{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:12:13Z","timestamp":1776467533381,"version":"3.51.2"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek Vlaanderen","doi-asserted-by":"crossref","award":["G.0433.12, G.A071.10N and G.0257.08"],"award-info":[{"award-number":["G.0433.12, G.A071.10N and G.0257.08"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Inter-University Atraction Poles (IUAP) Program 7\/10"},{"DOI":"10.13039\/501100004040","name":"Katholieke Universiteit Leuven","doi-asserted-by":"crossref","award":["OT\/12\/081"],"award-info":[{"award-number":["OT\/12\/081"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"crossref","award":["TBAG-106T527"],"award-info":[{"award-number":["TBAG-106T527"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.toxicon.2012.10.010","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T09:33:13Z","timestamp":1352280793000},"page":"72-82","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Novel potassium channel blocker venom peptides from Mesobuthus gibbosus (Scorpiones: Buthidae)"],"prefix":"10.1016","volume":"61","author":[{"given":"Elia","family":"Diego-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Peigneur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Debaveye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eveline","family":"Gheldof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Tytgat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Caliskan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.toxicon.2012.10.010_bib1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bbrc.2008.09.033","article-title":"A new Kaliotoxin selective towards Kv1.3 and Kv1.2 but not Kv1.1 channels expressed in oocytes","volume":"376","author":"Abbas","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.toxicon.2012.10.010_bib2","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.toxicon.2008.03.027","article-title":"OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae","volume":"51","author":"Abdel-Mottaleb","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.10.010_bib3","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nsmb.1430","article-title":"A structural link between inactivation and block of K+ channel","volume":"6","author":"Ader","year":"2008","journal-title":"Nat. Struc. Mol. Biol."},{"key":"10.1016\/j.toxicon.2012.10.010_bib4","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1038\/emboj.2009.218","article-title":"Coupling of the activation gate in a K+-channel: potassium and ligand sensitivity","volume":"28","author":"Ader","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.toxicon.2012.10.010_bib5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1590\/S1678-91992010000200004","article-title":"In\u00a0vivo and in\u00a0vitro effects of scorpion venoms in Turkey: a mini-review","volume":"16","author":"Adiguzel","year":"2010","journal-title":"J. Venom Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2012.10.010_bib6","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/0896-6273(95)90104-3","article-title":"Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins","volume":"5","author":"Aiyar","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.toxicon.2012.10.010_bib7","first-page":"15","article-title":"The childhood poisoning in Denizli","volume":"6","author":"Ak\u00e7ay","year":"2005","journal-title":"J. Adnan Menderes Uni. Med. Fac."},{"key":"10.1016\/j.toxicon.2012.10.010_bib8","first-page":"48","article-title":"Scorpion envenomation in children","volume":"37","author":"Alt\u0131nkaynak","year":"2002","journal-title":"T\u00fcrk Pediatri Ar\u015fivi"},{"key":"10.1016\/j.toxicon.2012.10.010_bib9","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1002\/pmic.200500525","article-title":"Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins","volume":"6","author":"Batista","year":"2006","journal-title":"Proteomics"},{"issue":"2","key":"10.1016\/j.toxicon.2012.10.010_bib10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1570-9639(02)00458-2","article-title":"Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities","volume":"1601","author":"Batista","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2012.10.010_bib11","series-title":"Jaspers Basic Mechanisms of the Epilepsies","article-title":"Potassium channelopathies of epilepsy","author":"Brenner","year":"2012"},{"key":"10.1016\/j.toxicon.2012.10.010_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.toxicon.2006.04.003","article-title":"Characterization of venom components from the scorpion Androctonus crassicauda of Turkey: peptides and genes","volume":"48","author":"Caliskan","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.10.010_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1590\/S0036-46652010000400010","article-title":"Scorpion stings in Turkey: epidemiological and clinical aspects between the years 1995 and 2004","volume":"52","author":"Cesaretli","year":"2010","journal-title":"Revista do Instituto de Medicina Tropical de Sao Paulo"},{"key":"10.1016\/j.toxicon.2012.10.010_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actatropica.2008.05.021","article-title":"Epidemiology of scorpionism: a global appraisal","volume":"107","author":"Chippaux","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.toxicon.2012.10.010_bib15","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/S0021-9258(18)45993-5","article-title":"Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca (2+)-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom","volume":"267","author":"Crest","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2012.10.010_bib16","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1074\/jbc.272.7.4302","article-title":"On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures","volume":"272","author":"Dauplais","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2012.10.010_bib17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.toxicon.2004.10.014","article-title":"The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function","volume":"45","author":"Diego-Garcia","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.10.010_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.5962\/bhl.part.80126","article-title":"Molecular and morphological evidence for the presence of a new buthid taxon (Scorpiones: Buthidae) on the island of Cyprus","volume":"107","author":"Gantenbein","year":"2000","journal-title":"Revue suisse de Zoologie"},{"issue":"12","key":"10.1016\/j.toxicon.2012.10.010_bib19","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.biochi.2010.08.003","article-title":"A potent potassium channel blocker from Mesobuthus eupeus scorpion venom","volume":"92","author":"Gao","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2012.10.010_bib20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cbpa.2011.03.027","article-title":"Molecular divergence of two orthologous scorpion toxins affecting potassium channels","volume":"159","author":"Gao","year":"2011","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"issue":"19","key":"10.1016\/j.toxicon.2012.10.010_bib21","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1021\/bi300060n","article-title":"Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes","volume":"51","author":"Gurrola","year":"2012","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.toxicon.2012.10.010_bib22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0014-5793(94)00622-9","article-title":"Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to functional expression in cultured myotomal muscle cells from Xenopus embryos","volume":"348","author":"Honor\u00e9","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2012.10.010_bib23","first-page":"1","article-title":"Cytotoxic and gelatinolytic activities of Mesobuthus gibbosus (Brull\u00e9, 1832) venom","volume":"36","author":"Incesu","year":"2005","journal-title":"Revista CENIC Ciencias Biol\u00f3gicas"},{"key":"10.1016\/j.toxicon.2012.10.010_bib24","series-title":"Advances in Arachnology and Developmental Biology, Monographs, Belgrade-Vienna-Sofia","first-page":"209","article-title":"Scorpions of the Eastern Mediterranean","author":"Kaltsas","year":"2008"},{"key":"10.1016\/j.toxicon.2012.10.010_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18590\/euscorpius.2003.vol2003.iss7.1","article-title":"Mesobuthus eupeus (C.L. Koch, 1839) (Scorpiones: Buthidae) in Turkey","volume":"7","author":"Karatas","year":"2003","journal-title":"Euscorpius"},{"issue":"13","key":"10.1016\/j.toxicon.2012.10.010_bib26","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1016\/j.febslet.2007.04.065","article-title":"Isolation of the first toxin from the scorpion Buthus occitanus israelis showing preference for Shaker potassium channels","volume":"581","author":"Kozminsky-Atias","year":"2007","journal-title":"FEBS Lett."},{"issue":"8","key":"10.1016\/j.toxicon.2012.10.010_bib27","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/pro.5560040805","article-title":"Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry","volume":"4","author":"Krezel","year":"1995","journal-title":"Protein Sci."},{"key":"10.1016\/j.toxicon.2012.10.010_bib28","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nature04649","article-title":"Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR","volume":"440","author":"Lange","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2012.10.010_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/103608","article-title":"Potassium channel blockers from the venom of Androctonus mauretanicus mauretanicus","author":"Martin-Eauclaire","year":"2012","journal-title":"J. Toxicol."},{"key":"10.1016\/j.toxicon.2012.10.010_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/BJ20041379","article-title":"K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom","volume":"385","author":"Mouhat","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2012.10.010_bib31","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.toxicon.2006.01.015","article-title":"Moving pieces in a taxonomic puzzle: venom 2D-LC\/MS and data clustering analyses to infer phylogenetic relationships in some scorpion from the Buthidae family (Scorpiones)","volume":"47","author":"Nascimento","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.10.010_bib32","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1111\/j.1365-294X.2006.02982.x","article-title":"Evolution of Mesobuthus gibbosus (Brulle, 1832) (Scorpiones: Buthidae) in the northeastern Mediterranean region","volume":"15","author":"Parmakelis","year":"2006","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.toxicon.2012.10.010_bib33","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0300-9084(00)01167-6","article-title":"Peptides and genes coding for scorpion toxins that affect ion-channels","volume":"82","author":"Possani","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2012.10.010_bib34","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.toxicon.2004.03.022","article-title":"Current views on scorpion toxins specific for K+-channels","volume":"43","author":"Rodriguez de la Vega","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.10.010_bib35","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.toxicon.2009.11.010","article-title":"Mining on scorpion venom biodiversity","volume":"56","author":"Rodriguez de la Vega","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.10.010_bib36","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1021\/bi971044w","article-title":"Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels","volume":"36","author":"Romi-Lebrun","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2012.10.010_bib37","doi-asserted-by":"crossref","first-page":"30040","DOI":"10.1074\/jbc.M111258200","article-title":"kappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity","volume":"277","author":"Srinivasan","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.toxicon.2012.10.010_bib38","first-page":"1","article-title":"Mu\u011fla devlet hastanesi acil servisine ba\u015fvuran akrep ve y\u0131lan sokma vakalar\u0131n\u0131n incelenmesi","volume":"1","author":"S\u00fczek","year":"2004","journal-title":"Int. J. Hum. Sci."},{"issue":"52","key":"10.1016\/j.toxicon.2012.10.010_bib39","doi-asserted-by":"crossref","first-page":"22211","DOI":"10.1073\/pnas.0910123106","article-title":"A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library","volume":"106","author":"Takacs","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2012.10.010_bib40","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0165-6147(99)01398-X","article-title":"A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies","volume":"20","author":"Tytgat","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.toxicon.2012.10.010_bib41","first-page":"61","article-title":"Cholinesterase inhibitory activities of the scorpion Mesobuthus gibbosus (Buthidae) venom peptides","volume":"28","author":"Ucar","year":"2003","journal-title":"FABAD J. Pharm. Sci."},{"key":"10.1016\/j.toxicon.2012.10.010_bib42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.toxicon.2004.09.009","article-title":"Monoamine oxidase inhibitory activities of the scorpion Mesobuthus gibbosus (Buthidae) venom peptides","volume":"45","author":"Ucar","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.10.010_bib43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.imlet.2009.12.015","article-title":"Ion channels in T lymphocytes: an update on facts, mechanisms and therapeutic targeting in autoimmune diseases","volume":"130","author":"Varga","year":"2010","journal-title":"Immunol. Lett."},{"issue":"2","key":"10.1016\/j.toxicon.2012.10.010_bib44","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/prot.20322","article-title":"The solution structure of BmTx3B, a member of the scorpion toxin subfamily alpha-KTx16","volume":"58","author":"Wang","year":"2005","journal-title":"Proteins"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101011200774X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101011200774X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T23:54:35Z","timestamp":1643586875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004101011200774X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":44,"alternative-id":["S004101011200774X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2012.10.010","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}