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Int."},{"key":"10.1016\/j.toxicon.2014.02.023_bib153","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.toxicon.2011.09.011","article-title":"Clinical picture and laboratorial evaluation in human loxoscelism","volume":"58","author":"Malaque","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2014.02.023_bib154","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4067\/S0716-10182009000600004","article-title":"Cutaneous and visceral loxoscelism: a systematic review","volume":"26","author":"Manr\u00edquez","year":"2009","journal-title":"Rev. Chil. Infectol."},{"key":"10.1016\/j.toxicon.2014.02.023_bib155","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1139\/o03-091","article-title":"Acid and neutral sphingomyelinases: roles and mechanisms of regulation","volume":"82","author":"Marchesini","year":"2004","journal-title":"Biochem. Cell. Biol."},{"key":"10.1016\/j.toxicon.2014.02.023_bib156","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0969-2126(00)00511-6","article-title":"Crystal structure of hyaluronidase, a major allergen of bee venom","volume":"8","author":"Markovic-Housley","year":"2000","journal-title":"Structure"},{"key":"10.1016\/j.toxicon.2014.02.023_bib157","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.toxicon.2013.05.014","article-title":"A novel ICK peptide from the Loxosceles intermedia (brown spider) venom gland: cloning, heterologous expression and immunological cross-reactivity approaches","volume":"71","author":"Matsubara","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2014.02.023_bib158","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jpeds.2009.07.021","article-title":"Brown recluse spider (Loxosceles reclusa) envenomation leading to acute hemolytic anemia in six adolescents","volume":"156","author":"McDade","year":"2010","journal-title":"J. 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Pathol."},{"key":"10.1016\/j.toxicon.2014.02.023_bib161","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1016\/j.biochi.2012.07.007","article-title":"Biochemical characterization and comparative analysis of two distinct serine proteases from Bothrops pirajai snake venom","volume":"94","author":"Menaldo","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2014.02.023_bib162","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1016\/j.vaccine.2013.03.048","article-title":"Generation and characterization of a recombinant chimeric protein (rCpLi) consisting of B-cell epitopes of a dermonecrotic protein from Loxosceles intermedia spider venom","volume":"31","author":"Mendes","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.toxicon.2014.02.023_bib163","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1046\/j.1432-1033.2003.03891.x","article-title":"The astacin protein family in Caenorhabditis elegans","volume":"270","author":"M\u00f6rhlen","year":"2003","journal-title":"Eur. 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Acarol."},{"key":"10.1016\/j.toxicon.2014.02.023_bib171","doi-asserted-by":"crossref","first-page":"25239","DOI":"10.1074\/jbc.M004142200","article-title":"Recombinant fibrinogen studies reveal that thrombin specificity dictates order of fibrinopeptide release","volume":"275","author":"Mullin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2014.02.023_bib172","doi-asserted-by":"crossref","first-page":"13658","DOI":"10.1074\/jbc.M412437200","article-title":"Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D","volume":"8","author":"Murakami","year":"2005","journal-title":"J. Biol. 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