{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:57:17Z","timestamp":1777489037678,"version":"3.51.4"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.toxicon.2015.09.041","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T07:45:33Z","timestamp":1445759133000},"page":"154-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity"],"prefix":"10.1016","volume":"108","author":[{"given":"Daniela Regina","family":"Buch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Nunes","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Otto","family":"Meissner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano Marcelo","family":"Morgon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Helena","family":"Gremski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria Pereira","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilza","family":"Trevisan-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Hitomi","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Boia-Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef Bacila","family":"Sade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Chaves-Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemiro","family":"Gremski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio Sanches","family":"Veiga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Meiri","family":"Chaim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Senff-Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.toxicon.2015.09.041_bib1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.toxicon.2003.09.006","article-title":"Production of monoclonal antibodies capable of neutralizing dermonecrotic activity of Loxosceles intermedia spider venom and their use in a specific immunometric assay","volume":"42","author":"Alvarenga","year":"2003","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxicon.2015.09.041_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tcb.2012.10.002","article-title":"TPT1\/TCTP-regulated pathways in phenotypic reprogramming","volume":"23","author":"Amson","year":"2013","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.toxicon.2015.09.041_bib3","first-page":"152","article-title":"Insights into brown spider and loxoscelism","volume":"2","author":"Appel","year":"2005","journal-title":"Invertebr. Surviv J."},{"key":"10.1016\/j.toxicon.2015.09.041_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbagen.2007.11.007","article-title":"Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase D) from brown spider (Loxosceles intermedia) venom","volume":"1780","author":"Appel","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.toxicon.2015.09.041_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0041-0101(02)00282-9","article-title":"Protection against dermonecrotic and lethal activities of Loxosceles intermedia spider venom by immunization with a fused recombinant protein","volume":"41","author":"Araujo","year":"2003","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxicon.2015.09.041_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0041-0101(94)90027-2","article-title":"Antigenic cross-reactivity of venoms from medically important Loxosceles (Araneae) species in Brazil","volume":"32","author":"Barbaro","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib7","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.toxicon.2004.12.009","article-title":"Enzymatic characterization, antigenic cross-reactivity and neutralization of dermonecrotic activity of five Loxosceles spider venoms of medical importance in the Americas","volume":"45","author":"Barbaro","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib8","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/molbev\/msn274","article-title":"Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms","volume":"26","author":"Binford","year":"2009","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.toxicon.2015.09.041_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1357-2725(03)00213-9","article-title":"The translationally controlled tumour protein (TCTP)","volume":"36","author":"Bommer","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.toxicon.2015.09.041_bib10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A\u00a0rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of Protein-Dye-Binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.toxicon.2015.09.041_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.taap.2005.05.015","article-title":"Brown spider dermonecrotic toxin directly induces nephrotoxicity","volume":"211","author":"Chaim","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxicon.2015.09.041_bib12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/toxins3030309","article-title":"Brown spider (Loxosceles genus) venom toxins: tools for biological purposes","volume":"3","author":"Chaim","year":"2011","journal-title":"Toxins"},{"issue":"2","key":"10.1016\/j.toxicon.2015.09.041_bib13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbalip.2010.11.005","article-title":"Phospholipase-D activity and inflammatory response induced by brown spider dermonecrotic toxin: endothelial cell membrane phospholipids as targets for toxicity","volume":"1811","author":"Chaim","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.toxicon.2015.09.041_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.toxicon.2012.03.007","article-title":"Cutaneous loxoscelism caused by Loxosceles similis venom and neutralization capacity of its specific antivenom","volume":"60","author":"Chatzaki","year":"2012","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.toxicon.2015.09.041_bib15","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0041-0101(97)00159-1","article-title":"ELISA for the detection of venom antigens in experimental and clinical envenoming by Loxosceles intermedia spiders","volume":"36","author":"Ch\u00e1vez-Ol\u00f3rtegui","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.toxicon.2004.07.012","article-title":"Brown spiders and loxoscelism","volume":"44","author":"da Silva","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib17","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0041-0101(02)00078-8","article-title":"Identification of proteases in the extract of venom glands from brown spiders","volume":"40","author":"da Silveira","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib18","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.biochi.2006.02.008","article-title":"Molecular cloning and functional characterization of two isoforms of dermonecrotic toxin from Loxosceles intermedia (brown spider) venom gland","volume":"88","author":"da Silveira","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2015.09.041_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.biochi.2006.12.002","article-title":"Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from brown spider (Loxosceles intermedia) venom: from cloning to functional characterization","volume":"89","author":"da Silveira","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2015.09.041_bib20","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.toxicon.2006.11.024","article-title":"Hyaluronidases in Loxosceles intermedia (Brown spider) venom are endo-beta-N-acetyl-dhexosaminidases hydrolases","volume":"49","author":"da Silveira","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.toxicon.2004.05.028","article-title":"Identification and molecular cloning of insecticidal toxins from the venom of the brown spider Loxosceles intermedia","volume":"44","author":"de Castro","year":"2004","journal-title":"Toxicon"},{"issue":"45","key":"10.1016\/j.toxicon.2015.09.041_bib22","doi-asserted-by":"crossref","first-page":"7992","DOI":"10.1016\/j.vaccine.2011.08.065","article-title":"Protection against the toxic effects of Loxosceles intermedia spider venom elicited by mimotope peptides","volume":"29","author":"de Moura","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.toxicon.2015.09.041_bib23","doi-asserted-by":"crossref","first-page":"933","DOI":"10.2174\/092986609788923383","article-title":"Brown recluse spider venom: proteomic analysis and proposal of a putative mechanism of action","volume":"16","author":"dos Santos","year":"2009","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.toxicon.2015.09.041_bib24","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.toxicon.2009.09.019","article-title":"A\u00a0protective immune response against lethal, dermonecrotic and hemorrhagic effects of Loxosceles intermedia venom elicited by a 27-residue peptide","volume":"55","author":"Dias-Lopes","year":"2010","journal-title":"Toxicon"},{"issue":"18","key":"10.1016\/j.toxicon.2015.09.041_bib25","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1016\/j.vaccine.2014.02.012","article-title":"Generation and molecular characterization of a monoclonal antibody reactive with conserved epitope in sphingomyelinases D from Loxosceles spider venoms","volume":"32","author":"Dias-Lopes","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.toxicon.2015.09.041_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.toxicon.2014.10.023","article-title":"Anti-loxoscelic horse serum produced against a recombinant dermonecrotic protein of Brazilian Loxosceles intermedia spider neutralize lethal effects of Loxosceles laeta venom from Peru","volume":"93","author":"Duarte","year":"2015","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxicon.2015.09.041_bib27","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/JVI.55.3.836-839.1985","article-title":"Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide","volume":"55","author":"Emini","year":"1985","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.toxicon.2015.09.041_bib28","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0041-0101(97)00083-4","article-title":"Detection and characterization of metalloproteinases with gelatinolytic, fibronectinolytic and fibrinogenolytic activities in brown spider (Loxosceles intermedia) venom","volume":"36","author":"Feitosa","year":"1998","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.toxicon.2015.09.041_bib29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.toxicon.2006.06.019","article-title":"Functional characterization and epitope analysis of a recombinant dermonecrotic protein from Loxosceles intermedia spider","volume":"48","author":"Felicori","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib30","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1016\/j.vaccine.2009.04.038","article-title":"An in\u00a0vivo protective response against toxic effects of the dermonecrotic protein from Loxosceles intermedia spider venom elicited by synthetic epitopes","volume":"27","author":"Felicori","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.toxicon.2015.09.041_bib31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/1471-2164-9-279","article-title":"Transcriptome analysis of Loxosceles laeta (Araneae, Sicariidae) spider venomous gland using expressed sequence tags","volume":"9","author":"Fernandes-Pedrosa","year":"2008","journal-title":"BMC Genomics"},{"issue":"5","key":"10.1016\/j.toxicon.2015.09.041_bib32","doi-asserted-by":"crossref","first-page":"e2206","DOI":"10.1371\/journal.pntd.0002206","article-title":"A\u00a0novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization","volume":"7","author":"Ferrer","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2015.09.041_bib33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.toxicon.2014.05.007","article-title":"Innovative immunization protocols using chimeric recombinant protein for the production of polyspecific loxoscelic antivenom in horses","volume":"86","author":"Figueiredo","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00000441-199210000-00008","volume":"304","author":"Futrell","year":"1992","journal-title":"Loxoscelism. Am. J. Med. Sci."},{"key":"10.1016\/j.toxicon.2015.09.041_bib35","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.lfs.2007.02.037","article-title":"The magic glue hyaluronan and its eraser hyaluronidase: a biological overview","volume":"80","author":"Girish","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2015.09.041_bib36","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1039\/c004118a","article-title":"A\u00a0novel expression profile of the Loxosceles intermedia spider venomous gland revealed by transcriptome analysis","volume":"6","author":"Gremski","year":"2010","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.toxicon.2015.09.041_bib37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxicon.2014.02.023","article-title":"Recent advances in the understanding of brown spider venoms: from the biology of spiders to the molecular mechanisms of toxins","volume":"83","author":"Gremski","year":"2014","journal-title":"Toxicon"},{"issue":"9","key":"10.1016\/j.toxicon.2015.09.041_bib38","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0041-0101(01)00085-X","article-title":"Neutralization of dermonecrotic and lethal activities and differences among 32-35 kDa toxins of medically important Loxosceles spider venoms in Brazil revealed by monoclonal antibodies","volume":"39","author":"Guilherme","year":"2001","journal-title":"Toxicon"},{"issue":"6","key":"10.1016\/j.toxicon.2015.09.041_bib39","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.annemergmed.2004.08.028","article-title":"Loxoscelism: old obstacles, new directions","volume":"44","author":"Hogan","year":"2004","journal-title":"Ann. Emerg. Med."},{"issue":"12","key":"10.1016\/j.toxicon.2015.09.041_bib40","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/S0041-0101(02)00201-5","article-title":"Molecular cloning, expression and immunological properties of LiD1, a protein from the dermonecrotic family of Loxosceles intermedia spider venom","volume":"40","author":"Kalapothakis","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib41","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.toxicon.2007.07.001","article-title":"The Loxtox protein family in Loxosceles intermedia (Mello-Leitao) venom","volume":"50","author":"Kalapothakis","year":"2007","journal-title":"Toxicon"},{"issue":"1\u20132","key":"10.1016\/j.toxicon.2015.09.041_bib42","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","article-title":"A\u00a0semi-empirical method for prediction of antigenic determinants on protein antigens","volume":"276","author":"Kolaskar","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2015.09.041_bib43","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-7580-2-2","article-title":"Improved method for predicting linear B-cell epitopes","volume":"2","author":"Larsen","year":"2006","journal-title":"Immunome Res."},{"key":"10.1016\/j.toxicon.2015.09.041_bib44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/002215540405200404","article-title":"Experimental evidence for a direct cytotoxicity of Loxosceles intermedia (brown spider) venom in renal tissue","volume":"52","author":"Luciano","year":"2004","journal-title":"J.\u00a0Histochem Cytochem"},{"key":"10.1016\/j.toxicon.2015.09.041_bib45","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1002\/pmic.200401096","article-title":"Proteome analysis of brown spider venom: identification of loxnecrogin isoforms in Loxosceles gaucho venom","volume":"5","author":"Machado","year":"2005","journal-title":"Proteomics"},{"key":"10.1016\/j.toxicon.2015.09.041_bib46","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.toxicon.2013.05.014","article-title":"A\u00a0novel ICK peptide from the Loxosceles intermedia (brown spider) venom gland: cloning, heterologous expression and immunological cross-reactivity approaches","volume":"71","author":"Matsubara","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib47","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1016\/j.vaccine.2013.03.048","article-title":"Generation and characterization of a recombinant chimeric protein (rCpLi) consisting of B-cell epitopes of a dermonecrotic protein from Loxosceles intermedia spider venom","volume":"31","author":"Mendes","year":"2013","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.toxicon.2015.09.041_bib48","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.toxicon.2009.01.033","article-title":"Analysis of therapeutic benefits of antivenin at different time intervals after experimental envenomation in rabbits by venom of the brown spider (Loxosceles intermedia)","volume":"53","author":"Pauli","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib49","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/1471-2105-9-514","article-title":"ElliPro: a new structure-based tool for the prediction of antibody epitopes","volume":"9","author":"Ponomarenko","year":"2008","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.toxicon.2015.09.041_bib50","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.toxicon.2004.06.013","article-title":"Genetic and enzymatic characterization of sphingomyelinase D isoforms from the North American fiddleback spiders Loxosceles boneti and Loxosceles reclusa","volume":"44","author":"Ramos-Cerrillo","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.toxicon.2013.07.007","article-title":"Synthetic peptides for in\u00a0vitro evaluation of the neutralizing potency of Loxosceles antivenoms","volume":"73","author":"Ramada","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib52","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.toxicon.2007.08.001","article-title":"Biological and structural comparison of recombinant phospholipase D toxins from Loxosceles intermedia (brown spider) venom","volume":"50","author":"Ribeiro","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib53","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.biocel.2011.10.013","article-title":"Molecular cloning, heterologous expression and functional characterization of a novel translationally controlled tumor protein (TCTP) family member from Loxosceles intermedia (Brown spider) venom","volume":"44","author":"Sade","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.toxicon.2015.09.041_bib54","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.biotechadv.2007.12.003","article-title":"Biotechnological applications of brown spider (Loxosceles genus) venom toxins","volume":"26","author":"Senff-Ribeiro","year":"2008","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.toxicon.2015.09.041_bib55","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.clindermatol.2005.11.006","article-title":"Loxoscelism","volume":"24","author":"Swanson","year":"2006","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.toxicon.2015.09.041_bib56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.biochi.2009.10.003","article-title":"Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles)","volume":"92","author":"Trevisan-Silva","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2015.09.041_bib57","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.toxicon.2013.08.065","article-title":"Differential metalloprotease content and activity of three Loxosceles spider venoms revealed using two-dimensional electrophoresis approaches","volume":"76","author":"Trevisan-Silva","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib58","doi-asserted-by":"crossref","first-page":"15364","DOI":"10.1073\/pnas.0406776101","article-title":"Translationally controlled tumor protein is a target of tumor reversion","volume":"101","author":"Tuynder","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2015.09.041_bib59","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0041-0101(99)00197-X","article-title":"Identification of high molecular weight serine-proteases in Loxosceles intermedia (brown spider) venom","volume":"38","author":"Veiga","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib60","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1590\/S0100-879X2001000700002","article-title":"Extracellular matrix molecules as targets for brown spider venom toxins","volume":"34","author":"Veiga","year":"2001","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.toxicon.2015.09.041_bib61","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0049-3848(01)00254-7","article-title":"In\u00a0vivo and in\u00a0vitro cytotoxicity of brown spider venom for blood vessel endothelial cells","volume":"102","author":"Veiga","year":"2001","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2015.09.041_bib62","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.toxicon.2013.01.027","article-title":"Modulation of membrane phospholipids, the cytosolic calcium influx and cell proliferation following treatment of B16-F10 cells with recombinant phospholipase-D from Loxosceles intermedia (Brown spider) venom","volume":"67","author":"Wille","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.09.041_bib63","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0041-0101(00)00145-8","article-title":"Comparison of enzymatic activity from three species of necrotising arachnids in Australia: Loxosceles rufescens, Badumna insignis and Lampona cylindrata","volume":"39","author":"Young","year":"2001","journal-title":"Toxicon"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010115300982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010115300982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T06:57:06Z","timestamp":1599721026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010115300982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":63,"alternative-id":["S0041010115300982"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2015.09.041","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2015.09.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}