{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:05:49Z","timestamp":1790723149488,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.toxicon.2011.12.011","type":"journal-article","created":{"date-parts":[[2011,12,31]],"date-time":"2011-12-31T16:28:57Z","timestamp":1325348937000},"page":"373-378","source":"Crossref","is-referenced-by-count":40,"title":["Histopathological changes induced by Hemiscorpius lepturus scorpion venom in mice"],"prefix":"10.1016","volume":"59","author":[{"given":"Mojgan","family":"Heidarpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emna","family":"Ennaifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Ahari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najet","family":"Srairi-Abid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Borchani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghader","family":"Khalili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Amini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Ali","family":"Anvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Boubaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El-Ayeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delavar","family":"Shahbazzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2011.12.011_bib1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0041-0101(85)90379-4","article-title":"Renal cortical necrosis following Bothrops jararaca and B. jararacussu snake bite","volume":"23","author":"Amaral","year":"1985","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0041-0101(81)90004-0","article-title":"Systemic effect in mice of venom apparatus extract and toxin from the brown recluse spider (Loxosceles recluse)","volume":"19","author":"Babcock","year":"1981","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0755-4982(05)88241-7","article-title":"Cardiovascular dysfunction following severe scorpion envenomation. Mechanisms and physiopathology","volume":"34","author":"Bahloul","year":"2005","journal-title":"Presse Med."},{"issue":"3","key":"10.1016\/j.toxicon.2011.12.011_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0035-9203(02)90097-0","article-title":"Myocardial necrosis after envenomation by the scorpion Tityus serrulatus","volume":"96","author":"Benvenuti","year":"2002","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2011.12.011_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.toxicon.2011.12.011_bib6","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0041-0101(96)00219-X","article-title":"Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin tityustoxin-1","volume":"35","author":"Correa","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib7","first-page":"202","article-title":"Histhophatological assessment of Hemiscorpius lepturus venom effects on rats","volume":"10","author":"Dehghani","year":"2004","journal-title":"Iranian J. Leg. Med."},{"key":"10.1016\/j.toxicon.2011.12.011_bib8","series-title":"Identification of Scorpions","author":"Farzanpay","year":"1987"},{"key":"10.1016\/j.toxicon.2011.12.011_bib9","series-title":"Catalog of the Scorpions of the World (1758\u20131998)","author":"Fet","year":"2000"},{"key":"10.1016\/j.toxicon.2011.12.011_bib10","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0041-0101(94)90382-4","article-title":"Approaches to the treatment of scorpion envenoming","volume":"32","author":"Freire-Maia","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib11","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/0041-0101(94)90319-0","article-title":"Androctonus crassicauda (Olivier), a dangerous and unduly neglected scorpion-I. Pharmacological and clinical studies","volume":"32","author":"Ismail","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.toxicon.2009.09.012","article-title":"A review of epidemiological, clinical and in\u00a0vitro physiological studies of envenomation by the scorpion Hemiscorpius lepturus (Hemiscorpiidae) in Iran","volume":"55","author":"Jalali","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib13","series-title":"Histopathological and Biochemical Methods: Theory and Practice","author":"Kiernan","year":"1999"},{"key":"10.1016\/j.toxicon.2011.12.011_bib14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/biol.1998.0160","article-title":"Effect of Some variables on the in\u00a0vivo determination of Scorpion and viper venom toxicities","volume":"26","author":"Krifi","year":"1998","journal-title":"Biologicals"},{"key":"10.1016\/j.toxicon.2011.12.011_bib15","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0041-0101(79)90236-8","article-title":"Immunological studies on Iranian scorpions\u2019 venom and antiserum","volume":"17","author":"Latifi","year":"1979","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/002215540405200404","article-title":"Experimental evidence for a direct cytotoxicity of Loxosceles intermedia (brown spider) venom in renal tissue","volume":"52","author":"Luciano","year":"2004","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.toxicon.2011.12.011_bib17","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4269\/ajtmh.1978.27.623","article-title":"Acute renal failure following scorpion sting Am","volume":"27","author":"Malhotra","year":"1978","journal-title":"J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2011.12.011_bib18","first-page":"62","article-title":"Scorpion stings survey (including: residence, sex and age) and treatment strategy in Abuzar hospital-Ahvaz, Khuzestan during 1994\u20131999","volume":"14","author":"Mirdehghan","year":"2001","journal-title":"Iran. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2011.12.011_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.toxicon.2006.04.017","article-title":"In\u00a0vitro and in\u00a0vivo studies on some toxic effects of the venom from Hemiscorpius lepturus scorpion","volume":"48","author":"Pipelzadeh","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib20","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.toxicon.2007.07.018","article-title":"An epidemiological and a clinical study on scorpionism by the Iranian scorpion Hemiscorpius lepturus","volume":"50","author":"Pipelzadeh","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1096-0031.2000.tb00348.x","article-title":"Phylogeny and classification of the superfamily Scorpionidea Latreille (Chelicerata, Scorpioes): an examplear approach","volume":"16","author":"Prendini","year":"1802","journal-title":"Cladistics"},{"key":"10.1016\/j.toxicon.2011.12.011_bib22","first-page":"73","article-title":"Notes on the scorpions of Iraq","volume":"3","author":"Pringle","year":"1960","journal-title":"Bull. Endem. Dis."},{"key":"10.1016\/j.toxicon.2011.12.011_bib23","first-page":"327","article-title":"Clinical study of Hemiscorpion lepturus in Iran","volume":"93","author":"Radmanesh","year":"1990","journal-title":"J.\u00a0Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2011.12.011_bib24","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1046\/j.1365-4362.1998.00386.x","article-title":"Cutaneous manifestations of the Hemiscorpius lepturus sting: a clinical study","volume":"37","author":"Radmanesh","year":"1998","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.toxicon.2011.12.011_bib25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0041-0101(84)90032-1","article-title":"Lethal potency in mice of toxins from scorpion, sea anemone, snake and bee venoms following intraperitoneal and intracisternal injection","volume":"22","author":"Schweitz","year":"1984","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.toxicon.2010.05.008","article-title":"Enzymatic analysis of Hemiscorpius lepturus scorpion venom using zymography and venom-specific antivenin","volume":"56","author":"Seyedian","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.toxicon.2009.01.002","article-title":"Epidemiological and clinical survey of scorpionism in Khuzestan province, Iran (2003)","volume":"53","author":"Shahbazzadeh","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1042\/BJ20061404","article-title":"Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine sensitive Ca2+ channels","volume":"404","author":"Shahbazzadeh","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2011.12.011_bib29","doi-asserted-by":"crossref","first-page":"651","DOI":"10.4269\/ajtmh.1968.17.651","article-title":"A comparative study of the venom and other components of three species of Loxosceles","volume":"17","author":"Smith","year":"1968","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2011.12.011_bib30","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0041-0101(88)90258-9","article-title":"Respiratory failure in children following envenomation by the scorpion Leiurus quinquestriatus: hemodynamic and neurological aspects","volume":"26","author":"Sofer","year":"1988","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib31","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1111\/j.1742-4658.2008.06607.x","article-title":"Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus","volume":"275","author":"Srairi-Abid","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.toxicon.2011.12.011_bib32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0041-0101(97)00063-9","article-title":"Endotoxemic-like shock induced by Loxosceles spider venoms: pathological changes and putative cytokine mediators","volume":"36","author":"Tambourgi","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0041-0101(66)90052-3","article-title":"List of scorpions known in Egypt, Arabia, Israel, Libya, Syria, Jordan, Turkey, Iraq, Iran","volume":"4","author":"Vachon","year":"1966","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2011.12.011_bib34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4103\/0971-4065.45293","article-title":"Hemolytic uremic syndrome following Hemiscorpius lepturus (scorpion) sting","volume":"18","author":"Valavi","year":"2008","journal-title":"Indian J. Nephrol."},{"key":"10.1016\/j.toxicon.2011.12.011_bib35","series-title":"Progress in the Characterization of Venoms and Standardization of Antivenoms. Offset Publication","author":"World Health Organization","year":"1981"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010111003862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010111003862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T17:37:43Z","timestamp":1561138663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010111003862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0041010111003862"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2011.12.011","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}