{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:54:04Z","timestamp":1773802444867,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.toxicon.2008.03.025","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T16:21:12Z","timestamp":1207153272000},"page":"1490-1495","source":"Crossref","is-referenced-by-count":15,"title":["Genetic organization of Bungarus multicinctus protease inhibitor-like proteins,"],"prefix":"10.1016","volume":"51","author":[{"given":"Long-sen","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeh-Jeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Ching","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Min","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2008.03.025_bib1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1101\/gr.9.3.259","article-title":"Postsynaptic \u03b1-neurotoxin gene of the spitting cobra, Naja naja sputatrix: structure, organization, and phylogenetic analysis","volume":"9","author":"Afifiyan","year":"1999","journal-title":"Genome Res."},{"key":"10.1016\/j.toxicon.2008.03.025_bib2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.toxicon.2005.02.024","article-title":"Snake venom disintegrins: evolution of structure and function","volume":"45","author":"Calvete","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2008.03.025_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/15569540701209716","article-title":"Genetic diversity in snake three-finger proteins and phospholipase A2 enzymes","volume":"26","author":"Chang","year":"2007","journal-title":"Toxin Rev."},{"key":"10.1016\/j.toxicon.2008.03.025_bib4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/bbrc.1996.5916","article-title":"cDNA sequence analysis and expression of \u03ba-bungarotoxin from Taiwan banded krait","volume":"230","author":"Chang","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2008.03.025_bib5","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/oxfordjournals.jbchem.a021889","article-title":"A novel neurotoxin, cobrotoxin b, from Naja naja atra (Taiwan cobra) venom: purification, characterization and gene organization","volume":"122","author":"Chang","year":"1997","journal-title":"J. Biochem."},{"key":"10.1016\/j.toxicon.2008.03.025_bib6","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1093\/nar\/27.20.3970","article-title":"Genetic organization of \u03b1-bungarotoxins from Bungarus multicinctus (Taiwan banded krait): evidence showing that the production of \u03b1-bungarotoxin isotoxins are not derived from edited mRNAs","volume":"27","author":"Chang","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxicon.2008.03.025_bib7","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1006\/bbrc.2001.4878","article-title":"Purification and characterization of a chymotrypsin inhibitor from the venom of Ophiophagus hannah (King Cobra)","volume":"283","author":"Chang","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2008.03.025_bib8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1023\/B:BIGI.0000043955.35906.c2","article-title":"Molecular cloning and evolution of the genes encoding the precursors of Taiwan cobra cardiotoxin and cardiotoxin-like basic protein","volume":"42","author":"Chang","year":"2004","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.toxicon.2008.03.025_bib9","doi-asserted-by":"crossref","first-page":"45079","DOI":"10.1074\/jbc.M106182200","article-title":"Solution structure of a Kunitz-type chymotrypsin inhibitor isolated from the Elapid snake Bungarus fasciatus","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2008.03.025_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbapap.2004.11.006","article-title":"Taiwan cobra chymotrypsin inhibitor: cloning, functional expression and gene organization","volume":"1747","author":"Cheng","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2008.03.025_bib11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.toxicon.2005.11.009","article-title":"Divergence of genes encoding B chains of \u03b2-bungarotoxins","volume":"47","author":"Cheng","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2008.03.025_bib12","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/bioinformatics\/15.9.763","article-title":"K-Estimator: calculation of the number of nucleotide substitutions per site and the confidence intervals","volume":"15","author":"Comeron","year":"1999","journal-title":"Bioinformatics"},{"key":"10.1016\/j.toxicon.2008.03.025_bib13","first-page":"151","article-title":"Rapid evolution by positive selection and gene gain and loss: PLA2 venom genes in closely related Sistrurus Rattlesnakes with divergent diets","volume":"66","author":"Gibbs","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.toxicon.2008.03.025_bib14","series-title":"Snake Toxins","first-page":"131","article-title":"Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release","author":"Harvey","year":"1991"},{"key":"10.1016\/j.toxicon.2008.03.025_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0378-1119(00)00490-X","article-title":"Adaptive evolution of animal toxin multigene families","volume":"261","author":"Kordis","year":"2000","journal-title":"Gene"},{"key":"10.1016\/j.toxicon.2008.03.025_bib16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0969-2126(01)00246-5","article-title":"Structure of \u03b22-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action","volume":"3","author":"Kwong","year":"1995","journal-title":"Structure"},{"key":"10.1016\/j.toxicon.2008.03.025_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-5793(98)00894-1","article-title":"Structure and organization of the polymorphic cardiotoxin gene in Naja naja sputatrix","volume":"433","author":"Lachumanan","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2008.03.025_bib18","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.bi.49.070180.003113","article-title":"Protein inhibitors of proteases","volume":"49","author":"Laskowski","year":"1980","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.toxicon.2008.03.025_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2148-7-2","article-title":"Inventing an arsenal: adaptive evolution and neofunctionalization of snake venom phospholipase A2 genes","volume":"7","author":"Lynch","year":"2007","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.toxicon.2008.03.025_bib20","doi-asserted-by":"crossref","first-page":"5964","DOI":"10.1073\/pnas.90.13.5964","article-title":"Accelerated evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozyme","volume":"90","author":"Nakashima","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.toxicon.2008.03.025_bib21","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1073\/pnas.92.12.5605","article-title":"Accelerated evolution in the protein-coding regions is universal in crotalinae snake venom gland phospholipase A2 isozyme genes","volume":"92","author":"Nakashima","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.toxicon.2008.03.025_bib22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0079-6603(08)61036-3","article-title":"Molecular evolution of snake toxins: is the functional diversity of snake toxins associated with a mechanism of accelerated evolution?","volume":"59","author":"Ohno","year":"1998","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"10.1016\/j.toxicon.2008.03.025_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/1471-2148-7-175","article-title":"Expression pattern of three-finger toxin and phospholipase A2 genes in the venom glands of two sea snakes, Lapemis curtus and Acalyptophis peronii: comparison of evolution of theses toxins in land snakes, sea kraits and sea snakes","volume":"7","author":"Pahari","year":"2007","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.toxicon.2008.03.025_bib24","series-title":"Protein Evolution","author":"Patthy","year":"1999"},{"key":"10.1016\/j.toxicon.2008.03.025_bib25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0167-4838(83)90189-9","article-title":"The primary structure of Vipera ammodytes venom trypsin inhibitor I","volume":"748","author":"Ritonja","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2008.03.025_bib26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0014-5793(90)81426-O","article-title":"Purification and characterization of a chymotrypsin Kunitz inhibitor type of polypeptide from the venom of cobra (Naja naja naja)","volume":"275","author":"Shafqat","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2008.03.025_bib27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1432-1033.1990.tb15622.x","article-title":"Primary structure and functional properties of cobra (Naja naja naja) venom Kunitz-type trypsin inhibitor","volume":"194","author":"Shafqat","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2008.03.025_bib28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.gene.2006.09.020","article-title":"Molecular evolution of PIII-SVMP and RGD disintegrin genes from the genus Crotalus","volume":"389","author":"Soto","year":"2007","journal-title":"Gene"},{"key":"10.1016\/j.toxicon.2008.03.025_bib29","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0","volume":"24","author":"Tamura","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.toxicon.2008.03.025_bib31","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1046\/j.1432-1327.2000.01518.x","article-title":"Genetic organization of A chain and B chain of \u03b2-bungarotoxin from Taiwan banded krait (Bungarus multicinctus). A chain genes and B chain genes do not share a common origin","volume":"267","author":"Wu","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2008.03.025_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1042\/bj3340087","article-title":"Cloning and functional expression of B chains of \u03b2-bungarotoxin from Bungarus multicinctus (Taiwan banded krait)","volume":"334","author":"Wu","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2008.03.025_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-5793(03)00693-8","article-title":"Adaptive evolution in the snake venom Kunitz\/BPTI protein family","volume":"547","author":"Zupunski","year":"2003","journal-title":"FEBS Lett."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010108001189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010108001189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T11:54:47Z","timestamp":1684324487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010108001189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0041010108001189"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2008.03.025","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}