{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:10:14Z","timestamp":1777468214536,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.toxicon.2007.07.020","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T11:20:09Z","timestamp":1186572009000},"page":"1085-1094","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus of rat with global cerebral ischemia"],"prefix":"10.1016","volume":"50","author":[{"given":"Yi-Rong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren-Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Feng","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Qin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2007.07.020_bib1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0006-8993(91)90101-Z","article-title":"The effects of dizocilpine (MK-801), phencyclidine, and nimodipine on infarct size 48h after middle cerebral artery occlusion in the rat","volume":"552","author":"Bielenberg","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.toxicon.2007.07.020_bib2","doi-asserted-by":"crossref","first-page":"7162","DOI":"10.1073\/pnas.92.16.7162","article-title":"Apoptosis and necrosis: two distinct events induced respectively by mild and intense insults with N-methyl-D-aspartate or nitric oxide\/superoxide in cortical cell cultures","volume":"92","author":"Bonfoco","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.toxicon.2007.07.020_bib3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0304-3959(00)00458-9","article-title":"Pivotal role of capsaicin-sensitive primary afferents in development of both heat and mechanical hyperalgesia induced by intraplantar bee venom injection","volume":"91","author":"Chen","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2007.07.020_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0304-3959(99)00075-5","article-title":"Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: a comparative study with the formalin test","volume":"83","author":"Chen","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2007.07.020_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00174615","article-title":"Developmental cell death, morphological diversity, and multiple mechanisms","volume":"181","author":"Clarke","year":"1990","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.toxicon.2007.07.020_bib6","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/jcbfm.1995.118","article-title":"Global cerebral ischemia in the rat: online monitoring of oxygen free radical production using chemiluminescence in vivo","volume":"15","author":"Dirnagl","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.toxicon.2007.07.020_bib7","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1161\/01.STR.30.3.662","article-title":"Continuing postischemic neuronal death in CA1 influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats","volume":"30","author":"Frederick","year":"1999","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.toxicon.2007.07.020_bib8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.brainres.2006.03.086","article-title":"Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis","volume":"30, 1092","author":"Guan","year":"2006","journal-title":"Brain Res."},{"issue":"12","key":"10.1016\/j.toxicon.2007.07.020_bib9","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1097\/00004647-200112000-00005","article-title":"Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global cerebral ischemia","volume":"21","author":"Jin","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"32","key":"10.1016\/j.toxicon.2007.07.020_bib10","doi-asserted-by":"crossref","first-page":"10256","DOI":"10.1021\/bi00032a020","article-title":"Three-dimensional structure in solution of the calcium channel blocker omegaconotoxin MVIIA","volume":"34","author":"Kohno","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2007.07.020_bib11","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/01.STR.29.3.705","article-title":"Calcium in ischemic cell death","volume":"29","author":"Kristian","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.toxicon.2007.07.020_bib13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.toxicon.2004.02.005","article-title":"An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)]","volume":"43","author":"Liang","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.07.020_bib14","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0041-0101(93)90256-I","article-title":"Properties and amino acid sequence of Huwentoxin-1, a neurotoxin purified from the venom of the Chinese bird spider Ornithoctonus huwena","volume":"3","author":"Liang","year":"1993","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.07.020_bib15","first-page":"60","article-title":"Mechanisms of intracellular calcium accumulation in the CA1 region of rat hippocampus during anoxia in vitro","volume":"21","author":"Lipton","year":"1990","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.toxicon.2007.07.020_bib45","first-page":"678","article-title":"The effect of HWTX-I on bax, bcl-2 in the hippocampus of rats with cerebral ischemia","volume":"25","author":"Mao","year":"2006","journal-title":"Chinese Journal of Sports Medicine"},{"key":"10.1016\/j.toxicon.2007.07.020_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0361-9230(98)00024-0","article-title":"Neurodegeneration in excitotoxicity, global cerebral ischemia and target deprivation: a perspective on the contributions of apoptosis and necrosis","volume":"46","author":"Martin","year":"1998","journal-title":"Brain Res. Bull."},{"issue":"3","key":"10.1016\/j.toxicon.2007.07.020_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1750-3639.1994.tb00809.x","article-title":"Calcium-mediated mechanisms of ischemic injury and protection","volume":"4","author":"Morley","year":"1994","journal-title":"Brain Pathol."},{"issue":"4","key":"10.1016\/j.toxicon.2007.07.020_bib18","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1161\/01.STR.15.4.666","article-title":"Failure of flunarizine to improve cerebral blood flow or neurologic recovery in a canine model of complete cerebral ischemia","volume":"15","author":"Newberg","year":"1984","journal-title":"Stroke"},{"key":"10.1016\/j.toxicon.2007.07.020_bib19","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1523\/JNEUROSCI.15-02-01001.1995","article-title":"Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis","volume":"15","author":"Nitatori","year":"1995","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.toxicon.2007.07.020_bib20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0022-510X(91)90293-G","article-title":"The effect of a dihydropyridine calcium antagonist (isradipine) on selective neuronal necrosis","volume":"103","author":"Ohta","year":"1991","journal-title":"J Neurol. Sci."},{"key":"10.1016\/j.toxicon.2007.07.020_bib21","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1073\/pnas.87.13.5144","article-title":"Oxidative damage to brain proteins, loss of glutamine synthetase activity and production of free radicals during ischemia\/reperfusion-induced injury to gerbil brain","volume":"87","author":"Oliver","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.toxicon.2007.07.020_bib22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0041-0101(00)00150-1","article-title":"The effect of Huwentoxin-I on Ca2+ channels in differentiated NG108-15 cells, a patch-clamp study","volume":"39","author":"Peng","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.07.020_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0022-510X(97)00196-2","article-title":"SNX-111, a novel, presynaptic N-type calcium channel antagonist, is neuroprotective against focal cerebral ischemia in rabbits","volume":"153","author":"Perez-Pinzon","year":"1997","journal-title":"J. Neurol. Sci."},{"issue":"4","key":"10.1016\/j.toxicon.2007.07.020_bib24","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1152\/physrev.1999.79.4.1431","article-title":"Ischemic cell death in brain neurons","volume":"79","author":"Peter","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.toxicon.2007.07.020_bib25","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1161\/01.STR.27.11.2124","article-title":"Selective N-type calcium channel antagonist omega conotoxin MVIIA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal-slice cultures","volume":"27","author":"Pringle","year":"1996","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.toxicon.2007.07.020_bib26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/01.STR.10.3.267","article-title":"A new model of bilateral hemispheric ischemic in the unanesthetized rat","volume":"10","author":"Pulsinelli","year":"1979","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.toxicon.2007.07.020_bib27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1023\/A:1026314722607","article-title":"Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena. 2. Three-dimensional structure in solution","volume":"16","author":"Qu","year":"1997","journal-title":"J. Prot. Chem."},{"issue":"10","key":"10.1016\/j.toxicon.2007.07.020_bib28","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1161\/01.STR.26.10.1888","article-title":"Reduction of infarct size by intra-arterial nimodipine administered at reperfusion in a rat model of partially reversible brain focal ischemia","volume":"26","author":"Roda","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.toxicon.2007.07.020_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ana.410190202","article-title":"Glutamate and the pathophysiology of hypoxic\u2013ischemic brain damage","volume":"19","author":"Rothman","year":"1986","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.toxicon.2007.07.020_bib30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3940(96)12460-5","article-title":"Early increases in TNF-alpha, IL-6 and IL-1-beta levels following transient cerebral ischemia in gerbil brain","volume":"206","author":"Saito","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.toxicon.2007.07.020_bib31","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/hipo.450020303","article-title":"The mechanism of cerebral hypoxic\u2013ischemic damage","volume":"2","author":"Schurr","year":"1992","journal-title":"Hippocampus"},{"key":"10.1016\/j.toxicon.2007.07.020_bib32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0006-8993(91)91398-K","article-title":"Neurotoxicity of quinolinic acid and its derivatives in hypoxic rat hippocampal slices","volume":"568","author":"Schurr","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.toxicon.2007.07.020_bib33","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0306-4522(93)90628-S","article-title":"The effects amelior of chlormethiazole and nimodipine on cortical infarct area after focal cerebral ischaemia in the rat","volume":"53","author":"Snape","year":"1993","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.toxicon.2007.07.020_bib34","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/elps.1150160162","article-title":"Destaining of Coomassie Brilliant Blue R-250-stained polyacrylamide gels with sodium chloride solutions","volume":"16","author":"Sreeramulu","year":"1995","journal-title":"Electrophoresis"},{"issue":"1","key":"10.1016\/j.toxicon.2007.07.020_bib35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/jcbfm.1984.10","article-title":"Cerebral blood flow and neurologic outcome when nimodipine is given after complete cerebral ischemia in the dog","volume":"4","author":"Steen","year":"1984","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.toxicon.2007.07.020_bib36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/ana.410300309","article-title":"Na+\u2013Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter","volume":"30","author":"Stys","year":"1991","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.toxicon.2007.07.020_bib37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1602\/neurorx.1.1.17","article-title":"Neuronal death\/survival signaling pathways in cerebral ischemia","volume":"1","author":"Sugawara","year":"2004","journal-title":"NeuroRx"},{"issue":"6","key":"10.1016\/j.toxicon.2007.07.020_bib38","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/01.ccx.0000145096.28446.f7","article-title":"Hypothermia and injury","volume":"10","author":"Tisherman","year":"2004","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.toxicon.2007.07.020_bib39","first-page":"7894","article-title":"A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia [J]","volume":"90","author":"Valentino","year":"1993","journal-title":"Neurobiology"},{"key":"10.1016\/j.toxicon.2007.07.020_bib40","first-page":"51","article-title":"A new species of genus Ornithoctonus from south China","volume":"16","author":"Wang","year":"1993","journal-title":"Acta Sci. Natl. Univ. Norm. Hunan"},{"key":"10.1016\/j.toxicon.2007.07.020_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1046\/j.1471-4159.1994.63010215.x","article-title":"Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate stimulated dopamine release in global cerebral ischemia\/reperfusion","volume":"63","author":"Werling","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2007.07.020_bib43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0074-7696(08)62312-8","article-title":"Cell death: the significance of apoptosis","volume":"68","author":"Wyllie","year":"1980","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.toxicon.2007.07.020_bib44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0031-9384(76)90029-9","article-title":"Chronic catheterization of the spinal subarachnoid space","volume":"17","author":"Yaksh","year":"1976","journal-title":"Physiol. Behav."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010107002851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010107002851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T08:54:45Z","timestamp":1708160085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010107002851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0041010107002851"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2007.07.020","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}