{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T03:13:12Z","timestamp":1767928392466,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.toxicon.2013.05.013","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:47:00Z","timestamp":1369874820000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Glycolic acid inhibits enzymatic, hemorrhagic and edema-inducing activities of BaP1, a P\u2013I metalloproteinase from Bothrops asper snake venom: Insights from docking and molecular modeling"],"prefix":"10.1016","volume":"71","author":[{"given":"Jaime Andr\u00e9s","family":"Perea\u00f1ez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arley Camilo","family":"Pati\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Rey-Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitelbina","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel Cristina","family":"Henao Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Rucavado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2013.05.013_bib1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.toxicon.2008.12.014","article-title":"Biochemistry and toxicology of toxins purified from the venom of the snake Bothrops asper","volume":"54","author":"Angulo","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib2","first-page":"429","article-title":"Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin","volume":"27","author":"Bernstein","year":"2001","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.toxicon.2013.05.013_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0041-0101(96)83647-6","article-title":"The serum \u2013 therapie was discovered 100 years ago","volume":"34","author":"Bon","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib4","doi-asserted-by":"crossref","first-page":"5738","DOI":"10.1016\/j.bmc.2012.08.014","article-title":"Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold","volume":"20","author":"Cheng","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.toxicon.2013.05.013_bib5","series-title":"GaussView, Version 5","author":"Dennington","year":"2009"},{"key":"10.1016\/j.toxicon.2013.05.013_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0190-9622(96)80110-1","article-title":"Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study","volume":"34","author":"Ditre","year":"1996","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.toxicon.2013.05.013_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0006-2952(00)00302-6","article-title":"Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper","volume":"60","author":"Escalante","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxicon.2013.05.013_bib8","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.abb.2006.09.018","article-title":"Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study","volume":"455","author":"Escalante","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2013.05.013_bib9","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jprot.2011.03.026","article-title":"Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases","volume":"74","author":"Escalante","year":"2011","journal-title":"J. Proteomics"},{"key":"10.1016\/j.toxicon.2013.05.013_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.toxicon.2006.01.009","article-title":"Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines","volume":"47","author":"Fernandes","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib11","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.toxicon.2005.02.012","article-title":"Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases","volume":"45","author":"Fox","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib12","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1111\/j.1742-4658.2008.06466.x","article-title":"Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity","volume":"275","author":"Fox","year":"2008","journal-title":"FEBS. J."},{"key":"10.1016\/j.toxicon.2013.05.013_bib13","series-title":"Gaussian 09, Revision B.01","author":"Frisch","year":"2010"},{"key":"10.1016\/j.toxicon.2013.05.013_bib14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.clindermatol.2009.06.023","article-title":"Clinical and cosmeceutical uses of hydroxyacids","volume":"27","author":"Green","year":"2009","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.toxicon.2013.05.013_bib15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0041-0101(85)90380-0","article-title":"Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom","volume":"23","author":"Guti\u00e9rrez","year":"1985","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0041-0101(94)00138-X","article-title":"Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo)","volume":"33","author":"Guti\u00e9rrez","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib17","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0041-0101(98)00145-7","article-title":"Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom","volume":"36","author":"Guti\u00e9rrez","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib18","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0300-9084(00)01163-9","article-title":"Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage","volume":"82","author":"Guti\u00e9rrez","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2013.05.013_bib19","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.toxicon.2009.01.038","article-title":"Experimental pathology of local tissue damage induced by Bothrops asper snake venom","volume":"54","author":"Guti\u00e9rrez","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib20","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.toxicon.2009.11.020","article-title":"Snakebite envenoming from a global perspective: towards an integrated approach","volume":"56","author":"Guti\u00e9rrez","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib21","series-title":"Chelating Agents and Metal Chelates","first-page":"95","article-title":"Bidentate chelates","author":"Harris","year":"1964"},{"key":"10.1016\/j.toxicon.2013.05.013_bib22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/mc.1050","article-title":"Inhibitory effect of glycolic acid on ultraviolet-induced skin tumorigenesis in SKH-1 hairless mice and its mechanism of action","volume":"31","author":"Hong","year":"2001","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.toxicon.2013.05.013_bib23","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1016\/j.bmc.2010.06.042","article-title":"Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease","volume":"18","author":"Huang","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.toxicon.2013.05.013_bib24","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1038\/jid.2008.118","article-title":"Skin pathology induced by snake venom metalloproteinase: acute damage, revascularization, and re-epithelization in a mouse ear model","volume":"128","author":"Jim\u00e9nez","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.toxicon.2013.05.013_bib25","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2013.05.013_bib26","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1021\/bi9002315","article-title":"High-resolution crystal structure of the snake venom metalloproteinase BaP1 complexed with a peptidomimetic: insight into inhibitor binding","volume":"48","author":"Lingott","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2013.05.013_bib27","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.2174\/156802611797633447","article-title":"The polyphenol 3,4,5-tri-hydroxy benzoic acid inhibits Indian Daboia russelli venom and its hemorrhagic complex induced local toxicity","volume":"11","author":"Mahadeswaraswamy","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.toxicon.2013.05.013_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003495-199700543-00003","article-title":"Snake venoms","volume":"54","author":"Markland","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.toxicon.2013.05.013_bib29","first-page":"1093","article-title":"Synergistic effect of glycolic acid on the antioxidant activity of alpha-tocopherol and melatonin in lipid bilayers and in human skin homogenates","volume":"42","author":"Morreale","year":"1997","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.toxicon.2013.05.013_bib30","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2174\/156802607780487696","article-title":"Group IIA secretory PLA2 inhibition by ursolic acid: a potent anti-inflammatory molecule","volume":"7","author":"Nataraju","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.toxicon.2013.05.013_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1034\/j.1600-0625.12.s2.9.x","article-title":"Biological effects of glycolic acid on dermal matrix metabolism mediated by dermal fibroblasts and epidermal keratinocytes","volume":"12","author":"Okano","year":"2003","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.toxicon.2013.05.013_bib32","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.toxicon.2009.07.001","article-title":"Epidemiological, clinical and therapeutic aspects of Bothrops asper bites","volume":"54","author":"Otero-Pati\u00f1o","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib33","first-page":"6671","article-title":"Glycolic acid peeling in the treatment of mild to moderate inflammatory facial acne vulgaris","volume":"6","author":"Peri\u0107","year":"2011","journal-title":"Scientific Res. Essays"},{"key":"10.1016\/j.toxicon.2013.05.013_bib34","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1524-4725.1996.tb00343.x","article-title":"Photoprotective and antiinflammatory effects of topical glycolic acid","volume":"22","author":"Perricone","year":"1996","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.toxicon.2013.05.013_bib35","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.3390\/molecules14093198","article-title":"Molecular docking studies and anti-snake venom metalloproteinase activity of Thai mango seed kernel extract","volume":"14","author":"Pithayanukul","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.toxicon.2013.05.013_bib36","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/exmp.1995.1042","article-title":"Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom","volume":"63","author":"Rucavado","year":"1995","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.toxicon.2013.05.013_bib37","first-page":"245","article-title":"Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper","volume":"79","author":"Rucavado","year":"1998","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.toxicon.2013.05.013_bib38","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4269\/ajtmh.2000.63.313","article-title":"Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA","volume":"63","author":"Rucavado","year":"2000","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2013.05.013_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bbamcr.2009.04.003","article-title":"Matrix metalloproteinases: fold and function of their catalytic domains","volume":"1803","author":"Tallant","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2013.05.013_bib40","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.toxicon.2008.12.018","article-title":"Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom","volume":"53","author":"Toyama","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2013.05.013_bib41","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.toxicon.2013.05.013_bib42","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1054\/mehy.1998.0788","article-title":"A theory for the mechanism of action of the alpha-hydroxy acids applied to the skin","volume":"53","author":"Wang","year":"1999","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.toxicon.2013.05.013_bib43","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbrc.2004.09.031","article-title":"A novel P-I class metalloproteinase with broad substrate-cleaving activity, agkislysin, from Agkistrodon acutus venom","volume":"324","author":"Wang","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2013.05.013_bib44","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1110\/ps.03102403","article-title":"Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities","volume":"12","author":"Watanabe","year":"2003","journal-title":"Protein Sci."},{"key":"10.1016\/j.toxicon.2013.05.013_bib45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1473-2130.2004.00059.x","article-title":"Alpha-hydroxyacids and carboxylic acids","volume":"3","author":"Yu","year":"2004","journal-title":"J. Cosmet. Dermatol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010113001943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010113001943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T09:33:34Z","timestamp":1715420014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010113001943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":45,"alternative-id":["S0041010113001943"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2013.05.013","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycolic acid inhibits enzymatic, hemorrhagic and edema-inducing activities of BaP1, a P\u2013I metalloproteinase from Bothrops asper snake venom: Insights from docking and molecular modeling","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2013.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}