{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:50:10Z","timestamp":1792097410018,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.toxicon.2008.04.171","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T05:43:27Z","timestamp":1212126207000},"page":"62-71","source":"Crossref","is-referenced-by-count":5,"title":["Involvement of spinal nitric oxide (NO) in rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch"],"prefix":"10.1016","volume":"52","author":[{"given":"Tong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Yan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hua","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2008.04.171_bib1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0304-3959(93)90156-J","article-title":"\u2018Mirror pain\u2019 in the formalin test: behavioral and 2-deoxyglucose studies","volume":"55","author":"Aloisi","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2008.04.171_bib2","first-page":"257","article-title":"Clinical manifestations and management of scorpion envenomation","volume":"26","author":"Amitai","year":"1998","journal-title":"Public Health Rev."},{"key":"10.1016\/j.toxicon.2008.04.171_bib3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0168-0102(02)00177-3","article-title":"c-Fos expression in rat spinal cord induced by scorpion BmK venom via plantar subcutaneous injection","volume":"44","author":"Bai","year":"2002","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.toxicon.2008.04.171_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2006.09.018","article-title":"Rat pain-related responses induced by experimental scorpion BmK sting","volume":"552","author":"Bai","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2008.04.171_bib5","first-page":"349","article-title":"Scorpionism in the old world","volume":"vol. 3","author":"Balozet","year":"1971"},{"key":"10.1016\/j.toxicon.2008.04.171_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pain.2004.06.001","article-title":"Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators","volume":"111","author":"Chacur","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2008.04.171_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0304-3959(99)00075-5","article-title":"Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: a comparative study with the formalin test","volume":"83","author":"Chen","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2008.04.171_bib7","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0892-0362(01)00174-X","article-title":"Scorpion BmK venom induces nociceptive response of rats by plantar injection","volume":"23","author":"Chen","year":"2001","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.toxicon.2008.04.171_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0041-0101(01)00248-3","article-title":"Asian scorpion BmK venom induces plasma extravasation and thermal hyperalgesia in the rat","volume":"40","author":"Chen","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2008.04.171_bib10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neulet.2005.08.003","article-title":"The modulation effects of BmK I, an alpha-like scorpion neurotoxin, on voltage-gated Na(+) currents in rat dorsal root ganglion neurons","volume":"390","author":"Chen","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.toxicon.2008.04.171_bib11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.pain.2005.09.024","article-title":"Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain","volume":"119","author":"Chu","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2008.04.171_bib12","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1523\/JNEUROSCI.12-09-03671.1992","article-title":"The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury","volume":"12","author":"Coderre","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxicon.2008.04.171_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1744-8069-3-29","article-title":"Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice","volume":"3","author":"Guan","year":"2007","journal-title":"Mol. Pain"},{"key":"10.1016\/j.toxicon.2008.04.171_bib14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1046\/j.1471-4159.1994.62020807.x","article-title":"Modulation of in vivo striatal transmitter release by nitric oxide and cyclic GMP","volume":"62","author":"Guevara-Guzman","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2008.04.171_bib15","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1111\/j.1476-5381.1995.tb15078.x","article-title":"The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM): a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse","volume":"116","author":"Handy","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2008.04.171_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2008.04.171_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0169-328X(94)90053-1","article-title":"Expression of nitric oxide synthase and colocalisation with Jun, Fos and Krox transcription factors in spinal cord neurons following noxious stimulation of the rat hindpaw","volume":"22","author":"Herdegen","year":"1994","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.toxicon.2008.04.171_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0304-3940(96)12702-6","article-title":"Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw","volume":"210","author":"Lam","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.toxicon.2008.04.171_bib21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2220\/biomedres.17.451","article-title":"Purification and the partial amino acid sequence of a novel activator of Ryanodine (BmK AS-1) from mammalian skeletal muscle","volume":"17","author":"Liu","year":"1996","journal-title":"Biomed. Res."},{"key":"10.1016\/j.toxicon.2008.04.171_bib19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejphar.2007.07.057","article-title":"Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom","volume":"575","author":"Liu","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2008.04.171_bib20","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.toxicon.2007.07.012","article-title":"Intrathecal injection of glutamate receptor antagonists\/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch","volume":"50","author":"Liu","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2008.04.171_bib22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0304-3959(93)90028-N","article-title":"Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats","volume":"54","author":"Malmberg","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2008.04.171_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0306-4522(94)90250-X","article-title":"The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat","volume":"60","author":"Meller","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.toxicon.2008.04.171_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0304-3959(93)90124-8","article-title":"Nitric oxide (NO) and nociceptive processing in the spinal cord","volume":"52","author":"Meller","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2008.04.171_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/1056-8719(94)90087-6","article-title":"A method to perform direct transcutaneous intrathecal injection in rats","volume":"32","author":"Mestre","year":"1994","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.toxicon.2008.04.171_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/cne.902300112","article-title":"The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord","volume":"230","author":"Molander","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.toxicon.2008.04.171_bib27","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7508638","article-title":"Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex","volume":"263","author":"Montague","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2008.04.171_bib28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.toxicon.2004.12.020","article-title":"Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus","volume":"45","author":"Nascimento","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2008.04.171_bib29","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(94)90266-6","article-title":"Nitric oxide synthases: roles, tolls, and controls","volume":"78","author":"Nathan","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.toxicon.2008.04.171_bib30","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1038\/sj.bjp.0702508","article-title":"Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia","volume":"126","author":"Osborne","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.toxicon.2008.04.171_bib31","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.toxicon.2008.01.005","article-title":"Activation of spinal ERK signaling pathway contributes to pain-related responses induced by scorpion Buthus martensi Karch venom","volume":"51","author":"Pang","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2008.04.171_bib32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/09622935020138811","article-title":"The dynamics of cytokine d nitric oxide secretion in mice injected with Tityus serrulatus scorpion venom","volume":"11","author":"Petricevich","year":"2002","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.toxicon.2008.04.171_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0014-2999(98)00618-9","article-title":"Is neuronal nitric oxide involved in adjuvant-induced joint inflammation?","volume":"359","author":"Pozza","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2008.04.171_bib34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0304-3959(96)03025-4","article-title":"A nitric oxide synthesis inhibitor (l-NAME) reduces licking behavior and Fos-labeling in the spinal cord of rats during formalin-induced inflammation","volume":"66","author":"Roche","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2008.04.171_bib35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0304-3940(88)90346-1","article-title":"The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system","volume":"85","author":"Shu","year":"1988","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.toxicon.2008.04.171_bib36","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1126\/science.1353273","article-title":"Nitric oxide: first in a new class of neurotransmitters","volume":"257","author":"Snyder","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2008.04.171_bib37","first-page":"506","article-title":"NMDA receptors mediating Fos expression in rat spinal cord induced by subcutaneous injection of formalin","volume":"19","author":"Tao","year":"1998","journal-title":"Zhongguo Yao Li Xue Bao"},{"key":"10.1016\/j.toxicon.2008.04.171_bib38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.niox.2007.04.004","article-title":"Nitric oxide (NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors","volume":"17","author":"Xu","year":"2007","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.toxicon.2008.04.171_bib39","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.neuropharm.2007.01.013","article-title":"Signal pathways coupled to\u00a0activation of neuronal nitric oxide synthase in the spinal cord by nociceptin\/orphanin FQ","volume":"52","author":"Xu","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.toxicon.2008.04.171_bib40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2004.06.041","article-title":"Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom","volume":"1021","author":"Zanchet","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.toxicon.2008.04.171_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0361-9230(02)00752-9","article-title":"Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch","volume":"58","author":"Zhang","year":"2002","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.toxicon.2008.04.171_bib42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010108003589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010108003589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T15:48:10Z","timestamp":1557589690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010108003589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0041010108003589"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2008.04.171","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}