{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:51:05Z","timestamp":1777693865330,"version":"3.51.4"},"reference-count":15,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.toxicon.2007.08.011","type":"journal-article","created":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T11:23:07Z","timestamp":1188991387000},"page":"151-156","source":"Crossref","is-referenced-by-count":52,"title":["Loxosceles venom-induced cytokine activation, hemolysis, and acute kidney injury"],"prefix":"10.1016","volume":"51","author":[{"given":"A.L.","family":"de Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Malaque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sztajnbok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.C.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.","family":"Seguro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9453","key":"10.1016\/j.toxicon.2007.08.011_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0140-6736(04)17667-8","article-title":"Septic shock","volume":"365","author":"Annane","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.toxicon.2007.08.011_bib2","series-title":"Animais Pe\u00e7onhentos no Brasil","first-page":"160","article-title":"Mecanismo de a\u00e7\u00e3o do veneno de Loxosceles e aspectos cl\u00ednicos do loxoscelismo","author":"Barbaro","year":"2003"},{"key":"10.1016\/j.toxicon.2007.08.011_bib3","series-title":"Robbins Pathologic Basis of Disease","first-page":"518","article-title":"Diseases of red cells and bleeding disorders","author":"Cotran","year":"1994"},{"issue":"7","key":"10.1016\/j.toxicon.2007.08.011_bib4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.toxicon.2004.07.012","article-title":"Brown spiders and loxoscelism","volume":"44","author":"da Silva","year":"2004","journal-title":"Toxicon"},{"issue":"6","key":"10.1016\/j.toxicon.2007.08.011_bib6","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.annemergmed.2004.08.028","article-title":"Loxoscelism: old obstacles, new directions","volume":"44","author":"Hogan","year":"2004","journal-title":"Ann. Emerg. Med."},{"issue":"3","key":"10.1016\/j.toxicon.2007.08.011_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0736-4679(03)00202-6","article-title":"Sudden unexplained hemolysis occurring in an infant due to presumed Loxosceles envenomation","volume":"25","author":"Hostetler","year":"2003","journal-title":"J. Emerg. Med."},{"issue":"3","key":"10.1016\/j.toxicon.2007.08.011_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0036-46651999000300009","article-title":"Production of TNF-alpha by primary cultures of human keratinocytes challenged with Loxosceles gaucho venom","volume":"41","author":"Malaque","year":"1999","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"issue":"3","key":"10.1016\/j.toxicon.2007.08.011_bib8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1590\/S0036-46652002000300005","article-title":"Clinical and epidemiological features of definitive and presumed loxoscelism in S\u00e3o Paulo, Brazil","volume":"44","author":"Malaque","year":"2002","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"issue":"2","key":"10.1016\/j.toxicon.2007.08.011_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.toxicon.2006.05.005","article-title":"The efficacy of antivenom in loxoscelism treatment","volume":"48","author":"Pauli","year":"2006","journal-title":"Toxicon"},{"issue":"7","key":"10.1016\/j.toxicon.2007.08.011_bib10","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1056\/NEJMra041184","article-title":"Bites of brown recluse spiders and suspected necrotic arachnidism","volume":"352","author":"Swanson","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.toxicon.2007.08.011_bib11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0041-0101(97)00063-9","article-title":"Endotoxemic-like shock induced by Loxosceles spider venoms: pathological changes and putative cytokine mediators","volume":"36","author":"Tambourgi","year":"1998","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.toxicon.2007.08.011_bib12","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/blood.V95.2.683","article-title":"Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis","volume":"95","author":"Tambourgi","year":"2000","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.toxicon.2007.08.011_bib13","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molimm.2006.02.002","article-title":"Sphingomyelinases D induce direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis","volume":"44","author":"Tambourgi","year":"2007","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.toxicon.2007.08.011_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1084\/jem.169.1.333","article-title":"The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome","volume":"169","author":"Waage","year":"1989","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.toxicon.2007.08.011_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00001721-200203000-00009","article-title":"Morphological and biochemical evidence of blood vessel damage and fibrinogenolysis triggered by brown spider venom","volume":"13","author":"Zanetti","year":"2002","journal-title":"Blood Coagul. Fibrinol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010107003121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010107003121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T09:10:32Z","timestamp":1587892232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010107003121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0041010107003121"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2007.08.011","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}