley","year":"2004"},{"key":"10.1016\/j.toxicon.2007.06.011_bib9","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1110\/ps.9.4.637","article-title":"Elucidation of the solution structure of cardiotoxin analogue V from the Taiwan cobra (Naja naja atra), identification of structural features important for the lethal action of snake venom cardiotoxins","volume":"9","author":"Jayaraman","year":"2000","journal-title":"Protein Sci."},{"key":"10.1016\/j.toxicon.2007.06.011_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1054\/ceca.1999.0083","article-title":"Calcium signals in prostate cancer cells: specific activation by bone-matrix proteins","volume":"27","author":"Lecrone","year":"2000","journal-title":"Cell Calcium"},{"key":"10.1016\/j.toxicon.2007.06.011_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1014520126856","article-title":"Separation and structure\u2013function studies of Taiwan cobra cardiotoxins","volume":"21","author":"Lin","year":"2002","journal-title":"J. Protein Chem."},{"key":"10.1016\/j.toxicon.2007.06.011_bib12","series-title":"Techniques in Protein Modification","author":"Lundblad","year":"1995"},{"key":"10.1016\/j.toxicon.2007.06.011_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1042\/bj20020437","article-title":"Cytotoxic potency of cardiotoxin from Naja sputatrix: development of a new cytolytic assay","volume":"366","author":"Ma","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2007.06.011_bib14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0006-291X(88)81143-4","article-title":"Localization of the toxic site of Naja mossambica cardiotoxins: small synthetic peptides express an in vivo lethality","volume":"153","author":"Marchot","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2007.06.011_bib15","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1016\/S0006-3495(96)79521-8","article-title":"Effect of cholesterol and charge on pore formation in bilayer vesicles by a pH-sensitive peptide","volume":"71","author":"Nicol","year":"1996","journal-title":"Biophys. J."},{"key":"10.1016\/j.toxicon.2007.06.011_bib16","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0006-3495(00)76639-2","article-title":"Effect of phospholipid composition on an amphipathic peptide-mediated pore formation in bilayer vesicles","volume":"78","author":"Nicol","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.toxicon.2007.06.011_bib17","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1074\/jbc.272.3.1484","article-title":"Heparin and heparan sulfate bind to snake cardiotoxin. Sulfated oligosaccharides as a potential target for cardiotoxin action","volume":"272","author":"Patel","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2007.06.011_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BJ20031946","article-title":"Topology of the substrate-binding site of a Lys49-phospholipase A2 influences Ca2+-independent membrane-damaging activity","volume":"382","author":"Sa","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2007.06.011_bib19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1023\/A:1020648927776","article-title":"Influence of disulfide bonds on the induction of helical conformation in proteins","volume":"18","author":"Sivaraman","year":"1999","journal-title":"J. Protein Chem."},{"key":"10.1016\/j.toxicon.2007.06.011_bib20","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/taap.1996.0162","article-title":"Chemical modification of methionines in a cobra venom cytotoxin differentiates between lytic and binding domains","volume":"139","author":"Stevens-Truss","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxicon.2007.06.011_bib21","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0041-0101(96)00188-2","article-title":"Activities of cobra venom cytotoxins toward heart and leukemic T-cells depend on localized amino acid differences","volume":"35","author":"Stevens-Truss","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.06.011_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0041-008X(03)00327-2","article-title":"Cardiotoxin-III selectively enhances activation-induced apoptosis of human CD8+ T lymphocytes","volume":"193","author":"Su","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxicon.2007.06.011_bib23","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1074\/jbc.M104887200","article-title":"Heparin binding stabilizes the membrane-bound form of cobra cardiotoxin","volume":"277","author":"Sue","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2007.06.011_bib24","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1021\/bi962594h","article-title":"Crystal structure of cardiotoxin V from Taiwan cobra venom: pH-dependent conformational change and a novel membrane-binding motif identified in the three-finger loops of P-type cardiotoxin","volume":"36","author":"Sun","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2007.06.011_bib25","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/0005-2736(71)90058-7","article-title":"Circular dichroism of biological membranes. I. Mitochondria and red blood cell ghosts","volume":"241","author":"Urry","year":"1971","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2007.06.011_bib26","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1016\/j.febslet.2005.05.006","article-title":"Amphiphilic \u03b2-sheet cobra cardiotoxin targets mitochondria and disrupts its network","volume":"579","author":"Wang","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2007.06.011_bib31","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.toxicon.2005.06.012","article-title":"Cobra cardiotoxin-induced cell death in fetal rat cardiomyocytes and cortical neurons: different pathway but similar cell surface target","volume":"46","author":"Wang","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.06.011_bib27","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1074\/jbc.M507880200","article-title":"Glycosphingolipid-facilitated membrane insertion and internalization of cobra cardiotoxin. The sulfatide-cardiotoxin complex structure in a membrane-like environment suggests a lipid-dependent cell-penetrating mechanism for membrane binding polypeptides","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2007.06.011_bib28","doi-asserted-by":"crossref","first-page":"7937","DOI":"10.1074\/jbc.M513035200","article-title":"Non-cytotoxic cobra cardiotoxin A5 binds to \u03b1v\u03b23 integrin and inhibits bone resorption. Identification of cardiotoxins as non-RGD integrin-binding proteins of the Ly-6 family","volume":"281","author":"Wu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2007.06.011_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10930-006-9009-4","article-title":"Mutagenesis studies on the N-terminus and Thr54 of Naja naja atra (Taiwan cobra) chymotrypsin inhibitor","volume":"25","author":"Yan","year":"2006","journal-title":"Protein J."},{"key":"10.1016\/j.toxicon.2007.06.011_bib30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/emm.2006.51","article-title":"Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-XL involved in cardiotoxin III-induced apoptosis in K562 cells","volume":"38","author":"Yang","year":"2006","journal-title":"Exp. Mol. Med."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010107002243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010107002243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T06:28:09Z","timestamp":1546756089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010107002243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0041010107002243"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2007.06.011","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}