{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:01:41Z","timestamp":1773072101763,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.toxicon.2011.05.016","type":"journal-article","created":{"date-parts":[[2011,6,5]],"date-time":"2011-06-05T18:43:01Z","timestamp":1307299381000},"page":"130-139","source":"Crossref","is-referenced-by-count":48,"title":["Heminecrolysin, the first hemolytic dermonecrotic toxin purified from scorpion venom"],"prefix":"10.1016","volume":"58","author":[{"given":"Lamia","family":"Borchani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atfa","family":"Sassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delavar","family":"Shahbazzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Strub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha\u00effa","family":"Tounsi-Guetteti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Samir","family":"Boubaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abolfazl","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Van Dorsselaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"El Ayeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2011.05.016_bib1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1126\/science.3983643","article-title":"Comparative toxicology of Loxosceles reclusa and Corynebacterium pseudotuberculosis","volume":"228","author":"Bernheimer","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2011.05.016_bib2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.toxicon.2004.11.011","article-title":"Sphingomyelinase D from venoms of Loxosceles spiders: evolutionary insights from cDNA sequences and gene structure","volume":"45","author":"Binford","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.05.016_bib3","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.4049\/jimmunol.146.12.4234","article-title":"The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes","volume":"146","author":"Chonn","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxicon.2011.05.016_bib4","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/bioinformatics\/bti811","article-title":"Lateral gene transfer of a dermonecrotic toxin between spiders and bacteria","volume":"22","author":"Cordes","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.toxicon.2011.05.016_bib5","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.toxicon.2004.07.012","article-title":"Brown spiders and loxoscelism","volume":"44","author":"Da Silva","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.05.016_bib6","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0003-9861(78)90046-2","article-title":"Red blood-cell lysis induced by venom of brown recluse spider - role of Sphingomyelinase-D","volume":"187","author":"Forrester","year":"1978","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2011.05.016_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00000441-199210000-00008","article-title":"Loxoscelism","volume":"304","author":"Futrell","year":"1992","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.toxicon.2011.05.016_bib8","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.2460\/ajvr.1985.46.05.1206","article-title":"Corynebacterium pseudotuberculosis exotoxin: fatal hemolytic anemia induced in gnotobiotic neonatal small ruminants by parenteral administration of preparations containing exotoxin","volume":"46","author":"Hsu","year":"1985","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.toxicon.2011.05.016_bib9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.toxicon.2009.09.012","article-title":"A review of epidemiological, clinical and in\u00a0vitro physiological studies of envenomation by the scorpion Hemiscorpius lepturus (Hemiscorpiidae) in Iran","volume":"55","author":"Jalali","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.05.016_bib10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1042\/BJ20050043","article-title":"Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA)","volume":"391","author":"Lee","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2011.05.016_bib11","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/clinids\/4.6.1220","article-title":"Infections caused by nondiphtheria corynebacteria","volume":"4","author":"Lipsky","year":"1982","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/j.toxicon.2011.05.016_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/S0104-79302001000100002","article-title":"The scorpions\u2019 families and their geographical distribution","volume":"7","author":"Louren\u00e7o","year":"2001","journal-title":"J. Venom. Anim. Toxins."},{"key":"10.1016\/j.toxicon.2011.05.016_bib13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1365-2958.1994.tb01080.x","article-title":"Targeted mutagenesis of the phospholipase D gene results in decreased virulence of Corynebacterium pseudotuberculosis","volume":"12","author":"McNamara","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.toxicon.2011.05.016_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0378-1119(95)00002-N","article-title":"Toxic phospholipases D of Corynebacterium pseudotuberculosis, C. ulcerans and Arcanobacterium haemolyticum: cloning and sequence homology","volume":"156","author":"McNamara","year":"1995","journal-title":"Gene"},{"key":"10.1016\/j.toxicon.2011.05.016_bib15","doi-asserted-by":"crossref","first-page":"13658","DOI":"10.1074\/jbc.M412437200","article-title":"Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D","volume":"280","author":"Murakami","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.05.016_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbrc.2006.01.123","article-title":"Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodi\u00e9st\u00e9rases","volume":"342","author":"Murakami","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2011.05.016_bib17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0006-291X(02)02521-4","article-title":"Molecular cloning and expression of a functional dermonecrotic and haemolytic factor from Loxosceles laeta venom","volume":"298","author":"Fernandes-Pedrosa","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2011.05.016_bib18","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.toxicon.2007.07.018","article-title":"An epidemiological and a clinical study on scorpionism by the Iranian scorpion Hemiscorpius lepturus","volume":"50","author":"Pipelzadeh","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.05.016_bib19","first-page":"327","article-title":"Clinical study of Hemiscorpius lepturus sting in Iran","volume":"93","author":"Radmanesh","year":"1990","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2011.05.016_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1046\/j.1365-4362.1998.00386.x","article-title":"Cutaneous manifestation of Hemiscorpius lepturus sting: a clinical study","volume":"37","author":"Radmanesh","year":"1998","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.toxicon.2011.05.016_bib21","article-title":"Molecular cloning of a protein from the dermonecrotic family of Loxosceles gaucho spider venom","author":"Silvestre","year":"2005","journal-title":"EMBL\/GenBank\/DDBJ Databases"},{"key":"10.1016\/j.toxicon.2011.05.016_bib22","first-page":"57","article-title":"High-level systematics and phylogeny of the extant scorpions (Scorpiones: Orthosterni)","volume":"11","author":"Soleglad","year":"2003","journal-title":"Euscorpius."},{"key":"10.1016\/j.toxicon.2011.05.016_bib23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0966-842X(97)01005-6","article-title":"Bacterial phospholipases and their role in virulence","volume":"5","author":"Songer","year":"1997","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.toxicon.2011.05.016_bib24","first-page":"3","article-title":"Sphingomyelinases","volume":"26","author":"Spence","year":"1993","journal-title":"Adv. Lipid Res."},{"key":"10.1016\/j.toxicon.2011.05.016_bib25","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/bbrc.1998.9474","article-title":"Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis","volume":"251","author":"Tambourgi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2011.05.016_bib26","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/blood.V95.2.683","article-title":"Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis","volume":"95","author":"Tambourgi","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.toxicon.2011.05.016_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1365-2567.2002.01483.x","article-title":"Mechanism of induction of complement susceptibility of erythrocytes by spider and bacterial sphingomyelinases","volume":"41","author":"Tambourgi","year":"2002","journal-title":"Immunology"},{"key":"10.1016\/j.toxicon.2011.05.016_bib28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.molimm.2004.03.027","article-title":"Molecular cloning, expression, function and immunoreactivities of members of a gene family of sphingomyelinases from Loxosceles venom glands","volume":"41","author":"Tambourgi","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.toxicon.2011.05.016_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1388-1981(02)00133-6","article-title":"Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids","volume":"1582","author":"Tokumura","year":"2002","journal-title":"BBA. Mol. Cell Biol. L."},{"key":"10.1016\/j.toxicon.2011.05.016_bib30","first-page":"275","article-title":"Sphingomyelinase D: a pathogenic agent produced by bacteria and arthropods","volume":"26","author":"Truett","year":"1993","journal-title":"Adv. Lipid Res."},{"key":"10.1016\/j.toxicon.2011.05.016_bib31","doi-asserted-by":"crossref","first-page":"10833","DOI":"10.1074\/jbc.C300563200","article-title":"Spider and bacterial sphingomyelinases D target cellular LPA receptors by hydrolyzing lysophosphatidylcholine","volume":"279","author":"Van Meeteren","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2011.05.016_bib32","series-title":"Clinical Toxicology of Animal Venoms and Poisons","first-page":"259","article-title":"Clinical toxicology of spider bites","author":"White","year":"1995"},{"key":"10.1016\/j.toxicon.2011.05.016_bib33","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1182\/blood.V95.7.2420","article-title":"Lysophosphatidic acid opens a Ca++ channel in human erythrocytes","volume":"95","author":"Yang","year":"2000","journal-title":"Blood"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010111001838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010111001838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:06:20Z","timestamp":1741219580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010111001838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0041010111001838"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2011.05.016","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}