{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:29:38Z","timestamp":1780723778661,"version":"3.54.1"},"reference-count":45,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.toxicon.2014.04.017","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T13:47:07Z","timestamp":1399643227000},"page":"52-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The intrahippocampal infusion of crotamine from Crotalus durissus terrificus venom enhances memory persistence in rats"],"prefix":"10.1016","volume":"85","author":[{"given":"Liane S.","family":"Vargas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus V.S.","family":"Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rithiele","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanusa","family":"Mandredini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Alberto","family":"Ponce-Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Marangoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7010-6503","authenticated-orcid":false,"given":"Ch\u00e1riston A.","family":"Dal Belo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e2mela B.","family":"Mello-Carpes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.toxicon.2014.04.017_bib1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s002210050544","article-title":"N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes","volume":"123","author":"Adriani","year":"1998","journal-title":"Exp. Brain Res."},{"issue":"3\u20134","key":"10.1016\/j.toxicon.2014.04.017_bib2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12640-010-9155-5","article-title":"Persistence of long-term memory storage: new insights into its molecular signatures in the hippocampus and related structures","volume":"18","author":"Bekinschtein","year":"2010","journal-title":"Neurotox. Res."},{"issue":"7","key":"10.1016\/j.toxicon.2014.04.017_bib3","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/j.bbamcr.2013.01.022","article-title":"Calcium responses to synaptically activated bursts of action potentials and their synapse-independent replay in cultured networks of hippocampal neurons","volume":"1833","author":"Bengtson","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.toxicon.2014.04.017_bib4","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.yhbeh.2006.03.016","article-title":"Angiotensin II disrupts inhibitory avoidance memory retrieval","volume":"50","author":"Bonini","year":"2006","journal-title":"Horm. Behav."},{"issue":"9","key":"10.1016\/j.toxicon.2014.04.017_bib5","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/0041-0101(93)90124-2","article-title":"Toxins as tools in the study of sodium channel distribution in the muscle fibre membrane","volume":"31","author":"Brazil","year":"1993","journal-title":"Toxicon"},{"issue":"6","key":"10.1016\/j.toxicon.2014.04.017_bib6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0041-0101(00)00222-1","article-title":"Gyroxin fails to modify in\u00a0vitro release of labelled dopamine and acetylcholine from rat and mouse striatal tissue","volume":"39","author":"Camillo","year":"2001","journal-title":"Toxicon"},{"issue":"47","key":"10.1016\/j.toxicon.2014.04.017_bib7","doi-asserted-by":"crossref","first-page":"12143","DOI":"10.1523\/JNEUROSCI.2667-06.2006","article-title":"Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons","volume":"26","author":"Chen","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxicon.2014.04.017_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/943520","article-title":"In Vitro antiophidian mechanisms of Hypericum brasiliense choisy standardized extract: quercetin-dependent neuroprotection","author":"Dal Belo","year":"2013","journal-title":"Biomed. Res. Int."},{"issue":"2","key":"10.1016\/j.toxicon.2014.04.017_bib8","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.nlm.2008.05.013","article-title":"Cholinergic modulation of hippocampal CA1 basal-dendritic long-term potentiation","volume":"90","author":"Doralp","year":"2008","journal-title":"Neurobiol. Learn Mem."},{"issue":"1","key":"10.1016\/j.toxicon.2014.04.017_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav. Brain Res."},{"issue":"17","key":"10.1016\/j.toxicon.2014.04.017_bib10","doi-asserted-by":"crossref","first-page":"7603","DOI":"10.1523\/JNEUROSCI.4181-12.2013","article-title":"Nuclear factor kappaB-dependent histone acetylation is specifically involved in persistent forms of memory","volume":"33","author":"Federman","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxicon.2014.04.017_bib43","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/sj.bjp.0701709","article-title":"Influence of potassium channel modulators on cognitive processes in mice","volume":"123","author":"Ghelardini","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2014.04.017_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.toxicon.2013.08.059","article-title":"The selective A-type K+ current blocker Tx3-1 isolated from the Phoneutria nigriventer venom enhances memory of naive and Abeta(25-35)-treated mice","volume":"76","author":"Gomes","year":"2013","journal-title":"Toxicon"},{"issue":"6","key":"10.1016\/j.toxicon.2014.04.017_bib12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0041-0101(75)90176-2","article-title":"Central neurotoxicity of apamin, crotamin, phospholipase A and alpha-amanitin","volume":"13","author":"Habermann","year":"1975","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxicon.2014.04.017_bib13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbr.2009.02.011","article-title":"The role of hippocampal nitric oxide (NO) on learning and immediate, short- and long-term memory retrieval in inhibitory avoidance task in male adult rats","volume":"201","author":"Harooni","year":"2009","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.toxicon.2014.04.017_bib14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/mus.23714","article-title":"Beneficial effect of crotamine in the treatment of myasthenic rats","volume":"47","author":"Hernandez-Oliveira e Silva","year":"2013","journal-title":"Muscle Nerve"},{"issue":"4","key":"10.1016\/j.toxicon.2014.04.017_bib15","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0306-4522(95)00319-E","article-title":"Dopamine D1 receptor ligands modulate cognitive performance and hippocampal acetylcholine release in memory-impaired aged rats","volume":"69","author":"Hersi","year":"1995","journal-title":"Neuroscience"},{"issue":"6636","key":"10.1016\/j.toxicon.2014.04.017_bib16","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/43119","article-title":"K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons","volume":"387","author":"Hoffman","year":"1997","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.toxicon.2014.04.017_bib17","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.1523\/JNEUROSCI.22-15-06781.2002","article-title":"Two time periods of hippocampal mRNA synthesis are required for memory consolidation of fear-motivated learning","volume":"22","author":"Igaz","year":"2002","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.toxicon.2014.04.017_bib18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0301-0082(03)00085-6","article-title":"Dopamine: a potential substrate for synaptic plasticity and memory mechanisms","volume":"69","author":"Jay","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.toxicon.2014.04.017_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnsyn.2013.00001","article-title":"Postsynaptic protein synthesis is required for presynaptic enhancement in persistent forms of long-term potentiation","volume":"5","author":"Johnstone","year":"2013","journal-title":"Front. Synaptic Neurosci."},{"issue":"12","key":"10.1016\/j.toxicon.2014.04.017_bib20","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1517\/13543784.2010.534457","article-title":"Biological versatility of crotamine \u2013 a cationic peptide from the venom of a South American rattlesnake","volume":"19","author":"Kerkis","year":"2010","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"2","key":"10.1016\/j.toxicon.2014.04.017_bib21","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbr.2010.11.033","article-title":"Acetylcholine and attention","volume":"221","author":"Klinkenberg","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"24","key":"10.1016\/j.toxicon.2014.04.017_bib22","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1007\/s00018-006-6315-0","article-title":"Snake venom components and their applications in biomedicine","volume":"63","author":"Koh","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.toxicon.2014.04.017_bib44","first-page":"511","article-title":"Transient Hippocampal Down-Regulation of Kv1.1 Subunit mRNA During Associative Learning in Rats","volume":"vol. 12","author":"Kourrich","year":"2005"},{"issue":"2","key":"10.1016\/j.toxicon.2014.04.017_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0091-3057(91)90272-4","article-title":"Interactive effects of D1 and D2 agonists with scopolamine on radial-arm maze performance","volume":"38","author":"Levin","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.toxicon.2014.04.017_bib24","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.neuroscience.2008.02.040","article-title":"Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in the hippocampal\u2013prefrontal cortex pathway of rats in\u00a0vivo: a possible involvement of monoaminergic systems","volume":"153","author":"Lopes Aguiar","year":"2008","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.toxicon.2014.04.017_bib25","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0041-0101(98)00117-2","article-title":"The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study","volume":"36","author":"Mancin","year":"1998","journal-title":"Toxicon"},{"issue":"2\u20133","key":"10.1016\/j.toxicon.2014.04.017_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0014-2999(98)00152-6","article-title":"Tension generation and increase in voltage-activated Na+ current by crotamine","volume":"348","author":"Matavel","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.toxicon.2014.04.017_bib27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0041-0101(89)90132-3","article-title":"Behavioural, electroencephalographic and neuropathological effects of the intrahippocampal injection of the venom of the South American rattlesnake (Crotalus durissus terrificus)","volume":"27","author":"Mello","year":"1989","journal-title":"Toxicon"},{"issue":"2\u20133","key":"10.1016\/j.toxicon.2014.04.017_bib28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0165-0173(02)00268-0","article-title":"Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasks","volume":"41","author":"Myhrer","year":"2003","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.toxicon.2014.04.017_bib29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnbeh.2012.00024","article-title":"Cholinergic modulation of cognitive processing: insights drawn from computational models","volume":"6","author":"Newman","year":"2012","journal-title":"Front. Behav. Neurosci."},{"issue":"2","key":"10.1016\/j.toxicon.2014.04.017_bib30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/15569549809009250","article-title":"Structure, function and biophysical aspects of the myotoxins from snake venoms","volume":"17","author":"Ownby","year":"1998","journal-title":"Toxin Rev."},{"key":"10.1016\/j.toxicon.2014.04.017_bib45","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"issue":"1","key":"10.1016\/j.toxicon.2014.04.017_bib31","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1124\/mol.112.078188","article-title":"Crotamine pharmacology revisited: novel insights based on the inhibition of KV channels","volume":"82","author":"Peigneur","year":"2012","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.toxicon.2014.04.017_bib32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J. Neurosci. Methods"},{"issue":"6","key":"10.1016\/j.toxicon.2014.04.017_bib33","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1101\/lm.6.6.600","article-title":"Two time windows of anisomycin-induced amnesia for inhibitory avoidance training in rats: protection from amnesia by pretraining but not pre-exposure to the task apparatus","volume":"6","author":"Quevedo","year":"1999","journal-title":"Learn. Mem."},{"issue":"2","key":"10.1016\/j.toxicon.2014.04.017_bib34","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bbr.2011.01.055","article-title":"Involvement of the cholinergic system in conditioning and perceptual memory","volume":"221","author":"Robinson","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"5943","key":"10.1016\/j.toxicon.2014.04.017_bib35","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1126\/science.1172545","article-title":"Dopamine controls persistence of long-term memory storage","volume":"325","author":"Rossato","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2014.04.017_bib36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nlm.2013.07.012","article-title":"Consolidation of object recognition memory requires simultaneous activation of dopamine D1\/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus","volume":"106","author":"Rossato","year":"2013","journal-title":"Neurobiol. Learn. Mem."},{"issue":"3","key":"10.1016\/j.toxicon.2014.04.017_bib37","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/ana.410430315","article-title":"End-plate voltage-gated sodium channels are lost in clinical and experimental myasthenia gravis","volume":"43","author":"Ruff","year":"1998","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.toxicon.2014.04.017_bib38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0165-0270(89)90124-6","article-title":"An improved method for tail-flick testing with adjustment for tail-skin temperature","volume":"26","author":"Tjolsen","year":"1989","journal-title":"J. Neurosci. Methods"},{"issue":"1","key":"10.1016\/j.toxicon.2014.04.017_bib39","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bandc.2009.10.013","article-title":"Developmental changes in dopamine neurotransmission in adolescence: behavioral implications and issues in assessment","volume":"72","author":"Wahlstrom","year":"2010","journal-title":"Brain Cogn."},{"issue":"10","key":"10.1016\/j.toxicon.2014.04.017_bib40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1101\/lm.026997.112","article-title":"Administration of the phosphodiesterase type 4 inhibitor rolipram into the amygdala at a specific time interval after learning increases recognition memory persistence","volume":"19","author":"Werenicz","year":"2012","journal-title":"Learn. Mem."},{"issue":"1","key":"10.1016\/j.toxicon.2014.04.017_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2012.02.002","article-title":"Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease","volume":"97","author":"Xu","year":"2012","journal-title":"Prog. Neurobiol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010114001263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010114001263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T06:10:48Z","timestamp":1565417448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010114001263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":45,"alternative-id":["S0041010114001263"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2014.04.017","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The intrahippocampal infusion of crotamine from Crotalus durissus terrificus venom enhances memory persistence in rats","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2014.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}