{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:24:07Z","timestamp":1791321847302,"version":"4.3.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.toxicon.2007.12.012","type":"journal-article","created":{"date-parts":[[2007,12,19]],"date-time":"2007-12-19T16:27:00Z","timestamp":1198081620000},"page":"835-852","source":"Crossref","is-referenced-by-count":46,"title":["New analysis of the toxic compounds from the Androctonus mauretanicus mauretanicus scorpion venom"],"prefix":"10.1016","volume":"51","author":[{"given":"Naoual","family":"Oukkache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Rosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Alami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norredine","family":"Ghalim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Sa\u00efle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Hassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre E.","family":"Bougis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-France","family":"Martin-Eauclaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2007.12.012_bib1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1042\/bj20030688","article-title":"Characterization of Amm VIII from Androctonus mauretanicus mauretanicus: a new scorpion toxin that discriminates between neuronal and skeletal sodium channels","volume":"375","author":"Alami","year":"2003","journal-title":"Biochem. J."},{"issue":"7","key":"10.1016\/j.toxicon.2007.12.012_bib2","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0041-0101(02)00084-3","article-title":"Enzymes with gelatinolytic activity can be found in Tityus bahiensis and Tityus serrulatus venoms","volume":"40","author":"Almeida","year":"2002","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxicon.2007.12.012_bib3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbapap.2005.08.010","article-title":"Proteomic analysis of the venom and characterization of toxins specific for Na+ and K+-channels from the Colombian scorpion Tityus pachyurus","volume":"1764","author":"Barona","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"issue":"12","key":"10.1016\/j.toxicon.2007.12.012_bib4","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1002\/pmic.200500525","article-title":"anProteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins","volume":"6","author":"Batista","year":"2006","journal-title":"Proteomics"},{"key":"10.1016\/j.toxicon.2007.12.012_bib5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cbpc.2006.12.004","article-title":"Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species","volume":"146","author":"Batista","year":"2007","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.toxicon.2007.12.012_bib6","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1126\/science.1720574","article-title":"Refined structureof the charybdotoxin: common motifs in scorpion toxins and insect defensins","volume":"254","author":"Bontems","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2007.12.012_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.toxicon.2006.04.003","article-title":"Characterization of venom components from the scorpion Androctonus crassicauda of Turkey: peptides and genes","volume":"48","author":"Caliskan","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.12.012_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0014-5793(01)02336-5","article-title":"Evidence for a position-specific deletion as an evolutionary link between long- and short-chain scorpion toxins","volume":"494","author":"C\u00e9ard","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2007.12.012_bib9","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","article-title":"Molecular mechanisms of neurotoxin action on voltage-gated sodium channels","volume":"82","author":"Cestele","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2007.12.012_bib10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1042\/BJ20041705","article-title":"An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis","volume":"388","author":"Chagot","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2007.12.012_bib11","doi-asserted-by":"crossref","first-page":"C361","DOI":"10.1152\/ajpcell.1993.264.2.C361","article-title":"Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion","volume":"264","author":"DeBin","year":"1993","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.toxicon.2007.12.012_bib12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0041-0101(97)00099-8","article-title":"Comparison and characterization of the venoms of three Parabuthus scorpion species occurring in southern Africa","volume":"36","author":"Debont","year":"1998","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxicon.2007.12.012_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0041-0101(81)90044-1","article-title":"Scorpion venoms and neurotoxins: an immunological study","volume":"19","author":"Delori","year":"1981","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxicon.2007.12.012_bib14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.toxicon.2004.10.014","article-title":"The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function","volume":"45","author":"Diego-Garcia","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.12.012_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.peptides.2006.06.012","article-title":"Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of \u201corphan\u201d components","volume":"28","author":"Diego-Garc\u00eda","year":"2007","journal-title":"Peptides"},{"issue":"7","key":"10.1016\/j.toxicon.2007.12.012_bib16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0161-5890(83)90047-0","article-title":"Immunochemistry of scorpion alpha-neurotoxins. Determination of the antigenic site number and isolation of a highly enriched antibody specific to a single antigenic site of toxin II of Androctonus australis Hector","volume":"20","author":"El Ayeb","year":"1983","journal-title":"Mol. Immunol."},{"issue":"17","key":"10.1016\/j.toxicon.2007.12.012_bib17","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1002\/(SICI)1097-0231(199711)11:17<1891::AID-RCM94>3.0.CO;2-X","article-title":"High-performance liquid chromatography matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry peptide fingerprinting of tarantula venoms in the genus Brachypelma: chemotaxonomic and biochemical applications","volume":"11","author":"Escoubas","year":"1997","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"18","key":"10.1016\/j.toxicon.2007.12.012_bib51","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1002\/(SICI)1097-0231(19990930)13:18<1861::AID-RCM730>3.0.CO;2-7","article-title":"Comparison of matrix-assisted laser desorption\/ionization time-of-flight and liquid chromatography electrospray ionization mass spectrometry methods for the analysis of crude tarantula venoms in the Pterinochilus group","volume":"13","author":"Escoubas","year":"1999","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"12","key":"10.1016\/j.toxicon.2007.12.012_bib18","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1046\/j.1432-1033.2003.03643.x","article-title":"An \u2018Old World\u2019 scorpion beta-toxin that recognizes both insect and mammalian sodium channels","volume":"270","author":"Gordon","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2007.12.012_bib19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0161-5890(89)90001-1","article-title":"The antigenic structure of a scorpion toxin","volume":"26","author":"Granier","year":"1989","journal-title":"Mol. Immunol."},{"issue":"3","key":"10.1016\/j.toxicon.2007.12.012_bib20","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1073\/pnas.242735499","article-title":"One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action","volume":"100","author":"Inceoglu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.toxicon.2007.12.012_bib21","first-page":"628","article-title":"Isolation and some properties of a lectin from the venom of the Vietnamese scorpion Buthus occitanus sp","volume":"37","author":"Khoang","year":"2001","journal-title":"Prikl. Biokhim. Mikrobiol."},{"issue":"1","key":"10.1016\/j.toxicon.2007.12.012_bib52","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/abio.1996.9871","article-title":"BIA\/MS: interfacing biomolecular interaction analysis with mass spectrometry","volume":"244","author":"Krone","year":"1997","journal-title":"Anal Biochem."},{"key":"10.1016\/j.toxicon.2007.12.012_bib22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0014-5793(98)00780-7","article-title":"Evidence for a new class of scorpion toxins active on K+ channels","volume":"431","author":"Legros","year":"1998","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.toxicon.2007.12.012_bib23","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/bi00217a007","article-title":"An anti-insect toxin purified from the scorpion Androctonus australis Hector also acts on the alpha- and beta-sites of the mammalian sodium channel: sequence and circular dichroism study","volume":"30","author":"Loret","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2007.12.012_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/nt.2620010112","article-title":"The amino acid sequence of toxin IV from the Androctonus australis scorpion: different effects of natural mutations in scorpion alpha-toxins on their antigenic and toxic properties","volume":"1","author":"Mansuelle","year":"1992","journal-title":"Nat. Toxins"},{"key":"10.1016\/j.toxicon.2007.12.012_bib25","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0041-0101(84)90153-3","article-title":"Purification and amino acid sequence of toxin I\u201d from the venom of the North African scorpion Androctonus australis Hector","volume":"22","author":"Martin","year":"1984","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.12.012_bib26","series-title":"Handbook. Neurotoxicology","first-page":"683","article-title":"Scorpion neurotoxins: effects and mechanisms","author":"Martin-Eauclaire","year":"1995"},{"issue":"2","key":"10.1016\/j.toxicon.2007.12.012_bib27","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.bbrc.2005.05.148","article-title":"New \u201cBirtoxin analogs\u201d from Androctonus australis venom","volume":"333","author":"Martin-Eauclaire","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.toxicon.2007.12.012_bib28","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/j.vaccine.2005.11.016","article-title":"A natural anatoxin, Amm VIII, induces neutralizing antibodies against the potent scorpion alpha-toxins","volume":"24","author":"Martin-Eauclaire","year":"2006","journal-title":"Vaccine"},{"issue":"19","key":"10.1016\/j.toxicon.2007.12.012_bib29","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1046\/j.1432-1033.2002.03177.x","article-title":"Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa","volume":"269","author":"Moerman","year":"2002","journal-title":"Eur. J. Biochem."},{"issue":"2","key":"10.1016\/j.toxicon.2007.12.012_bib31","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.toxicon.2005.10.014","article-title":"Purification and properties of hyaluronidase from Palamneus gravimanus (Indian black scorpion) venom","volume":"47","author":"Morey","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2007.12.012_bib32","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.toxicon.2006.01.015","article-title":"Moving pieces in a taxonomic puzzle: venom 2D-LC\/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones)","volume":"47","author":"Nascimento","year":"2006","journal-title":"Toxicon"},{"issue":"17","key":"10.1016\/j.toxicon.2007.12.012_bib33","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1002\/rcm.415","article-title":"Moving pieces in a proteomic puzzle: mass fingerprinting of toxic fractions from the venom of Tityus serrulatus (Scorpiones, Buthidae)","volume":"15","author":"Pimenta","year":"2001","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.toxicon.2007.12.012_bib34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/rcm.934","article-title":"Individual variability in Tityus serrulatus (Scorpiones, Buthidae) venom elicited by matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry","volume":"17","author":"Pimenta","year":"2003","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.toxicon.2007.12.012_bib35","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0300-9084(00)01167-6","article-title":"Peptides and genes coding for scorpion toxins that affect ion-channels","volume":"82","author":"Possani","year":"2000","journal-title":"Biochimie"},{"issue":"5","key":"10.1016\/j.toxicon.2007.12.012_bib36","first-page":"931","article-title":"Purification and properties of phospholipase A2 from the venom of scorpion, (Heterometrus fulvipes)","volume":"20","author":"Ramanaiah","year":"1990","journal-title":"Biochem. Int."},{"key":"10.1016\/j.toxicon.2007.12.012_bib37","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.toxicon.2005.09.006","article-title":"Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure\u2013function relationships and evolution","volume":"46","author":"Rodriguez de la Vega","year":"2005","journal-title":"Toxicon"},{"issue":"35","key":"10.1016\/j.toxicon.2007.12.012_bib53","doi-asserted-by":"crossref","first-page":"26302","DOI":"10.1016\/S0021-9258(19)74315-4","article-title":"Synthesis and characterization of kaliotoxin. Is the 26\u201332 sequence essential for potassium channel recognition?","volume":"268","author":"Romi","year":"1993","journal-title":"J Biol Chem."},{"issue":"1","key":"10.1016\/j.toxicon.2007.12.012_bib38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0041-0101(85)90114-X","article-title":"Characterization of ten proteins from the venom of the Moroccan scorpion Androctonus mauretanicus mauretanicus, six of which are toxic to the mouse","volume":"23","author":"Rosso","year":"1985","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxicon.2007.12.012_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbapap.2004.09.020","article-title":"Isolation and molecular characterization of LVP1 lipolysis activating peptide from scorpion Buthus occitanus tunetanus","volume":"1747","author":"Soudani","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.toxicon.2007.12.012_bib40","first-page":"317","article-title":"Strat\u00e9gie nationale de lutte contre les piq\u00fbres et envenimations scorpioniques. Application et \u00e9valuation","volume":"96","author":"Soulaymani Bencheikh","year":"2003","journal-title":"Bull. Soc. Pathol. Exot."},{"issue":"2","key":"10.1016\/j.toxicon.2007.12.012_bib41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/protein\/7.2.285","article-title":"The semisynthesis of [octadeutero-PheB1-octadeutero-ValB2]-porcine insulin and its characterization by mass spectrometry","volume":"7","author":"St\u00f6cklin","year":"1994","journal-title":"Protein Eng."},{"key":"10.1016\/j.toxicon.2007.12.012_bib42","first-page":"317","article-title":"Mass spectrometry of proteins and peptides","volume":"146","author":"St\u00f6cklin","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.toxicon.2007.12.012_bib43","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0165-6147(99)01398-X","article-title":"A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies","volume":"20","author":"Tytgat","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"issue":"24","key":"10.1016\/j.toxicon.2007.12.012_bib44","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1046\/j.1432-1033.2002.03294.x","article-title":"Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus","volume":"269","author":"Vacher","year":"2002","journal-title":"Eur. J. Biochem."},{"issue":"18","key":"10.1016\/j.toxicon.2007.12.012_bib45","doi-asserted-by":"crossref","first-page":"11886","DOI":"10.1074\/jbc.272.18.11886","article-title":"The mechanism of inhibition of ryanodine receptor channels by imperatoxin I, a heterodimeric protein from the scorpion Pandinus imperator","volume":"272","author":"Zamudio","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2007.12.012_bib46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/15216540500058899","article-title":"Scorpion venom peptides without disulfide bridges","volume":"57","author":"Zeng","year":"2005","journal-title":"IUBMB Life"},{"key":"10.1016\/j.toxicon.2007.12.012_bib47","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0041-0101(91)90078-6","article-title":"Analysis by high-performance liquid chromatography of Androctonus mauretanicus mauretanicus (black scorpion) venom","volume":"29","author":"Zerrouk","year":"1991","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxicon.2007.12.012_bib48","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0014-5793(93)80583-G","article-title":"Characterization of a new leiurotoxin I-like scorpion toxin. P05 from Androctonus mauretanicus mauretanicus","volume":"320","author":"Zerrouk","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2007.12.012_bib49","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1399-3011.1996.tb00870.x","article-title":"Characterization of PO1, a new peptide ligand of the apamin-sensitive Ca2+ activated K+ channel","volume":"48","author":"Zerrouk","year":"1996","journal-title":"Int. J. Peptide Protein Res."},{"issue":"23","key":"10.1016\/j.toxicon.2007.12.012_bib50","doi-asserted-by":"crossref","first-page":"14810","DOI":"10.1074\/jbc.272.23.14810","article-title":"Identification of structural elements of a scorpion alpha-neurotoxin important for receptor site recognition","volume":"272","author":"Zilberberg","year":"1997","journal-title":"J. Biol. Chem."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010107004618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010107004618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:55:55Z","timestamp":1630371355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010107004618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0041010107004618"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2007.12.012","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}