{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:20:44Z","timestamp":1790889644431,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.toxicon.2008.01.005","type":"journal-article","created":{"date-parts":[[2008,1,20]],"date-time":"2008-01-20T00:51:08Z","timestamp":1200790268000},"page":"994-1007","source":"Crossref","is-referenced-by-count":22,"title":["Activation of spinal ERK signaling pathway contributes to pain-related responses induced by scorpion Buthus martensi Karch venom"],"prefix":"10.1016","volume":"51","author":[{"given":"Xue-Yan","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hua","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.toxicon.2008.01.005_bib1","first-page":"257","article-title":"Clinical manifestations and management of scorpion envenomation","volume":"26","author":"Amitai","year":"1998","journal-title":"Public Health Rev."},{"issue":"4","key":"10.1016\/j.toxicon.2008.01.005_bib2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0168-0102(02)00177-3","article-title":"c-Fos expression in rat spinal cord induced by scorpion BmK venom via plantar subcutaneous injection","volume":"44","author":"Bai","year":"2002","journal-title":"Neurosci. Res."},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0041-008X(03)00260-6","article-title":"Fos expression in rat spinal cord induced by peripheral injection of BmK I, an alpha-like scorpion neurotoxin","volume":"192","author":"Bai","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.toxicon.2008.01.005_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2006.09.018","article-title":"Rat pain-related responses induced by experimental scorpion BmK sting","volume":"552","author":"Bai","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2008.01.005_bib5","first-page":"349","article-title":"Scorpionism in the old world","volume":"vol. 3","author":"Balozet","year":"1971"},{"issue":"3","key":"10.1016\/j.toxicon.2008.01.005_bib6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1042\/BJ20060035","article-title":"Chinese-scorpion (Buthus martensi Karsch) toxin BmK alphaIV, a novel modulator of sodium channels: from genomic organization to functional analysis","volume":"399","author":"Chai","year":"2006","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.toxicon.2008.01.005_bib7","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0892-0362(01)00174-X","article-title":"Scorpion BmK venom induces nociceptive response of rats by plantar injection","volume":"23","author":"Chen","year":"2001","journal-title":"Neurotoxicol. Teratol."},{"issue":"5","key":"10.1016\/j.toxicon.2008.01.005_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0041-0101(01)00248-3","article-title":"Asian scorpion BmK venom induces plasma extravasation and thermal hyperalgesia in the rat","volume":"40","author":"Chen","year":"2002","journal-title":"Toxicon"},{"issue":"1\u20132","key":"10.1016\/j.toxicon.2008.01.005_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3940(00)00955-1","article-title":"Contralateral heat hyperalgesia induced by unilaterally intraplantar bee venom injection is produced by central changes: a behavioral study in the conscious rat","volume":"284","author":"Chen","year":"2000","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3940(00)01728-6","article-title":"Establishment of bee venom-induced contralateral heat hyperalgesia in the rat is dependent upon central temporal summation of afferent input from the site of injury","volume":"298","author":"Chen","year":"2001","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0304-3959(99)00075-5","article-title":"Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: a comparative study with the formalin test","volume":"83","author":"Chen","year":"1999","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.toxicon.2008.01.005_bib12","first-page":"299","article-title":"Fos, nociception and the dorsal horn","volume":"77","author":"Coggeshall","year":"2005","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/08990220601143265","article-title":"The activation of the ERK pathway contributes to the spinal c-fos expression observed after noxious bladder stimulation","volume":"24","author":"Cruz","year":"2007","journal-title":"Somatosensory Mot. Res."},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-3940(02)00078-2","article-title":"Activation of spinal extracellular signaling-regulated kinase-1 and -2 by intraplantar carrageenan in rodents","volume":"322","author":"Galan","year":"2002","journal-title":"Neurosci. Lett."},{"issue":"1\u20132","key":"10.1016\/j.toxicon.2008.01.005_bib14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0169-328X(03)00284-5","article-title":"Extracellular signaling-regulated kinase-1 and -2 (ERK 1\/2) mediate referred hyperalgesia in a murine model of visceral pain","volume":"116","author":"Galan","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"9","key":"10.1016\/j.toxicon.2008.01.005_bib16","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0041-0101(02)00142-3","article-title":"An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch","volume":"40","author":"Goudet","year":"2002","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0896-6273(00)80747-3","article-title":"Making new connections: role of ERK\/MAP kinase signaling in neuronal plasticity","volume":"23","author":"Impey","year":"1999","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.toxicon.2008.01.005_bib19","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/16040","article-title":"Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity","volume":"2","author":"Ji","year":"1999","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.toxicon.2008.01.005_bib20","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1523\/JNEUROSCI.22-02-00478.2002","article-title":"ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity","volume":"22","author":"Ji","year":"2002","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib23","first-page":"42","article-title":"Amino acid sequence of an excitatory insect-selective toxin (BmK IT) from venom of the scorpion Buthus martensi Karsch","volume":"37","author":"Ji","year":"1994","journal-title":"Sci. China B"},{"issue":"9","key":"10.1016\/j.toxicon.2008.01.005_bib22","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0041-0101(96)00065-7","article-title":"Two neurotoxins (BmK I and BmK II) from the venom of the scorpion Buthus martensi Karsch: purification, amino acid sequences and assessment of specific activity","volume":"34","author":"Ji","year":"1996","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxicon.2008.01.005_bib21","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0041-0101(98)00190-1","article-title":"Covalent structures of BmK AS and BmK AS-1, two novel bioactive polypeptides purified from Chinese scorpion Buthus martensi Karsch","volume":"37","author":"Ji","year":"1999","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0014-2999(02)02363-4","article-title":"The binding of BmK abT, a unique neurotoxin, to mammal brain and insect Na(+) channels using biosensor","volume":"454","author":"Ji","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.toxicon.2008.01.005_bib25","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1523\/JNEUROSCI.21-11-03771.2001","article-title":"Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice","volume":"21","author":"Karim","year":"2001","journal-title":"J. Neurosci."},{"issue":"38","key":"10.1016\/j.toxicon.2008.01.005_bib26","doi-asserted-by":"crossref","first-page":"8310","DOI":"10.1523\/JNEUROSCI.2396-04.2004","article-title":"Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization","volume":"24","author":"Kawasaki","year":"2004","journal-title":"J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.toxicon.2008.01.005_bib27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0006-8993(02)04229-4","article-title":"Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuritis of the nerve root","volume":"967","author":"Kominato","year":"2003","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.toxicon.2008.01.005_bib28","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0896-6273(00)80322-0","article-title":"A kinase to remember: dual roles for MAP kinase in long-term memory","volume":"18","author":"Kornhauser","year":"1997","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.toxicon.2008.01.005_bib29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1399-3011.2000.00750.x","article-title":"Binding characteristics of BmK I, an alpha-like scorpion neurotoxic polypeptide, on cockroach nerve cord synaptosomes","volume":"56","author":"Li","year":"2000","journal-title":"J. Pept. Res."},{"issue":"3","key":"10.1016\/j.toxicon.2008.01.005_bib30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0168-0102(00)00164-4","article-title":"The binding of BmK IT2, a depressant insect-selective scorpion toxin on mammal and insect sodium channels","volume":"38","author":"Li","year":"2000","journal-title":"Neurosci. Res."},{"issue":"4","key":"10.1016\/j.toxicon.2008.01.005_bib31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0197-0186(03)00148-7","article-title":"Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus","volume":"44","author":"Li","year":"2004","journal-title":"Neurochem. Int."},{"issue":"1\u20133","key":"10.1016\/j.toxicon.2008.01.005_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejphar.2007.07.057","article-title":"Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom","volume":"575","author":"Liu","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.toxicon.2008.01.005_bib33","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.toxicon.2007.07.012","article-title":"Intrathecal injection of glutamate receptor antagonists\/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch","volume":"50","author":"Liu","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2008.01.005_bib34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2220\/biomedres.17.451","article-title":"Purification and the partial amino acid sequence of a novel activator of Ryanodine (BmK AS-1) from mammalian skeletal muscle","volume":"17","author":"Liu","year":"1996","journal-title":"Biomed. Res."},{"issue":"1\u20132","key":"10.1016\/j.toxicon.2008.01.005_bib35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0304-3959(02)00097-0","article-title":"Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus","volume":"99","author":"Ma","year":"2002","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.toxicon.2008.01.005_bib36","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1517\/14728222.9.4.699","article-title":"The ERK\/MAPK pathway, as a target for the treatment of neuropathic pain","volume":"9","author":"Ma","year":"2005","journal-title":"Expert Opinion Ther. Targets"},{"issue":"4","key":"10.1016\/j.toxicon.2008.01.005_bib37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/1056-8719(94)90087-6","article-title":"A method to perform direct transcutaneous intrathecal injection in rats","volume":"32","author":"Mestre","year":"1994","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"21","key":"10.1016\/j.toxicon.2008.01.005_bib38","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.lfs.2004.01.007","article-title":"MAPK activation in nociceptive neurons and pain hypersensitivity","volume":"74","author":"Obata","year":"2004","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib39","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0166-2236(98)01306-X","article-title":"Is the Ras-MAPK signalling pathway necessary for long-term memory formation?","volume":"22","author":"Orban","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.toxicon.2008.01.005_bib40","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1744-8069-3-4","article-title":"Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation","volume":"3","author":"Polgar","year":"2007","journal-title":"Mol. Pain"},{"issue":"2","key":"10.1016\/j.toxicon.2008.01.005_bib41","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0955-0674(97)80061-0","article-title":"Mitogen-activated protein kinase pathways","volume":"9","author":"Robinson","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"issue":"9","key":"10.1016\/j.toxicon.2008.01.005_bib42","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1096\/fasebj.9.9.7601337","article-title":"The MAPK signaling cascade","volume":"9","author":"Seger","year":"1995","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.toxicon.2008.01.005_bib43","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0304-3940(88)90346-1","article-title":"The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system","volume":"85","author":"Shu","year":"1988","journal-title":"Neurosci. Lett."},{"issue":"7","key":"10.1016\/j.toxicon.2008.01.005_bib44","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1745-7254.2005.00123.x","article-title":"Activation of ERK\/CREB pathway in spinal cord contributes to chronic constrictive injury-induced neuropathic pain in rats","volume":"26","author":"Song","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.toxicon.2008.01.005_bib45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.conb.2004.04.001","article-title":"Mitogen-activated protein kinases in synaptic plasticity and memory","volume":"14","author":"Sweatt","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.toxicon.2008.01.005_bib46","series-title":"Textbook of Pain","first-page":"101","article-title":"The dorsal horn: state-dependent sensory processing and the generation of pain","author":"Woolf","year":"1994"},{"issue":"1\u20132","key":"10.1016\/j.toxicon.2008.01.005_bib47","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neulet.2005.02.033","article-title":"Activation of spinal extracellular signaling-regulated kinases by intraplantar melittin injection","volume":"381","author":"Yu","year":"2005","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.toxicon.2008.01.005_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0361-9230(02)00752-9","article-title":"Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch","volume":"58","author":"Zhang","year":"2002","journal-title":"Brain Res. Bull."},{"issue":"1\u20132","key":"10.1016\/j.toxicon.2008.01.005_bib49","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pain.2004.12.022","article-title":"ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model","volume":"114","author":"Zhuang","year":"2005","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.toxicon.2008.01.005_bib50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.toxicon.2008.01.005_bib51","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1385\/MN:30:3:265","article-title":"Molecular mechanism of scorpion neurotoxins acting on sodium channels: insight into their diverse selectivity","volume":"30","author":"Zuo","year":"2004","journal-title":"Mol. Neurobiol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010108000196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010108000196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T02:31:31Z","timestamp":1557196291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010108000196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0041010108000196"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2008.01.005","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}