{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:35:23Z","timestamp":1768682123948,"version":"3.49.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T00:00:00Z","timestamp":1299628800000},"content-version":"vor","delay-in-days":251,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.toxicon.2010.03.004","type":"journal-article","created":{"date-parts":[[2010,3,10]],"date-time":"2010-03-10T07:15:33Z","timestamp":1268205333000},"page":"1527-1530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of the synthetic coumarin, ethyl 2-oxo-2H-chromene-3-carboxylate, on activity of Crotalus durissus ruruima sPLA2 as well as on edema and platelet aggregation induced by this factor"],"prefix":"10.1016","volume":"55","author":[{"given":"F.V.","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"L.","family":"Baldissera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.A.","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.B.S.","family":"Diz-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.G.","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.O.S.","family":"Beriam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.O.","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.A.","family":"Cotrim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.H.","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.toxicon.2010.03.004_bib1","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1021\/jm00161a011","article-title":"Synthesis and antihypertensive activity of 4-(cyclic amido)-2H-1-benzopyrans","volume":"29","author":"Ashwood","year":"1986","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.toxicon.2010.03.004_bib2","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0041-0101(00)00107-0","article-title":"Leucocyte recruitment induced by type II phospholipases A2 into the rat pleural cavity","volume":"38","author":"de Castro","year":"2000","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxicon.2010.03.004_bib3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.toxicon.2008.10.021","article-title":"Enzymatic and structural characterization of new PLA2 isoform isolated from white venom of Crotalus durissus ruruima","volume":"53","author":"Diz Filho","year":"2009","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxicon.2010.03.004_bib4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10930-006-9001-z","article-title":"Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom","volume":"25","author":"Fonseca","year":"2006","journal-title":"Protein J."},{"issue":"3","key":"10.1016\/j.toxicon.2010.03.004_bib5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1006\/jmbi.2001.5148","article-title":"Crystal structure of gamma-chymotrypsin in complex with 7-hydroxycoumarin","volume":"314","author":"Ghani","year":"2001","journal-title":"J. Mol. Biol."},{"issue":"25","key":"10.1016\/j.toxicon.2010.03.004_bib6","doi-asserted-by":"crossref","first-page":"7200","DOI":"10.1021\/bi00346a028","article-title":"Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors","volume":"24","author":"Harper","year":"1985","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.toxicon.2010.03.004_bib7","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/chir.20038","article-title":"Spacer length effect of a chiral stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid","volume":"16","author":"Hyun","year":"2004","journal-title":"Chirality"},{"issue":"7","key":"10.1016\/j.toxicon.2010.03.004_bib8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.toxicon.2005.07.017","article-title":"Effects of morin on snake venom phospholipase A2 (PLA2)","volume":"46","author":"Iglesias","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2010.03.004_bib9","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2174\/1385272023374094","article-title":"Synthesis of cyclic compounds from the Baylis-Hillman Adducts","volume":"6","author":"Kim","year":"2002","journal-title":"Curr. Org. Chem."},{"issue":"7","key":"10.1016\/j.toxicon.2010.03.004_bib10","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/jat.1348","article-title":"Role of phospholipase A2 and tyrosine kinase in Clostridium difficile toxin A-induced disruption of epithelial integrity, histologic inflammatory damage and intestinal secretion","volume":"28","author":"Lima","year":"2008","journal-title":"J Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.toxicon.2010.03.004_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jphotobiol.2008.04.008","article-title":"Spectroscopic studies on binding of 1-phenyl-3-(coumarin-6-yl) sulfonylurea to bovine serum albumin","volume":"92","author":"Liu","year":"2008","journal-title":"J. Photochem. Photobiol. B: Biol."},{"issue":"3","key":"10.1016\/j.toxicon.2010.03.004_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1023\/A:1015320616206","article-title":"Structural and functional characterization of basic PLA2 isolated from Crotalus durissus terrificus venom","volume":"21","author":"Oliveira","year":"2002","journal-title":"J. Protein Chem."},{"key":"10.1016\/j.toxicon.2010.03.004_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2091-9-16","article-title":"Modulation of the pharmacological effects of enzymatically-active PLA2 by BTL-2, an isolectin isolated from the Bryothamnion triquetrum red alga","volume":"9","author":"Oliveira","year":"2008","journal-title":"BMC Biochem."},{"issue":"4","key":"10.1016\/j.toxicon.2010.03.004_bib14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.toxicon.2008.12.018","article-title":"Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom","volume":"53","author":"Toyama","year":"2009","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.toxicon.2010.03.004_bib15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0041-0101(03)00085-0","article-title":"Structural, enzymatic and biological properties of new PLA(2) isoform from Crotalus durissus terrificus venom","volume":"41","author":"Toyama","year":"2003","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.toxicon.2010.03.004_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10930-004-1517-5","article-title":"Biological and structural characterization of a new PLA2 from the Crotalus durissus collilineatus venom","volume":"24","author":"Toyama","year":"2005","journal-title":"Protein J."},{"key":"10.1016\/j.toxicon.2010.03.004_bib17","first-page":"59","article-title":"Increasing molecular diversity of secreted phospholipase A2 and their receptor and binding protein","volume":"1488","author":"Valentin","year":"2000","journal-title":"Biochem. Biphys. Acta"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010110001042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010110001042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:08:03Z","timestamp":1758575283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010110001042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0041010110001042"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2010.03.004","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of the synthetic coumarin, ethyl 2-oxo-2H-chromene-3-carboxylate, on activity of Crotalus durissus ruruima sPLA2 as well as on edema and platelet aggregation induced by this factor","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2010.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}