{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:59:25Z","timestamp":1791575965113,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Conselho Nacional de Pesquisa\/CNPq"},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa de Minas Gerais\/FAPEMIG","award":["APQ-04436-10"],"award-info":[{"award-number":["APQ-04436-10"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo\/FAPESP"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia (INCT-NanoBiofar)- Brazil"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.toxicon.2014.10.007","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T20:51:09Z","timestamp":1413406269000},"page":"81-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["DisBa-01 inhibits angiogenesis, inflammation and fibrogenesis of sponge-induced-fibrovascular tissue in mice"],"prefix":"10.1016","volume":"92","author":[{"given":"Puebla","family":"Cassini-Vieira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Ramos","family":"Deconte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Carla","family":"Tomiosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Peixoto","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyntia de Freitas","family":"Montenegro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heloisa Sobreiro","family":"Selistre-de-Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00edola Silva","family":"Barcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Passos","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda de Assis","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2014.10.007_bib1","first-page":"755","article-title":"Quantitative in-vivo studies on angiogenesis in a rat sponge model","volume":"68","author":"Andrade","year":"1987","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.toxicon.2014.10.007_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biopha.2009.03.003","article-title":"Atorvastatin inhibits inflammatory angiogenesis in mice through down regulation of VEGF, TNF-alpha and TGF-beta1","volume":"64","author":"Araujo","year":"2010","journal-title":"Biomed. Pharnacother."},{"key":"10.1016\/j.toxicon.2014.10.007_bib3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1189\/jlb.1104682","article-title":"Impaired inflammatory angiogenesis, but not leukocyte influx, in mice lacking TNFR1","volume":"78","author":"Barcelos","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.toxicon.2014.10.007_bib4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.mvr.2009.04.009","article-title":"Role of the chemokines CCL3\/MIP-1 alpha and CCL5\/RANTES in sponge-induced inflammatory angiogenesis in mice","volume":"78","author":"Barcelos","year":"2009","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.toxicon.2014.10.007_bib5","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nrm3599","article-title":"Integrins inactivators: balancing cellular functions in\u00a0vitro and in\u00a0vivo","volume":"14","author":"Bouvard","year":"2013","journal-title":"Nat.\u00a0Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.toxicon.2014.10.007_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.toxicon.2012.09.005","article-title":"The continuing saga of snake venom disintegrin","volume":"62","author":"Calvete","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2014.10.007_bib7","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1524-475X.2008.00381.x","article-title":"Mechanisms of wound healing responses in lupus-prone New Zealand White mouse stain","volume":"16","author":"Campos","year":"2008","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.toxicon.2014.10.007_bib8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrd3455","article-title":"Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases","volume":"10","author":"Carmeliet","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.toxicon.2014.10.007_bib9","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.semcancer.2009.05.002","article-title":"Integrins as \u201cfunctional hubs\u201d in the regulation of pathological angiogenesis","volume":"19","author":"Contois","year":"2009","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.toxicon.2014.10.007_bib10","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nrd3266","article-title":"Integrins as therapeutic targets: lessons and opportunities","volume":"9","author":"Cox","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.toxicon.2014.10.007_bib11","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1021\/mp3002733","article-title":"RGD-based strategies to target\u00a0alpha(v) beta(3) integrin in cancer therapy and diagnosis","volume":"9","author":"Danhier","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.toxicon.2014.10.007_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev-pathol-020712-163930","article-title":"Host responses in tissue repair and fibrosis","volume":"24","author":"Duffield","year":"2013","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.toxicon.2014.10.007_bib13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0955-0674(00)00252-0","article-title":"Adhesion events in angiogenesis","volume":"13","author":"Eliceiri","year":"2001","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.toxicon.2014.10.007_bib14","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1056\/NEJM199512283332608","article-title":"Clinical applications of research on angiogenesis","volume":"333","author":"Folkman","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.toxicon.2014.10.007_bib15","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nrc3627","article-title":"VEGF targets the tumor cell","volume":"13","author":"Goel","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.toxicon.2014.10.007_bib16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.tips.2012.04.002","article-title":"Integrins as therapeutic targets","volume":"33","author":"Goodman","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.toxicon.2014.10.007_bib17","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1538-7836.2010.04163.x","article-title":"Improvements in endotoxemic syndromes using a disintegrin, rhodostomin, through integrin \u03b1v\u03b23-dependent pathway","volume":"9","author":"Hsu","year":"2011","journal-title":"J. Tromb. Haemost."},{"key":"10.1016\/j.toxicon.2014.10.007_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5483\/BMBRep.2007.40.3.439","article-title":"Saxatilin suppresses tumor-induced angiogenesis by regulation VEGF expression in NCI-H460 human lung cancer cells","volume":"40","author":"Jang","year":"2007","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.toxicon.2014.10.007_bib19","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.mvr.2011.08.011","article-title":"Genetic background determines mouse strain differences in inflammatory angiogenesis","volume":"82","author":"Marques","year":"2011","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.toxicon.2014.10.007_bib20","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.biochi.2012.04.020","article-title":"Blocking \u03b1v\u03b23 integrin by a recombinant RGD disintegrin impairs VEGF signaling in endothelial cells","volume":"94","author":"Montenegro","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2014.10.007_bib21","doi-asserted-by":"crossref","first-page":"9343","DOI":"10.1073\/pnas.0803728105","article-title":"Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis","volume":"105","author":"Murphy","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2014.10.007_bib22","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/labinvest.3700350","article-title":"Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis","volume":"85","author":"Olfa","year":"2005","journal-title":"Lab. Investig."},{"key":"10.1016\/j.toxicon.2014.10.007_bib23","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.toxicon.2012.02.005","article-title":"Sponge implant in swiss mice as a model for studying loxoscelism","volume":"59","author":"Pereira","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2014.10.007_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10585-007-9101-y","article-title":"A novel alpha(v)beta (3)-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis","volume":"25","author":"Ramos","year":"2008","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.toxicon.2014.10.007_bib25","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1111\/febs.12160","article-title":"Synstatin: a selective inhibitor of the syndecan-1-coupled IGF!R- av\u03b23 integrin complex in tumorigenesis and angiogenesis","volume":"10","author":"Rapraeger","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.toxicon.2014.10.007_bib26","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ceb.2011.03.014","article-title":"The role of \u03b23-integrins in tumor angiogenesis: context is everything","volume":"23","author":"Robinson","year":"2011","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.toxicon.2014.10.007_bib27","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.3390\/toxins2112606","article-title":"Snake venom disintegrins and cell migration","volume":"11","author":"Selistre-de-Araujo","year":"2010","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.toxicon.2014.10.007_bib28","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1161\/ATVBAHA.108.172015","article-title":"Integrins: the keys to unlocking angiogenesis","volume":"10","author":"Silva","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.toxicon.2014.10.007_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12013-008-9040-5","article-title":"Integrin and growth factor receptor alliance in angiogenesis","volume":"53","author":"Somanath","year":"2009","journal-title":"Cell. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2014.10.007_bib30","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm.2537","article-title":"Tumor angiogenesis: molecular pathways and therapeutic targets","volume":"17","author":"Weis","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.toxicon.2014.10.007_bib31","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1172\/JCI31487","article-title":"Common and unique mechanism regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.toxicon.2014.10.007_bib32","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1124\/mol.59.5.1333","article-title":"Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective alpha(v) beta(3) blockade of endothelial cells","volume":"59","author":"Yeh","year":"2001","journal-title":"Mol. Pharmacol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010114003389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010114003389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T07:05:19Z","timestamp":1565939119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010114003389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":32,"alternative-id":["S0041010114003389"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2014.10.007","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DisBa-01 inhibits angiogenesis, inflammation and fibrogenesis of sponge-induced-fibrovascular tissue in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2014.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}