{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:37:53Z","timestamp":1781005073407,"version":"3.54.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":220,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.toxicon.2010.01.001","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T05:36:17Z","timestamp":1262928977000},"page":"1125-1131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Biochemical profile of dogs experimentally envenomed with Tityus serrulatus scorpion venom"],"prefix":"10.1016","volume":"55","author":[{"given":"E.L.","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.L.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.","family":"Labarr\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.R.O.","family":"Paes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.O.","family":"Paes-Leme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ch\u00e1vez-Ol\u00f3rtegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2010.01.001_bib1","first-page":"97","article-title":"Lung compliance, plasma electrolyte levels and acid-base balance are affected by scorpion envenomation in anesthetized rats under mechanical ventilation","volume":"138","author":"Andrade","year":"2004","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.toxicon.2010.01.001_bib2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/gut.18.8.623","article-title":"Exocrine pancreatic response to the venom of the scorpion, Tityus trinitatis","volume":"18","author":"Bartholomew","year":"1977","journal-title":"Gut"},{"key":"10.1016\/j.toxicon.2010.01.001_bib3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0041-0101(02)00391-4","article-title":"Effects of Tityus serrulatus scorpion venom and its major toxin, TsTX-I, on the complement system in vivo","volume":"41","author":"Bertazzi","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib4","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1093\/clinchem\/38.11.2203","article-title":"Development of monoclonal antibodies for an assay of cardiac troponin I and preliminary results in suspected cases of myocardial infarction","volume":"38","author":"Bodor","year":"1992","journal-title":"Clin. Chem."},{"key":"10.1016\/j.toxicon.2010.01.001_bib5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1590\/S0036-46651995000400008","article-title":"A comparative study of severe scorpion envenomation in children caused by Tityus bahiensis and Tityus serrulatus","volume":"37","author":"Bucaretchi","year":"1995","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"10.1016\/j.toxicon.2010.01.001_bib6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1590\/S1678-91992004000100008","article-title":"Envenomation by scorpion in dog \u2013 case report","volume":"10","author":"Cardoso","year":"2004","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2010.01.001_bib7","series-title":"Clinical Biochemistry of Domestic Animals","first-page":"407","article-title":"Skeletal muscle function","author":"Cardinet","year":"1997"},{"key":"10.1016\/j.toxicon.2010.01.001_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1590\/S1678-91992006000100003","article-title":"Clinical and cardiovascular alterations produced by scorpions envenomation in dogs","volume":"12","author":"Cordeiro","year":"2006","journal-title":"J. Venom. Anim. Toxins incl. Trop. Dis"},{"key":"10.1016\/j.toxicon.2010.01.001_bib9","series-title":"Tratado de Fisiologia Veterin\u00e1ria","author":"Cunningham","year":"2004"},{"key":"10.1016\/j.toxicon.2010.01.001_bib10","series-title":"Animais Pe\u00e7onhentos no Brasil: Biologia Cl\u00ednica e Terap\u00eautica dos Acidentes","first-page":"198","article-title":"Escorpionismo","author":"Cupo","year":"2003"},{"key":"10.1016\/j.toxicon.2010.01.001_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ijcard.2006.02.015","article-title":"Acute left ventricular dysfunction of severe scorpion envenomation is related to myocardial perfusion disturbance","volume":"116","author":"Cupo","year":"2007","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.toxicon.2010.01.001_bib12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0041-0101(02)00080-6","article-title":"Cardiac troponin I release after severe scorpion envenoming by Tityus serrulatus","volume":"40","author":"Cupo","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1590\/S0036-46651994000100011","article-title":"Severe scorpion envenomation in Brazil. Clinical, laboratorial and anatomopathological aspects","volume":"36","author":"Cupo","year":"1994","journal-title":"Inst. Med. Trop. S\u00e3o Paulo"},{"key":"10.1016\/j.toxicon.2010.01.001_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1590\/S0102-09352007000100015","article-title":"Cardiac trauma confirmed by cardiac markers in dog: two cases reports","volume":"59","author":"Diniz","year":"2007","journal-title":"Arq. Bras. Med. Vet. Zoot."},{"key":"10.1016\/j.toxicon.2010.01.001_bib15","first-page":"551","article-title":"Metabolic effect of scorpion venom","volume":"vol. 2","author":"El-Asmar","year":"1984"},{"key":"10.1016\/j.toxicon.2010.01.001_bib16","series-title":"Clinical Biochemistry of Domestic Animals","first-page":"441","article-title":"Kidney function","author":"Finco","year":"1997"},{"key":"10.1016\/j.toxicon.2010.01.001_bib17","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0041-0101(96)00093-1","article-title":"Action of new world scorpion venom and its neurotoxins in secretion","volume":"34","author":"Fletcher","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib18","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.taap.2003.12.026","article-title":"The kinin system in the envenomation caused by the Tityus serrulatus scorpion sting","volume":"196","author":"Fukuhara","year":"2004","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1016\/j.toxicon.2010.01.001_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0041-0101(02)00208-8","article-title":"Increased plasma levels of IL-1\u03b2, IL-6, IL-8, IL-10, and TNF-\u03b1 in patients moderately or severely envenomed by Tityus serrulatus scorpion sting","volume":"41","author":"Fukuhara","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib20","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1016\/j.vaccine.2004.12.027","article-title":"Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines","volume":"23","author":"Gazarian","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.toxicon.2010.01.001_bib21","first-page":"577","article-title":"Production of scorpion anivenin","volume":"vol. 2","author":"Hassan","year":"1984"},{"key":"10.1016\/j.toxicon.2010.01.001_bib22","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/clinchem\/44.7.1430","article-title":"Cardiac troponins I and T in patients with suspected acute coronary syndrome: a comparative study in a routine setting","volume":"44","author":"Hetland","year":"1998","journal-title":"Clin. Chem."},{"key":"10.1016\/j.toxicon.2010.01.001_bib23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0041-0101(95)00005-7","article-title":"The scorpion envenoming syndrome","volume":"33","author":"Ismail","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0041-0101(88)90215-2","article-title":"Are the toxicological effects of scorpion envenomation related to tissue venom concentration?","volume":"26","author":"Ismail","year":"1988","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib25","series-title":"Essentials of Veterinary Hematology","author":"Jain","year":"1993"},{"key":"10.1016\/j.toxicon.2010.01.001_bib26","series-title":"Clinical Biochemistry of Domestic Animals","first-page":"45","article-title":"Carboydrate metabolism and its diseases","author":"Kaneko","year":"1997"},{"key":"10.1016\/j.toxicon.2010.01.001_bib27","series-title":"Clinical Biochemistry of Domestic Animals","first-page":"885","article-title":"Appendixes","author":"Kaneko","year":"1997"},{"key":"10.1016\/j.toxicon.2010.01.001_bib28","series-title":"Clinical Biochemistry of Domestic Animals","first-page":"303","article-title":"Clinical enzymology","author":"Kramer","year":"1997"},{"key":"10.1016\/j.toxicon.2010.01.001_bib29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2010.01.001_bib30","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0041-0101(99)00202-0","article-title":"Acid-base balance following Tityus serrulatus scorpion envenoming in anaesthetized rats","volume":"38","author":"Magalh\u00e3es","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib31","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0041-0101(98)00251-7","article-title":"Serum levels of cytokines in patients envenomed by Tityus serrulatus scorpion sting","volume":"37","author":"Magalh\u00e3es","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0041-0101(02)00155-1","article-title":"Significance of assessment of serum cardiac troponin I and interleukin-8 in scorpion envenomed children","volume":"41","author":"Meki","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib33","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0041-0101(98)00106-8","article-title":"Serum interleukin-1\u03b2, interleukin-6, nitric oxide and \u03b11-antitrypsin in scorpion envenomed children","volume":"36","author":"Meki","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1590\/S0104-79301999000100004","article-title":"The blood levels of glucagon, cortisol and insulin following the injection of venom by the scorpion (Mesobuthus tamulus concanesis, Pocock) in dogs","volume":"5","author":"Murthy","year":"1999","journal-title":"J. Venom. Anim. Toxins"},{"key":"10.1016\/j.toxicon.2010.01.001_bib35","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0041-0101(94)90387-5","article-title":"Scorpion envenoming and the role of insulin","volume":"32","author":"Murthy","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1590\/S0100-879X2004000300016","article-title":"Age effects on the pharmacokinetics of tityustoxin from Tityus serrulatus scorpion venom in rats","volume":"37","author":"Nunan","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.toxicon.2010.01.001_bib37","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0024-3205(03)00264-9","article-title":"Effect of age on body distribution of tityustoxin from Tityus serrulatus scorpion venom in rats","volume":"73","author":"Nunan","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2010.01.001_bib38","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/clinchem\/46.3.338","article-title":"Correlation of antemortem serum creatine kinase, creatine kinase-MB, troponin I, and troponin T with cardiac pathology","volume":"46","author":"Ooi","year":"2000","journal-title":"Clin. Chem."},{"key":"10.1016\/j.toxicon.2010.01.001_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.toxicon.2006.04.017","article-title":"In vitro and in vivo studies on some toxics effects of the venom from Hemiscorpious lepturus scorpion","volume":"48","author":"Pipelzadeh","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib40","first-page":"35","article-title":"Structural and functional characteristics of toxins purified from venom of the Brazilian scorpion Tityus serrulatus Lutz and Mello","volume":"54","author":"Possani","year":"1992","journal-title":"Mem. Inst. Butantan"},{"key":"10.1016\/j.toxicon.2010.01.001_bib41","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0002-9149(60)90121-1","article-title":"Key position of catecholamines in functional and degenerative cardiovascular pathology","volume":"5","author":"Raab","year":"1960","journal-title":"Am. J. Cardiol"},{"key":"10.1016\/j.toxicon.2010.01.001_bib42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1590\/S0102-09352009000100019","article-title":"Hemograma de c\u00e3es submetidos ao envenenamento experimental por Tityus serrulatus","volume":"61","author":"Ribeiro","year":"2009","journal-title":"Arq. Bras. Med. Vet. Zootec."},{"key":"10.1016\/j.toxicon.2010.01.001_bib43","series-title":"Estat\u00edstica Aplicada \u00e0 Experimenta\u00e7\u00e3o Animal","author":"Sampaio","year":"2007"},{"key":"10.1016\/j.toxicon.2010.01.001_bib44","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/0006-2952(83)90632-9","article-title":"Action of the venom of the scorpion Tityus trinitatis on pancreatic insulin secretion","volume":"32","author":"Sankaran","year":"1983","journal-title":"Biochem. Pharmacol"},{"key":"10.1016\/j.toxicon.2010.01.001_bib45","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/0041-0101(96)00050-5","article-title":"Pharmacokinetics of Tityus serrulatus scorpion venom determined by enzyme-linked immunosorbent assay in the rat","volume":"34","author":"Santana","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib46","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1939-1676.2001.tb01582.x","article-title":"Cardiac troponin I in the normal dog and cat","volume":"15","author":"Sleeper","year":"2001","journal-title":"J. Vet. Intern. Med"},{"key":"10.1016\/j.toxicon.2010.01.001_bib47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1590\/S0037-86822002000400013","article-title":"Escorpionismo em Belo Horizonte, MG: um estudo retrospectivo","volume":"35","author":"Soares","year":"2002","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.toxicon.2010.01.001_bib48","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0041-0101(95)00136-0","article-title":"Interleukin-6 release following scorpion sting in children","volume":"34","author":"Sofer","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib49","series-title":"Fundamentals of Veterinary Clinical Pathology","author":"Stockham","year":"2002"},{"key":"10.1016\/j.toxicon.2010.01.001_bib50","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00003246-199902000-00044","article-title":"Effects of adrenergic-receptor blockade and ligation of spleen vessels on the hemodynamics of dogs injected with scorpion venom","volume":"25","author":"Tarasiuk","year":"1999","journal-title":"Crit. Care Med"},{"key":"10.1016\/j.toxicon.2010.01.001_bib51","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0041-0101(00)00200-2","article-title":"Evidence for a direct action of Tityus serrulatus scorpion venom on the cardiac muscle","volume":"39","author":"Teixeira","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.001_bib52","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1751-0813.1998.tb12339.x","article-title":"Measurement of creatine kinase MB in canine cardiac patients","volume":"76","author":"Wyatt","year":"1998","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.toxicon.2010.01.001_bib53","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1590\/S0104-79301999000200007","article-title":"Insulin administrations in severe scorpion envenoming","volume":"5","author":"Yugandhar","year":"1999","journal-title":"J. Venom. Anim. Toxins"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010110000024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010110000024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:07:58Z","timestamp":1758575278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010110000024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0041010110000024"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2010.01.001","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biochemical profile of dogs experimentally envenomed with Tityus serrulatus scorpion venom","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2010.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}