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Biophys. Res. Commun."},{"issue":"Pt 12","key":"10.1016\/j.toxicon.2015.09.009_bib78","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1099\/00221287-143-12-3841","article-title":"The haemagglutinin of Clostridium botulinum type C progenitor toxin plays an essential role in binding of toxin to the epithelial cells of guinea pig small intestine, leading to the efficient absorption of the toxin","volume":"143","author":"Fujinaga","year":"1997","journal-title":"Microbiology"},{"key":"10.1016\/j.toxicon.2015.09.009_bib79","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1099\/mic.0.26805-0","article-title":"Molecular characterization of binding subcomponents of Clostridium botulinum type C progenitor toxin for intestinal epithelial cells and erythrocytes","volume":"150","author":"Fujinaga","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.toxicon.2015.09.009_bib80","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0014-5793(95)01241-5","article-title":"Molecular characterization of two forms of nontoxic-nonhemagglutinin components of Clostridium botulinum type A progenitor toxins","volume":"376","author":"Fujita","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2015.09.009_bib81","doi-asserted-by":"crossref","first-page":"27668","DOI":"10.1074\/jbc.M802557200","article-title":"Membrane interaction of botulinum neurotoxin A translocation (T) domain. 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Microbiol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib107","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1574-6968.1993.tb06081.x","article-title":"Genetic interrelationships of saccharolytic Clostridium botulinum types B, E and F and related clostridia as revealed by small-subunit rRNA gene sequences","volume":"108","author":"Hutson","year":"1993","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.toxicon.2015.09.009_bib108","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.1074\/jbc.271.18.10786","article-title":"Genetic characterization of Clostridium botulinum type A containing silent type B neurotoxin gene sequences","volume":"271","author":"Hutson","year":"1996","journal-title":"J.\u00a0Biol. 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Microbiol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib115","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1099\/mic.0.2008\/016915-0","article-title":"Phylogenetic analysis of Clostridium botulinum type A by multi-locus sequence typing","volume":"154","author":"Jacobson","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.toxicon.2015.09.009_bib116","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0306-4522(99)00370-X","article-title":"SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family","volume":"94","author":"Janz","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.toxicon.2015.09.009_bib117","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/prot.20595","article-title":"Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin","volume":"61","author":"Jayaraman","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.toxicon.2015.09.009_bib118","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/nature05387","article-title":"Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity","volume":"444","author":"Jin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2015.09.009_bib119","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1099\/mic.0.021246-0","article-title":"Disruption of the epithelial barrier by botulinum haemagglutinin (HA) proteins - differences in cell tropism and the mechanism of action between HA proteins of types A or B, and HA proteins of type C","volume":"155","author":"Jin","year":"2009","journal-title":"Microbiology"},{"key":"10.1016\/j.toxicon.2015.09.009_bib120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1099\/00221287-88-2-229","article-title":"Taxonomy of the Clostridia: ribosomal ribonucleic acid homologies among the species","volume":"88","author":"Johnson","year":"1975","journal-title":"J.\u00a0Gen. Microbiol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib121","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1128\/AEM.01662-10","article-title":"Different substrate recognition requirements for cleavage of synaptobrevin-2 by Clostridium baratii and Clostridium botulinum type F neurotoxins","volume":"77","author":"Kalb","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib122","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1021\/ac504716v","article-title":"Functional characterization of botulinum neurotoxin serotype H as a hybrid of known serotypes F and A (BoNT F\/A)","volume":"87","author":"Kalb","year":"2015","journal-title":"Anal. 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Lett."},{"key":"10.1016\/j.toxicon.2015.09.009_bib128","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.micpath.2006.10.006","article-title":"Differential contribution of the residues in C-terminal half of the heavy chain of botulinum neurotoxin type B to its binding to the ganglioside GT1b and the synaptotagmin 2\/GT1b complex","volume":"42","author":"Kohda","year":"2007","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.toxicon.2015.09.009_bib129","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nsb879","article-title":"Translocation of botulinum neurotoxin light chain protease through the heavy chain channel","volume":"10","author":"Koriazova","year":"2003","journal-title":"Nat. Struct. 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Lett."},{"key":"10.1016\/j.toxicon.2015.09.009_bib135","doi-asserted-by":"crossref","first-page":"e0116381","DOI":"10.1371\/journal.pone.0116381","article-title":"Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype","volume":"10","author":"Kull","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.toxicon.2015.09.009_bib136","first-page":"2647","article-title":"Binding and cytotoxic effects of Clostridium botulinum type A, C1 and E toxins in primary neuron cultures from foetal mouse brains","volume":"133","author":"Kurokawa","year":"1987","journal-title":"J.\u00a0Gen. Microbiol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib137","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.sbi.2015.03.013","article-title":"Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery","volume":"31","author":"Lam","year":"2015","journal-title":"Curr. Opin. Struct. 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Microbiol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib145","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/AEM.01882-09","article-title":"Expression of the Clostridium botulinum A2 neurotoxin gene cluster proteins and characterization of the A2 complex","volume":"76","author":"Lin","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib146","doi-asserted-by":"crossref","first-page":"6094","DOI":"10.1128\/AEM.01009-09","article-title":"Neurotoxin gene clusters in Clostridium botulinum type Ab strains","volume":"75","author":"Luquez","year":"2009","journal-title":"Appl. Environ. 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J."},{"key":"10.1016\/j.toxicon.2015.09.009_bib151","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1128\/IAI.67.9.4708-4712.1999","article-title":"Pure botulinum neurotoxin is absorbed from the stomach and small intestine and produces peripheral neuromuscular blockade","volume":"67","author":"Maksymowych","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.toxicon.2015.09.009_bib152","doi-asserted-by":"crossref","first-page":"21950","DOI":"10.1074\/jbc.273.34.21950","article-title":"Binding and transcytosis of botulinum neurotoxin by polarized human colon carcinoma cells","volume":"273","author":"Maksymowych","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.toxicon.2015.09.009_bib153","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1124\/jpet.104.066845","article-title":"Structural features of the botulinum neurotoxin molecule that govern binding and transcytosis across polarized human intestinal epithelial cells","volume":"310","author":"Maksymowych","year":"2004","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxicon.2015.09.009_bib154","doi-asserted-by":"crossref","first-page":"5698","DOI":"10.1128\/IAI.66.12.5698-5702.1998","article-title":"TetR is a positive regulator of the tetanus toxin gene in Clostridium tetani and is homologous to botR","volume":"66","author":"Marvaud","year":"1998","journal-title":"Infect. 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Sci."},{"key":"10.1016\/j.toxicon.2015.09.009_bib171","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0167-4781(96)00006-1","article-title":"Mosaic structures of neurotoxins produced from Clostridium botulinum types C and D organisms","volume":"1307","author":"Moriishi","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2015.09.009_bib172","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1128\/AEM.62.2.662-667.1996","article-title":"Molecular cloning of the gene encoding the mosaic neurotoxin, composed of parts of botulinum neurotoxin types C1 and D, and PCR detection of this gene from Clostridium botulinum type C organisms","volume":"62","author":"Moriishi","year":"1996","journal-title":"Appl. Environ. 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Biophys. Acta"},{"key":"10.1016\/j.toxicon.2015.09.009_bib179","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jmb.2007.12.031","article-title":"Sugar-binding sites of the HA1 subcomponent of Clostridium botulinum type C progenitor toxin","volume":"376","author":"Nakamura","year":"2008","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib180","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.abb.2011.05.012","article-title":"Molecular diversity of the two sugar-binding sites of the beta-trefoil lectin HA33\/C (HA1) from Clostridium botulinum type C neurotoxin","volume":"512","author":"Nakamura","year":"2011","journal-title":"Arch. Biochem. 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Cell Physiol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib186","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1128\/IAI.16.1.107-109.1977","article-title":"Oral toxicities of Clostridium botulinum toxins in response to molecular size","volume":"16","author":"Ohishi","year":"1977","journal-title":"Infect. Immun."},{"key":"10.1016\/j.toxicon.2015.09.009_bib187","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/newbio244157a0","article-title":"Tetanus toxin inhibits amino acid release from nerve endings in\u00a0vitro","volume":"244","author":"Osborne","year":"1973","journal-title":"Nat. New Biol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib188","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/(SICI)1096-9861(19960401)367:2<222::AID-CNE5>3.0.CO;2-7","article-title":"Common and distinct fusion proteins in axonal growth and transmitter release","volume":"367","author":"Osen-Sand","year":"1996","journal-title":"J.\u00a0Comp. 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Physiol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib192","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1242\/jcs.103564","article-title":"Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins","volume":"125","author":"Peng","year":"2012","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.toxicon.2015.09.009_bib193","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/ncomms2462","article-title":"Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival","volume":"4","author":"Peng","year":"2013","journal-title":"Nat. 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Microbiol."},{"key":"10.1016\/j.toxicon.2015.09.009_bib200","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.anaerobe.2004.01.001","article-title":"Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani","volume":"10","author":"Raffestin","year":"2004","journal-title":"Anaerobe"},{"key":"10.1016\/j.toxicon.2015.09.009_bib201","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1128\/AEM.03109-09","article-title":"Sequence diversity of genes encoding botulinum neurotoxin type F","volume":"76","author":"Raphael","year":"2010","journal-title":"Appl. Environ. 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