{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:31:42Z","timestamp":1789050702539,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institute for Science and Technology","award":["573534\/2008-0"],"award-info":[{"award-number":["573534\/2008-0"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.toxicon.2013.05.007","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T16:03:47Z","timestamp":1369843427000},"page":"113-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria\u00a0juncea and Crotalaria retusa in donkeys"],"prefix":"10.1016","volume":"71","author":[{"given":"C.R.M.","family":"Pessoa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.A.","family":"Pessoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.A.","family":"Maia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.T.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Colegate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.S.","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.P.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Riet-Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.toxicon.2013.05.007_bib1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1177\/1040638712460673","article-title":"Crotalariosis equorum (\u201cjaagsiekte\u201d) in horses in southern Mozambique, a rare form of pyrrolizidine alkaloid poisoning","volume":"24","author":"Botha","year":"2012","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.toxicon.2013.05.007_bib2","series-title":"The Pyrrolizidine Alkaloids: Their Chemistry, Pathogenicity and Other Biological Properties","author":"Bull","year":"1968"},{"key":"10.1016\/j.toxicon.2013.05.007_bib3","first-page":"1577","article-title":"Endocardial fibrosis associated with monocrotaline-induced pulmonary hypertension in nonhuman primates (Macaca arctoides)","volume":"34","author":"Chesney","year":"1973","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.toxicon.2013.05.007_bib4","article-title":"Dehydropyrrolizidine alkaloids in two Cryptantha species: including two new open chain diesters one of which is amphoteric","author":"Colegate","year":"2012","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.toxicon.2013.05.007_bib5","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1021\/jf205296s","article-title":"Dehydropyrrolizidine alkaloids, including monoesters with an unusual esterifying acid, from cultivated Crotalaria juncea (Sunn Hemp cv.\u2018Tropic Sun\u2019)","volume":"60","author":"Colegate","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxicon.2013.05.007_bib6","series-title":"Resolu\u00e7\u00e3o N\u00b0 1000, 11 de maio, 2012","author":"Conselho Federal de Medicina Veterin\u00e1ria","year":"2012"},{"key":"10.1016\/j.toxicon.2013.05.007_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1071\/CH9630239","article-title":"Alkaloids of Crotalaria crispata F. Muell. ex Benth., the structures of crispatine and fulvine","volume":"16","author":"Culvenor","year":"1962","journal-title":"Aust. J. Chem."},{"issue":"5","key":"10.1016\/j.toxicon.2013.05.007_bib8","first-page":"409","article-title":"Tansy ragwort poisoning in a horse in southern Ontario","volume":"41","author":"de Lanux-Van Gorder","year":"2000","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.toxicon.2013.05.007_bib9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/jf8026099","article-title":"Pyrrolizidine alkaloids in Crotalaria taxa from northern Australia: risk to grazing livestock","volume":"57","author":"Fletcher","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxicon.2013.05.007_bib10","doi-asserted-by":"crossref","first-page":"11888","DOI":"10.1021\/jf203147x","article-title":"Crotalaria medicaginea associated with horse deaths in Northern Australia: new pyrrolizidine alkaloids","volume":"59","author":"Fletcher","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxicon.2013.05.007_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/path.1700890106","article-title":"Studies on Crotalaria crispata, a newly recognized cause of Kimberly horse disease","volume":"89","author":"Gardiner","year":"1965","journal-title":"J. Comp. Path. Bact."},{"issue":"1","key":"10.1016\/j.toxicon.2013.05.007_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1590\/S0100-736X1997000100006","article-title":"Senecio spp. poisoning of horses in southern Brazil","volume":"17","author":"Gava","year":"1997","journal-title":"Pesq. Vet. Bras."},{"issue":"3","key":"10.1016\/j.toxicon.2013.05.007_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.2042-3306.1983.tb01781.x","article-title":"Outbreak of ragwort (Senecio jacobaea) poisoning in horses","volume":"15","author":"Giles","year":"1983","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.toxicon.2013.05.007_bib14","series-title":"Effects of Poisonous Plants on Livestock","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/B978-0-12-403250-7.50022-4","article-title":"Pyrrolizidine alkaloid poisoning \u2013 pathology with particular reference to differences in animal and plant species","author":"Hooper","year":"1978"},{"key":"10.1016\/j.toxicon.2013.05.007_bib15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.2042-3306.1990.tb04288.x","article-title":"Ultrastructural findings in horses with chronic obstructive pulmonary disease (COPD)","volume":"22","author":"Kaup","year":"1999","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.toxicon.2013.05.007_bib16","series-title":"Plant Poisonings and Mycotoxicoses of Livestock in Southern Africa","author":"Kellerman","year":"2005"},{"key":"10.1016\/j.toxicon.2013.05.007_bib17","first-page":"647","article-title":"Cynoglossum officinale (hound\u2019s-toung) a cause of pyrrolizidine alkaloid poisoning in horses","volume":"185","author":"Knight","year":"1984","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.toxicon.2013.05.007_bib18","first-page":"1776","article-title":"Clinicopathologic study of horses surviving pyrrolizidine alkaloid (Senecio vulgaris) toxicosis","volume":"47","author":"Lessard","year":"1986","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.toxicon.2013.05.007_bib19","series-title":"Chemistry and Toxicology of Pyrrolizidine Alkaloids","author":"Mattocks","year":"1986"},{"key":"10.1016\/j.toxicon.2013.05.007_bib20","series-title":"Australia's Poisonous Plants, Fungi and Cyanobacteria. A Guide to Species of Medical and Veterinary Importance","author":"McKenzie","year":"2012"},{"key":"10.1016\/j.toxicon.2013.05.007_bib21","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1152\/jappl.1978.45.6.962","article-title":"Monocrotaline model of noncardiogenic pulmonary edema in dogs","volume":"45","author":"Miller","year":"1978","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.toxicon.2013.05.007_bib22","first-page":"445","article-title":"Crotalaria juncea intoxication in horses","volume":"36","author":"Nobre","year":"1994","journal-title":"Vet. Hum. Toxicol."},{"issue":"3","key":"10.1016\/j.toxicon.2013.05.007_bib23","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1590\/S0100-736X2004000300004","article-title":"Intoxica\u00e7\u00e3o por Crotalaria retusa (Fabaceae) em equ\u00eddeos no semi-\u00e1rido da Para\u00edba","volume":"24","author":"Nobre","year":"2004","journal-title":"Pesq. Vet. Bras."},{"key":"10.1016\/j.toxicon.2013.05.007_bib24","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1751-0813.1997.tb10065.x","article-title":"Liver biopsy techniques for adult horses and neonatal foals to assess copper status","volume":"75","author":"Pearce","year":"1997","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.toxicon.2013.05.007_bib25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1751-0813.1957.tb08270.x","article-title":"Field and experimental investigation of walkabout disease of horses (Kimberly horse disease) in Northern Australia: Crotalaria poisoning in horses. Part I","volume":"33","author":"Rose","year":"1957","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.toxicon.2013.05.007_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1751-0813.1957.tb08270.x","article-title":"Field and experimental investigation of walkabout disease of horses (Kimberly horse disease) in Northern Australia: Crotalaria poisoning in horses. Part II","volume":"34","author":"Rose","year":"1957","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.toxicon.2013.05.007_bib27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0041-008X(91)90223-2","article-title":"Effect of monocrotaline ingestion on liver and lungs in rats","volume":"60","author":"Roth","year":"1981","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxicon.2013.05.007_bib28","series-title":"Veterinary and Clinical Chemistry","author":"Thrall","year":"2012"},{"key":"10.1016\/j.toxicon.2013.05.007_bib29","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1939-1676.2006.tb01813.x","article-title":"Percutaneous lung biopsy in the horse: comparison of two instruments and repeated biopsy in horses with induced acute interstitial pneumopathy","volume":"20","author":"Venner","year":"2006","journal-title":"J. Vet. Intern. Med."},{"issue":"4","key":"10.1016\/j.toxicon.2013.05.007_bib30","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1017\/S0043174500060410","article-title":"Occurrence, concentration, and toxicity of pyrrolizidine alkaloids in Crotalaria seeds","volume":"35","author":"Williams","year":"1987","journal-title":"Weed Sci."},{"key":"10.1016\/j.toxicon.2013.05.007_bib31","first-page":"13","article-title":"Toxic components of the seeds of Crotalaria juncea and their toxicity for pigs","volume":"7","author":"Zhang","year":"1985","journal-title":"Chinese J. Vet. Sci. Tech."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010113001888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010113001888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T07:00:11Z","timestamp":1563087611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010113001888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":31,"alternative-id":["S0041010113001888"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2013.05.007","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria\u00a0juncea and Crotalaria retusa in donkeys","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2013.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}