{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:30:45Z","timestamp":1791401445144,"version":"4.3.3"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.toxicon.2011.03.006","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T08:16:52Z","timestamp":1300263412000},"page":"889-896","source":"Crossref","is-referenced-by-count":31,"title":["Cytotoxic and antimitotic activities in aqueous extracts of eight cyanobacterial strains isolated from the marine sponge Petrosia ficiformis"],"prefix":"10.1016","volume":"57","author":[{"given":"Patrizia","family":"Pagliara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Caroppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2011.03.006_bib1","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1128\/AEM.70.6.3313-3320.2004","article-title":"Evaluation of Nostoc strain ATCC 53789 as a potential source of natural pesticides","volume":"70","author":"Biondi","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.toxicon.2011.03.006_bib2","series-title":"Bergey\u2019s Manual of Systematic Bacteriology","author":"Boone","year":"2001"},{"key":"10.1016\/j.toxicon.2011.03.006_bib3","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1128\/AEM.01183-08","article-title":"Cytomorphological and Genetic characterization of Troglobitic Leptolyngbya strains isolated from Roman Hypogea","volume":"75","author":"Bruno","year":"2009","journal-title":"Appl. Environm. Microbiol."},{"key":"10.1016\/j.toxicon.2011.03.006_bib4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/1522-7278(2000)15:5<370::AID-TOX3>3.0.CO;2-S","article-title":"Ecotoxicity assessment of metals and wastewater using multitrophic assays","volume":"15","author":"Castillo","year":"2000","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.toxicon.2011.03.006_bib5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1471-4892(01)00063-7","article-title":"Natural products in anticancer therapy","volume":"1","author":"Da Rocha","year":"2001","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.toxicon.2011.03.006_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1574-6976.1998.tb00365.x","article-title":"Exocellular polysaccharides from cyanobacteria and their possible applications","volume":"22","author":"De Philippis","year":"1998","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.toxicon.2011.03.006_bib7","series-title":"Harmful Marine Algal Blooms Technique et Documentation","first-page":"427","article-title":"Effect of toxic dinoflagellates on the feeding and mortality of Artemia franciscana larvae","author":"Demaret","year":"1995"},{"key":"10.1016\/j.toxicon.2011.03.006_bib8","series-title":"Probits Analysis","author":"Finney","year":"1971"},{"key":"10.1016\/j.toxicon.2011.03.006_bib9","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/1522-7278(2000)15:5<376::AID-TOX4>3.0.CO;2-7","article-title":"The use of conventional bioassays, microbiotests, and some \u2018\u2018rapid\u2019\u2019 methods in the selection of an optimal test battery for the assessment of pesticides toxicity","volume":"15","author":"Fochtman","year":"2000","journal-title":"Environ. Toxicol."},{"issue":"6","key":"10.1016\/j.toxicon.2011.03.006_bib10","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.3390\/md8061908","article-title":"Are Known cyanotoxins involved in the toxicity of Picoplanktonic and filamentous North Atlantic marine cyanobacteria?","volume":"8","author":"Fraz\u00e3o","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.toxicon.2011.03.006_bib11","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.2307\/1939045","article-title":"In situ determination of the effect of symbiotic algae on the growth of the freshwater sponge Spongilla lacustris","volume":"61","author":"Frost","year":"1980","journal-title":"Ecology"},{"key":"10.1016\/j.toxicon.2011.03.006_bib12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/gcc.10083","article-title":"Cadherin and catenin alterations in human cancer","volume":"34","author":"Hajra","year":"2002","journal-title":"Genes Chrom. Cancer"},{"key":"10.1016\/j.toxicon.2011.03.006_bib13","series-title":"Proc 7th Int Seaweed Symp, Sapporo","first-page":"569","article-title":"Screening of the toxic algae on coral reefs","author":"Hashimoto","year":"1972"},{"key":"10.1016\/j.toxicon.2011.03.006_bib14","first-page":"333","article-title":"Occurrence of a toxic blue-green alga inducing skin dermatitis in Okinawa","volume":"Vol. I","author":"Hashimoto","year":"1976"},{"key":"10.1016\/j.toxicon.2011.03.006_bib15","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1349-7006.2003.tb01485.x","article-title":"Cell adhesion system and human cancer morphogenesis","volume":"94","author":"Hirohashi","year":"2003","journal-title":"Cancer Sci."},{"issue":"3","key":"10.1016\/j.toxicon.2011.03.006_bib16","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2307\/1467652","article-title":"Ecology of Pectinatella magnifica (Bryozoa) in an Alabama oxbow lake: colony growth and association with algae","volume":"11","author":"Joo","year":"1992","journal-title":"J. N. Am. Benthol. Soc."},{"key":"10.1016\/j.toxicon.2011.03.006_bib17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0198-0149(87)90001-X","article-title":"Effect of irradiances up to 2000 \u03bcE m\u22122 s\u22121 on marine Synechococcus WH7803-I. Growth, pigmentation and cell composition","volume":"34","author":"Kana","year":"1987","journal-title":"Deep-Sea Res."},{"key":"10.1016\/j.toxicon.2011.03.006_bib18","series-title":"Cyanoprokaryota, Part 1: Chroococcales, S\u00fcsswasserflora von Mitteleuropa","author":"Kom\u00e1rek","year":"1998"},{"key":"10.1016\/j.toxicon.2011.03.006_bib19","series-title":"Cyanoprokaryota, Part 2: Oscillatoriales, S\u00fcsswasserflora von Mitteleuropa","author":"Kom\u00e1rek","year":"2005"},{"key":"10.1016\/j.toxicon.2011.03.006_bib20","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1021\/jm800516j","article-title":"Book Review of bioactive natural products. Detection, Isolation, and Structural determination","volume":"51","author":"Krueger","year":"2008","journal-title":"J. Med. Chem."},{"issue":"5686","key":"10.1016\/j.toxicon.2011.03.006_bib21","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1126\/science.1099128","article-title":"Discovery of symbiotic Nitrogen-Fixing cyanobacteria in corals","volume":"305","author":"Lesser","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2011.03.006_bib22","series-title":"Prochloron, a Microbial Enigma","author":"Lewin","year":"1989"},{"key":"10.1016\/j.toxicon.2011.03.006_bib23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/md8030471","article-title":"Primary screening of the bioactivity of Brackishwater cyanobacteria: toxicity of crude extracts to Artemia salina larvae and Paracentrotus lividus embryos","volume":"8","author":"Lopes","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.toxicon.2011.03.006_bib24","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.toxicon.2007.06.020","article-title":"Toxicity assessment of crude and partially purified extracts of marine Synechocystis and Synechococcus cyanobacterial strains in marine invertebrates","volume":"50","author":"Martins","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.03.006_bib25","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/S0041-0101(98)00128-7","article-title":"The cyanobacterial toxin Microcystin-LR, can induce apoptosis in a variety of cell types","volume":"36","author":"McDermott","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.03.006_bib26","series-title":"Red Tide: Biology, Environmental Science and Toxicology","first-page":"367","article-title":"Hemolytic toxins in marine cyanobacterium Synechococcus sp.","author":"Mitsui","year":"1988"},{"key":"10.1016\/j.toxicon.2011.03.006_bib27","series-title":"Biomedical Importance of Marine Organisms. California Academy of Sciences","first-page":"143","article-title":"New pharmaceuticals from cultured blue-green algae","author":"Moore","year":"1988"},{"key":"10.1016\/j.toxicon.2011.03.006_bib28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1078\/1438-4639-00045","article-title":"Biochemical and pharmacological investigations of selected cyanobacteria","volume":"203","author":"Mundt","year":"2001","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.toxicon.2011.03.006_bib29","doi-asserted-by":"crossref","first-page":"601","DOI":"10.4319\/lo.1981.26.4.0601","article-title":"Estimating the daily contribution of carbon from zooxanthellae to coral animal respiration","volume":"26","author":"Muscatine","year":"1981","journal-title":"Limnol. Oceanogr"},{"key":"10.1016\/j.toxicon.2011.03.006_bib30","series-title":"Proceedings of the 12th International Congress on Photosynthesis","article-title":"An extracellular hemolysin homolog from cyanobacterium Synechocystis sp. PCC6803 [A]","author":"Nagai","year":"2001"},{"key":"10.1016\/j.toxicon.2011.03.006_bib31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.envpol.2005.12.037","article-title":"Use of the genus Artemia in ecotoxicity testing","volume":"14","author":"Nunes","year":"2006","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.toxicon.2011.03.006_bib32","first-page":"669","article-title":"Biotechnological applications of cyanobacteria","volume":"55","author":"Patterson","year":"1996","journal-title":"J. Sci. Ind. Res."},{"key":"10.1016\/j.toxicon.2011.03.006_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0166-445X(96)00013-6","article-title":"Toxic effects of caulerpenyne extracted from Caulerpa taxifolia on mechanisms related to sea urchin egg cleavage","volume":"35","author":"Pesando","year":"1996","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.toxicon.2011.03.006_bib34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1039\/b310175b","article-title":"Metabolites from symbiotic bacteria","volume":"21","author":"Piel","year":"2004","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.toxicon.2011.03.006_bib35","first-page":"139","article-title":"The dolastatins, a family of promising antineoplastic agents. Curr. Pharmaceut","volume":"5","author":"Poncet","year":"1999","journal-title":"Des"},{"key":"10.1016\/j.toxicon.2011.03.006_bib36","first-page":"55","article-title":"Antimicrobial activity of cyanobacteria. ICES J","volume":"23","author":"Rao","year":"1994","journal-title":"Mar. Sci."},{"key":"10.1016\/j.toxicon.2011.03.006_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/00221287-111-1-1","article-title":"Generic assignments, strain histories and properties of pure cultures of cyanobateria","volume":"111","author":"Rippka","year":"1979","journal-title":"J. Gen. Microbiol."},{"key":"10.1016\/j.toxicon.2011.03.006_bib38","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1128\/JB.188.10.3535-3542.2006","article-title":"Purification and characterization of a hemolysin-like protein, Sll1951, a non-toxic member of the RTX protein family from the cyanobacterium Synechocystis sp. strain PCC 6803","volume":"188","author":"Sakiyama","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.toxicon.2011.03.006_bib39","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/eesa.1999.1862","article-title":"Anti-HIV activity of extracts and compounds from algae and cyanobacteria","volume":"45","author":"Schaeffer","year":"2000","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.toxicon.2011.03.006_bib40","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0043-1354(99)00181-5","article-title":"Toxic effects of Gymnodinium cf. mikimotoi unsaturated fatty acids to gametes and embryos of the sea urchin Paracentrotus lividus","volume":"34","author":"Sellem","year":"2000","journal-title":"Water Res."},{"key":"10.1016\/j.toxicon.2011.03.006_bib41","series-title":"New Microbiotests for Routine Toxicity Screening and Biomonitoring","first-page":"527","article-title":"The toxicity of cyanobacterial blooms as determined by microbiotests and mouse assays","author":"Tarczy\u0144ska","year":"2000"},{"key":"10.1016\/j.toxicon.2011.03.006_bib42","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1389-0344(03)00069-8","article-title":"Phylogenetic identification of bacteria with antimicrobial activities isolated from Mediterranean sponges","volume":"20","author":"Thiel","year":"2003","journal-title":"Biomol. Eng."},{"key":"10.1016\/j.toxicon.2011.03.006_bib43","first-page":"167","article-title":"The biogeography and phylogeny of unicellular cyanobacterial symbionts in selected sponges from Australia and the Mediterranean. Microb","volume":"48","author":"Usher","year":"2004","journal-title":"Ecol"},{"key":"10.1016\/j.toxicon.2011.03.006_bib44","first-page":"271","article-title":"Etude en microscopie electronique de l\u2019association entre bacteries et spongiaires du genre Verongia (Dictyoceratida)","volume":"23","author":"Vacelet","year":"1975","journal-title":"J. Microsc. Biol. Cell."},{"key":"10.1016\/j.toxicon.2011.03.006_bib45","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF00235254","article-title":"Promotion of plantlet formation from somatic embryos of carrot treated with a high molecular weight extract from a marine cyanobacterium","volume":"11","author":"Wake","year":"1992","journal-title":"Plant Cell. Rep."},{"key":"10.1016\/j.toxicon.2011.03.006_bib46","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.toxicon.2004.10.016","article-title":"Inhibition of embryonic development by microcystin-LR in zebrafish, Danio Rerio","volume":"45","author":"Wang","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.03.006_bib47","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1073\/pnas.75.5.2301","article-title":"Carotenoids, chlorophyll-protein composition and photosynthetic unit size of Prochloron sp., a prokaryotic green alga","volume":"75","author":"Withers","year":"1978","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010111000924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010111000924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T01:26:42Z","timestamp":1543886802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010111000924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0041010111000924"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2011.03.006","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}