{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T03:29:23Z","timestamp":1767929363955,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010324","name":"Secretar\u00eda General de Ciencia y T\u00e9cnica, Universidad Nacional del Nordeste","doi-asserted-by":"crossref","award":["P.I. B013-2010"],"award-info":[{"award-number":["P.I. B013-2010"]}],"id":[{"id":"10.13039\/501100010324","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006668","name":"FonCyT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SGCyT"},{"DOI":"10.13039\/501100010325","name":"UNNE","doi-asserted-by":"crossref","award":["PICTO 2007-00143"],"award-info":[{"award-number":["PICTO 2007-00143"]}],"id":[{"id":"10.13039\/501100010325","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.toxicon.2012.11.028","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T13:47:11Z","timestamp":1355406431000},"page":"104-111","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Effect of monospecific antibodies against baltergin in myotoxicity induced by Bothrops alternatus venom from northeast of Argentina. Role of metalloproteinases in muscle damage"],"prefix":"10.1016","volume":"63","author":[{"given":"Carolina","family":"Gay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Maru\u00f1ak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Teibler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Leiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofelia","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2012.11.028_bib1","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1021\/pr800332p","article-title":"Snake venomics of the lancehead pitviper Bothrops asper: geographic, individual, and ontogenetic variations","volume":"7","author":"Alape-Giron","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.toxicon.2012.11.028_bib2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0300-9084(00)01150-0","article-title":"Myotoxic phospholipases A(2) in Bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu","volume":"82","author":"Andriao-Escarso","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2012.11.028_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0163-7258(94)90049-3","article-title":"Hemorrhagic metalloproteinases from snake venoms","volume":"62","author":"Bjarnason","year":"1994","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.toxicon.2012.11.028_bib4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.toxicon.2011.11.007","article-title":"Synergism between baltergin metalloproteinase and Ba SPII RP4 PLA2 from Bothrops alternatus venom on skeletal muscle (C2C12) cells","volume":"59","author":"Bustillo","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0041-0101(96)00119-5","article-title":"An enzyme-linked immunosorbent assay\u00a0(ELISA) that discriminates between the venoms of Brazilian Bothrops\u00a0species and Crotalus durissus","volume":"35","author":"Chavez-Olortegui","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/(SICI)1099-1352(200001\/02)13:1<14::AID-JMR484>3.0.CO;2-F","article-title":"Membrane-perturbing activity of Viperidae myotoxins: an electrostatic surface potential approach to a puzzling problem","volume":"13","author":"Falconi","year":"2000","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.toxicon.2012.11.028_bib7","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.toxicon.2005.02.012","article-title":"Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases","volume":"45","author":"Fox","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.toxicon.2010.02.031","article-title":"Isolation and functional characterization of a new acidic PLA2 Ba SpII RP4 of the Bothrops alternatus snake venom from Argentina","volume":"56","author":"Garcia Denegri","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib9","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.toxicon.2005.06.019","article-title":"Proteolytic, edematogenic and myotoxic activities of a hemorrhagic metalloproteinase isolated from Bothrops alternatus venom","volume":"46","author":"Gay","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.toxicon.2008.10.010","article-title":"Systemic alterations induced by a Bothrops alternatus hemorrhagic metalloproteinase (baltergin) in mice","volume":"53","author":"Gay","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib11","first-page":"211","article-title":"Local tissue damage induced by Bothrops snake venoms: a review","volume":"51","author":"Guti\u00e9rrez","year":"1989","journal-title":"Mem. Inst. Butantan."},{"key":"10.1016\/j.toxicon.2012.11.028_bib12","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/0041-0101(95)00085-Z","article-title":"Phospholipase A2 myotoxins from Bothrops snake venoms","volume":"33","author":"Guti\u00e9rrez","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib13","series-title":"Venom Phospholipase A2 Enzymes: Structure, Function, and Mechanism","first-page":"321","article-title":"Phospholipase A2 myotoxins from Bothrops snake venoms","author":"Guti\u00e9rrez","year":"1997"},{"key":"10.1016\/j.toxicon.2012.11.028_bib14","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.toxicon.2003.11.005","article-title":"Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity","volume":"42","author":"Guti\u00e9rrez","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/exmp.1995.1004","article-title":"Skeletal muscle necrosis and regeneration after injection of BaH1, a hemorrhagic metalloproteinase isolated from the venom of the snake Bothrops asper (Terciopelo)","volume":"62","author":"Guti\u00e9rrez","year":"1995","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.toxicon.2012.11.028_bib16","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0300-9084(00)01163-9","article-title":"Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage","volume":"82","author":"Guti\u00e9rrez","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2012.11.028_bib17","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.toxicon.2009.01.038","article-title":"Experimental pathology of local tissue damage induced by Bothrops asper snake venom","volume":"54","author":"Guti\u00e9rrez","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib18","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.toxicon.2009.08.006","article-title":"Tissue pathology induced by snake venoms: how to understand a complex pattern of alterations from a systems biology perspective?","volume":"55","author":"Gutierrez","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib19","first-page":"538","article-title":"Morphology of local tissue damage in experimental snake envenomation","volume":"52","author":"Homma","year":"1971","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.toxicon.2012.11.028_bib20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.7883\/yoken1952.13.43","article-title":"Studies on the quantitative method for determination of hemorrhagic activity of Habu snake venom","volume":"13","author":"Kondo","year":"1960","journal-title":"Jpn. J. Med. Sci. Biol."},{"key":"10.1016\/j.toxicon.2012.11.028_bib21","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2012.11.028_bib22","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.toxicon.2009.03.015","article-title":"Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: contributions to understanding snakebite envenomings and their treatment","volume":"54","author":"Lomonte","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib23","first-page":"9","article-title":"Ethical standards for animal experiments in toxinological research","volume":"31","author":"Meier","year":"1993","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/qjmed\/90.5.323","article-title":"Snakebites by the jararacucu (Bothrops jararacussu): clinicopathological studies of 29 proven cases in Sao Paulo state","volume":"90","author":"Milani","year":"1997","journal-title":"Brazil Q. J. Med."},{"key":"10.1016\/j.toxicon.2012.11.028_bib25","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.toxicon.2003.11.014","article-title":"A structure based model for liposome disruption and the role of catalytic activity in myotoxic phospholipase A2s","volume":"42","author":"Murakami","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib26","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jmb.2005.04.072","article-title":"Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug suramin","volume":"350","author":"Murakami","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.toxicon.2012.11.028_bib27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0020-711X(91)90011-B","article-title":"Isolation and characterization of hemorrhagic toxin from the venom of Trimeresurus elegans","volume":"23","author":"Nikai","year":"1991","journal-title":"Int. J. Biochem."},{"key":"10.1016\/j.toxicon.2012.11.028_bib28","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1021\/pr901128x","article-title":"The venomics of Bothrops alternatus is a pool of acidic proteins with predominant hemorrhagic and coagulopathic activities","volume":"9","author":"Ohler","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.toxicon.2012.11.028_bib29","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1699-0463.1949.tb00751.x","article-title":"Antigen-antibody reactions in gels","volume":"26","author":"Ouchterlony","year":"1949","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"10.1016\/j.toxicon.2012.11.028_bib30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/15569549809009250","article-title":"Structure, function and biophysical aspects of the myotoxins from snake venoms","volume":"17","author":"Ownby","year":"1998","journal-title":"Toxin Rev."},{"key":"10.1016\/j.toxicon.2012.11.028_bib31","first-page":"201","article-title":"Hemorrhagic toxins from rattlesnake (Crotalus atrox) venom. Pathogenesis of hemorrhage induced by three purified toxins","volume":"93","author":"Ownby","year":"1978","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.toxicon.2012.11.028_bib32","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0041-0101(09)80006-8","article-title":"Pathogenesis of hemorrhage induced by bilitoxin, a hemorrhagic toxin isolated from the venom of the common cantil (Agkistrodon bilineatus bilineatus)","volume":"28","author":"Ownby","year":"1990","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib33","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0041-0101(98)00188-3","article-title":"Lysine 49 phospholipase A2 proteins","volume":"37","author":"Ownby","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib34","series-title":"Gu\u00eda de prevenci\u00f3n, diagn\u00f3stico, tratamiento y vigilancia epidemiol\u00f3gica de los envenenamientos of\u00eddicos","author":"PNGCAM","year":"2007"},{"key":"10.1016\/j.toxicon.2012.11.028_bib35","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbagen.2006.11.015","article-title":"Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus","volume":"1770","author":"Ponce-Soto","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2012.11.028_bib36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0041-0101(85)90158-8","article-title":"Pathological changes in muscle caused by haemorrhagic and proteolytic factors from Bothrops jararaca snake venom","volume":"23","author":"Queiroz","year":"1985","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib37","series-title":"Natural Toxins Animal, Plant and Microbial","first-page":"129","article-title":"The relationship between enzymatic activity and pharmacological properties of phospholipases in natural poisons","author":"Rosenberg","year":"1986"},{"key":"10.1016\/j.toxicon.2012.11.028_bib38","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0041-0101(95)00039-O","article-title":"Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper","volume":"33","author":"Rucavado","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2012.11.028_bib39","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/exmp.1995.1042","article-title":"Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom","volume":"63","author":"Rucavado","year":"1995","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.toxicon.2012.11.028_bib40","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.2174\/1385272043369610","article-title":"Phospholipase A2 myotoxins from Bothrops snake venoms: structure\u2013function relationship","volume":"8","author":"Soares","year":"2004","journal-title":"Curr. Org. Chem."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010112008264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010112008264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T02:54:04Z","timestamp":1588820044000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010112008264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":40,"alternative-id":["S0041010112008264"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2012.11.028","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}