{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:06:18Z","timestamp":1780412778550,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Maulana Azad National Fellowship"},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.toxicon.2015.10.011","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T23:12:37Z","timestamp":1446505957000},"page":"216-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Russell's viper venom affects regulation of small GTPases and causes nuclear damage"],"prefix":"10.1016","volume":"108","author":[{"given":"Jigni","family":"Pathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansie","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajdeep","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibakar","family":"Chakrabarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angshuman","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2015.10.011_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/bcmd.2000.0357","article-title":"Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis","volume":"27","author":"Abraham","year":"2001","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.toxicon.2015.10.011_bib2","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1259\/bjr\/54004230","article-title":"Resazurin assay of radiation response in cultured cells","volume":"78","author":"Anoopkumar-Dukie","year":"2005","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.toxicon.2015.10.011_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0079-6603(01)67029-6","article-title":"Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors","volume":"67","author":"Aznar","year":"2001","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"issue":"Pt 2","key":"10.1016\/j.toxicon.2015.10.011_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj3480241","article-title":"Rho GTPases and their effector proteins","volume":"348","author":"Bishop","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2015.10.011_bib5","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2174\/092986606777790520","article-title":"Cytotoxic action in myoblasts and myotubes (C2C12) and enzymatic characterization of a new phospholipase A2 isoform (Bj-V) from Bothrops jararacussu venom","volume":"13","author":"Bonfim","year":"2006","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.toxicon.2015.10.011_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1590\/S1678-91992009000100004","article-title":"Cytotoxicity and morphological analysis of cell death induced by Bothrops venoms from the northeast of Argentina","volume":"15","author":"Bustillo","year":"2009","journal-title":"J.\u00a0Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2015.10.011_bib7","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0041-0101(99)00243-3","article-title":"Haemorrhagic protein of Russell's viper venom with fibrinolytic and esterolytic activities","volume":"38","author":"Chakrabarty","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.10.011_bib8","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrc883","article-title":"The Bcl2 family: regulators of the cellular life-or-death switch","volume":"2","author":"Cory","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.toxicon.2015.10.011_bib9","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.toxicon.2006.11.014","article-title":"Cytotoxicity of Lachesis muta muta snake (bushmaster) venom and its purified basic phospholipase A2 (LmTX-I) in cultured cells","volume":"49","author":"Damico","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.10.011_bib10","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1053\/j.gastro.2009.01.070","article-title":"Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms","volume":"136","author":"Dudeja","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.toxicon.2015.10.011_bib11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.toxicon.2015.10.011_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00441-002-0653-5","article-title":"Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C","volume":"311","author":"Fuchs","year":"2003","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.toxicon.2015.10.011_bib13","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0014-5793(03)01294-8","article-title":"Caspase 8 mediated apoptotic cell death induced by beta-sheet forming polyalanine peptides","volume":"555","author":"Giri","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2015.10.011_bib14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","article-title":"Rho GTPases and the actin cytoskeleton","volume":"279","author":"Hall","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2015.10.011_bib15","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1111\/j.1742-4658.2009.06989.x","article-title":"ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells","volume":"276","author":"Jiang","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.toxicon.2015.10.011_bib16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.biochem.68.1.459","article-title":"Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells","volume":"68","author":"Kaibuchi","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.toxicon.2015.10.011_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.vascn.2010.09.001","article-title":"Validation of a cell-based assay to differentiate between the cytotoxic effects of elapid snake venoms","volume":"63","author":"Kalam","year":"2011","journal-title":"J.\u00a0Pharmacol. Toxicol. Methods"},{"issue":"2","key":"10.1016\/j.toxicon.2015.10.011_bib18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4062\/biomolther.2013.103","article-title":"Enhanced anti-cancer effect of snake venom activated NK cells on lung cancer cells by inactivation of NF-\u03baB","volume":"22","author":"Kollipara","year":"2014","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.toxicon.2015.10.011_bib19","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2015.10.011_bib20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cca.2005.02.008","article-title":"The variability of Vipera ammodytes ammodytes venoms from Croatia\u2013biochemical properties and biological activity","volume":"140","author":"Lang Balija","year":"2005","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.toxicon.2015.10.011_bib21","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1038\/sj.onc.1203553","article-title":"Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway","volume":"19","author":"Lassus","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.toxicon.2015.10.011_bib22","first-page":"63","article-title":"Acute myocardial infarction complicating snake bite","volume":"52","author":"Maheshwari","year":"2004","journal-title":"J.\u00a0Assoc. Physicians India"},{"key":"10.1016\/j.toxicon.2015.10.011_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0041-0101(94)00133-S","article-title":"A\u00a0major lethal factor of the venom of Burmese Russell's viper (Daboia russelli siamensis): isolation, N-terminal sequencing and biological activities of daboiatoxin","volume":"33","author":"Maung Maung","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2015.10.011_bib24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.201009059","article-title":"p53 and its mutants in tumor cell migration and invasion","volume":"192","author":"Muller","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.toxicon.2015.10.011_bib25","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1046\/j.1432-1327.2000.01606.x","article-title":"Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity","volume":"267","author":"O'Brien","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2015.10.011_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1590\/S1678-91992004000300004","article-title":"Biochemical and morphological analysis of cell death induced by Egyptian cobra (Naja haje) venom on cultured cells","volume":"10","author":"Omran","year":"2004","journal-title":"J.\u00a0Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2015.10.011_bib27","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.82.17.5791","article-title":"In\u00a0vitro screening assay for teratogens using growth inhibition of human embryonic cells","volume":"82","author":"Pratt","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2015.10.011_bib28","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1093\/carcin\/bgh213","article-title":"Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it","volume":"25","author":"Rashmi","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.toxicon.2015.10.011_bib29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1007429904664","article-title":"Apoptosis: identification of dying cells","volume":"14","author":"Renvoize","year":"1998","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.toxicon.2015.10.011_bib30","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/ncb1019","article-title":"Differing modes of tumour cell invasion have distinct requirements for Rho\/ROCK signalling and extracellular proteolysis","volume":"5","author":"Sahai","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.toxicon.2015.10.011_bib31","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.4161\/cc.8.10.8490","article-title":"Rho-GTPase signaling drives melanoma cell plasticity","volume":"8","author":"Sanz-Moreno","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.toxicon.2015.10.011_bib32","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1158\/1535-7163.MCT-06-0328","article-title":"Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor kappaB","volume":"6","author":"Son","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.toxicon.2015.10.011_bib33","first-page":"145","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"24","author":"Towbin","year":"1992","journal-title":"Biotechnology"},{"key":"10.1016\/j.toxicon.2015.10.011_bib34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","article-title":"Surfing the p53 network","volume":"408","author":"Vogelstein","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2015.10.011_bib35","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1016\/j.lfs.2005.01.001","article-title":"Induction of apoptosis in human leukemia K562 cells by cardiotoxin III","volume":"76","author":"Yang","year":"2005","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.toxicon.2015.10.011_bib36","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.tiv.2007.04.008","article-title":"A\u00a0cytotoxin isolated from Agkistrodon acutus snake venom induces apoptosis via Fas pathway in A549 cells","volume":"21","author":"Zhang","year":"2007","journal-title":"Toxicol. In\u00a0Vitro"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010115301148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010115301148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T03:25:33Z","timestamp":1537241133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010115301148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":36,"alternative-id":["S0041010115301148"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2015.10.011","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Russell's viper venom affects regulation of small GTPases and causes nuclear damage","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2015.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}