{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T17:07:28Z","timestamp":1777223248116,"version":"3.51.4"},"reference-count":78,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.toxicon.2010.01.019","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T10:02:16Z","timestamp":1265709736000},"page":"1274-1282","source":"Crossref","is-referenced-by-count":22,"title":["Comparative analyses of venoms from American and African Sicarius spiders that differ in sphingomyelinase D activity"],"prefix":"10.1016","volume":"55","author":[{"given":"Pamela A.","family":"Zobel-Thropp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa R.","family":"Bodner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta J.","family":"Binford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2010.01.019_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbagen.2007.11.007","article-title":"Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase D) from brown spider (Loxosceles intermedia) venom","volume":"1780","author":"Appel","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2010.01.019_bib3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/icb.1985.59","article-title":"The effects of season of collection, feeding, maturation and gender on the potentcy of funnel-web spider (Atrax infensus) venom","volume":"63","author":"Atkinson","year":"1985","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"key":"10.1016\/j.toxicon.2010.01.019_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/icb.1981.24","article-title":"Comparisons of the neurotoxic activity of the venom of several species of funnel web spiders (Atrax)","volume":"59","author":"Atkinson","year":"1981","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"key":"10.1016\/j.toxicon.2010.01.019_bib4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0041-0101(81)90105-7","article-title":"Purification and characterization of a toxin from brown recluse spider (Loxosceles reclusa) venom gland extracts","volume":"19","author":"Babcock","year":"1981","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF01886859","article-title":"Compared chemical properties of dermonecrotic and lethal toxins from spiders of the genus Loxosceles(Araneae)","volume":"15","author":"Barbaro","year":"1996","journal-title":"J. Protein Chem."},{"key":"10.1016\/j.toxicon.2010.01.019_bib6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.toxicon.2004.12.009","article-title":"Enzymatic characterization, antigenic cross-reactivity and neutralization of dermonecrotic activity of five Loxosceles spider venoms of medical importance in the Americas","volume":"45","author":"Barbaro","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib7","first-page":"147","article-title":"Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species","volume":"146","author":"Batista","year":"2007","journal-title":"Comp. Biochem. Physiol. C."},{"key":"10.1016\/j.toxicon.2010.01.019_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1096-4959(03)00045-9","article-title":"The phylogenetic distribution of sphingomyelinase D activity in venoms of Haplogyne spiders","volume":"135","author":"Binford","year":"2003","journal-title":"Comp. Biochem. Physiol. B."},{"key":"10.1016\/j.toxicon.2010.01.019_bib11","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.ympev.2008.08.003","article-title":"Phylogenetic relationships of Loxosceles and Sicarius spiders are consistent with Western Gondwanan vicariance","volume":"49","author":"Binford","year":"2008","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.toxicon.2010.01.019_bib12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/molbev\/msn274","article-title":"Molecular evolution, functional variation and proposed nomenclature of the gene family that includes sphingomyelinase D in Sicariid spider venoms","volume":"26","author":"Binford","year":"2009","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.toxicon.2010.01.019_bib8","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0041-0101(00)00234-8","article-title":"An analysis of geographic and intersexual chemical variation in venoms of the spider Tegenaria agrestis (Agelenidae)","volume":"39","author":"Binford","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1095-8312.2001.tb01415.x","article-title":"Differences in venom composition between orb-weaving and wandering Hawaiian Tetragnatha (Araneae)","volume":"74","author":"Binford","year":"2001","journal-title":"Biol. J.\u00a0Linn. Soc."},{"key":"10.1016\/j.toxicon.2010.01.019_bib13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1074\/mcp.M600419-MCP200","article-title":"The diversity of bioactive proteins in Australian snake venoms","volume":"6","author":"Birrell","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.toxicon.2010.01.019_bib14","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1007\/s00018-005-5283-0","article-title":"Conotoxins and the posttranslational modification of secreted gene products","volume":"62","author":"Buczek","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.toxicon.2010.01.019_bib15","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.toxicon.2005.02.024","article-title":"Snake venom disintegrins: evolution of structure and function","volume":"45","author":"Calvete","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.taap.2005.05.015","article-title":"Brown spider dermonecrotic toxin directly induces nephrotoxicity","volume":"211","author":"Chaim","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxicon.2010.01.019_bib18","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0041-0101(91)90116-9","article-title":"Snake venom variability: methods of study, results and interpretation","volume":"29","author":"Chippaux","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1023\/A:1023470829671","article-title":"Purification and characterization of Loxnecrogin, a dermonecrotic toxin from Loxosceles gaucho brown spider venom","volume":"22","author":"Cunha","year":"2003","journal-title":"J. Protein Chem."},{"key":"10.1016\/j.toxicon.2010.01.019_bib20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.toxicon.2004.07.012","article-title":"Brown spiders and loxoscelism","volume":"44","author":"da Silva","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib21","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.biochi.2006.02.008","article-title":"Molecular cloning and functional characterization of two isoforms of dermonecrotic toxin from Loxosceles intermedia (brown spider) venom gland","volume":"88","author":"da Silveira","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2010.01.019_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.biochi.2006.12.002","article-title":"Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from brown spider (Loxosceles intermedia) venom: from cloning to functional characterization","volume":"89","author":"da Silveira","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2010.01.019_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0041-0101(95)00122-0","article-title":"Electrophoretic profiles and biological activities: intraspecific variation in the venom of the Malayan pit viper (Calloselasma rhodostoma)","volume":"34","author":"Daltry","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.toxicon.2004.05.028","article-title":"Identification and molecular cloning of insecticidal toxins from the venom of the brown spider Loxosceles intermedia","volume":"44","author":"de Castro","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0041-0101(98)00130-5","article-title":"Sex-linked variation of Loxosceles intermedia spider venoms","volume":"37","author":"de Oliveira","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.toxicon.2004.08.022","article-title":"Variations in Loxosceles spider venom composition and toxicity contribute to the severity of envenomation","volume":"45","author":"de Oliveira","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib27","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.toxicon.2009.02.013","article-title":"SMase II, a new sphingomyelinase D from Loxosceles laeta venom gland: molecular cloning, expression, function and structural analysis","volume":"53","author":"de Santi Ferrara","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib28","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1098\/rspb.2007.1039","article-title":"Convergent setal morphology in sand covering spiders suggests a design principle for particle capture","volume":"274","author":"Duncan","year":"2007","journal-title":"Proc. R. Soc. B."},{"key":"10.1016\/j.toxicon.2010.01.019_bib29","doi-asserted-by":"crossref","first-page":"6554","DOI":"10.1002\/pmic.200600263","article-title":"Post-translational modification accounts for the presence of varied forms of nerve growth factor in Australian elapid snake venoms","volume":"6","author":"Earl","year":"2006","journal-title":"Proteomics"},{"key":"10.1016\/j.toxicon.2010.01.019_bib31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.toxicon.2004.02.007","article-title":"Tarantulas: eight-legged pharmacists and combinatorial chemists","volume":"43","author":"Escoubas","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib30","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/rcm.595","article-title":"Matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry and high-performance liquid chromatography study of quantitative and qualitative variation in tarantula spider venoms","volume":"16","author":"Escoubas","year":"2002","journal-title":"Rapid Commun. Mass. Spectrom."},{"key":"10.1016\/j.toxicon.2010.01.019_bib32","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.toxicon.2006.01.018","article-title":"Venom landscapes: mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach","volume":"47","author":"Escoubas","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib33","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11030-006-9050-4","article-title":"Molecular diversification in spider venoms: a web of combinatorial peptide libraries","volume":"10","author":"Escoubas","year":"2006","journal-title":"Mol. Divers."},{"key":"10.1016\/j.toxicon.2010.01.019_bib34","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.toxicon.2006.06.019","article-title":"Functional characterization and epitope analysis of a recombinant dermonecrotic protein from Loxosceles intermedia spider","volume":"48","author":"Felicori","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib35","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0006-291X(02)02521-4","article-title":"Molecular cloning and expression of a functional dermonecrotic and haemolytic factor from Loxosceles laeta venom","volume":"298","author":"Fernandes-Pedrosa","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2010.01.019_bib36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/1471-2164-9-279","article-title":"Transcriptome analysis of Loxosceles laeta (Araneae, Sicariidae) spider venomous gland using expressed sequence tags","volume":"9","author":"Fernandes-Pedrosa","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.toxicon.2010.01.019_bib37","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1603\/0022-2585(2005)042[0756:MOBLIA]2.0.CO;2","article-title":"Microhabitats occupied by Loxosceles intermedia and Loxosceles laeta (Araneae: Sicariidae) in Curitiba, Parana. Braz","volume":"42","author":"Fischer","year":"2005","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.toxicon.2010.01.019_bib38","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0041-0101(89)90178-5","article-title":"Immobilizing and lethal effects of spider venoms on the cockroach and the common mealbeetle","volume":"27","author":"Friedel","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1074\/mcp.M700094-MCP200","article-title":"Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia)","volume":"7","author":"Fry","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.toxicon.2010.01.019_bib40","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.toxicon.2009.01.025","article-title":"Comparison of the peptidome and insecticidal activity of venom from a taxonomically diverse group of theraphosid spiders","volume":"53","author":"Gentz","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib41","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0003-9861(76)90327-1","article-title":"Isolation and characterization of toxins from brown recluse spider venom (Loxosceles reclusa)","volume":"174","author":"Geren","year":"1976","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2010.01.019_bib42","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0041-0101(02)00136-8","article-title":"Intersexual variations in the venom of the Brazilian \u201carmed\u201d spider Phoneutria nigriventer (Keyserling, 1891)","volume":"40","author":"Herzig","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib43","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.toxicon.2008.02.001","article-title":"Intersexual variations in Northerns (Missulena pruinosa) and Eastern (M. bradleyi) mouse spider venom","volume":"51","author":"Herzig","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib44","first-page":"1","article-title":"The biology of the brown recluse spider","volume":"711","author":"Hite","year":"1966","journal-title":"Agric. Exp. Sta. Bull."},{"key":"10.1016\/j.toxicon.2010.01.019_bib45","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.toxicon.2007.07.001","article-title":"The Loxtox protein family in Loxosceles intermedia (Mello-Leit\u00e3o) venom","volume":"50","author":"Kalapothakis","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0378-1119(00)00490-X","article-title":"Adaptive evolution of animal toxin multigene families","volume":"261","author":"Kordis","year":"2000","journal-title":"Gene"},{"key":"10.1016\/j.toxicon.2010.01.019_bib47","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0304-4165(81)90128-8","article-title":"Platelet aggregation and sphingomyelinase D activity of a purified toxin from the venom of Loxosceles reclusa","volume":"678","author":"Kurpiewski","year":"1981","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2010.01.019_bib48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1155\/1969\/96480","article-title":"Eggcase construction and further observations on the sexual behavior of the spider Sicarius (Araneae: Sicariidae)","volume":"76","author":"Levi","year":"1969","journal-title":"Psyche"},{"key":"10.1016\/j.toxicon.2010.01.019_bib49","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1002\/pmic.200401096","article-title":"Proteome analysis of brown spider venom: identification of loxnecrogin isoforms in Loxosceles gaucho venom","volume":"5","author":"Machado","year":"2005","journal-title":"Proteomics"},{"key":"10.1016\/j.toxicon.2010.01.019_bib50","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1590\/S1678-91992003000200004","article-title":"Insects as biological models to assay spider and scorpion venom toxicity","volume":"9","author":"Manzoli-Palma","year":"2003","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2010.01.019_bib51","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0041-0101(65)90004-8","article-title":"An immunological and electrophoretical comparison of the venoms of the North American Latrodectus spiders","volume":"3","author":"McCrone","year":"1965","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib52","first-page":"44","article-title":"The relative toxicity and polypeptide composition of the venom of two Southern African widow spider species: Latrodectus indistinctus and Latrodectus geometricus","volume":"85","author":"M\u00fcller","year":"1989","journal-title":"S. Afr. J. Sci."},{"key":"10.1016\/j.toxicon.2010.01.019_bib53","first-page":"113","article-title":"Comparison of the toxicity, neurotransmitter releasing potency and polypeptide composition of the venoms from Steatoda foravae, Latrodectus indistinctus and L. geometricus (Araneae: Theridiidae)","volume":"88","author":"M\u00fcller","year":"1992","journal-title":"S. Afr. J. Sci."},{"key":"10.1016\/j.toxicon.2010.01.019_bib54","doi-asserted-by":"crossref","first-page":"13658","DOI":"10.1074\/jbc.M412437200","article-title":"Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D","volume":"280","author":"Murakami","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2010.01.019_bib55","first-page":"235","article-title":"Review of southern African spiders of medical importance, with notes on the signs and symptoms of envenomation","volume":"73","author":"Newlands","year":"1988","journal-title":"S. Afr. Med. J."},{"key":"10.1016\/j.toxicon.2010.01.019_bib56","first-page":"1","article-title":"Spinneret morphology and the phylogeny of Haplogyne spiders (Araneae, Araneomorphae)","volume":"3016","author":"Platnick","year":"1991","journal-title":"Am. Mus. Novit."},{"key":"10.1016\/j.toxicon.2010.01.019_bib57","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.toxicon.2004.12.002","article-title":"Analysis of the toxic potential of venom from Loxosceles adelaida, a Brazilian brown spider from karstic areas","volume":"45","author":"Pretel","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib58","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/jee\/85.1.33","article-title":"Insecticidal activity of spider (Araneae), Centipede (Chilopoda), scorpion (Scorpionida), and snake (Serpentes) venoms","volume":"85","author":"Quistad","year":"2002","journal-title":"J. Econ. Entomol."},{"key":"10.1016\/j.toxicon.2010.01.019_bib59","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.toxicon.2004.06.013","article-title":"Genetic and enzymatic characterization of sphingomyelinase D isoforms from the North American fiddleback spiders Loxosceles boneti and Loxosceles reclusa","volume":"44","author":"Ramos-Cerrillo","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib60","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0041-0101(01)00199-4","article-title":"Pharmacology and biochemistry of spider venoms","volume":"40","author":"Rash","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib61","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.toxicon.2007.02.016","article-title":"Molecular isoforms of cobra venom factor-like proteins in the venom of Austrelaps superbus","volume":"50","author":"Rehana","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib62","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1365-294X.2007.03627.x","article-title":"Evolution of ecological specialization and venom of a predatory marine gastropod","volume":"17","author":"Remigio","year":"2008","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.toxicon.2010.01.019_bib63","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.toxicon.2007.08.001","article-title":"Biological and structural comparison of recombinant phospholipase D toxins from Loxosceles intermedia (brown spider) venom","volume":"50","author":"Ribeiro","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib64","first-page":"173","article-title":"Comparison of the partial proteomes of the venoms of Brazilian spiders of the genus Phoneutria","volume":"142","author":"Richardson","year":"2006","journal-title":"Comp. Biochem. Physiol. C."},{"key":"10.1016\/j.toxicon.2010.01.019_bib65","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.toxicon.2004.03.022","article-title":"Current views on scorpion toxins specific for K+-channels","volume":"43","author":"Rodr\u00edguez de la Vega","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib17","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.toxicon.2005.09.006","article-title":"Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution","volume":"46","author":"Rodr\u00edguez de la Vega","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib66","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.toxicon.2005.09.002","article-title":"Characterization of the venom from the Brazilian brown spider Loxosceles similis Moenkhaus, 1989 (Araneae, Sicariidae)","volume":"46","author":"Silvestre","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib67","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/bbrc.1998.9474","article-title":"Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis","volume":"251","author":"Tambourgi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2010.01.019_bib68","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1365-2567.2002.01483.x","article-title":"Mechanism of induction of complement susceptibility of erythrocytes by\u00a0spider and bacterial sphingomyelinases","volume":"107","author":"Tambourgi","year":"2002","journal-title":"Immunology"},{"key":"10.1016\/j.toxicon.2010.01.019_bib69","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.molimm.2004.03.027","article-title":"Molecular cloning, function and immunoreactivities of members of a gene family of sphingomyelinases from Loxosceles venom glands","volume":"41","author":"Tambourgi","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.toxicon.2010.01.019_bib73","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0041-0101(96)00203-6","article-title":"Venom of a six-eyed crab spider, Sicarius testaceus (Purcell, 1908), causes necrotic and haemorrhagic lesions in the rabbit","volume":"35","author":"van Aswegen","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib70","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0041-0101(98)00198-6","article-title":"Oligoscaccharide residues of Loxosceles intermedia (brown spider) venom proteins: dependence on glycosylation for dermonecrotic activity","volume":"37","author":"Veiga","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib71","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1023\/A:1004031019827","article-title":"Effect of brown spider venom on basement membrane structures","volume":"32","author":"Veiga","year":"2000","journal-title":"Histochem. J."},{"key":"10.1016\/j.toxicon.2010.01.019_bib72","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1590\/S0100-879X2001000700002","article-title":"Extracellular matrix molecules as targets for brown spider venom toxins","volume":"34","author":"Veiga","year":"2001","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.toxicon.2010.01.019_bib74","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1636\/RSt08-06.1","article-title":"Spiders of the genus Loxosceles (Araneae, Sicariidae): a review of biological, medical and psychological aspects regarding envenomations","volume":"1","author":"Vetter","year":"2008","journal-title":"J. Arachnol."},{"key":"10.1016\/j.toxicon.2010.01.019_bib75","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF03165785","article-title":"Physiological and biochemical analysis of L. tredecimguttatus venom collected by electrical stimulation","volume":"63","author":"Wang","year":"2007","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.toxicon.2010.01.019_bib76","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0003-9861(73)90469-4","article-title":"Hyaluronidase and esterase activities of the venom of the poisonous brown recluse spider","volume":"159","author":"Wright","year":"1973","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2010.01.019_bib77","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0041-0101(00)00145-8","article-title":"Comparison of enzymatic activity from three species of necrotizing arachnids in Australia: Loxosceles rufescens, Badumna insignis and Lampona cylindrata","volume":"39","author":"Young","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.01.019_bib78","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0169-5347(03)00033-8","article-title":"Evolution by gene duplication: an update","volume":"18","author":"Zhang","year":"2003","journal-title":"Trends Ecol. Evol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010110000358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010110000358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T05:51:40Z","timestamp":1544680300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010110000358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":78,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0041010110000358"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2010.01.019","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}