{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:26:10Z","timestamp":1777501570139,"version":"3.51.4"},"reference-count":67,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.toxicon.2009.12.023","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T09:08:54Z","timestamp":1262682534000},"page":"1275-1283","source":"Crossref","is-referenced-by-count":27,"title":["Venom neutralization by purified bioactive molecules: Synthetic peptide derivatives of the endogenous PLA2 inhibitory protein PIP (a mini-review)"],"prefix":"10.1016","volume":"56","author":[{"given":"Maung\u2013Maung","family":"Thwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramar Perumal","family":"Samy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seetharama D.","family":"Satyanarayanajois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ponnampalam","family":"Gopalakrishnakone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2009.12.023_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/13880200600746253","article-title":"Ethnomedical treatment of poisonous snakebites: plant extract neutralized Naja nigricollis venom","volume":"44","author":"Abubakar","year":"2006","journal-title":"Pharma. Biol."},{"key":"10.1016\/j.toxicon.2009.12.023_bib2","first-page":"974","article-title":"Marine sponge metabolites for the control of inflammatory diseases","volume":"7","author":"Alcaraz","year":"2006","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.toxicon.2009.12.023_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0014-5793(02)03481-6","article-title":"Expression and function of phospholipase A2 in brain","volume":"531","author":"Balboa","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2009.12.023_bib4","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.1194\/jlr.R800033-JLR200","article-title":"Phospholipase A2 structure\/function, mechanism, and signaling","volume":"50","author":"Burke","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.toxicon.2009.12.023_bib5","doi-asserted-by":"crossref","first-page":"41079","DOI":"10.1074\/jbc.M206130200","article-title":"Crystal structure of a complex formed between a snake venom phospholipase A2 and a potent peptide inhibitor Phe-Leu-Ser-Tyr-Lys at 1.8\u00a0\u00c5 resolution","volume":"277","author":"Chandra","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib6","first-page":"1813","article-title":"Design of specific peptide inhibitors of phospholipase A2: structure of a complex formed between Russell's viper phospholipase A2 and a designed peptide Leu-Ala-Ile-Tyr-Ser","volume":"D58","author":"Chandra","year":"2002","journal-title":"Acta Cryst."},{"key":"10.1016\/j.toxicon.2009.12.023_bib7","doi-asserted-by":"crossref","first-page":"33156","DOI":"10.1074\/jbc.M101272200","article-title":"A novel approach to the design of inhibitors of human secreted phospholipase A2 based on native peptide inhibition","volume":"276","author":"Church","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib8","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1089\/neu.2004.21.1683","article-title":"Systemic treatment of cerebral cortex lesions in rats with a new secreted phospholipase A2 inhibitor","volume":"21","author":"Cunningham","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.toxicon.2009.12.023_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0022-2836(81)90081-4","article-title":"Structure of bovine pancreatic phospholipase A2 at 1.7A resolution","volume":"147","author":"Dijkstra","year":"1981","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.toxicon.2009.12.023_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bbamem.2005.06.014","article-title":"Inhibition of crotoxin binding to synaptosomes by a receptor-like protein from Crotalus durissus terrificus (the South American rattlesnake)","volume":"1717","author":"Dos Santos","year":"2005","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Biomembranes"},{"key":"10.1016\/j.toxicon.2009.12.023_bib11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1124\/pr.58.3.7","article-title":"Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders","volume":"58","author":"Farooqui","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.toxicon.2009.12.023_bib12","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.toxicon.2006.01.009","article-title":"Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines","volume":"47","author":"Fernandes","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib13","first-page":"489","article-title":"A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation","volume":"18","author":"Gilroy","year":"2004","journal-title":"Fed. Am. Soc. Exp. Biol. J."},{"key":"10.1016\/j.toxicon.2009.12.023_bib14","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.toxicon.2009.01.038","article-title":"Experimental pathology of local tissue damage induced by Bothrops asper snake venom","volume":"54","author":"Guti\u00e9rrez","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib15","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.toxicon.2006.11.020","article-title":"Neutralization of the haemorrhagic activities of viperine snake venoms and venom metalloproteinases using synthetic peptide inhibitors and chelators","volume":"49","author":"Howes","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib16","series-title":"Venom Phospholipase A2 Enzymes. Structure, Function and Mechanism","first-page":"155","author":"Kini","year":"1997"},{"key":"10.1016\/j.toxicon.2009.12.023_bib17","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0041-0101(98)00159-7","article-title":"Proline brackets and identification of potential functional sites in proteins: toxins to therapeutics","volume":"36","author":"Kini","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib18","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1002\/eji.200324475","article-title":"Inflammatory pathogenesis of snake venom metalloproteinase-induced skin necrosis","volume":"33","author":"Laing","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.toxicon.2009.12.023_bib19","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1021\/bi00004a026","article-title":"Differential binding of nicotine and alpha- bungarotoxin to residues 173\u2013204 of the nicotinic acetylcholine receptor alpha 1 subunit","volume":"34","author":"Lentz","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2009.12.023_bib20","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1471-4159.2004.02540.x","article-title":"Induction of secretory phospholipase A2 in reactive astrocytes in response to transient focal cerebral ischemia in the rat brain","volume":"90","author":"Lin","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib21","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.toxicon.2003.11.007","article-title":"Natural phospholipase A2 myotoxin inhibitor proteins from snakes, mammals and plants","volume":"42","author":"Lizano","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib22","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.toxicon.2009.03.015","article-title":"Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: contributions to understanding snakebite envenomings and their treatment","volume":"54","author":"Lomonte","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1074-5521(03)00094-2","article-title":"Rational design and molecular diversity for the construction of anti-\u03b1-bungarotoxin antidotes with high affinity and in vivo efficiency","volume":"10","author":"Lozzi","year":"2003","journal-title":"Chem. Biol."},{"key":"10.1016\/j.toxicon.2009.12.023_bib24","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2174\/156802607780487614","article-title":"Snake venom phospholipase A2 inhibitors: medicinal chemistry and therapeutic potential","volume":"7","author":"Marcussi","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib25","first-page":"10","article-title":"Developing sophisticated protein-based drugs: peptide drugs","volume":"25","author":"Marrow","year":"2005","journal-title":"Genet. Eng. News"},{"key":"10.1016\/j.toxicon.2009.12.023_bib26","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/bj3180701","article-title":"Release of secretory phospholipase A2 from rat neuronal cells and its possible function in the regulation of catecholamine secretion","volume":"318","author":"Matsuzawa","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2009.12.023_bib27","series-title":"Handbook of Clinical Toxicology of Animal Venoms and Poisons","author":"Meier","year":"1995"},{"key":"10.1016\/j.toxicon.2009.12.023_bib28","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.2174\/1381612053507521","article-title":"Phospholipase A2 inhibitors as potential anti-inflammatory agents","volume":"1","author":"Meyer","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.toxicon.2009.12.023_bib29","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/cbic.200700217","article-title":"Scalaradial, a dialdehyde-containing marine metabolite that causes an unexpected noncovalent PLA2 Inactivation","volume":"8","author":"Monti","year":"2007","journal-title":"Chembiochem"},{"key":"10.1016\/j.toxicon.2009.12.023_bib30","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2174\/156802607780487678","article-title":"Chemistry and structural evaluation of different phospholipase A2 inhibitors in arachidonic acid pathway mediated inflammation and snake venom toxicity","volume":"7","author":"Narendra Sharath Chandra","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib31","series-title":"Handbook of Venoms and Toxins of Reptiles","first-page":"259","article-title":"Natural inhibitors: innate immunity to snake venoms","author":"Neves-Ferreira","year":"2009"},{"key":"10.1016\/j.toxicon.2009.12.023_bib32","doi-asserted-by":"crossref","first-page":"17811","DOI":"10.1074\/jbc.M111152200","article-title":"Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (\u03b1\u03b2\u03b3\u03b4) but a poorly reversible antagonist of neuronal alpha 7 nicotinic acetylcholine receptors","volume":"277","author":"Nirthanan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0003-9861(02)00551-9","article-title":"Identification of beta-type phospholipase A2 inhibitor in a nonvenomous snake","volume":"408","author":"Okumura","year":"2002","journal-title":"Elaphe Quadrivirgata. Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2009.12.023_bib34","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.toxicon.2005.08.017","article-title":"Glial inflammation and neurodegeneration induced by candoxin, a novel neurotoxin from Bungarus candidus venom: global gene expression analysis using microarray","volume":"46","author":"Pachiappan","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib35","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/0041-0101(94)90353-0","article-title":"Isolation and partial characterization of an anti-bothropic complex from the serum of South American Didelphidae","volume":"32","author":"Perales","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib36","first-page":"691","article-title":"Paralysis, rhabdomyolysis and haemolysis caused by bites of Russell's viper (Vipera russelli pulchella) in Sri Lanka: failure of Haffkine antivenom","volume":"68","author":"Phillips","year":"1988","journal-title":"Q. J. Med."},{"key":"10.1016\/j.toxicon.2009.12.023_bib37","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2174\/156802607780487641","article-title":"Phospholipase inhibition: medicinal chemistry and therapeutic potential of PLA2 inhibitors","volume":"7","author":"Rangappa","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0041-0101(94)00124-Q","article-title":"Antivenom activity of opossum (Didelphis marsupialis) serum fraction","volume":"33","author":"Rodriguez-Acosta","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib39","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/08923970802279019","article-title":"Inhibitors of snake venoms and development of new therapeutics","volume":"30","author":"Sanchez","year":"2008","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.toxicon.2009.12.023_bib40","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.bbalip.2006.07.011","article-title":"The phospholipase A2 superfamily and its group numbering system","volume":"1761","author":"Schaloske","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2009.12.023_bib41","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1073\/pnas.111164298","article-title":"\u03b2-hairpin structure in a 13-mer peptide that binds \u03b1-bungarotoxin with high affinity and neutralizes its toxicity","volume":"98","author":"Scherf","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.toxicon.2009.12.023_bib42","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nsb0695-458","article-title":"Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2","volume":"2","author":"Schevitz","year":"1995","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.toxicon.2009.12.023_bib43","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1126\/science.2274788","article-title":"Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue","volume":"250","author":"Scott","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2009.12.023_bib44","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.1948070","article-title":"Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudates","volume":"254","author":"Scott","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2009.12.023_bib45","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.toxicon.2009.02.001","article-title":"Identification and characterization of phospholipase A2 inhibitors from the serum of the Japanese rat snake, Elaphe climacophora","volume":"53","author":"Shirai","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib65","doi-asserted-by":"crossref","first-page":"11701","DOI":"10.1021\/bi035076x","volume":"42","author":"Singh","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2009.12.023_bib46","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/10611860500254450","article-title":"Crystal structure of the complex of group I PLA2 with a group II-specific peptide Leu-Ala-Ile-Tyr-Ser at 2.6\u00a0\u00c5 resolution","volume":"13","author":"Singh","year":"2005","journal-title":"J. Drug Target."},{"key":"10.1016\/j.toxicon.2009.12.023_bib47","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/jmr.960","article-title":"Simultaneous inhibition of anti-coagulation and inflammation:crystal structure of phospholipase A2 complexed with indomethacin at 1.4\u00a0\u00c5 resolution reveals the presence of the new common ligand-binding","volume":"22","author":"Singh","year":"2009","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.toxicon.2009.12.023_bib48","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2174\/138920106777950799","article-title":"Editorial: are peptide therapeutics the future?","volume":"7","author":"Sivaram","year":"2006","journal-title":"Curr. Pharm. Biotech."},{"key":"10.1016\/j.toxicon.2009.12.023_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(00)00105-0","article-title":"The expanding superfamily of phospholipase A2 enzymes: classification and characterization","volume":"1488","author":"Six","year":"2000","journal-title":"BBA- Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.toxicon.2009.12.023_bib50","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1358\/dof.2004.029.11.851973","article-title":"Neutralizing effects of Brazilian plants against snake venoms","volume":"29","author":"Soares","year":"2004","journal-title":"Drugs of the Future"},{"key":"10.1016\/j.toxicon.2009.12.023_bib51","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.2174\/092986705774370655","article-title":"Medicinal plants with inhibitory properties against snake venoms","volume":"12","author":"Soares","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib52","first-page":"309","article-title":"Medicinal plant extracts and molecules as the source of new anti-snake venom drugs","volume":"4","author":"Soares","year":"2009","journal-title":"Front. Med. Chem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib53","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.toxicon.2007.09.009","article-title":"Koninginins, phospholipase A2 inhibitors from endophytic fungus Trichoderma koningii","volume":"51","author":"Souza","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib66","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1194\/jlr.R300016-JLR200","article-title":"Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases","volume":"45","author":"Sun","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.toxicon.2009.12.023_bib56","doi-asserted-by":"crossref","first-page":"9604","DOI":"10.1021\/bi000395z","article-title":"Recombinant antitoxic and antiinflammatory factor from the non-venomous snake Python reticulatus: phospholipase A2 inhibition and venom neutralizing potential","volume":"39","author":"Thwin","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2009.12.023_bib68","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1046\/j.0014-2956.2001.02711.x","article-title":"Functional site of endogenous phospholipase A2 inhibitor from python serum","volume":"269","author":"Thwin","year":"2002","journal-title":"Eur. J. Biochem"},{"key":"10.1016\/j.toxicon.2009.12.023_bib57","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00221-003-1476-7","article-title":"Secretory phospholipase A2 activity in the normal and kainate injected rat brain, and inhibition by a peptide derived from python serum","volume":"150","author":"Thwin","year":"2003","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.toxicon.2009.12.023_bib54","doi-asserted-by":"crossref","first-page":"R282","DOI":"10.1186\/ar1179","article-title":"Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study","volume":"6","author":"Thwin","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.toxicon.2009.12.023_bib58","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.1021\/jm070385x","article-title":"Novel peptide inhibitors of human secretory phospholipase A2 with antiinflammatory activity: solution structure and molecular modeling","volume":"50","author":"Thwin","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib55","doi-asserted-by":"crossref","first-page":"R138","DOI":"10.1186\/ar2810","article-title":"Suppressive effect of secretory phospholipase A2 inhibitory peptide on IL-1-beta-induced matrix metalloproteinases production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice","volume":"11","author":"Thwin","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.toxicon.2009.12.023_bib59","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0041-0101(87)90117-6","article-title":"Purification of three antihemorrhagic factors from the serum of a mongoose (Herpestes edwardsii)","volume":"25","author":"Tomihara","year":"1987","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2009.12.023_bib60","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/prot.340190408","article-title":"X-ray crystal structure and molecular dynamics simulation of bovine pancreas phospholipase A2- n-dodecylphosphorylcholine complex","volume":"19","author":"Tomoo","year":"1994","journal-title":"Proteins: Struct. Fun. Gen."},{"key":"10.1016\/j.toxicon.2009.12.023_bib61","doi-asserted-by":"crossref","first-page":"23992","DOI":"10.1074\/jbc.271.39.23992","article-title":"Native peptide inhibition: specific inhibition of type ii phospholipases A2 by synthetic peptides derived from the primary sequence","volume":"271","author":"Tseng","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2009.12.023_bib62","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1126\/science.2274787","article-title":"Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue","volume":"250","author":"White","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2009.12.023_bib63","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1124\/mol.61.1.114","article-title":"Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis","volume":"61","author":"Yagami","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxicon.2009.12.023_bib64","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1034\/j.1600-0404.2002.01238.x","article-title":"Secretory phospholipase A2 and phospholipids in neural membranes in an experimental epilepsy model","volume":"106","author":"Yegin","year":"2002","journal-title":"Acta Neurol. Scand."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010109005923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010109005923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T05:54:54Z","timestamp":1544766894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010109005923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":67,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0041010109005923"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2009.12.023","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}