{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:21:21Z","timestamp":1792192881378,"version":"4.4.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Deputy of Research Affairs of Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"crossref","award":["U-86089"],"award-info":[{"award-number":["U-86089"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.toxicon.2015.03.023","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T09:14:43Z","timestamp":1428311683000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["A forward to optimization of antivenom therapy: An in\u00a0vivo study upon the effectiveness of the antivenom against early and delayed nephrotoxicity induced by the venom of the Iranian scorpion Hemiscorpius lepturus in rat"],"prefix":"10.1016","volume":"100","author":[{"given":"Mohammad Hassan","family":"Pipelzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Jalali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rahman","family":"Dezfulian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra Nazari","family":"Khorasgani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somie","family":"Sarvestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein","family":"Ghalambor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armita","family":"Azarpanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2015.03.023_bib1","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1093\/ndt\/17.11.1890","article-title":"Urinary N-acetyl-beta-glucosaminidase excretion is a marker of tubular cell dysfunction and a predictor of outcome in primary glomerulonephritis","volume":"17","author":"Bazzi","year":"2002","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.toxicon.2015.03.023_bib2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.toxicon.2013.03.012","article-title":"The pathological effects of Heminecrolysin, a dermonecrotic toxin from Hemiscorpius lepturus scorpion venom are mediated through its lysophospholipase D activity","volume":"68","author":"Borchani","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.03.023_bib3","first-page":"345","article-title":"Classification and biology of scorpions","volume":"vol. III","author":"Bucheri","year":"1971"},{"key":"10.1016\/j.toxicon.2015.03.023_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/08860229409044857","article-title":"Urinary enzymes as biomarkers of renal injury in experimental nephrotoxicity of immunosuppressive drugs","volume":"16","author":"Burdmann","year":"1994","journal-title":"Ren. Fail."},{"key":"10.1016\/j.toxicon.2015.03.023_bib6","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.3109\/0886022X.2013.828367","article-title":"Is the urinary biomarkers assessment a non-invasive approach to tubular lesions of the solitary kidney?","volume":"35","author":"Gadalean","year":"2013","journal-title":"Ren. Fail."},{"key":"10.1016\/j.toxicon.2015.03.023_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/oxfordjournals.ndt.a027066","article-title":"Cisplatin nephrotoxicity and protection by silibinin","volume":"11","author":"Gaedeke","year":"1996","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.toxicon.2015.03.023_bib9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2165\/00003088-200342080-00002","article-title":"Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation","volume":"42","author":"Guti\u00e9rrez","year":"2003","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.toxicon.2015.03.023_bib10","series-title":"Handbook of Toxins","first-page":"577","article-title":"Production of scorpion antivenom","volume":"vol. 2","author":"Hassan","year":"1984"},{"key":"10.1016\/j.toxicon.2015.03.023_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/105172397243132","article-title":"An improved method for evaluation of nephrotoxicity by assay of urinary N-acetyl-\u03b2-D-glucosaminidase (NAG) activity","volume":"7","author":"Hosseini","year":"1997","journal-title":"Toxicol. Methods"},{"key":"10.1016\/j.toxicon.2015.03.023_bib12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/105172397243105","article-title":"An improved kinetic method for measurement of urinary alanine aminopeptidase (AAP) activity as a nephrotoxic marker","volume":"7","author":"Hosseini","year":"1997","journal-title":"Toxicol. Methods"},{"key":"10.1016\/j.toxicon.2015.03.023_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJMra1401108","article-title":"Scorpion envenomation","volume":"371","author":"Isbister","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.toxicon.2015.03.023_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0041-0101(88)90215-2","article-title":"Are the toxicological effects of scorpion envenoming related to tissue venom concentration?","volume":"26","author":"Ismail","year":"1988","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.03.023_bib16","first-page":"1","article-title":"The pharmacokinetics of Hemiscorpius lepturus scorpion venom and Razi antivenom following intramuscular administration in rat","volume":"3","author":"Jalali","year":"2012","journal-title":"J.\u00a0Venom. Res."},{"key":"10.1016\/j.toxicon.2015.03.023_bib17","first-page":"743","article-title":"Epidemiological review of scorpion envenoming in Iran","volume":"13","author":"Jalali","year":"2014","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.toxicon.2015.03.023_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.toxicon.2009.09.012","article-title":"A\u00a0review of epidemiological, clinical and in\u00a0vitro physiological studies of envenoming by the scorpion Hemiscorpius lepturus (Hemiscorpiidae) in Iran","volume":"55","author":"Jalali","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.03.023_bib19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1684\/ecn.2011.0278","article-title":"Serum TNF-a levels reflect the clinical severity of envenoming following a Hemiscorpius lepturus sting","volume":"22","author":"Jalali","year":"2011","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.toxicon.2015.03.023_bib20","first-page":"1","article-title":"In\u00a0vitro pharmacological study upon the effectiveness of available antivenom against Hemiscorpius lepturus venom","volume":"6","author":"Jalali","year":"2011","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"10.1016\/j.toxicon.2015.03.023_bib21","first-page":"85","article-title":"Preparation of a potent anti-scorpion-venom-serum against the venom of red scorpion (Buthus tamales)","volume":"44","author":"Kanokonkar","year":"1988","journal-title":"J.\u00a0Postgrad. Med."},{"key":"10.1016\/j.toxicon.2015.03.023_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.toxicon.2006.04.017","article-title":"In\u00a0vitro and in\u00a0vivo studies on some toxic effects of the venom from Hemiscorpious lepturus scorpion","volume":"48","author":"Pipelzadeh","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.03.023_bib23","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.toxicon.2007.07.018","article-title":"An epidemiological and a clinical study on scorpionism by the Iranian scorpion Hemiscorpius lepturus","volume":"50","author":"Pipelzadeh","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.03.023_bib24","first-page":"327","article-title":"Clinical study of Hemiscorpius lepturus sting in Iran: a clinical study","volume":"93","author":"Radmanesh","year":"1990","journal-title":"J.\u00a0Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2015.03.023_bib25","first-page":"295","article-title":"A\u00a0biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats","volume":"18","author":"Seyedian","year":"2012","journal-title":"J.\u00a0Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2015.03.023_bib27","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4103\/0971-4065.45293","article-title":"Hemolytic uremic syndrome following Hemiscorpius lepturus (scorpion) sting","volume":"18","author":"Valavi","year":"2008","journal-title":"Indian J. Nephrol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010115000914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010115000914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T14:12:58Z","timestamp":1598883178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010115000914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":23,"alternative-id":["S0041010115000914"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2015.03.023","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A forward to optimization of antivenom therapy: An in\u00a0vivo study upon the effectiveness of the antivenom against early and delayed nephrotoxicity induced by the venom of the Iranian scorpion Hemiscorpius lepturus in rat","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2015.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}