{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:35:01Z","timestamp":1791048901301,"version":"4.1.0"},"reference-count":166,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":874,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.toxicon.2011.01.002","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T09:15:04Z","timestamp":1294910104000},"page":"497-511","source":"Crossref","is-referenced-by-count":108,"title":["Arthropod venoms and cancer"],"prefix":"10.1016","volume":"57","author":[{"given":"Tiago Elias","family":"Heinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz","family":"Gorini da Veiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2011.01.002_bib1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.bbrc.2006.03.068","article-title":"Losac, a factor X activator from Lonomia obliqua bristle extract: its role in the pathophysiological mechanisms and cell survival","volume":"343","author":"Alvarez Flores","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2011.01.002_bib2","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1021\/bi00328a017","article-title":"N-terminal analogues of cecropin A: synthesis, antibacterial activity, and conformational properties","volume":"24","author":"Andreu","year":"1985","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2011.01.002_bib3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1182\/blood-2006-06-029934","article-title":"Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis","volume":"109","author":"Arbiser","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.toxicon.2011.01.002_bib4","doi-asserted-by":"crossref","first-page":"10106","DOI":"10.1016\/S0021-9258(18)90935-X","article-title":"Isolation and characterization of two new peptides, mastoparan C and crabrolin, from the venom of the European hornet, Vespa crabro","volume":"259","author":"Argiolas","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib5","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0021-9258(18)89611-9","article-title":"Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus","volume":"260","author":"Argiolas","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/(SICI)1097-4652(199606)167:3<434::AID-JCP7>3.0.CO;2-Q","article-title":"Hepatocellular carcinoma cells resist necrosis during anoxia by preventing phospholipase-mediated calpain activation","volume":"167","author":"Arora","year":"1996","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1248\/bpb.27.727","article-title":"Inhibitory effect of propolis on the growth of human leukemia U937","volume":"27","author":"Aso","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.toxicon.2011.01.002_bib8","doi-asserted-by":"crossref","first-page":"35501","DOI":"10.1074\/jbc.M302967200","article-title":"Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo","volume":"278","author":"Bai","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biotechadv.2003.09.004","article-title":"Streptokinase \u2013 a clinically useful thrombolytic agent","volume":"22","author":"Banerjee","year":"2004","journal-title":"Biotech. Adv."},{"key":"10.1016\/j.toxicon.2011.01.002_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0304-4157(93)90002-6","article-title":"Ribosome-inactivating proteins from plants","volume":"1154","author":"Barbieri","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2011.01.002_bib11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbamem.2003.08.010","article-title":"The hemolytic activity of six arachnid cationic peptides is affected by the phosphatidylcholine to-sphingomyelin ratio in lipid bilayers","volume":"1617","author":"Belokoneva","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2011.01.002_bib12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0367-326X(02)00189-2","article-title":"Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon","volume":"73","author":"Borelli","year":"2002","journal-title":"Fitoterapia"},{"key":"10.1016\/j.toxicon.2011.01.002_bib13","doi-asserted-by":"crossref","first-page":"C1282","DOI":"10.1152\/ajpcell.00077.2004","article-title":"Cation selectivity and inhibition of malignant glioma Na+ channels by Psalmotoxin 1","volume":"287","author":"Bubien","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib14","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1002\/cbic.200900133","article-title":"Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae)","volume":"10","author":"Cerovsk\u00fd","year":"2009","journal-title":"Chembiochem"},{"key":"10.1016\/j.toxicon.2011.01.002_bib15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3816\/CGC.2007.n.031","article-title":"The AKT inhibitor perifosine in biochemically recurrent prostate cancer: a phase II California\/Pittsburgh cancer consortium trial","volume":"5","author":"Chee","year":"2007","journal-title":"Clin. Genitourin Cancer"},{"key":"10.1016\/j.toxicon.2011.01.002_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-4165(97)00024-X","article-title":"Effects of the anti-bacterial peptide cecropin B and its analogs, cecropins B-1 and B-2, on liposomes, bacteria, and cancer cells","volume":"1336","author":"Chen","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2011.01.002_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bcp.2003.07.020","article-title":"Propolin C from propolis induces apoptosis through activating caspases, Bid and cytochrome c release in human melanoma cells","volume":"67","author":"Chen","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib18","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jep.2009.12.007","article-title":"Bee venom suppresses PMA-mediated MMP-9 gene activation via JNK\/p38 and NF-kappaB-dependent mechanisms","volume":"127","author":"Cho","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib19","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.lfs.2006.09.024","article-title":"Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells","volume":"80","author":"Chu","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2011.01.002_bib21","first-page":"2253","article-title":"Calmodulin: an overview","volume":"41","author":"Chueng","year":"1982","journal-title":"Fed. Proc."},{"key":"10.1016\/j.toxicon.2011.01.002_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3350001","article-title":"Protein kinase B (c- Akt): a multifunctional mediator of phosphatidylinositol 3- kinase activation","volume":"335","author":"Coffer","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2011.01.002_bib23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1042\/bj3590035","article-title":"Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator","volume":"359","author":"Corzo","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2011.01.002_bib24","doi-asserted-by":"crossref","first-page":"23627","DOI":"10.1074\/jbc.M200511200","article-title":"Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins","volume":"277","author":"Corzo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0945-053X(01)00172-X","article-title":"The six hyaluronidase like genes in the human and mouse genomes","volume":"20","author":"Csoka","year":"2001","journal-title":"Matrix Biol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib26","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/0041-0101(91)90128-E","article-title":"Chloride channel inhibition by the venom of the scorpion Leiurus quinquestriatus","volume":"29","author":"DeBin","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1152\/ajpcell.1993.264.2.C361","article-title":"Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion","volume":"264","author":"DeBin","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib28","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1074\/jbc.M205662200","article-title":"Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2","volume":"278","author":"Deshane","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/0005772X.1987.11098915","article-title":"Honeybee venom","volume":"68","author":"Dotimas","year":"1987","journal-title":"Bee World"},{"key":"10.1016\/j.toxicon.2011.01.002_bib30","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(05)64961-6","article-title":"Intracerebral haemorrhage after contact with Lonomia caterpillars","volume":"348","author":"Duarte","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.toxicon.2011.01.002_bib31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1096\/fasebj.8.2.8119494","article-title":"Cytolysis mediated by ionophores and pore-forming agents: role of intracellular calcium in apoptosis","volume":"8","author":"Duke","year":"1994","journal-title":"FASEB J."},{"key":"10.1016\/j.toxicon.2011.01.002_bib32","doi-asserted-by":"crossref","first-page":"25116","DOI":"10.1074\/jbc.M003643200","article-title":"Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels","volume":"275","author":"Escoubas","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib33","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11030-006-9050-4","article-title":"Molecular diversification in spider venoms: a web of combinatorial peptide libraries","volume":"10","author":"Escoubas","year":"2006","journal-title":"Mol. Divers."},{"key":"10.1016\/j.toxicon.2011.01.002_bib34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.toxicon.2006.01.013","article-title":"Mass spectrometry in toxinology: a 21st-century technology for the study of biopolymers from venoms","volume":"47","author":"Escoubas","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib35","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/jm950670t","article-title":"Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action","volume":"39","author":"Evers","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib36","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.toxicon.2006.01.020","article-title":"Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen","volume":"47","author":"Favreau","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib37","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/ps.1833","article-title":"Insecticidal activity of scorpion toxin (ButaIT) and snowdrop lectin (GNA) containing fusion proteins towards pest species of different orders","volume":"66","author":"Fitches","year":"2010","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.toxicon.2011.01.002_bib39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2006.10.056","article-title":"Therapeutic potential of chlorotoxin-like neurotoxin from the Chinese scorpion for human gliomas","volume":"412","author":"Fu","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.toxicon.2011.01.002_bib40","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1248\/bpb.31.722","article-title":"A quinone isolated from the nest of Vespa simillima and its growth-inhibitory effect on rat liver cancer cells","volume":"31","author":"Fujiwara","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.toxicon.2011.01.002_bib41","first-page":"812","article-title":"Inhibitory effect of the venom of spider Macrothele raveni on proliferation of human hepatocellular carcinoma cell line BEL-7402 and its mechanism","volume":"24","author":"Gao","year":"2005","journal-title":"Ai Zheng"},{"key":"10.1016\/j.toxicon.2011.01.002_bib42","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1745-7254.2005.00052.x","article-title":"Effects of spider Macrothele raven venom on cell proliferation and cytotoxicity in HeLa cells","volume":"26","author":"Gao","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.toxicon.2011.01.002_bib43","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/dna.2007.0579","article-title":"Effect of spider venom on cell apoptosis and necrosis rates in MCF-7 cells","volume":"26","author":"Gao","year":"2007","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib44","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.toxicon.2008.06.003","article-title":"Purification and N-terminal sequence of a serine proteinase-like protein (BMK-CBP) from the venom of the Chinese scorpion (Buthus martensii Karsch)","volume":"52","author":"Gao","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib45","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/10428190902755505","article-title":"Up-regulation of PTEN involved in scorpion venom-induced apoptosis in a lymphoma cell line","volume":"50","author":"Gao","year":"2009","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.toxicon.2011.01.002_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/gyno.2001.6558","article-title":"Effects of a lytic peptide conjugated to beta HCG on ovarian cancer: studies in vitro and in vivo","volume":"85","author":"Gawronska","year":"2002","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib47","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1210\/endo-121-5-1766","article-title":"Inhibition by melittin and fluphenazine of melanotropin receptor function and adenylate cyclase in M2R melanoma cell membranes","volume":"121","author":"Gest","year":"1987","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxicon.2011.01.002_bib48","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0006-3495(84)84255-1","article-title":"Melittin and the 8-26 fragment. Differences in ionophoric properties as measured by monolayer method","volume":"45","author":"Gevod","year":"1984","journal-title":"Biophys. J."},{"key":"10.1016\/j.toxicon.2011.01.002_bib49","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1582-4934.2008.00129.x","article-title":"Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway","volume":"12","author":"Ghavami","year":"2008","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.toxicon.2011.01.002_bib50","first-page":"921","article-title":"The magic glue hyaluronan and its eraser hyaluronidase: a biological overview","volume":"80","author":"Girisk","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2011.01.002_bib51","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0041-0101(02)00142-3","article-title":"An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch","volume":"40","author":"Goudet","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib52","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.toxicon.2004.11.008","article-title":"Identification and partial characterization of hyaluronidades in Lonomia obliqua venom","volume":"45","author":"Gouveia","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib53","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.leukres.2005.04.010","article-title":"Evaluation of Manisa propolis effect on leukemia cell line by telomerase activity","volume":"29","author":"Gunduz","year":"2005","journal-title":"Leuk. Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib54","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cbi.2009.11.006","article-title":"Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: through mitochondrial pathway and inhibition of heat shock proteins","volume":"183","author":"Gupta","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.toxicon.2011.01.002_bib55","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1046\/j.1440-1681.2002.03726.x","article-title":"Autonomic effects of some scorpion venoms and toxins","volume":"29","author":"Gwee","year":"2002","journal-title":"Clin. Exp. Pharm. Physiol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib56","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1126\/science.177.4046.314","article-title":"Bee and wasp venom: the biochemistry and pharmacology of their peptides and enzymes are reviewed","volume":"177","author":"Habermann","year":"1972","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2011.01.002_bib57","first-page":"5","article-title":"Inhibition of growth of L1210 cyclic leukemic cells by inhibitors of nucleotide phosphodiesterase and calmodulin","volume":"2","author":"Hait","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib58","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/BF00258116","article-title":"Inhibition of growth of leukemic cells by inhibitors of calmodulin: phenothiazines and melittin","volume":"14","author":"Hait","year":"1985","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib59","first-page":"93","article-title":"A matrix metalloproteinase 2 cleavable melittin\/avidin conjugate specifically targets tumor cells in vitro and in vivo","volume":"22","author":"Holle","year":"2003","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1211\/jpp.58.1.0010","article-title":"Effect of polypeptides in bee venom on growth inhibition and apoptosis induction of the human hepatoma cell line SMMC-7721 in-vitro and Balb\/c nude mice in-vivo","volume":"58","author":"Hu","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib61","first-page":"237","article-title":"The role of mitochondria in bee venom-induced apoptosis in human breast cancer MCF7 cells","volume":"22","author":"Ip","year":"2008","journal-title":"In Vivo"},{"key":"10.1016\/j.toxicon.2011.01.002_bib62","first-page":"833","article-title":"Bee venom induced cell cycle arrest and apoptosis in human cervical epidermoid carcinoma Ca Ski cells","volume":"28","author":"Ip","year":"2008","journal-title":"Anticancer Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib63","doi-asserted-by":"crossref","first-page":"8273","DOI":"10.1021\/bi010223h","article-title":"Solution structure of an insect-specific neurotoxin from the new world scorpion Centruroides sculpturatus Ewing","volume":"40","author":"Jablonsky","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2011.01.002_bib64","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.ne.12.030189.002201","article-title":"Spider toxins: recent applications in neurobiology","volume":"12","author":"Jackson","year":"1989","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.toxicon.2011.01.002_bib65","first-page":"39","article-title":"Potent pleiotropic anti-angiogenic effects of TM601, a synthetic chlorotoxin peptide","volume":"30","author":"Jacoby","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib66","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1124\/mol.65.3.630","article-title":"Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro","volume":"65","author":"J\u00e4ger","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib67","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1254\/jphs.91.95","article-title":"Bee venom induces apoptosis and inhibits expression of cyclooxygenase-2 mRNA in human lung cancer cell line NCI-H1299","volume":"91","author":"Jang","year":"2003","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.toxicon.2011.01.002_bib68","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00280-004-0941-8","article-title":"Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells","volume":"56","author":"Kekre","year":"2005","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib69","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/15569549509019465","article-title":"Hemorrhagic syndrome induced by contact with caterpillars of the genus Lonomia (Saturniidae, Hemileucinae)","volume":"14","author":"Kelen","year":"1995","journal-title":"J. Toxicol. Toxin. Rev."},{"key":"10.1016\/j.toxicon.2011.01.002_bib70","doi-asserted-by":"crossref","first-page":"16934","DOI":"10.1021\/bi980995m","article-title":"Role of caspases in immunotoxin-induced apoptosis of cancer cells","volume":"37","author":"Keppler-Hafkemeyer","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2011.01.002_bib71","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/BJ20060302","article-title":"Anticoagulant proteins from snake venoms: structure, function and mechanism","volume":"397","author":"Kini","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2011.01.002_bib72","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0024-3205(85)90120-1","article-title":"Growth inhibition of C6 astrocytoma cells by inhibitions of calmodulin","volume":"36","author":"Lee","year":"1985","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2011.01.002_bib73","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cbi.2007.06.036","article-title":"Cytotoxicity of honeybee (Apis mellifera) venom in normal human lymphocytes and HL-60 cells","volume":"169","author":"Lee","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.toxicon.2011.01.002_bib74","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/pros.10259","article-title":"Human prostate cancer cells and xenografts are targeted and destroyed through luteinizing hormone releasing hormone receptors","volume":"56","author":"Leuschner","year":"2003","journal-title":"Prostate"},{"key":"10.1016\/j.toxicon.2011.01.002_bib75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/A:1022169525521","article-title":"Membrane disrupting lytic peptide conjugates destroy hormone dependent and independent breast cancer cells in vitro and in vivo","volume":"78","author":"Leuschner","year":"2003","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.toxicon.2011.01.002_bib76","first-page":"367","article-title":"Growth arrest and apoptosis of the human hepatocellular carcinoma cell line BEL-7402 induced by melittin","volume":"29","author":"Li","year":"2006","journal-title":"Onkologie"},{"key":"10.1016\/j.toxicon.2011.01.002_bib78","first-page":"741","article-title":"Anti-hepatocarcinoma effect of recombinant adenovirus carrying melittin gene","volume":"12","author":"Ling","year":"2004","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"10.1016\/j.toxicon.2011.01.002_bib79","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/annonc\/mdi019","article-title":"Inhibitory effect of recombinant adenovirus carrying melittin gene on hepatocellular carcinoma","volume":"16","author":"Ling","year":"2005","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib80","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/bi00001a003","article-title":"NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels","volume":"34","author":"Lippens","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2011.01.002_bib81","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/ijc.2910620319","article-title":"Cinnamic acid: a natural product with potential use in cancer intervention","volume":"62","author":"Liu","year":"1995","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.toxicon.2011.01.002_bib82","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1211\/002235702320266235","article-title":"Effect of honey bee venom on proliferation of K1735M2 mouse melanoma cells in-vitro and growth of murine B16 melanomas in-vivo","volume":"54","author":"Liu","year":"2002","journal-title":"Pharm. Pharmacol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib83","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1081\/PB-120015456","article-title":"Isolation, purification, and N-terminal partial sequence of an antitumor peptide from the venom of the Chinese scorpion Buthus martensii Karsch","volume":"32","author":"Liu","year":"2002","journal-title":"Prep. Biochem. Biotechnol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib84","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1002\/hep.22240","article-title":"Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway","volume":"47","author":"Liu","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.toxicon.2011.01.002_bib85","first-page":"155","article-title":"Diversity and endemism in tropical versus temperate scorpion communities","volume":"70","author":"Louren\u00e7o","year":"1994","journal-title":"Biogeographica"},{"key":"10.1016\/j.toxicon.2011.01.002_bib86","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1517\/17425247.4.2.175","article-title":"Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601)","volume":"4","author":"Mamelak","year":"2007","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.toxicon.2011.01.002_bib87","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1200\/JCO.2005.05.4569","article-title":"Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade glioma","volume":"24","author":"Mamelak","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib88","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.toxicon.2005.02.016","article-title":"Practical applications of snake venom toxins in haemostasis","volume":"45","author":"Marsh","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib89","series-title":"Handbook of Neurotoxicology","first-page":"683","article-title":"Scorpion neurotoxins: effects and mechanisms","author":"Martin-Eauclaire","year":"1995"},{"key":"10.1016\/j.toxicon.2011.01.002_bib90","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/S0041-0101(01)00163-5","article-title":"Clostridial hydrolytic enzymes degrading extracellular components","volume":"39","author":"Matsushita","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib91","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0005-2736(97)00051-5","article-title":"Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of gram-negative bacteria","volume":"1327","author":"Matsuzaki","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2011.01.002_bib92","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1017\/S1740925X06000044","article-title":"A role for ion channels in glioma cell invasion","volume":"2","author":"McFerrin","year":"2006","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib93","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10495-005-1896-x","article-title":"Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis","volume":"10","author":"McLachlan","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.toxicon.2011.01.002_bib94","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.toxicon.2005.12.010","article-title":"\u2018Venomics\u2019 or: the venomous systems genome project","volume":"47","author":"Menez","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib95","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0304-3835(98)00195-5","article-title":"Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses","volume":"131","author":"Menzel","year":"1998","journal-title":"Cancer Lett."},{"key":"10.1016\/j.toxicon.2011.01.002_bib96","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0092-8674(00)80538-3","article-title":"hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization","volume":"90","author":"Meyerson","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.toxicon.2011.01.002_bib97","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.intimp.2006.07.027","article-title":"Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt","volume":"6","author":"Moon","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib98","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.toxicon.2007.08.015","article-title":"Melittin induces Bcl-2 and caspase-3-dependent apoptosis through downregulation of Akt phosphorylation in human leukemic U937 cells","volume":"51","author":"Moon","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib99","first-page":"265","article-title":"Preliminary experimental anticancer activity of cecropins","volume":"7","author":"Moore","year":"1994","journal-title":"Pept. Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib100","first-page":"405","article-title":"Scorpionism in South Africa-a report of 42 serious scorpion envenomations","volume":"83","author":"M\u00fcller","year":"1993","journal-title":"South Afr. Med. J."},{"key":"10.1016\/j.toxicon.2011.01.002_bib101","first-page":"115","article-title":"Amphiphilic peptides in wasp venom","volume":"25","author":"Nakajima","year":"1986","journal-title":"Biopolymers"},{"key":"10.1016\/j.toxicon.2011.01.002_bib102","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.277.5328.955","article-title":"Telomerase catalytic subunit homologs from fission yeast and human","volume":"277","author":"Nakamura","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2011.01.002_bib103","series-title":"Safety and Tolerability Study of 131I-TM-601 to Treat Adult Patients with Recurrent Glioma","author":"NIH \u2013; The National Institutes of Health","year":"2010"},{"key":"10.1016\/j.toxicon.2011.01.002_bib104","first-page":"405","article-title":"Spider venoms and spider toxins","volume":"17","author":"Ori","year":"1998","journal-title":"J. Toxicol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib105","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0041-0101(03)00045-X","article-title":"Inhibition of mammary carcinoma cell proliferation in vitro and tumor growth in vivo by bee venom","volume":"41","author":"Orsolic","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib106","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2478\/10004-1254-60-2009-1936","article-title":"Potentiation of bleomycin lethality in HeLa and V-79 cells by bee venom","volume":"60","author":"Orsolic","year":"2009","journal-title":"Arh. Hig. Rada. Toksikol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib107","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0041-0101(96)00078-5","article-title":"Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo","volume":"35","author":"Ownby","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib108","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10059-010-0028-9","article-title":"Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-kappaB and AP-1-dependent MMP-9 expression","volume":"29","author":"Park","year":"2010","journal-title":"Mol. Cells"},{"key":"10.1016\/j.toxicon.2011.01.002_bib109","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1074\/jbc.270.9.4923","article-title":"The peptide mastoparan is a potent facilitator of the mitochondrial permeability transition","volume":"270","author":"Pfeiffer","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib110","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.toxicon.2005.10.004","article-title":"Proteases from Lonomia obliqua venomous secretions: comparison of procoagulant fibrin(ogen)olytic and amidolytic activities","volume":"47","author":"Pinto","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib111","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/nm1095-1046","article-title":"Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apotosis","volume":"1","author":"Pisha","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.toxicon.2011.01.002_bib112","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0300-9084(00)01167-6","article-title":"Peptides and genes coding for scorpion toxins that affect ion-channels","volume":"82","author":"Possani","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2011.01.002_bib113","series-title":"Ion Channel Localization Methods and Protocols","first-page":"145","article-title":"High affinity scorpion toxins for studying potassium and sodium channels","author":"Possani","year":"2001"},{"key":"10.1016\/j.toxicon.2011.01.002_bib114","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1007\/s00262-006-0143-9","article-title":"Antitumor action and immune activation through cooperation of bee venom secretory phospholipase A2 and phosphatidylinositol-(3,4)-bisphosphate","volume":"55","author":"Putz","year":"2006","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.toxicon.2011.01.002_bib115","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00262-006-0220-0","article-title":"Bee venom secretory phospholipase A2 and phosphatidylinositol homologues cooperatively disrupt membrane integrity, abrogate signal transduction and inhibit proliferation of renal cancer cells","volume":"56","author":"Putz","year":"2007","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.toxicon.2011.01.002_bib116","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0041-0101(01)00199-4","article-title":"Pharmacology and biochemistry of spider venoms","volume":"40","author":"Rash","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib117","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0049-3848(01)00265-1","article-title":"A prothrombin activator serine protease from the Lonomia obliqua caterpillar venom (Lopap) biochemical characterization","volume":"102","author":"Reis","year":"2001","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib118","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1593\/neo.07885","article-title":"Effective topical treatment of subcutaneous murine B16F10-Nex2 melanoma by the antimicrobial peptide gomesin","volume":"10","author":"Rodrigues","year":"2008","journal-title":"Neoplasia"},{"key":"10.1016\/j.toxicon.2011.01.002_bib119","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00262-003-0457-9","article-title":"Cytotoxic properties of immunoconjugates containing melittin like peptide 101 against prostate cancer: in vitro and in vivo studies","volume":"53","author":"Russell","year":"2004","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.toxicon.2011.01.002_bib120","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0041-0101(99)00110-5","article-title":"Melittin activates endogenous phospholipase D during cytolysis of human monocytic leukemia cells","volume":"37","author":"Saini","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib121","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0041-0101(73)90147-5","article-title":"Composition and properties of tarantula Dugesiella hentzi (Girard) venom","volume":"11","author":"Schanbacher","year":"1973","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib122","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.bbrc.2006.02.071","article-title":"Purification of a phospholypase A2 from Lonomia obliqua caterpillar bristle extract","volume":"342","author":"Seibert","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2011.01.002_bib123","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0014-5793(97)00578-4","article-title":"The effect of melittin on proliferation and death of thymocytes","volume":"410","author":"Shaposhnikova","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2011.01.002_bib124","first-page":"193","article-title":"Melittin resistance: a counter selection for ras transformation","volume":"7","author":"Sharma","year":"1992","journal-title":"Oncogene"},{"key":"10.1016\/j.toxicon.2011.01.002_bib125","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4161\/cbt.7.3.5364","article-title":"Synergy of Pancratistatin and Tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria","volume":"7","author":"Siedlakowski","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.toxicon.2011.01.002_bib126","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.toxicon.2004.07.012","article-title":"Brown spiders and loxoscelism","volume":"44","author":"Silva","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib127","series-title":"The Biology of Scorpions","first-page":"414","article-title":"Venoms and toxins","author":"Simard","year":"1990"},{"key":"10.1016\/j.toxicon.2011.01.002_bib128","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0190-9622(97)70288-3","article-title":"Hyaluronidase enhances the therapeutic effect of vinblastine in intralesional treatment of Kaposis\u2019s sarcoma","volume":"36","author":"Smith","year":"1997","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib129","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1172\/JCI38842","article-title":"Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth","volume":"119","author":"Soman","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.toxicon.2011.01.002_bib130","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/jf010830b","article-title":"Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure\u2013activity relationship","volume":"50","author":"Son","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib131","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1158\/1535-7163.MCT-06-0328","article-title":"Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor kappa\u03b2","volume":"6","author":"Son","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.toxicon.2011.01.002_bib132","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1248\/bpb.31.1279","article-title":"A synthetic glycosphingolipid-induced antiproliferative effect in melanoma cells is associated with suppression of FAK, Akt, and Erk activation","volume":"31","author":"Sonoda","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.toxicon.2011.01.002_bib133","first-page":"4871","article-title":"Use of chlorotoxin for targeting of primary brain tumors","volume":"58","author":"Soroceanu","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib134","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1523\/JNEUROSCI.19-14-05942.1999","article-title":"Modulation of glioma cell migration and invasion using Cl\u2212 and K+ ion channel blockers","volume":"19","author":"Soroceanu","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxicon.2011.01.002_bib135","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1021\/bp049831p","article-title":"Purification and characterization of an anti-apoptotic protein isolated from Lonomia obliqua hemolymph","volume":"21","author":"Souza","year":"2005","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.toxicon.2011.01.002_bib136","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.peptides.2009.05.008","article-title":"Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista","volume":"30","author":"Souza","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.toxicon.2011.01.002_bib137","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0304-3940(02)01325-3","article-title":"A comparison of hyperalgesia and neurogenic inflammation induced by melittin and capsaicin in humans","volume":"337","author":"Sumikura","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.toxicon.2011.01.002_bib138","first-page":"8","article-title":"Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells","volume":"3","author":"Suttmann","year":"2008","journal-title":"BMC Urol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib139","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1388-1981(02)00326-8","article-title":"Phospholipase A2 and apoptosis","volume":"1585","author":"Taketo","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2011.01.002_bib140","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.toxicon.2004.02.010","article-title":"Australian funnel-web spiders: master insecticide chemists","volume":"43","author":"Tedford","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib141","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3181\/00379727-68-16429","article-title":"Streptococcal desoxyribonuclease: significance in lysis of purulent exudates and production by strains of hemolytic streptococci","volume":"68","author":"Tillet","year":"1948","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.toxicon.2011.01.002_bib142","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1046\/j.1432-1327.2000.01556.x","article-title":"Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus","volume":"267","author":"Torres-Larios","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib143","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.toxicon.2008.06.007","article-title":"Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells","volume":"52","author":"Tu","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib144","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0014-5793(98)01589-0","article-title":"Purification and partial characterization of a \u2019short\u2019 insectotoxin-like peptide from the venom of the scorpion Parabuthus schlechteri","volume":"441","author":"Tytgat","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2011.01.002_bib145","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0041-0101(01)00086-1","article-title":"Structures involved in production, secretion and injection of the venom produced by the caterpillar Lonomia obliqua (Lepidoptera, Saturniidae)","volume":"39","author":"Veiga","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib146","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.thromres.2003.08.020","article-title":"Fibrinogenolytic and procoagulant activities in the hemorrhagic syndrome caused by Lonomia obliqua caterpillars","volume":"111","author":"Veiga","year":"2003","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib147","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.gene.2005.05.002","article-title":"A catalog for the transcripts from the venomous structures of the caterpillar Lonomia obliqua: identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome","volume":"355","author":"Veiga","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.toxicon.2011.01.002_bib148","series-title":"Animal Toxins: State of the Art: Perspectives in Health and Biotechnology","first-page":"372","article-title":"Lonomia obliqua venom: Pharmaco-toxicological effects and biotechnological perspectives","author":"Veiga","year":"2009"},{"key":"10.1016\/j.toxicon.2011.01.002_bib149","doi-asserted-by":"crossref","first-page":"6882","DOI":"10.1158\/0008-5472.CAN-06-3948","article-title":"Tumor paint: a chlorotoxin: Cy5.5 bioconjugate for intraoperative visualization of cancer foci","volume":"67","author":"Veiseh","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib150","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/smll.200800646","article-title":"Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles","volume":"5","author":"Veiseh","year":"2009","journal-title":"Small"},{"key":"10.1016\/j.toxicon.2011.01.002_bib151","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.1158\/0008-5472.CAN-09-1157","article-title":"Specific targeting of brain tumors with an optical\/magnetic resonance imaging nanoprobe across the blood-brain barrier","volume":"69","author":"Veiseh","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib152","first-page":"247","article-title":"A novel class of pore-forming peptides in the venom of Parabuthus schlechteri Purcell (Scorpions: Buthidae)","volume":"16","author":"Verdonck","year":"2000","journal-title":"Cimbebasia"},{"key":"10.1016\/j.toxicon.2011.01.002_bib153","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1073\/pnas.87.12.4761","article-title":"All-D amino acid-containing channel forming antibiotic peptides","volume":"87","author":"Wade","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.toxicon.2011.01.002_bib154","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-004-4205-6","article-title":"Scorpion venom induces glioma cell apoptosis in vitro and inhibits glioma tumor growth in vivo","volume":"73","author":"Wang","year":"2005","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib155","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/j.1745-7270.2008.00476.x","article-title":"Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest","volume":"40","author":"Wang","year":"2008","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.toxicon.2011.01.002_bib156","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.peptides.2008.01.015","article-title":"Antitumor effects, cell selectivity and structure\u2013activity relationship of a novel antimicrobial peptide polybia-MPI","volume":"29","author":"Wang","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.toxicon.2011.01.002_bib157","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1074\/jbc.M807191200","article-title":"Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK\/p38 and inhibiting IkappaB alpha kinase-NFkappaB","volume":"284","author":"Wang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib158","first-page":"4997","article-title":"Expression of cyclooxygenase-2 in human lung carcinoma","volume":"58","author":"Wolff","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib159","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.4049\/jimmunol.160.12.5929","article-title":"Failure to activate cytosolic phospholipase A2 causes TNF resistance in human leukemic cells","volume":"160","author":"Wu","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxicon.2011.01.002_bib160","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0041-0101(99)00181-6","article-title":"The gene cloning and sequencing of Bm-12, a Chlorotoxin-like peptide from the scorpion Buthus martensii Karsch","volume":"38","author":"Wu","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib161","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.peptides.2009.02.004","article-title":"Structure and function of a custom anticancer peptide, CB1a","volume":"30","author":"Wu","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.toxicon.2011.01.002_bib162","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2091-2-16","article-title":"Isolation and characterization of a novel lepidopteran-selective toxin from the venom of South Indian red scorpion, Mesobuthus tamulus","volume":"2","author":"Wudayagiri","year":"2001","journal-title":"BMC Biochem."},{"key":"10.1016\/j.toxicon.2011.01.002_bib163","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.toxicon.2005.10.015","article-title":"Two families of antimicrobial peptides from wasp (Vespa magnifica) venom","volume":"47","author":"Xu","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib164","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2005.06.009","article-title":"Mitochondrial delivery of mastoparan with transferring liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy","volume":"303","author":"Yamada","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.toxicon.2011.01.002_bib165","first-page":"5815","article-title":"Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract","volume":"53","author":"Yanagihara","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxicon.2011.01.002_bib166","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.toxicon.2007.04.023","article-title":"Vespid chemotactic peptide precursor from the wasp, Vespa magnifica (Smith)","volume":"50","author":"Yu","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib167","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1055\/s-2003-39787","article-title":"Targeted destruction of normal and cancer cells through lutropin\/choriogonadotropin receptors using Hecate-betaCG conjugate","volume":"111","author":"Zaleska","year":"2003","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.toxicon.2011.01.002_bib168","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0041-0101(99)00212-3","article-title":"Cloning and characterization of a cDNA sequence encoding the precursor of a chlorotoxin-like peptide from the Chinese scorpion Buthus martensii Karsch","volume":"38","author":"Zeng","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.01.002_bib169","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1388-1981(02)00122-1","article-title":"Secretory phospholipase A2 induces apoptosis via a mechanism involving ceramide generation","volume":"1581","author":"Zhao","year":"2002","journal-title":"Biochim. Biophys. Acta"}],"updated-by":[{"DOI":"10.1016\/j.toxicon.2014.11.237","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000}}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010111000079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010111000079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:55:58Z","timestamp":1712105758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010111000079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":166,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0041010111000079"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2011.01.002","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.toxicon.2014.11.237","asserted-by":"object"}]},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}