{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:33:41Z","timestamp":1776263621965,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":320,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)"},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"},{"name":"National Institute for the Control of Plant Poisoning","award":["573534\/2008-0"],"award-info":[{"award-number":["573534\/2008-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.toxicon.2012.09.012","type":"journal-article","created":{"date-parts":[[2012,9,29]],"date-time":"2012-09-29T05:46:31Z","timestamp":1348897591000},"page":"1355-1362","source":"Crossref","is-referenced-by-count":29,"title":["Mechanism for the uncoupling of oxidative phosphorylation by juliprosopine on rat brain mitochondria"],"prefix":"10.1016","volume":"60","author":[{"given":"Marcos A.","family":"Maioli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo E.C.V.","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieli","family":"Guelfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyllana C.D.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franklin","family":"Riet-Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosane M.T.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Barbosa-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio E.","family":"Mingatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2012.09.012_bib1","first-page":"1","article-title":"Study on pharmacokinetics of juliflorine in rabbits and chick embryonated eggs","volume":"8","author":"Ahmad","year":"1991","journal-title":"Pak. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2012.09.012_bib2","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1021\/bi00651a013","article-title":"Temperature dependence of 1,6-diphenyl- 1,3,5-hexatriene fluorescence in phospholipid artificial membranes","volume":"15","author":"Andrich","year":"1976","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2012.09.012_bib3","volume":"vol. 18\/20","author":"Baca","year":"1966"},{"key":"10.1016\/j.toxicon.2012.09.012_bib4","series-title":"Biochemical Toxicology","first-page":"217","article-title":"Preparation and use of mitochondria in toxicological research","author":"Cain","year":"1987"},{"key":"10.1016\/j.toxicon.2012.09.012_bib5","unstructured":"Dollahite, J.W., Anthony, W.V., 1957. Malnutrition in Cattle on an Unbalanced Diet of Mesquite Beans. Agriculture Experimental Station, Texas, USA, Progress Report 193, 32 p."},{"key":"10.1016\/j.toxicon.2012.09.012_bib6","unstructured":"Dollahite, J.W., 1964. Management of the Disease Produced in Cattle on an Unbalanced Diet of Mesquite Beans. Agriculture Experimental Station, Texas, USA, Progress Report 2314, pp. 293\u2013296."},{"key":"10.1016\/j.toxicon.2012.09.012_bib7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0005-2728(86)90112-X","article-title":"Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties","volume":"850","author":"Emaus","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2012.09.012_bib8","first-page":"175","article-title":"Estudo cl\u00ednico e an\u00e1tomo-patol\u00f3gico da doen\u00e7a \u201ccara torta\u201d em bovinos no Nordeste Brasileiro","volume":"18","author":"Figueiredo","year":"1996","journal-title":"Arq. Esc. Med. Vet. UFBA, Salvador"},{"key":"10.1016\/j.toxicon.2012.09.012_bib9","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.toxicon.2010.02.004","article-title":"Comparative effects of lantadene and its reduced metabolite on mitochondrial bioenergetics","volume":"55","author":"Garcia","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.09.012_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0005-2728(03)00027-6","article-title":"Intrinsec and extrinsic uncoupling of oxidative phosphorylation","volume":"1604","author":"Kadenbach","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2012.09.012_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0891-5849(94)90008-6","article-title":"Cellular reducing equivalents and oxidative stress","volume":"17","author":"Kehrer","year":"1994","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxicon.2012.09.012_bib12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0891-5849(98)00195-6","article-title":"Modulation of cardiac mitochondrial membrane fluidity by age and calorie intake","volume":"26","author":"Lee","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxicon.2012.09.012_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1976.tb10625.x","article-title":"Continuous measurement and rapid kinetics of ATP synthesis in rat liver mitochondria, mitoplasts and inner membrane vesicles determined by firefly-luciferase luminescence","volume":"67","author":"Lemasters","year":"1976","journal-title":"Eur. J. Biochem."},{"issue":"Suppl.","key":"10.1016\/j.toxicon.2012.09.012_bib14","first-page":"36","article-title":"Intoxica\u00e7\u00e3o por favas de Prosopis juliflora (algaroba) em caprinos no nordeste do Brasil","volume":"24","author":"Lima","year":"2004","journal-title":"Pesq. Vet. Bras."},{"key":"10.1016\/j.toxicon.2012.09.012_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.anifeedsci.2005.01.016","article-title":"Evaluation of Meskit (Prosopis juliflora) pods as a feed for goats","volume":"121","author":"Mahgoub","year":"2005","journal-title":"Anim. Feed. Sci. Technol."},{"key":"10.1016\/j.toxicon.2012.09.012_bib16","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.toxicon.2007.06.006","article-title":"Dehydromonocrotaline inhibits mitochondrial complex I. A potential mechanism accounting for hepatotoxicity of monocrotaline","volume":"50","author":"Mingatto","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.09.012_bib17","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/sj.bjp.0703667","article-title":"Effects of nimesulide and its reduced metabolite on mitochondria","volume":"131","author":"Mingatto","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2012.09.012_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/191144a0","article-title":"Coupling of phosphorylation to electron and hydrogen transfer by a chemiosmotic type of mechanism","volume":"191","author":"Mitchell","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2012.09.012_bib19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1042\/bj1040588","article-title":"Respiration-driven proton translocation in rat liver mitochondria","volume":"104","author":"Mitchell","year":"1967","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2012.09.012_bib20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10725-004-5574-8","article-title":"Structure\u2013activity relationships of alkaloids from mesquite (Prosopis juliflora (Sw.) DC.)","volume":"44","author":"Nakano","year":"2004","journal-title":"Plant Growth Regul."},{"key":"10.1016\/j.toxicon.2012.09.012_bib21","series-title":"Bioenergetics: an Introduction to the Chemiosmotic Theory","author":"Nicholls","year":"1982"},{"key":"10.1016\/j.toxicon.2012.09.012_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0378-4274(98)00298-7","article-title":"Intracellular ATP, a switch in the decision between apoptosis and necrosis","volume":"102\u2013103","author":"Nicotera","year":"1998","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxicon.2012.09.012_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1023\/A:1007649815992","article-title":"Hepatotoxicity due to mitochondrial dysfunction","volume":"15","author":"Pessayre","year":"1999","journal-title":"Cell. Biol. Toxicol."},{"key":"10.1016\/j.toxicon.2012.09.012_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0272-0590(91)90084-H","article-title":"Assessment of mitochondrial membrane potential as an indicator of cytotoxicity","volume":"16","author":"Rahn","year":"1991","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.toxicon.2012.09.012_bib25","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/jcbfm.1987.130","article-title":"Cerebral ischemia and reperfusion: prevention of brain mitochondrial injury by lidoflazine","volume":"7","author":"Rosenthal","year":"1987","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.toxicon.2012.09.012_bib26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.toxicon.2009.03.004","article-title":"Dehydromonocrotaline induces cyclosporine A-insensitive mitochondrial permeability transition\/cytochrome c release","volume":"54","author":"Santos","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.09.012_bib27","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.toxicon.2006.07.037","article-title":"Alkaloids from Prosopis juliflora leaves induce glial activation, cytotoxicity and stimulate NO production","volume":"49","author":"Silva","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.09.012_bib28","series-title":"A algarobeira [Prosopis juliflora (Sw) DC] no nordeste do Brasil","author":"Silva","year":"1989"},{"key":"10.1016\/j.toxicon.2012.09.012_bib29","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0005-2728(97)00091-1","article-title":"Uncoupling: new approaches to and old problem of bioenergetics","volume":"1363","author":"Skulachev","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2012.09.012_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-4157(82)90012-0","article-title":"Anilinonaphthalene sulfonate as a probe of membrane composition and function","volume":"694","author":"Slav\u00edk","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2012.09.012_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1124\/pr.54.1.101","article-title":"Mitochondria as a pharmacological target","volume":"54","author":"Szewczyk","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.toxicon.2012.09.012_bib32","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1354\/vp.43-5-695","article-title":"Neurohistologic and ultrastructural lesions in cattle experimentally intoxicated with the plant Prosopis juliflora","volume":"43","author":"Tabosa","year":"2006","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.toxicon.2012.09.012_bib33","series-title":"Toxic Plants and Other Natural Toxicants","first-page":"341","article-title":"Intoxication by Prosopis juliflora pods (mesquite beans) in cattle and goats in Northeastern Brazil","author":"Tabosa","year":"2004"},{"key":"10.1016\/j.toxicon.2012.09.012_bib34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1590\/S0102-695X2000000100002","article-title":"Isolamento biomonitorado de alcal\u00f3ides t\u00f3xicos de Prosopis juliflora (algaroba)","volume":"9\/10","author":"Tabosa","year":"2000","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.toxicon.2012.09.012_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1289\/ehp.9087213","article-title":"Uncouplers of oxidative phosphorylation","volume":"87","author":"Terada","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxicon.2012.09.012_bib36","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1471-4159.2001.00548.x","article-title":"\u0394\u03c8m-dependent and independent production of reactive oxygen species by brain mitochondria","volume":"79","author":"Votyakova","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2012.09.012_bib37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.pharmtox.40.1.353","article-title":"Mitochondrial targets of drug toxicity","volume":"40","author":"Wallace","year":"2000","journal-title":"Annu. Rev. Pharmacol. Toxicol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010112007556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010112007556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T12:24:57Z","timestamp":1542716697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010112007556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0041010112007556"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2012.09.012","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}