{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:50:01Z","timestamp":1771617001478,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"BMBF"},{"name":"Committee of German\u2013Israeli Cooperation in Biotechnology"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.toxicon.2011.02.001","type":"journal-article","created":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T11:43:21Z","timestamp":1297856601000},"page":"695-703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["The tale of a resting gland: Transcriptome of a replete venom gland from the scorpion Hottentotta judaicus"],"prefix":"10.1016","volume":"57","author":[{"given":"David","family":"Morgenstern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina H.","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn F.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzachy","family":"Tal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Sher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliahu","family":"Zlotkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2011.02.001_bib1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.toxicon.2008.12.007","article-title":"Intraspecific variation in the Egyptian scorpion Scorpio maurus palmatus venom collected from different biotopes","volume":"53","author":"Abdel-Rahman","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib2","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1098\/rspb.2009.0048","article-title":"Co-evolution of diet and prey-specific venom activity supports the role of selection in snake venom evolution","volume":"276","author":"Barlow","year":"2009","journal-title":"Proc. R. Soc. B."},{"key":"10.1016\/j.toxicon.2011.02.001_bib3","first-page":"60","article-title":"Low atrial rhythm as a complication of buthotus judaicus (\u201cblack\u201d scorpion) evenomation","volume":"5","author":"Basis","year":"2005","journal-title":"Isr. J. Emerg. Med."},{"key":"10.1016\/j.toxicon.2011.02.001_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cbpc.2006.12.004","article-title":"Proteomic analysis of the venom from the scorpion Tityus stigmurus: Biochemical and physiological comparison with other Tityus species","volume":"146","author":"Batista","year":"2007","journal-title":"Comp. Biochem. Physiol. C Toxicol Pharmacol."},{"key":"10.1016\/j.toxicon.2011.02.001_bib5","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/0041-0101(95)00066-U","article-title":"Quantity and quality of venom released by a spider (Cupiennius salei, Ctenidae)","volume":"33","author":"Boev\u00e9","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.toxicon.2006.04.003","article-title":"Characterization of venom components from the scorpion Androctonus crassicauda of Turkey: peptides and genes","volume":"48","author":"Caliskan","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib7","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1186\/1471-2164-10-564","article-title":"Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts","volume":"10","author":"Casewell","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.toxicon.2011.02.001_bib8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actatropica.2008.05.021","article-title":"Epidemiology of scorpionism: a global appraisal","volume":"107","author":"Chippaux","year":"2008","journal-title":"Acta Tropica"},{"key":"10.1016\/j.toxicon.2011.02.001_bib9","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"Conesa","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.toxicon.2011.02.001_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/379537a0","article-title":"Diet and snake venom evolution","volume":"379","author":"Daltry","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2011.02.001_bib11","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1073\/pnas.93.12.6025","article-title":"Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries","volume":"93","author":"Diatchenko","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.toxicon.2011.02.001_bib12","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.biochi.2009.05.005","article-title":"Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans","volume":"91","author":"D\u2019Suze","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2011.02.001_bib13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0014-5793(89)81548-0","article-title":"Characterization of two different peptides from the venom of the scorpion Buthus sindicus","volume":"257","author":"Fazal","year":"1989","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2011.02.001_bib14","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1093\/molbev\/msg202","article-title":"pANT: a method for the pairwise assessment of nonfunctionalization times of processed pseudogenes","volume":"20","author":"Fleishman","year":"2003","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.toxicon.2011.02.001_bib15","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1074\/jbc.274.9.5769","article-title":"The putative bioactive surface of insect-selective scorpion excitatory neurotoxins","volume":"274","author":"Froy","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.02.001_bib16","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s00239-003-2497-3","article-title":"Isolation of a neurotoxin (\u03b1-colubritoxin) from a nonvenomous colubrid: evidence for early origin of venom in snakes","volume":"57","author":"Fry","year":"2003","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.toxicon.2011.02.001_bib17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0041-0101(98)00187-1","article-title":"Molecular cloning and genomic analysis of TsNTxp: an immunogenic protein from Tityus serrulatus scorpion venom","volume":"37","author":"Guatimosim","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib18","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1111\/j.1742-4658.2008.06545.x","article-title":"The Janus-faced atracotoxins are specific blockers of invertebrate KCa channels","volume":"275","author":"Gunning","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.toxicon.2011.02.001_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0014-5793(98)01710-4","article-title":"Aah VI, a novel, N-glycosylated anti-insect toxin from Androctonus australis hector scorpion venom: isolation, characterisation, and glycan structure determination","volume":"443","author":"Hassani","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2011.02.001_bib20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/ar1783","article-title":"ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis","volume":"7","author":"Jones","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.toxicon.2011.02.001_bib21","doi-asserted-by":"crossref","first-page":"770","DOI":"10.4269\/ajtmh.1971.20.770","article-title":"Secretory epithelium in venom glands of two species of scorpion of the genus Centruroides Marx","volume":"20","author":"Keegan","year":"1971","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2011.02.001_bib22","first-page":"361","article-title":"Structure and function of insecticidal neurotoxins from Australian funnel-web spiders","volume":"21","author":"King","year":"2002","journal-title":"Toxin Rev."},{"key":"10.1016\/j.toxicon.2011.02.001_bib23","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.toxicon.2008.05.020","article-title":"A rational nomenclature for naming peptide toxins from spiders and other venomous animals","volume":"52","author":"King","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/1471-2148-8-333","article-title":"Assembling an arsenal, the scorpion way","volume":"8","author":"Kozminsky-Atias","year":"2008","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.toxicon.2011.02.001_bib25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00239-004-0138-0","article-title":"Eggs-only diet: its implications for the toxin profile changes and ecology of the marbled sea snake (Aipysurus eydouxii)","volume":"60","author":"Li","year":"2005","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.toxicon.2011.02.001_bib26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.semcancer.2008.03.008","article-title":"Hyalurondiase: both a tumor promoter and suppressor","volume":"18","author":"Lokeshwar","year":"2008","journal-title":"Semin. Canc. Biol."},{"key":"10.1016\/j.toxicon.2011.02.001_bib27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/1471-2164-10-290","article-title":"Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal","volume":"10","author":"Ma","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.toxicon.2011.02.001_bib28","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/pmic.200900763","article-title":"Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis","volume":"10","author":"Ma","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/j.toxicon.2011.02.001_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1517\/17425247.4.2.175","article-title":"Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601)","volume":"4","author":"Mamelak","year":"2007","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.toxicon.2011.02.001_bib30","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/BF01025013","article-title":"The complete amino acid sequence of toxin TsTX-VI isolated from the venom of the scorpion Tityus serrulatus","volume":"9","author":"Marangoni","year":"1990","journal-title":"J. Protein Chem."},{"key":"10.1016\/j.toxicon.2011.02.001_bib31","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.bbrc.2005.05.148","article-title":"New \u201cBirtoxin analogs\u201d from Androctonus australis venom","volume":"333","author":"Martin-Eauclaire","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2011.02.001_bib32","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.toxicon.2006.01.015","article-title":"Moving pieces in a taxonomic puzzle: venom 2D-LC\/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones)","volume":"47","author":"Nascimento","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib33","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/pro.5560031022","article-title":"A common structural motif incorporating a cystine knot and a triple-stranded \u03b2-sheet in toxic and inhibitory polypeptides","volume":"3","author":"Pallaghy","year":"1994","journal-title":"Protein Sci."},{"key":"10.1016\/j.toxicon.2011.02.001_bib34","series-title":"The Biology of Scorpions","author":"Polis","year":"1990"},{"key":"10.1016\/j.toxicon.2011.02.001_bib35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1432-1327.1999.00625.x","article-title":"Scorpion toxins specific for Na+ channels","volume":"264","author":"Possani","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2011.02.001_bib36","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.toxicon.2009.10.027","article-title":"Parabutoporin, a cationic amphipathic peptide from scorpion venom: much more than an antibiotic","volume":"55","author":"Remijsen","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1432-1033.1997.00457.x","article-title":"Characterization of four toxins from Buthus Martensi scorpion venom, which act on apamin-sensitive calcium activated K+ channels","volume":"245","author":"Romi-Lebrun","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2011.02.001_bib38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2164-8-119","article-title":"Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones)","volume":"8","author":"Schwartz","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.toxicon.2011.02.001_bib39","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.toxicon.2009.04.010","article-title":"Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum","volume":"54","author":"Silva","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.peptides.2004.07.016","article-title":"Were arachnids the first to use combinatorial peptide libraries?","volume":"26","author":"Sollod","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.toxicon.2011.02.001_bib41","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1021\/bi050235t","article-title":"Genetic polymorphism and expression of a highly potent scorpion depressant toxin enable refinement of the effects on insect Na channels and illuminate the key role of Asn-58","volume":"44","author":"Strugatsky","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2011.02.001_bib42","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.toxicon.2007.11.010","article-title":"Positively selected sites of scorpion depressant toxins: possible roles in toxin functional divergence","volume":"51","author":"Tian","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib43","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.biochi.2004.05.005","article-title":"Biochemical, genetic and physiological characterization of venom components from two species of scorpions: Centruroides exilicauda Wood and Centruroides sculpturatus Ewing","volume":"86","author":"Valdez-Cruz","year":"2004","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2011.02.001_bib44","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.toxicon.2009.11.010","article-title":"Mining on scorpion venom biodiversity","volume":"56","author":"Rodriguez de la Vega","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib45","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/molbev\/msp310","article-title":"Positions under positive selection\u2014key for selectivity and potency of scorpion \u03b1-toxins","volume":"27","author":"Weinberger","year":"2010","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.toxicon.2011.02.001_bib46","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0014-5793(99)00651-1","article-title":"Genomic organization of three neurotoxins active on small conductance Ca2+-activated potassium channels from the scorpion Buthus martensi Karsch","volume":"452","author":"Wu","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2011.02.001_bib47","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.2174\/092986707780831186","article-title":"Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications","volume":"14","author":"Wulff","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.toxicon.2011.02.001_bib48","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/1471-2164-11-452","article-title":"Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components","volume":"11","author":"Zhao","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.toxicon.2011.02.001_bib49","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.toxicon.2005.11.013","article-title":"Genetic mechanisms of scorpion venom peptide diversification","volume":"47","author":"Zhijian","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.02.001_bib50","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00239-003-2534-2","article-title":"Adaptive evolution of scorpion sodium channel toxins","volume":"58","author":"Zhu","year":"2004","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.toxicon.2011.02.001_bib51","doi-asserted-by":"crossref","first-page":"26588","DOI":"10.1074\/jbc.M403284200","article-title":"Activation of skeletal ryanodine receptors by two novel scorpion toxins from Buthotus judaicus","volume":"279","author":"Zhu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.02.001_bib52","unstructured":"Zhu, S., Peigneur, S., Gao, B., Luo, L., Jin, D., Zhao, Y., Tytgat, J., Molecular diversity and functional evolution of scorpion potassium channel toxins. Mol. Cell. Proteomics, in press 10.1074\/mcp.M110.002832."},{"key":"10.1016\/j.toxicon.2011.02.001_bib53","series-title":"Arthropod Venoms","first-page":"317","article-title":"Chemistry and pharmacology of Buthinae scorpion venoms","author":"Zlotkin","year":"1978"},{"key":"10.1016\/j.toxicon.2011.02.001_bib54","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0041-0101(82)90235-5","article-title":"The chemistry and axonal action of two insect toxins derived from the venom of the scorpion","volume":"20","author":"Zlotkin","year":"1982","journal-title":"Toxicon"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010111000316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010111000316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:08:00Z","timestamp":1758575280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010111000316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0041010111000316"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2011.02.001","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The tale of a resting gland: Transcriptome of a replete venom gland from the scorpion Hottentotta judaicus","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2011.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}