{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:18:12Z","timestamp":1791091092219,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"vor","delay-in-days":297,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico","doi-asserted-by":"crossref","award":["306164\/2010-8"],"award-info":[{"award-number":["306164\/2010-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico","doi-asserted-by":"crossref","award":["481664\/2010-6"],"award-info":[{"award-number":["481664\/2010-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico","doi-asserted-by":"crossref","award":["476551\/2009-9"],"award-info":[{"award-number":["476551\/2009-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Toxinologia \u2013 Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia (INCT) em Medicina Molecular (MCT\/CNPq)"},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.toxicon.2013.08.059","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T09:31:30Z","timestamp":1377768690000},"page":"23-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["The selective A-type K+ current blocker Tx3-1 isolated from the Phoneutria nigriventer venom enhances memory of na\u00efve and A\u03b225-35-treated mice"],"prefix":"10.1016","volume":"76","author":[{"given":"Guilherme M.","family":"Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerusa D.","family":"Dalmolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta do Nascimento","family":"Cordeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus V.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel A.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2013.08.059_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0041-0101(02)00292-1","article-title":"Expression of functional recombinant Phoneutria nigriventer toxin active on K+ channels","volume":"41","author":"Carneiro","year":"2002","journal-title":"Toxicon"},{"issue":"47","key":"10.1016\/j.toxicon.2013.08.059_bib2","doi-asserted-by":"crossref","first-page":"12143","DOI":"10.1523\/JNEUROSCI.2667-06.2006","article-title":"Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons","volume":"26","author":"Chen","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxicon.2013.08.059_bib3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/syn.20599","article-title":"Amyloid \u03b2-protein fragments 25-35 and 31-35 potentiate long-term depression in hippocampal CA1 region of rats in\u00a0vivo","volume":"63","author":"Cheng","year":"2009","journal-title":"Synapse"},{"key":"10.1016\/j.toxicon.2013.08.059_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1749-6632.1999.tb11293.x","article-title":"Molecular diversity of K+ channels","volume":"868","author":"Coetzee","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.toxicon.2013.08.059_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0041-0101(93)90354-L","article-title":"Purification and amino acid sequences of six TX3 type neurotoxins from the venom of the Brazilian \u201carmed\u201d spider Phoneutria nigriventer","volume":"31","author":"Cordeiro","year":"1993","journal-title":"Toxicon"},{"issue":"10","key":"10.1016\/j.toxicon.2013.08.059_bib6","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.pain.2011.04.015","article-title":"Antinociceptive effect of Brazilian armed spider venom toxin Tx3-3 in animal models of neuropathic pain","volume":"152","author":"Dalmolin","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.toxicon.2013.08.059_bib7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0006-3223(88)90020-0","article-title":"4-Aminopyridine in the treatment of Alzheimer's disease","volume":"23","author":"Davidson","year":"1988","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.toxicon.2013.08.059_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0166-2236(96)10079-5","article-title":"Ionic effects of the Alzheimer's disease beta-amyloid precursor protein and its metabolic fragments","volume":"20","author":"Fraser","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.toxicon.2013.08.059_bib9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/379074a0","article-title":"Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein","volume":"379","author":"Furukawa","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2013.08.059_bib10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1023\/A:1021836403433","article-title":"Phoneutria nigriventer venom: a cocktail of toxins that affect ion channels","volume":"22","author":"Gomez","year":"2002","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.toxicon.2013.08.059_bib11","series-title":"Ionic Channels of Excitable Membranes","author":"Hille","year":"2001"},{"key":"10.1016\/j.toxicon.2013.08.059_bib12","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/42571","article-title":"K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons","volume":"387","author":"Hoffman","year":"1997","journal-title":"Nature"},{"issue":"1\u20133","key":"10.1016\/j.toxicon.2013.08.059_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ejphar.2007.01.040","article-title":"Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic and spatial learning","volume":"561","author":"Holscher","year":"2007","journal-title":"Eur. J. Pharm."},{"issue":"8","key":"10.1016\/j.toxicon.2013.08.059_bib15","doi-asserted-by":"crossref","first-page":"e6549","DOI":"10.1371\/journal.pone.0006549","article-title":"Biphasic somatic A-type K+ channel downregulation mediates intrinsic plasticity in hippocampal CA1 pyramidal neurons","volume":"4","author":"Jung","year":"2009","journal-title":"Plos ONE"},{"issue":"8","key":"10.1016\/j.toxicon.2013.08.059_bib16","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/WNR.0b013e3282ff636b","article-title":"Modulation of \u201cA\u201d-type K+ current by rodent and human forms of amyloid beta protein","volume":"19","author":"Kerrigan","year":"2008","journal-title":"Neuroreport"},{"issue":"3","key":"10.1016\/j.toxicon.2013.08.059_bib17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/1073858408315041","article-title":"Potassium channels: new found players in synaptic plasticity","volume":"14","author":"Kim","year":"2008","journal-title":"Neuroscientist"},{"key":"10.1016\/j.toxicon.2013.08.059_bib18","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1046\/j.1471-4159.1999.721472.x","article-title":"Phoneutria nigriventer toxin Tx3-1 blocks A-type K+ currents controlling Ca2+ oscillation frequency in GH3 cells","volume":"72","author":"Kushmerick","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2013.08.059_bib19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0160-5402(86)90038-0","article-title":"Intracerebroventricular injections in mice. Some methodological refinements","volume":"16","author":"Laursen","year":"1986","journal-title":"J. Pharmacol. Method"},{"key":"10.1016\/j.toxicon.2013.08.059_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(95)01032-7","article-title":"Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction","volume":"706","author":"Maurice","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.toxicon.2013.08.059_bib21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nrn810","article-title":"Emerging rules for the distribution of active dendritic conductance","volume":"3","author":"Migliore","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.toxicon.2013.08.059_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/jnr.20134","article-title":"Messenger RNA and protein expression analysis of voltage-gated potassium channels in the brain of A\u03b225-35-treated rats","volume":"77","author":"Pan","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.toxicon.2013.08.059_bib23","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.neurobiolaging.2005.09.038","article-title":"Amyloid \u03b2 peptide as a physiological modulator of \u201cA\u201d-type K+ currents","volume":"27","author":"Plant","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.toxicon.2013.08.059_bib24","series-title":"World Alzheimer Report \u2013 the Benefits of Early Diagnosis and Intervention","author":"Prince","year":"2009"},{"key":"10.1016\/j.toxicon.2013.08.059_bib25","doi-asserted-by":"crossref","first-page":"10144","DOI":"10.1073\/pnas.152620399","article-title":"A transient postsynaptic K+ current modulated by arachidonic acid regulates synaptic integration and threshold for LTP induction in hippocampal pyramidal cells","volume":"99","author":"Ramakers","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2013.08.059_bib27","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/sj.npp.1301256","article-title":"The Allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35 i.c.v.-injected mice: involvement of dopaminergic systems","volume":"32","author":"Wang","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.toxicon.2013.08.059_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00002093-199100510-00003","article-title":"Potassium channel blockers: could they work in Alzheimer disease?","volume":"5","author":"Wiseman","year":"1991","journal-title":"Alzheimer Dis. Assoc. Disord."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010113003437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010113003437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T16:27:17Z","timestamp":1539448037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010113003437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":26,"alternative-id":["S0041010113003437"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2013.08.059","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The selective A-type K+ current blocker Tx3-1 isolated from the Phoneutria nigriventer venom enhances memory of na\u00efve and A\u03b225-35-treated mice","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2013.08.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}